A novel, major, and validated QTL for grain zinc concentration independent of yield traits in tetraploid wheat by Zhaoyong Zeng, Jian Ma, Bingjie Chen, Huaping Tang, Xin Xian, Yuanfeng Huo, Yinggang Xu, Xiaoyan Tang, Xuesong Gao, Guangdeng Chen

“…A linkage map was constructed based on the wheat 55K single‐nucleotide polymorphism array, and phenotypic data were collected from five different environments. …”
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SIRE 2.0: a novel method for estimating polygenic host effects underlying infectious disease transmission, and analytical expressions for prediction accuracies by Christopher M. Pooley, Glenn Marion, Jamie Prentice, Ricardo Pong-Wong, Stephen C. Bishop, Andrea Doeschl-Wilson

“…Analytical expressions for prediction accuracies (PAs) for these traits are derived for simplified scenarios, revealing their dependence on genetic and phenotypic variances, and the distribution of related individuals within and between contact groups. …”
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Metformin reduces the risk of frailty: evidence from a Mendelian randomization study by Tong Chen, Yan-Lan Liu, Hui-Na Qiu, Chen-Ying Lin, Fan Wu, Jing-Bo Li, Jing-Na Lin

“…In the MR analysis, the inverse variance weighted method served as the primary analytical approach, supplemented by sensitivity analyses. …”
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A genome-wide metabolic QTL analysis in Europeans implicates two loci shaped by recent positive selection. by George Nicholson, Mattias Rantalainen, Jia V Li, Anthony D Maher, Daniel Malmodin, Kourosh R Ahmadi, Johan H Faber, Amy Barrett, Josine L Min, N William Rayner, Henrik Toft, Maria Krestyaninova, Juris Viksna, Sudeshna Guha Neogi, Marc-Emmanuel Dumas, Ugis Sarkans, MolPAGE Consortium, Peter Donnelly, Thomas Illig, Jerzy Adamski, Karsten Suhre, Maxine Allen, Krina T Zondervan, Tim D Spector, Jeremy K Nicholson, John C Lindon, Dorrit Baunsgaard, Elaine Holmes, Mark I McCarthy, Chris C Holmes

“…The study's longitudinal twin design allowed detailed variance-components analysis of the sources of population variation in metabolite levels. …”
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Establishing the relationships between obesity and genetically predicted serum micronutrient levels: a multivariable Mendelian randomization analysis by Rui Zhou, Yanxiang Zhang, Jiazhi Wang, Huacong Huang, Tianyou Liao, Weisheng Lai, Yongle Ju, Manzhao Ouyang

“…Three obesity-related datasets were obtained from the GWAS. Inverse variance weighted (IVW) is the main method used for MR analysis. …”
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Appraising the causal effects of circulating micronutrients on liver cirrhosis: Evidence from large‐scale Mendelian randomization analysis by Junlong Lin, Jialin Chen, Zhichao Li, Baifeng Qian, Yunpeng Hua

“…Primary analyses used random effects and inverse variance weighted (IVW) methods, with additional sensitivity analyses for validation. …”
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Celiac Disease and Skin Diseases: A Bidirectional Mendelian Randomization Study by Ge C, Wang Y, Zhao X, Hao J, Zhang J, Lu M, Li C, Feng J, Zhang Q

“…Therefore, this Mendelian randomization (MR) study evaluated the causality between CD and skin diseases.Methods: Bidirectional MR analysis was performed on single nucleotide polymorphism (SNP) candidates identified from genome-wide association study (GWAS) datasets using inverse variance weighted (IVW), weighted median, MR-egger, weighted mode and simple mode. …”
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Causal association between plasma proteins and lung adenocarcinoma: a two-sample mendelian randomization study by Weiyuan Zhang, Nan Chen, Changxi Li, Xitian Su, Zhuo Fu, Youshuang Zhong, Huojin Deng

“…The main analytical methods used are inverse-variance weighted (IVW) or Wald ratio to assess the causal relationship between circulating plasma protein levels and lung adenocarcinoma. …”
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Causal Associations of Sleep Apnea With Alzheimer Disease and Cardiovascular Disease: A Bidirectional Mendelian Randomization Analysis by Clémence Cavaillès, Shea J. Andrews, Yue Leng, Aadrita Chatterjee, Iyas Daghlas, Kristine Yaffe

“…Our primary analytic method was fixed‐effects inverse variance–weighted (IVW) Mendelian randomization; diagnostics tests and sensitivity analyses were conducted to verify the robustness of the results. …”
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Inflammatory cytokines and oral cancer risk: an integrated study combining two-sample Mendelian randomization with experimental validation by Yinhua Xia, Guanqun Wan, Simin Li, Shaonan Hu, Guohui Wu

“…Inverse-variance weighted analysis was used as the primary method, supplemented by MR Egger, weighted median, simple and weighted mode methods. …”
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Genetic Diversity and Population Structure of Cacao (<i>Theobroma cacao</i> L.) Germplasm from Sierra Leone and Togo Based on KASP–SNP Genotyping by Ranjana Bhattacharjee, Mohamed Mambu Luseni, Komivi Ametefe, Paterne A. Agre, P. Lava Kumar, Laura J. Grenville-Briggs

“…Analysis of molecular variance (AMOVA) revealed high genetic diversity (86%) within accessions. …”
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Association of diuretics with falls and wrist fractures: a Mendelian randomization study by Fei Liu, Jun-ze Dai, Xiao-xi Deng, Ren-shuang Cao, Yong-zhong Cheng, Chao-lu Wang

“…Therefore, in this study, we determined the association of diuretics with falls and wrist fractures by Mendelian randomization.MethodsWe used a two-sample Mendelian randomization (MR) approach to evaluate the effects of the loop diuretics\potassium-sparing diuretics\thiazide diuretics (LDs\PSDs\TDs) on the risk of falls and wrist fracture using the three diuretic-associated genetically-predicted single nucleotide polymorphisms (SNPs) as genetic tools. The inverse variance weighting (IVW) method was used as the main evaluation method, with odds ratio (OR) as the evaluation criterion. …”
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Homocysteine and coronary heart disease: meta-analysis of MTHFR case-control studies, avoiding publication bias. by Robert Clarke, Derrick A Bennett, Sarah Parish, Petra Verhoef, Mariska Dötsch-Klerk, Mark Lathrop, Peng Xu, Børge G Nordestgaard, Hilma Holm, Jemma C Hopewell, Danish Saleheen, Toshihiro Tanaka, Sonia S Anand, John C Chambers, Marcus E Kleber, Willem H Ouwehand, Yoshiji Yamada, Clara Elbers, Bas Peters, Alexandre F R Stewart, Muredach M Reilly, Barbara Thorand, Salim Yusuf, James C Engert, Themistocles L Assimes, Jaspal Kooner, John Danesh, Hugh Watkins, Nilesh J Samani, Rory Collins, Richard Peto, MTHFR Studies Collaborative Group

“…Within the meta-analysis of published studies, the OR was 1.12 (1.04-1.21) in the 14 larger studies (those with variance of log OR<0.05; total 13,119 cases) and 1.18 (1.09-1.28) in the 72 smaller ones (total 15,498 cases).…”
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Association between thyroid dysfunction and diabetic retinopathy: a two-sample bidirectional Mendelian randomization study by Jiali Chen, Jianghao Xiong, Fenfen Zhang, Wanyu Pan, Shaomin Cheng

“…Methods: The main analytical approach employed inverse variance weighting(IVW), supplemented by MR-Egger, Weighted mode method, weighted median, and Simple mode. …”
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Chemical composition and anti-microbial potential of essential oils from morphologically distinct Salvia rosmarinus (Spenn.) cultivars from Kashmir, India by Nafeesa Farooq Khan, Abid Bashir, Khursheed Ahmad Ganaie, Sumaya Quadir Shah, Romaan Nazir, Phalisteen Sultan, Qazi Parvaiz Hassan

“…Abundance distribution data displayed polymorphism in evaluated character/traits of rosemary accessions and a total of 21 classes were reported from an underrepresented region. …”
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Genetic insights into blood urea nitrogen as a risk factor for coronary artery disease: a Mendelian randomization study in East Asians by Lijuan Shen, Qianxin Zhang, Zhouyang Zhu, Zhouqing Huang

“…To ensure robustness, multiple MR methods, including MR-Egger, weighted median, inverse variance weighting (IVW), simple mode, and weighted mode, were employed to evaluate the causal relationship between BUN levels and CVDs. …”
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Mendelian randomization analysis of inflammatory biomarkers and hepatocellular carcinoma risk: genetic causality and single-cell transcriptomics by GuangXin Shao, Xiao Yun, Hongyue Xie, Beicheng Sun

“…Over 20–30 single nucleotide polymorphisms (SNPs) were employed as instrumental variables for each biomarker. …”
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Lipid‐Lowering Drugs and Pulmonary Vascular Disease: A Mendelian Randomization Study by Xingya Yuan, Peiwei Hong, JinQiu Zhou

“…Single‐nucleotide polymorphisms (SNPs) within or near drug target‐associated LDL‐C loci were selected as proxies for the lipid‐lowering drugs. …”
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Exploring the Impact of Neuroticism on Lung Cancer Risk: Insights From Mediated Mendelian Randomization by Jie Zhang, Xiao Ma, Zhiyu Liu, He Wang, Binbin Lu, Zhaoxia Wang

“…We applied four statistical methods: Inverse variance weighting (IVW), weighted median, MR‐Egger regression, and weighted mode. …”
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Causal relationships of anxiety, depression and neuroticism with recurrent spontaneous abortion: a Mendelian randomization analysis by YUAN Hao, YUAN Hao, LI Xiao, LI Xiao

“…Methods Genome-wide association study (GWAS) data were used to extract single nucleotide polymorphisms (SNPs) closely related to anxiety, depression and neuroticism as instrumental variables (IVs). …”
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