Inflammatory factor Interleukin-6 and its correlation with rheumatoid arthritis: A meta-analysis by Xiaojuan Hao, Huani Zhao, Linhui Zhu, Zhiteng Li, Jing Yang, Qian Bai

“…The search utilized keywords including “IL-6,” “Interleukin-6,” “Cytokines,” “Autoimmune diseases,” “Arthritis,” “rheumatoid arthritis,” “Inflammation,” “genetic polymorphism,” and “genetic variation.” Included studies focused on patients diagnosed with rheumatoid arthritis (RA), with healthy individuals or those without RA-related diseases as controls. …”
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Hydroxide and oxide of germanium(IV): synthesis and chemical-physical properties by E. E. Nikisihina, E. N. Lebedeva, A. V. Piletsky, D. V. Drobot

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Behcet's disease: demographic and genetic aspects (a literature review) by Fatima Ismailovna Izmailova, Z S Alekberova

“…A review of literature focused on Behcet's disease (BD) is presented. BD is systemic vasculitis of unknown etiology affecting multiple organs. …”
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Semantic Modeling for SNPs Associated with Ethnic Disparities in HapMap Samples by HyoYoung Kim, Won Gi Yoo, Junhyung Park, Heebal Kim, Byeong-Chul Kang

“…Single-nucleotide polymorphisms (SNPs) have been emerging out of the efforts to research human diseases and ethnic disparities. …”
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Family study of bipolar disorder with comorbid anxiety disorder points to THSD7A with possible role of parent‐of‐origin effect by Hiroaki Maki, Naomi Sakai, Muneko Kataoka, Kumiko Fujii, Yuki Kageyama, Takashi Hayama, Koji Matsuo, Masaki Nishioka, Tadafumi Kato

“…The family history of patients with BD with comorbid AS was assessed. Focusing on parent‐of‐origin effects and genomic imprinting from the results, imprinted genes and tested single nucleotide polymorphisms (SNPs) in the identified genes were investigated for an association with BD by transmission disequilibrium test (TDT) using published whole‐exome sequencing data. …”
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Porphyrins as Chiroptical Conformational Probes for Biomolecules by Gabriele Travagliante, Massimiliano Gaeta, Roberto Purrello, Alessandro D’Urso

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Research progress of genome-wide association study by Duan Zhongqu, Zhu Jun

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Impact of tumor necrosis factor-alpha gene variant in pediatric nephrotic syndrome: a meta-analysis by Yogalakshmi Venkatachalapathy, Praveenkumar Kochuthakidiyel Suresh, Thendral Hepsibha Balraj, Vettriselvi Venkatesan, Sangeetha Geminiganesan, Indira Bhagam, C. D. Mohana Priya

“…The primary goal of the meta-analysis was to investigate the relationship between Nephrotic Syndrome and the TNFα 308 G/A [rs1800629] polymorphism of the cytokine gene. We conducted a systematic search across electronic databases like PubMed and Google Scholar to collect data from five distinct case-control studies focused on the TNFα 308 G/A gene variant, covering the period from 2010 to 2022. …”
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Fibromyalgia as an interdisciplinary problem — the possibilities and prospects of diagnosis and treatment by O. V. Kolokolov, E. A. Salina, T. O. Kolokolova, E. V. Lukina, I. V. Sitkali

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THE REVOLUTION, WE HAVE ALMOST OVERSLEPT by D. A. Zateyshchikov, L. Monserrat

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THEORY OF INTEGRAL INDIVIDUALITY BY V. S. MERLIN: HISTORY AND NOWADAYS by B. A. Vyatkin, L. Ya. Dorfman

“…Next tasks can be set to further develop the theory of integral individuality. They focus on shift from the systemic viewpoint to a multi-systemic outline, to combine integrity and commonality, to provide an isomerism coming from the polymorphic framework.Practical significance. …”
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Treatment and Genotypic Characteristics of Patients with Rheumatoid Arthritis by Norbutoev Olimjon, Akhmedov Khalmurad, Abdurakhmanova Nargiza, Turaev Ikhtiyor

“…A key approach to addressing this problem is pharmacogenetics, which tailors treatments based on genetic characteristics. This study focuses on genotyping of MDR1 gene polymorphisms, specifically the C1236T, G2677T, and C3435T isoforms, in patients with RA. …”
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Cross‐Linked Protein Crystals With an Intense Nonconventional Full‐Color Photoluminescence Originating From Through‐Space Intermolecular Interaction by Renbin Zhou, Xiaoli Lu, Xuefeng Zhou, Xuejiao Liu, Shanmin Wang, Tymish Y. Ohulchanskyy, Da‐Chuan Yin, Junle Qu

“…We systematically investigated seven natural protein crystals (concanavalin, catalase, lysozyme, hemoglobin, α‐chymotrypsin, pepsin, and β‐lactoglobulin) cross‐linked with glutaraldehyde and demonstrated that cross‐linking induces broadband emission that is absent in natural crystals. Focusing on polymorphic lysozyme crystals (tetragonal, orthorhombic, and monoclinic), we found excitation‐dependent fluorescence with lifetimes in the nanosecond range and quantum yields up to 20% (in the monoclinic phase under 450 nm excitation). …”
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Computational Analysis of S1PR1 SNPs Reveals Drug Binding Modes Relevant to Multiple Sclerosis Treatment by Katarina Kores, Samo Lešnik, Urban Bren

“…While there is no known cure for MS, various disease-modifying treatments (DMTs) exist, including those targeting Sphingosine-1-Phosphate Receptors (S1PRs), which play important roles in immune response, CNS function, and cardiovascular regulation. This study focuses on understanding how nonsynonymous single nucleotide polymorphisms (rs1299231517, rs1323297044, rs1223284736, rs1202284551, rs1209378712, rs201200746, and rs1461490142) in the S1PR1’s active site affect the binding of endogenous ligands, as well as different drugs used in MS management. …”
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Computational Immunogenetic Analysis of Botulinum Toxin A Immunogenicity and HLA Gene Haplotypes: New Insights by Eqram Rahman, Parinitha Rao, Munim Ahmed, William Richard Webb, Jean D. A. Carruthers

“…This study applies computational immunogenetics to explore BoNT-A immunogenicity, focusing on HLA binding and the influence of accessory proteins. …”
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Genetic Associations of <i>TCF7L2</i> (<i>rs7903146</i>) and <i>PPARG</i> (<i>rs1801282</i>) with Prediabetes in the Ethnic Kazakh Population by Azhar Dyussupova, Gulnara Svyatova, Galina Berezina, Altay Dyussupov, Bauyrzhan Omarkulov, Anastassiya Dzharmukhametova, Oxana Yurkovskaya, Venera Akhmetova, Asylzhan Dyussupova

“…There was a significant increase in the risk of developing prediabetes for both the <i>rs1801282</i> polymorphism of the <i>PPARG</i> gene and the <i>rs7903146</i> polymorphism of the <i>TCF7L2</i> gene. …”
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Clinical pharmacogenetics of angiotensin II receptor blockers: new perspectives of pharmacotherapy individualization by D. A. Sychev, G. S. Anikin, V. G. Belolipetskaya, I. B. Ignatyev, V. G. Kukes

“…The review focuses on clinical practice perspectives for angiotensin II receptor blockers (ARB). …”
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Association between CAPN-10 gene variant and diabetes mellitus in Nigeria: a review by David Olufemi Adebo, Mathew Folaranmi Olaniyan, Christian Onosetale Ugege, Odekunle Bola Odegbemi

“…Aim and objective This study aimed to conduct a meta-analysis to investigate the associations of single nucleotide polymorphisms (SNPs) in the CAPN-10 gene with T2DM among various populations, focusing specifically on Nigerian cohorts. …”
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Computational analysis of congenital heart disease associated SNPs: unveiling their impact on the gene regulatory system by Shikha Vashisht, Costantino Parisi, Cecilia L. Winata

“…Concurrently, coding CHD-SNPs were represented as a protein interaction network and its subsequent binding energy analysis focused on a pair of proteins within this network, pinpointed a deleterious coding CHD-SNP, rs770030288, located in C2 domain of MYBPC3 protein. …”
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Genetic variants in TMPRSS2 influence SARS-CoV-2 infection susceptibility within Mexican Mestizos by Rebeca I. Montero, Cinthia L. Dionicio, Cinthia L. Dionicio, Gino Noris, Maricela Piña-Pozas, Maricela Piña-Pozas, Carla Santana, Rocío Gómez

“…Since host genetics is one of the primary factors contributing to COVID-19 susceptibility and its clinical progression, several studies have focused on analysing the implications of genetic polymorphisms associated with COVID-19. …”
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