GRK5 intronic (CA)n polymorphisms associated with type 2 diabetes in Chinese Hainan Island. by Zhenfang Xia, Tubao Yang, Zhuansuo Wang, Jianping Dong, Chunyan Liang

“…Further studies should focus on verifying these finding using a large sample size and analyzing the splicing mechanism of intronic (CA)n in rs10886471.…”
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Exploring the presence of the GPR126 single nucleotide polymorphism (rs536714306) in periodontal patients of European ancestry by Eirini Chatzopoulou, Galinos Fanourakis, Nikolaos Papanikolaou, Ioulia Chatzistamou, Xanthippi Dereka, Heleni Vastardis

“…This is the first focused report evaluating the presence of this polymorphism in periodontitis patients in a European population. …”
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Single nucleotide polymorphisms with cis-regulatory effects on long non-coding transcripts in human primary monocytes. by Jonas Carlsson Almlöf, Per Lundmark, Anders Lundmark, Bing Ge, Tomi Pastinen, Cardiogenics Consortium, Alison H Goodall, François Cambien, Panos Deloukas, Willem H Ouwehand, Ann-Christine Syvänen

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TIM3 and CTLA4 immune checkpoint polymorphisms are associated with acute myeloid leukemia in Saudi Arabia by Mashael Alqahtani, Ali Aljuaimlani, Jameel Al-Tamimi, Suliman Alomar, Lamjed Mansour

“…A significantly higher expression of TIM-3 in the blood of individuals with AML was observed.Conclusion This is the first study focusing on single nucleotide polymorphisms (SNPs) for CTLA-4 and TIM-3 in acute myeloid leukemia patients in a Saudi community and could be a potential new prognostic factor for this disease.…”
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Correlation of tumor necrosis factor-α and interleukin-1 single-nucleotide polymorphisms with the risk of migraine development by Guijiao Huang, Xin Dong, Xiaojiao Shao, Mengping Wu, Shan Gao, Yixuan Wang, Xinying Guan

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Synthesis and Characterization of New Organoammonium, Thiazolium, and Pyridinium Triiodide Salts: Crystal Structures, Polymorphism, and Thermal Stability by Madhushi Bandara, Khadijatul Kobra, Spencer R. Watts, Logan Grady, Connor Hudson, Claudina Veas, Timothy W. Hanks, Rakesh Sachdeva, Jorge Barroso, Colin D. McMillen, William T. Pennington

“…The structural features of the triiodide anion, Raman spectroscopic analysis, and melting and thermal decomposition behavior of the salts, as well as a computational analysis of the polymorphs, are discussed. The polymorphic pairs here are distinguished by symmetric versus asymmetric triiodide anions, as well as different packing patterns. …”
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Impact of CCL5 gene polymorphisms on coronary artery disease risk and severity in the context of diabetes mellitus by Hajer Foddha, Ikram Ben Jeddou, Hana Saoud, Saoussen Chouchene, Abdelhak Foddha, Besma Bel Haj Jrad, Hassen Ben Abdennabi, Amel Haj Khelil

“…This study examined the association of -403G/A and In1.1T/C polymorphisms in the CCL5 gene with CAD risk and severity, focusing on the role of diabetes mellitus (DM). …”
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A comprehensive integration of data on the association of ITPKC polymorphisms with susceptibility to Kawasaki disease: a meta-analysis by Atefeh Habibi, Hanieh Talebi, Reza Bahrami, Mohammad Golshan-Tafti, Amirhossein Shahbazi, Seyed Alireza Dastgheib, Azadeh Tahooni, Maryam Vafapour, Heewa Rashnavadi, Melina Pourkazemi, Maryam Yeganegi, Elnaz Sheikhpour, Hossein Neamatzadeh

“…Subgroup analysis indicated this polymorphism correlates with KD susceptibility in Asians but not in the Chinese population. …”
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Association of NCF2, NCF4, and CYBA Gene Polymorphisms with Rheumatoid Arthritis in a Chinese Population by Tian-Ping Zhang, Rui Li, Qian Huang, Han-Feng Pan, Dong-Qing Ye, Xiao-Mei Li

“…Objective. Recent studies have focused on the special roles of NADPH-oxidase in multiple autoimmune diseases. …”
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Haloxylon ammodendron adapts to desert environments through seed polymorphism during diaspore germination and seedling establishment by Ziyi Wang, Weizhi Chen, Minghao Yang, Lamei Jiang, Lamei Jiang, Ze Wang, Cai Ren, Cai Ren, Xianhua Zhang

“…Previous studies have mainly focused on annual plants; therefore, little is known about in perennial species, particularly in desert constructive plants.MethodsThis study investigated seed polymorphism in Haloxylon ammodendron, a foundational desert shrub critical for maintaining the stability of fragile arid ecosystems. …”
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Relationship between human evolution and neurally mediated syncope disclosed by the polymorphic sites of the adrenergic receptor gene α2B-AR. by Tomoyoshi Komiyama, Takatsugu Hirokawa, Kyoko Sato, Akira Oka, Hiroshi Kamiguchi, Eiichiro Nagata, Hiroshi Sakura, Kuniaki Otsuka, Hiroyuki Kobayashi

“…We focused on the following three genotypes of the repeat polymorphism site at Glu 301-303 in the α2B-AR gene: Glu12/12, Glu12/9, and Glu9/9. …”
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Polymorphic positions 349 and 725 of the autoimmunity-protective allotype 10 of ER aminopeptidase 1 are key in determining its unique enzymatic properties by Galateia Georgaki, Galateia Georgaki, Anastasia Mpakali, Anastasia Mpakali, Myrto Trakada, Athanasios Papakyriakou, Efstratios Stratikos, Efstratios Stratikos

“…ERAP1 allotype 10 is highly protective toward developing some forms of autoimmunity and displays unusual functional properties, including very low activity versus some substrates.MethodsTo understand the molecular mechanisms that underlie the biology of allotype 10, we studied its enzymatic and biophysical properties focusing on its unique polymorphisms V349M and Q725R.ResultsCompared to ancestral allotype 1, allotype 10 is much less effective in trimming small substrates but presents allosteric kinetics that ameliorate activity differences at high substrate concentrations. …”
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The role of interleukin 1 in the development of human diseases: focus on Anakinra (IL-1 receptor antagonist) by E. L. Nasonov, M. Yu. Samsonov

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GCKR Polymorphisms Increase the Risks of Low Bone Mineral Density in Young and Non‐Obese Patients With MASLD and Hyperuricemia by Tzu‐Hao Li, Yu‐Shin Huang, Chia‐Chen Ma, Shin‐Yu Tsai, Hung‐Cheng Tsai, Hsiao‐Yun Yeh, Hsiao‐Chin Shen, Shiao‐Ya Hong, Chien‐Wei Su, Hwai‐I Yang, Ying‐Ying Yang, Ming‐Chih Hou

“…This study aimed to investigate the genetic effects of risk single nucleotide polymorphisms (SNPs) on the occurrence of low BMD in patients with MASLD and HU, particularly focusing on relatively young or non‐obese populations. …”
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Lack of association between the TMPRSS6 gene polymorphism (rs855791) and anemia: a comprehensive meta-analysis by Jethendra Kumar Muruganantham, Ramakrishnan Veerabathiran

“…Methods: A thorough literature search was conducted across databases, including Embase, Google Scholar, and PubMed, focusing on studies investigating TMPRSS6 gene polymorphisms and anemia. …”
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Novel polymorphisms in the Alpha-Lactalbumin (Lalba) gene and analysis of gene expression in dairy buffaloes (Bubalus bubalis) of the Amazon by Cintia L. Santos, Elem C. Macedo Barra de Sousa, Rafaelle C. Guimarães, Juliana V. Figueiredo, Roberta d. Silva, Elizabeth M. Barbosa, Priscila di Paula B. Santana, Ednaldo d. Filho

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The rs13388259 Intergenic Polymorphism in the Genomic Context of the BCYRN1 Gene Is Associated with Parkinson’s Disease in the Hungarian Population by Sándor Márki, Anikó Göblös, Eszter Szlávicz, Nóra Török, Péter Balicza, Benjamin Bereznai, Annamária Takáts, József Engelhardt, Péter Klivényi, László Vécsei, Mária Judit Molnár, Nikoletta Nagy, Márta Széll

“…To date, approximately 50 genes have been implicated in PD pathogenesis, including both Mendelian genes with rare mutations and low-penetrance genes with common polymorphisms. Previous studies of low-penetrance genes focused on protein-coding genes, and less attention was given to long noncoding RNAs (lncRNAs). …”
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Global and population-specific association of MTHFR polymorphisms with preterm birth risk: a consolidated analysis of 44 studies by Maryam Vafapour, Hanieh Talebi, Mahsa Danaei, Maryam Yeganegi, Sepideh Azizi, Seyed Alireza Dastgheib, Reza Bahrami, Melina Pourkazemi, Fatemeh Jayervand, Amirhossein Shahbazi, Heewa Rashnavadi, Ali Masoudi, Amirmasoud Shiri, Hossein Neamatzadeh

“…Among these studies, 29 focused on the MTHFR C677T polymorphism, while 15 examined the MTHFR A1298C variant. …”
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Enhanced rice breeding with GLR1_CAPS marker for glabrous hull selection by Jae-Ryoung Park, Jeonghwan Seo, Chang-Min Lee, Hyeonso Ji, O-Young Jeong, Hyun-Su Park

“…Conclusions Overall, the GLR1_CAPS marker is an efficient and reliable tool for breeding programs focused on the development of glabrous rice varieties. …”
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Prediction of single nucleotide polymorphisms of RNA dependent RNA polymerase for the potato leafroll virus using computational and experimental approaches by Dalia G. Aseel, Ayaat M. Elmaghraby, Ali El-Far

“…These single nucleotide polymorphisms (SNPs) are not just statistical anomalies; they have real implications. …”
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