Meta-Analysis of Genome-Wide Association Studies Identifies Novel Functional CpG-SNPs Associated with Bone Mineral Density at Lumbar Spine by Chuan Qiu, Hui Shen, Xiaoying Fu, Chao Xu, Hongwen Deng

“…To search for additional genetic susceptibility loci underlying BMD variation, an effective strategy is to focus on testing of specific variants with high potential of functional effects. …”
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Genome Variability for the Development of Coronary Heart Disease in Type 2 Diabetes Mellitus: A Bibliometric Analysis by Bekenova NB, Vochshenkova TA, Zhylkybekova A, Ablakimova N, Mussin NM, Albayev RK, Kaliyev AA, Tamadon A

“…In numerous studies, it has been established that genetic polymorphism of genes influences the onset, progression, and complications of coronary heart disease (CHD) and type 2 diabetes mellitus (T2DM). …”
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Obesity impact on leukocyte telomere shortening and immune aging assessed by Mendelian randomization and transcriptomics analysis by Zhijun Feng, Jiacheng Li, Huimin Zhang, Shupeng Liu, Yinghui Wang, Meijuan Zhou, Zhenhua Ding, Lin Xiao

“…Additionally, we analyzed transcriptome sequencing data from peripheral blood mononuclear cells (PBMCs) across three groups: lean individuals, individuals with obesity before undergoing bariatric surgery, and individuals with obesity after surgery, and focus on the expression changes of cellular senescence and telomere dynamics related genes in PBMCs of individuals with obesity before and after weight loss intervention. …”
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Two new Loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and german study groups. by André Scherag, Christian Dina, Anke Hinney, Vincent Vatin, Susann Scherag, Carla I G Vogel, Timo D Müller, Harald Grallert, H-Erich Wichmann, Beverley Balkau, Barbara Heude, Marjo-Riitta Jarvelin, Anna-Liisa Hartikainen, Claire Levy-Marchal, Jacques Weill, Jérôme Delplanque, Antje Körner, Wieland Kiess, Peter Kovacs, Nigel W Rayner, Inga Prokopenko, Mark I McCarthy, Helmut Schäfer, Ivonne Jarick, Heiner Boeing, Eva Fisher, Thomas Reinehr, Joachim Heinrich, Peter Rzehak, Dietrich Berdel, Michael Borte, Heike Biebermann, Heiko Krude, Dieter Rosskopf, Christian Rimmbach, Winfried Rief, Tobias Fromme, Martin Klingenspor, Annette Schürmann, Nadja Schulz, Markus M Nöthen, Thomas W Mühleisen, Raimund Erbel, Karl-Heinz Jöckel, Susanne Moebus, Tanja Boes, Thomas Illig, Philippe Froguel, Johannes Hebebrand, David Meyre

“…In summary, we have completed a meta-analysis of two GWAS which both focus on extremely obese children and adolescents and replicated our findings in a large followed-up data set. …”
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Germline variants of the genes involved in NF-kB activation are associated with the risk of COPD and lung cancer development by Baranasic Jurica, Niazi Yasmeen, Chattopadhyay Subhayan, Rumora Lada, Ćorak Lorna, Dugac Andrea Vukić, Jakopović Marko, Samaržija Miroslav, Försti Asta, Knežević Jelena

“…Therefore, the aim of this study was to search for the potential overlapping genetic biomarkers, with a focus on single nucleotide polymorphisms (SNPs) located in the regulatory regions of immune-related genes. …”
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Association between chronic obstructive pulmonary disease and osteoporosis: Mendelian randomization combined with bibliometric analysis by Fangjun Yang, Huaming Wang, Miaomiao Liu, Shengtai Pei, Xiaoming Qiu

“…Methods Single nucleotide polymorphisms (SNPs) that have been found to be strongly associated with COPD were used as instrumental variables (IVs) in MR Analysis. …”
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Incorporating gene expression and environment for genomic prediction in wheat by Jia Liu, Jia Liu, Andrew Gock, Kerrie Ramm, Sandra Stops, Tanya Phongkham, Adam Norman, Russell Eastwood, Eric Stone, Shannon Dillon

“…In the search for improved methodologies that incorporate novel sources of variation for the assessment of genetic merit, GS remains a focus of crop breeding research globally. Here we explored the role transcriptome data could play in enhancing GS in wheat.MethodsAcross 286 wheat lines, we integrated phenotype and multi-omic data from controlled environment and field experiments including ca. 40K single nucleotide polymorphisms (SNP), abundance data for ca. 50K transcripts as well as meta-data (e.g. categorical environments) to predict individual genetic merit for two agronomic traits, flowering time and height. …”
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Mitochondrial genome insights into the spatio-temporal distribution and genetic diversity of Dendrobium hancockii Rolfe (Orchidaceae) by Zhenyu Hou, Zhenyu Hou, Mengting Wang, Mengting Wang, Mengting Wang, Yu Jiang, Yu Jiang, Qingyun Xue, Qingyun Xue, Wei Liu, Wei Liu, Zhitao Niu, Zhitao Niu, Xiaoyu Ding, Xiaoyu Ding

“…IntroductionWith its distinctive evolutionary rate and inheritance patterns separate from the nuclear genome, mitochondrial genome analysis has become a prominent focus of current research. Dendrobium hancockii Rolfe, a species of orchid with both medicinal and horticultural value, will benefit from the application of the fully assembled and annotated mitochondrial genome. …”
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Molecular clustering of patients with diabetes and pulmonary tuberculosis: A systematic review and meta-analysis. by Francles Blanco-Guillot, Guadalupe Delgado-Sánchez, Norma Mongua-Rodríguez, Pablo Cruz-Hervert, Leticia Ferreyra-Reyes, Elizabeth Ferreira-Guerrero, Mercedes Yanes-Lane, Rogelio Montero-Campos, Miriam Bobadilla-Del-Valle, Pedro Torres-González, Alfredo Ponce-de-León, José Sifuentes-Osornio, Lourdes Garcia-Garcia

“…Clustering of patients with DM in TB transmission chains should be investigated in areas where both diseases are prevalent and focus on specific contexts.…”
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Influence of puberty timing on adiposity and cardiometabolic traits: A Mendelian randomisation study. by Joshua A Bell, David Carslake, Kaitlin H Wade, Rebecca C Richmond, Ryan J Langdon, Emma E Vincent, Michael V Holmes, Nicholas J Timpson, George Davey Smith

“…The cardiometabolic traits examined were heavily lipid-focused and did not include hormone-related traits such as insulin and insulin-like growth factors.…”
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Variability in grain, flour, functional properties and protein profiling in newly developed wheat genotypes grown in temperate climate of Western Himalayas by Taha Mukhtar, Abida Jabeen, Syed Zameer Hussain, Raashid Ahmad Siddiqi, Shabir H. Wani, Anju Mahendru-Singh, Tawheed Amin, Quraazah A. Amin, Mohmad Sayeed Bhat

“…BackgroundSince wheat varieties and breeding lines developed by plant breeders in the western Himalayan region (Kashmir) have received limited attention with respect to their physical and protein quality characterization, the focus of the study is to evaluate the diversity in grain, flour and the various protein fractions in newly released wheat genotypes grown in temperate regions of the Western Himalayas.MethodsThe present study investigated the grain and flour quality in various newly developed advanced wheat genotypes, viz., KWQ-21-1, KWQ-21-2, KWQ-21-3, KWQ-21-4, SKW 374, KWQ-21-6, KWQ-21-7, and SKW 357, along with two released varieties (Shalimar Wheat-2 and Shalimar Wheat-3). …”
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Elucidating biogeographical patterns in Australian native canids using genome wide SNPs. by Kylie M Cairns, Laura M Shannon, Janice Koler-Matznick, J William O Ballard, Adam R Boyko

“…Conservation efforts on mainland Australia should focus on the SE dingo population that is under pressure from domestic dog hybridization and high levels of lethal control. …”
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Comparative Genomic Analysis of Tigecycline Resistance Development in Clinical Acinetobacter baumannii Isolates by Li X, Liu J, Zhang X, Li J, Xuan L, Yuan S, Li J, Sun Y, Du X

“…Whole-genome sequencing and comparative genomic analysis were performed to identify single nucleotide polymorphisms and small insertions/deletions between paired strains, aiming to pinpoint mutated genes. …”
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Shiga toxin-producing Escherichia coli illness in Aotearoa | New Zealand, 2016-2022: epidemiological, genomic and traditional typing analyses provide insight into a significant end... by Jacqueline Wright, David Duncan, Hugo Strydom, Shevaun Paine, Sarah Jefferies, Joep de Ligt, Joep de Ligt, Lucia Rivas, Michael Addidle, Michael Addidle, Adrian L. Cookson, Adrian L. Cookson, David Winter, Hilary Miller, Geraldine Casey, Geraldine Casey, Jing Wang

“…Single nucleotide polymorphism (SNP) analysis indicated that most STEC cases were sporadic as 5-SNP genomic clusters were uncommon. …”
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Emergence of antimicrobial resistance among invasive Haemophilus influenzae isolates in Belgium: epidemiology and genomic characterization by Ms Magali Wautier, Dr Ricardo El Nouwar, Mr Benoit Prevost, Ms Farida Ahajjam, Ms Ariane Deplano, Ms Rim Fekkak, Dr Nicolas Yin, Dr Maya Hites, Prof Delphine Martiny

“…A whole genome single nucleotide polymorphism (SNP) analysis demonstrated they had less than four SNPs of difference. …”
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Outbreaks of tularemia in Russia (1997–2023) by T. N. Demidova, T. V. Mikhailova, A. S. Semikhin, D. V. Tranquilevsky, E. A. Gurina, N. V. Sheenkov

“…With the cessation of human morbidity, the natural focus of tularemia does not cease to exist, and with a decrease in the number of vaccinated, and therefore susceptible to the pathogen, a threat of a new outbreak arises.Conclusions. …”
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A Review of Multidisciplinary Evidence on the Role of Urban Green Space in Improving the Sleep Quality of the Elderly by Ning KANG, Han XIE, Tao JIANG

“…Significant individual variations in these health benefits, influenced by genetics, are also identified. Genetically, polymorphisms in circadian rhythm genes influence sleep patterns of the elderly. …”
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H and D ∕ H analysis in olivine and wadsleyite with a multi-analytical approach combining Raman spectroscopy and ion and nuclear probes by A. Gautier, N. Bolfan-Casanova, B. Moine, H. Bureau, H. Khodja, A. C. Withers, L. Piani

“…Here we focus on the quantification of total H<span class="inline-formula">₂</span>O content, dissolved as hydroxyl (OH), as well as hydrogen isotopic composition, i.e. …”
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Cervical Cancer Genetic Susceptibility: A Systematic Review and Meta-Analyses of Recent Evidence. by Gabriela A Martínez-Nava, Julián A Fernández-Niño, Vicente Madrid-Marina, Kirvis Torres-Poveda

“…However, only a few polymorphisms have shown consistency among studies.<h4>Materials and methods</h4>We conducted a systematic review of all recent case-control studies focused on the evaluation of single nucleotide polymorphisms (SNPs) and CC risk, stringently following the "PRISMA" statement recommendations. …”
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Exploring the Temperature‐Dependent Structural Evolution of Mechanically Synthesized Na3PS4 Solid Electrolyte through In Situ X‐Ray Diffraction by Sergio Federico Mayer, Marta Mirolo, Alisson Andrea Iles Velez, Ove Korjus, Emmanuelle Suard, Laureline Lecarme, Jean‐Baptiste Ducros, Claire Villevieille

“…Herein, Na3PS4 thiophosphate solid electrolyte is focused on. While its tetragonal α phase is initially studied for Na solid‐state batteries, the impact of heat treatment and the phase transitions of amorphous and semicrystalline polymorphs obtained by mechanochemical synthesis remains poorly understood. …”
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