Genetically Predicted Causal Relationship between Gut Microbiota and Various Kidney Diseases by Zi-Jin Chen, Rui Wang, Meng-Ying Yao, Jing-Hong Zhao, Bo Liang

“…Results: We identified 1,531 single-nucleotide polymorphisms. There were 6 positive and 9 negative causal effects between gut microbiota and three types of kidney diseases. …”
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Association Between Educational Attainment and Chronic Pain: A Mediation Mendelian Randomization Study by Wang H, Liu M, Li H, Xu S

“…Inverse-variance weighted (IVW), weighted median, penalized weighted median, maximum likelihood (ML), and MR-Egger methods were used to estimate causal effects. …”
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Antagonistic genetic correlations for milking traits within the genome of dairy cattle. by Olivier Gervais, Ricardo Pong-Wong, Pau Navarro, Chris S Haley, Yoshitaka Nagamine

“…Furthermore, regional genomic mapping can be used to estimate regional variance and clarify the genomic relationships within and outside regions but has not previously been applied to milk traits in cattle. …”
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The role of preeclampsia in breast cancer risk: insights from Mendelian randomization study by Chenfei Qian, Ganwei Xiong, Shihao Hong, Linzhe Miao, Yitao Guo

“…A two-sample Mendelian randomization (TSMR) approach was applied, primarily using inverse variance weighting (IVW) to assess the causal impact of preeclampsia on breast cancer risk. …”
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Mediating factors between autoimmune thyroiditis and breast cancer: a bidirectional Mendelian randomization study by Pei Xin, Lei Wang, Xianyang Chen, Huazhi Li, Nan Jiang

“…Inverse variance weighted (IVW) is adopted as the main method. …”
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Severe traumatic brain injury and risk for osteoporosis: a Mendelian randomization study by Guoqiang Wang, Jiachen Wang, Dinglong Yang, Lin Liu, Peng Xu

“…Single nucleotide polymorphisms (SNPs) that underwent strict screening were regarded as instrumental variables. …”
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Genetic diversity and population structure in banana (Musa spp.) breeding germplasm by Violet Akech, Therése Bengtsson, Rodomiro Ortiz, Rony Swennen, Brigitte Uwimana, Claudia F. Ferreira, Delphine Amah, Edson P. Amorim, Elizabeth Blisset, Ines Van den Houwe, Ivan K. Arinaitwe, Liana Nice, Priver Bwesigye, Steve Tanksley, Subbaraya Uma, Backiyarani Suthanthiram, Marimuthu S. Saraswathi, Hassan Mduma, Allan Brown

“…Analysis of molecular variance displayed low genetic variation among accessions and diploids and a higher variation among tetraploids (p < 0.001). …”
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Genetic relationship analysis and core collection construction of Eucalyptus grandis from Dongmen improved variety base: the largest eucalypt germplasm resource in China by Chenhe Li, Lei Zhang, Zhibang Peng, Xia Li, Zhao Liu, Te Lu, Xiangyang Kang, Jun Yang

“…Additionally, the analysis of molecular variance (AMOVA) indicated that the majority of variation occurred within populations. …”
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Nighttime fluorescence phenotyping reduces environmental variability for photosynthetic traits and enables the identification of candidate loci in maize by Fangyi Li, Fangyi Li, Fangyi Li, Marcin Grzybowski, Marcin Grzybowski, Marcin Grzybowski, Rebecca L. Roston, Rebecca L. Roston, James C. Schnable, James C. Schnable

“…Four of the significant signal nucleotide polymorphisms identified in GWAS conducted using nighttime collected data also exhibited statistically significant associations with the same phenotypes during the day. …”
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Causal Relationship between Gut Microbiota and Pulmonary Embolism: An Analysis Using Mendelian Randomization by CEN LILAN, QIN LING, CHEN WANLING, WEI LIHUA, TANG CAIXIA, TENG XIANG, TIAN ZHE

“…The principal analytical methodology utilized in this research was inverse variance weighting (IVW), complemented by assessments for pleiotropy and heterogeneity to confirm the results’ resilience. …”
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Causal associations between inflammatory bowel disease and sepsis: a two-sample Mendelian randomization study by Renyang Tong, Ziting Liang, Chengui Zhuo, Xueyang Bai, Ling Dao, Lu Yu, Ling Li, Zhaohui Tong, Youyou Du, Longwei Xu

“…Methods A genome-wide significant threshold (P < 5 × 10–8) was achieved in order to identify single nucleotide polymorphisms (SNPs) as instrumental variables (IVs) for two types of IBD, such as Crohn's disease (CD) and ulcerative colitis (UC). …”
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Causal relationship between gastroesophageal reflux disease and the risk of chronic suppurative otitis media: a mendelian randomization analysis by Qianyou Zheng, Ce Wu, Yaru Li, Jing Wu, Wenrui Tang, Qiuyang Zhu, Shaokang Ren, Xiaowen Zhang, Shenling Li, Tao Fu

“…Independent single nucleotide polymorphisms, rigorously screened as instrumental variables, were used in the analysis. …”
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Causal association between non-thyroidal autoimmune diseases and Graves' ophthalmopathy: A mendelian randomization study by Lan Ma, Xue Jiang, Zhijia Hou, Dongmei Li

“…Bidirectional MR analysis was conducted using inverse variance weighted (IVW) method, weighted median (WM) method and MR-Egger test. …”
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Pan-cancer analysis of the impact of fatty acids: a two-sample and multivariable Mendelian randomization study by Xiaogen Kuang, Bingquan Wu, Dan Hu, Juliet Matsika, Chunliang Cheng, Jiatong Xiao, Zhiyong Cai, Mingyong Li, Jinbo Chen, Weimin Zhou, Bolong Liu

“…Methods Single nucleotide polymorphisms (SNPs) significantly associated with circulating FAs were selected from 500,000 UK Biobank blood samples and 114,999 plasma samples from a large GWAS. …”
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Picolinate-mediated immunomodulation: insights from Mendelian randomization on the role of NK cell percentage in the pathogenesis of lichen planus by Jianye Cao, Tiantao Du, Jian Li, Baiyu Chen, Xianting Xie, Guoshu Zhang, Jia Feng, Tao Xu

“…Leveraging summary statistics from genome-wide association studies (GWAS) involving 731 immune cell traits (N = 3757), 1091 plasma metabolite traits (N = 8299), and lichen planus (N = 367668), inverse variance weighting (IVW) is adopted as the primary MR analytical method. …”
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From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture by Gongzi Zhang, Juan Zheng, Ying Zhou, Ming Zhou, Jiali Zhang, Yangxiaoxue Liu, Yuhan Geng, Wenxin Wang, Min Xin, Bo Yang, Lihai Zhang, Liping Huang

“…The estimates were primarily derived using inverse variance weighted (IVW) methods. Sensitivity analyses included weighted median, MR-egger, and Leave-one-out test. …”
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Bidirectional Mendelian randomization study of the relationship between brain imaging-derived phenotypes and obstructive sleep apnea by ZHANG Huihua, GAN Jing, HOU Miaomiao, LU Na

“…Twenty-seven single nucleotide polymorphisms (SNPs) were screened out as instrumental variables of OSA. …”
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Mendelian Randomization Study Investigating the Causal Relationship Between Thyroid Dysfunction and Cerebral Infarction by Letai Li, Jiajie Leng, Haibing Xiong, Zishan Deng, Meng Ye, Haiyan Wang, Xin Guo, Shi Zeng, Haofeng Xiong, Jianhong Huo

“…For the forward MR analysis, the exposures were hyperthyroidism, hypothyroidism, TSH, and FT4. The inverse variance weighted (IVW) method, weighted median (WM), and MR‐Egger revealed the causality with CI. …”
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CYP2C19 variability and clinical outcomes of clopidogrel, proton pump inhibitors, and voriconazole in Southeast Asia: a systematic review and meta-analysis by Harri Hardi, Agian Jeffilano Barinda, Agian Jeffilano Barinda, Liganda Endo Mahata, Liganda Endo Mahata, Zahra Fitrianti

“…IntroductionPolymorphism in CYP2C19 is more prevalent in East Asia than in other regions of the world. …”
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Genome-wide association studies of serum magnesium, potassium, and sodium concentrations identify six Loci influencing serum magnesium levels. by Tamra E Meyer, Germaine C Verwoert, Shih-Jen Hwang, Nicole L Glazer, Albert V Smith, Frank J A van Rooij, Georg B Ehret, Eric Boerwinkle, Janine F Felix, Tennille S Leak, Tamara B Harris, Qiong Yang, Abbas Dehghan, Thor Aspelund, Ronit Katz, Georg Homuth, Thomas Kocher, Rainer Rettig, Janina S Ried, Christian Gieger, Hanna Prucha, Arne Pfeufer, Thomas Meitinger, Josef Coresh, Albert Hofman, Mark J Sarnak, Yii-Der Ida Chen, André G Uitterlinden, Aravinda Chakravarti, Bruce M Psaty, Cornelia M van Duijn, W H Linda Kao, Jacqueline C M Witteman, Vilmundur Gudnason, David S Siscovick, Caroline S Fox, Anna Köttgen, Genetic Factors for Osteoporosis Consortium, Meta Analysis of Glucose and Insulin Related Traits Consortium

“…Study-specific results were combined using fixed-effects inverse-variance weighted meta-analysis. SNPs demonstrating genome-wide significant (p<5 x 10(-8)) or suggestive associations (p<4 x 10(-7)) were evaluated for replication in an additional 8,463 subjects of European descent. …”
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