Investigating bidirectional causal relationships between gut microbiota and insomnia by Fuquan Zhang, Ancha Baranova, Hongbao Cao, Shangyun Shi, Dongming Liu

“…Cochrane’s Q test indicated no significant heterogeneity between most single-nucleotide polymorphisms. In addition, no significant level of pleiotropy was found according to MR-Egger and MR-PRESSO.Conclusions Our study highlighted the reciprocal relationships between gut microbiota and insomnia, which may provide new insights into the treatment and prevention of insomnia.…”
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Exploring Causality Between Bone Mineral Density and Cervical Spondylosis: Bidirectional and Multivariable Mendelian Randomization Study by Mao W, Wu L

“…Single Nucleotide Polymorphisms (SNPs) that had a significant genetic association with exposures were used as instrumental variables (IVs). …”
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The effects of coagulation factors on the risk of lung cancer: a Mendelian randomization study by Heran Zhou, Xinye Mao, Junhua Guo, Xuefei Yang, Ting Huang

“…Bidirectional two sample MR analyses were performed using genome-wide significant single nucleotide polymorphisms (SNPs) as instrumental variables. To evaluate bidirectional causality between 14 coagulation factors and LC, including its subtypes, we applied multiple analytical methods, including inverse variance weighting (IVW), MR-Egger, weighted median, weighted mode, and simple mode. …”
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Mendelian randomization study of self-reported long sleep duration, short sleep duration, and insomnia and cognitive function. by Yunyun Guo

“…MR estimation was performed using the inverse variance weighted (IVW) method as the primary method, supplemented by MR-Egger regression and weighted median estimator methods. …”
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Unveiling the genetic association between rheumatoid arthritis and four common hand pathologies by Zhengtao Lv, Yujie Yang, Yuan Bao, Chunchu Deng

“…Leave-one-out analyses demonstrated that no individual single nucleotide polymorphism (SNP) significantly impacted RA's overall causal effect estimates on CTS and TF. …”
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Genetically proxied inhibition of Phosphodiesterase-5 and cancer risks: A drug-target Mendelian randomization analysis by Kefu Tang, Binbin Li, Xi Wu, Meng Wang

“…Uncorrelated (linkage disequilibrium [LD] r2 < 0.001) single-nucleotide polymorphisms (SNPs) in PDE5A gene associated (P < 5.0 × 10−8) with circulating levels of PDE5A protein identified from UKB-PPP were used as genetic instrument to mimic the action of PDE5 inhibition. …”
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Coffee consumption and risk of breast cancer: A Mendelian randomization study. by Merete Ellingjord-Dale, Nikos Papadimitriou, Michail Katsoulis, Chew Yee, Niki Dimou, Dipender Gill, Dagfinn Aune, Jue-Sheng Ong, Stuart MacGregor, Benjamin Elsworth, Sarah J Lewis, Richard M Martin, Elio Riboli, Konstantinos K Tsilidis

“…Random-effects inverse variance weighted (IVW) MR analyses were performed along with several sensitivity analyses to assess the impact of potential MR assumption violations.…”
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Causal effects between gut microbiota and endometriosis: a two-sample Mendelian randomisation study by Tiefeng Cao, Yunfei Wang, Shen Huimin

“…Initially, a two-sample Mendelian randomisation (MR) analysis was performed to identify specific bacteria associated with endometriosis. Inverse variance-weighted (IVW) was used as the main MR analysis to infer causal relationships. …”
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COVID-19 infection may reduce serum testosterone levels and increase the risk of erectile dysfunction: A two-sample Mendelian randomization study by Ting Wang, Chao Li, Jinbo Song

“…Materials and Methods: Summary-level data for serum testosterone levels (199,569 samples and 12,321,875 single nucleotide polymorphisms [SNPs]) were obtained from Rebecca's study, while data for ED (6,175 cases and 217,630 controls) were sourced from Bovijn's study. …”
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Genome-wide association study of cassava starch paste properties. by Cristiano Silva Dos Santos, Massaine Bandeira Sousa, Ana Carla Brito, Luciana Alves de Oliveira, Carlos Wanderlei Piler Carvalho, Eder Jorge de Oliveira

“…The GWAS was performed using 23,078 single-nucleotide polymorphisms (SNPs). The rapid viscoanalyzer (RVA) parameters were pasting temperature (PastTemp), peak viscosity (PeakVisc), hot-paste viscosity (Hot-PVisc), cool-paste viscosity (Cold-PVisc), final viscosity (FinalVis), breakdown (BreDow), and setback (Setback). …”
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Association between mild cognitive impairment and APOE Ɛ4, low education level, and lack of spousal relationship in community-dwelling older persons in Nigeria by Isyaku Gwarzo Mukhtar, Mohamed Mabrouk Elkhashab, Muhammad Ali Salim, Salisu Ahmed Ibrahim, Isyaku Umar Yarube

“…Aims: This study aimed to determine the sex-related differences in mild cognitive impairment (MCI) and its association with apolipoprotein E (APOE) polymorphism and sociodemographic factors amongst community-dwelling older persons in Kano, Nigeria. …”
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Navigating Host Immunity and Concurrent Ozone Stress: Strain‐Resolved Metagenomics Reveals Maintenance of Intraspecific Diversity and Genetic Variation in Xanthomonas on Pepper by Amanpreet Kaur, Ivory Russell, Ranlin Liu, Auston Holland, Rishi Bhandari, Neha Potnis

“…We observed increased disease severity with greater variance on the resistant cultivar under elevated O3, yet no apparent change on the susceptible cultivar. …”
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Unraveling the Controversy: The Causal Link Between Osteoarthritis and Alzheimer's Disease by Jingkai Di, Yujia Xi, Yaru Liu, Likun Qi, Tingting Chen, Shuai Chen, Chuan Xiang

“…Inverse variance weighting (IVW) was used to assess these causal relationships, and meta‐analysis was used to combine MR results from multiple IVWs. …”
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Causality Between 91 Circulating Inflammatory Proteins and Various Asthma Phenotypes: A Mendelian Randomization Study by Zhang S, Zhang X, Wei C, Zhang L, Li Z

“…Various asthma phenotypes were derived from the FinnGen Biobank. Inverse variance weighting (IVW) was used as the main method for MR Analysis, supplemented by Mr-Egger, Weighted median, Simple mode, and Weighted mode. …”
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Blood metabolites, mitochondrial biofunction, and cervical cancer: a bidirectional Mendelian randomization study by Chongze Yang, Lan-hui Qin, Liwei Li, Meng-na Lan, Qiu-ying Wei, Yi Li, Jin-yuan Liao

“…The study employed single nucleotide polymorphisms (SNPs) as instrumental variables and utilizes Inverse Variance Weighted (IVW), MR Egger, and Weighted Median methods for Mendelian randomization analysis. …”
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QTL mapping and candidate gene identification for fodder quality traits in Pearl millet by Harmanpreet Singh Daduwal, Ruchika Bhardwaj, Jaspal Singh Lamba, Yogesh Vikal, Rakesh K. Srivastava

“…A linkage map was constructed using 755 single-nucleotide polymorphisms (SNPs) markers, spanning a total length of 3080.44 cM. …”
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Tea intake and non-alcoholic fatty liver disease risk: A two-sample Mendelian randomization study by Cuncun Lu, Lixin Ke, Alexios-Fotios A. Mentis, Qiang Zhang, Ziyi Wang, Zhifei Wang

“…The random‐effects inverse‐variance weighted (IVW) was used as the primary approach for estimating the causal effect, and MR Egger, weighted median, simple mode, and weighted mode were used to verify the robustness of the primary results. …”
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Causal relationship between oral microbiota and epilepsy risk: Evidence from Mendelian randomization analysis in East Asians by Chenyang Zhao, Fei Chen, Qiong Li, Wei Zhang, Lixiu Peng, Chaoyan Yue

“…Single nucleotide polymorphisms (SNPs) independent of confounders served as instrumental variables (IVs) to deduce causality. …”
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Exploring the association between 91 circulating inflammatory proteins and the risk of carcinoid syndrome: a Mendelian randomization analysis by Jingzhi Wang, Simin Peng

“…In heterogeneity tests, the selected single-nucleotide polymorphisms (SNPs) did not show heterogeneity, and analysis using Egger intercept and MR-PRESSO test did not detect pleiotropy of SNPs, thus validating the reliability of the study. …”
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Genome-Wide Association Studies for Striga asiatica Resistance in Tropical Maize by Arthur Pfunye, Rwafa Rwafa, Stanford Mabasa, Edmore Gasura

“…The objective of this study was to identify single nucleotide polymorphism (SNP) markers for Striga resistance using the genome-wide association study (GWAS). …”
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