Accelerated epigenetic aging in Huntington’s disease involves polycomb repressive complex 1 by Baptiste Brulé, Rafael Alcalá-Vida, Noémie Penaud, Jil Scuto, Coline Mounier, Jonathan Seguin, Sina Vincent Khodaverdian, Brigitte Cosquer, Etienne Birmelé, Stéphanie Le Gras, Charles Decraene, Anne-Laurence Boutillier, Karine Merienne

“…We show accelerated de-repression of developmental genes in HD striatal neurons, involving histone re-acetylation and depletion of H2AK119 ubiquitination and H3K27 trimethylation marks, which are catalyzed by polycomb repressive complexes 1 and 2 (PRC1 and PRC2), respectively. …”
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ERK1/2 signalling dynamics promote neural differentiation by regulating chromatin accessibility and the polycomb repressive complex. by Claudia I Semprich, Lindsay Davidson, Adriana Amorim Torres, Harshil Patel, James Briscoe, Vicki Metzis, Kate G Storey

“…Importantly, ERK1/2 inhibition induces precocious neural gene transcription, and this involves dissociation of the polycomb repressive complex from key gene loci. …”
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Mariner Transposons Contain a Silencer: Possible Role of the Polycomb Repressive Complex 2. by Solenne Bire, Sophie Casteret, Benoît Piégu, Linda Beauclair, Nathalie Moiré, Peter Arensbuger, Yves Bigot

“…We also present experimental evidence that silencing is mainly achieved by co-opting the host Polycomb Repressive Complex 2 pathway. However, we observe that when PRC2 is impaired another host silencing pathway potentially takes over to maintain weak silencer activity. …”
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EZH1 as a key mediator of exercise-induced H3K27me3 and H3K4me3 in mouse skeletal muscle by Junya Shimizu, Naoki Horii, Yusuke Ono, Fuminori Kawano

“…The distribution of suppressor of zeste 12, a component of polycomb repressive complex 2, also increased at these sites, while the distribution of EZH2 decreased after training. …”
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Kicking against the PRCs - A Domesticated Transposase Antagonises Silencing Mediated by Polycomb Group Proteins and Is an Accessory Component of Polycomb Repressive Complex 2. by Shih Chieh Liang, Ben Hartwig, Pumi Perera, Santiago Mora-García, Erica de Leau, Harry Thornton, Flavia de Lima Alves, Juri Rappsilber, Suxin Yang, Geo Velikkakam James, Korbinian Schneeberger, E Jean Finnegan, Franziska Turck, Justin Goodrich

“…Consistent with this, immunoprecipitation and mass spectrometry (IP-MS) show that ALP1 associates, in vivo, with core components of POLYCOMB REPRESSIVE COMPLEX 2 (PRC2), a widely conserved PcG protein complex which functions as a H3K27me3 histone methyltransferase. …”
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Increased maternal genome dosage bypasses the requirement of the FIS polycomb repressive complex 2 in Arabidopsis seed development. by David Kradolfer, Lars Hennig, Claudia Köhler

“…The fertilization independent seed (FIS) Polycomb Repressive Complex 2 (PRC2) is essential for endosperm development; however, the underlying forces that led to the evolution of the FIS-PRC2 remained unknown. …”
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Correction: Kicking against the PRCs--A Domesticated Transposase Antagonises Silencing Mediated by Polycomb Group Proteins and Is an Accessory Component of Polycomb Repressive Comp... by Shih Chieh Liang, Ben Hartwig, Pumi Perera, Santiago Mora-García, Erica de Leau, Harry Thornton, Flavia de Lima Alves, Juri Rappsilber, Suxin Yang, Geo Velikkakam James, Korbinian Schneeberger, E Jean Finnegan, Franziska Turck, Justin Goodrich

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Involvement of Polycomb Repressive Complex 2 in Maturation of Induced Pluripotent Stem Cells during Reprogramming of Mouse and Human Fibroblasts. by Niusha Khazaie, Mohammad Massumi, Ping Wee, Mahdieh Salimi, Abdulshakour Mohammadnia, Moein Yaqubi

“…Interestingly, in addition to pluripotency factors, the polycomb repressive complex 2 (PRC2) members Ezh2, Eed, Jarid2, Mtf2, and Suz12 are crucially recruited during the maturation phase of reprogramming. …”
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CBX4 regulation of senescence and associated diseases: Molecular pathways and mechanisms by Qianxing Hu, Linming Su, Wanli Zhao, Yinuo Jin, Liang Jin, Yue Yang, Fangfang Zhang

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Retraction Notice to: Polycomb repressive complex 2 binds and stabilizes NANOG to suppress differentiation-related genes to promote self-renewal by Da-Wei Yeh, Cheng Liu, Juan Carlos Hernandez, Stanley M. Tahara, Hidekazu Tsukamoto, Keigo Machida

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RNA polymerase II primes Polycomb‐repressed developmental genes throughout terminal neuronal differentiation by Carmelo Ferrai, Elena Torlai Triglia, Jessica R Risner‐Janiczek, Tiago Rito, Owen JL Rackham, Inês de Santiago, Alexander Kukalev, Mario Nicodemi, Altuna Akalin, Meng Li, Mark A Ungless, Ana Pombo

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The expression and role of SUZ12 in lung adenocarcinoma by Xingsheng Hu, Chunhong Hu, Ping Zhong

“…Abstract Background SUZ12 is one of the core members of the polycomb repressive complex 2 (PRC2), but its expression and role in lung adenocarcinoma (LUAD) are unclear. …”
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EZH2: A Crucial Competing Endogenous RNA in Cancer Research-A Scoping Review by Sadra Salehi-Mazandarani, Sharareh Mahmoudian-Hamedani, Ziba Farajzadegan, Parvaneh Nikpour

“…Enhancer of zeste 2 polycomb repressive complex 2 subunit (EZH2) is a ceRNA that has been introduced as a potential therapeutic target in many cancers. …”
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Epigenetic and Immune Profile Characteristics in Sinonasal Undifferentiated Carcinoma by Hyang Joo Ryu, Chung Lee, Sun Och Yoon

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BMI1 regulates human erythroid self-renewal through both gene repression and gene activation by Kathleen E. McGrath, Jayme L. Olsen, Anne D. Koniski, Kristin E. Murphy, Michael Getman, Hyun Hyung An, Vincent P. Schulz, Ah Ram Kim, Bin Zhang, Taylor L. Carlson, Julien Papoin, Lionel Blanc, Paul D. Kingsley, Connie M. Westhoff, Patrick G. Gallagher, Stella T. Chou, Laurie A. Steiner, James Palis

“…Abstract The limited proliferative capacity of erythroid precursors is a major obstacle to generate sufficient in vitro-derived red blood cells for clinical purposes. While BMI1, a Polycomb Repressive Complex 1 member, is both necessary and sufficient to drive extensive proliferation of self-renewing erythroblasts, its mechanism of action remains poorly understood. …”
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A noncanonical role of roX RNAs in autosomal epigenetic repression by Jianjian Li, Shuyang Xu, Zicong Liu, Liuyi Yang, Zhe Ming, Rui Zhang, Wenjuan Zhao, Huipai Peng, Jeffrey J. Quinn, Manyin Wu, Yushan Geng, Yuying Zhang, Jiazhi He, Minghai Chen, Nan Li, Ning-Yi Shao, Qing Ma

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Brachyury co-operates with polycomb protein RYBP to regulate gastrulation and axial elongation in vitro by Lilla Kokity, Lilla Kokity, Zsolt Czimmerer, Bernadett Benyhe-Kis, Bernadett Benyhe-Kis, Anna Poscher, Anna Poscher, Emese Belai, Emese Belai, Gábor Steinbach, Zoltan Lipinszki, Zoltan Lipinszki, Melinda Katalin Pirity

“…This process is regulated by transcription factors and epigenetic regulators, including non-canonical polycomb repressive complex 1s (ncPRC1s). Previously, we reported that ncPRC1-member RYBP (RING1 and YY1 binding protein) is crucial for embryonic implantation and cardiac lineage commitment in mice. …”
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Several distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locus. by Goedele N Maertens, Selma El Messaoudi-Aubert, Tomas Racek, Julie K Stock, James Nicholls, Marc Rodriguez-Niedenführ, Jesus Gil, Gordon Peters

“…Misexpression of Polycomb repressive complex 1 (PRC1) components in human cells profoundly influences the onset of cellular senescence by modulating transcription of the INK4a tumor suppressor gene. …”
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Interaction and regulatory expression of Polycomb and NuRD complexes in mouse embryonic stem cell under PKC inhibition by Fangfang Wu, Zhihui Liu, Jing Huang, Yuan Gao, Lan Yang, Fuliang Du

“…Abstract Polycomb repressive complexes (PRC) and nucleosome remodeling and deacetylase (NuRD) complex are crucial for regulating the expression of pluripotent and developmental genes and maintaining the characteristics of mouse embryonic stem cells (mESCs). …”
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The Impact of Polycomb Group Proteins on 3D Chromatin Structure and Environmental Stresses in Plants by Yali Liu, Suxin Xiao, Minqi Yang, Guangqin Guo, Yue Zhou

“…The two multi-subunit complexes, Polycomb Repressive Complex 1 and 2 (PRC1/2), act synergistically during development to maintain the gene silencing state among different species. …”
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