Right-sided hemicolectomy in 90-year-old patient with cecum cancer by A. M. Sidorenko, T. A. Semenova, V. V. Varvarov

“…Activity on the Karnofsky scale - 90%, on ESOG - 1 point. Further dispensary observation is recommended. …”
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Primary progressive aphasia by V. A. Mikhailov, Yu. V. Kotsiubinskaya, N. Yu. Safonova, N. I. Ananieva, I. K. Stulov

“…Primary progressive aphasia (PPA) is a heterogeneous group of neurodegenerative diseases related to focal degenerations of the brain and mainly manifested by a gradual loss of speech functions. This symptom is characterized by specific speech disorders. …”
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Improving the Accuracy of Neural Network Pattern Recognition by Fractional Gradient Descent by Ruslan I. Abdulkadirov, Pavel A. Lyakhov, Valentina A. Baboshina, Nikolay N. Nagornov

“…The adjusting of size and direction of the fractional gradient, supported by momentum and Nesterov condition, let the proposed optimizer descend into the global minimum of loss functions of neural networks. Utilizing the proposed optimization algorithm in a linear neural network and a visual transformer lets us attain higher accuracy, precision, recall, Macro F1 score by 1.8-4 percentage points than known analogs than state-of-the-art methods in solving pattern recognition problems on images from MNIST and CIFAR10 datasets. …”
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Extensive striated muscle damage in a rat model of Duchenne muscular dystrophy with Dmd exons 10–17 duplication by Jean-Daniel Masson, Valentina Taglietti, François Ruby, Hiroya Ono, Nadir Mouri, Alan Jorge, Laurent Guillaud, Laurent Tiret, Frederic Relaix

“…Consequently, patients experience progressive muscle weakness, loss of ambulation and cardiorespiratory failure. …”
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Curvature-Adaptive Learning Rate Optimizer: Theoretical Insights and Empirical Evaluation on Neural Network Training by Kehelwala Dewage Gayan Maduranga

“…Theoretical analysis confirms CALR’s convergence properties, while empirical evaluations on benchmark functions—Rosenbrock, Himmelblau, and Saddle Point—highlight its efficiency in complex optimization landscapes. …”
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R post-vocalique et histoire de l’anglais by Jacques Durand

“…The paper will attempt to show that, while the selection of particular traits to separate dialects is usually arbitrary from a strict linguistic point of view, once a trait has been selected and functions as a ‘shibboleth’ in the Biblical sense (Judges, xii, 5-6, “King James Version”, 1611) powerful societal forces can conjoin to maintain and reinforce it. …”
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KRIT1 regulates the homeostasis of intracellular reactive oxygen species. by Luca Goitre, Fiorella Balzac, Simona Degani, Paolo Degan, Saverio Marchi, Paolo Pinton, Saverio Francesco Retta

“…Taken together, our results point to a new model where KRIT1 limits the accumulation of intracellular oxidants and prevents oxidative stress-mediated cellular dysfunction and DNA damage by enhancing the cell capacity to scavenge intracellular ROS through an antioxidant pathway involving FoxO1 and SOD2, thus providing novel and useful insights into the understanding of KRIT1 molecular and cellular functions.…”
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AHG-YOLO: multi-category detection for occluded pear fruits in complex orchard scenes by Na Ma, Na Ma, Na Ma, Yile Sun, Yile Sun, Chenfei Li, Chenfei Li, Zonglin Liu, Zonglin Liu, Haiyan Song, Haiyan Song

“…Finally, the boundary box loss function is changed to Generalized Intersection over Union (GIoU), improving the model’s convergence speed and further enhancing detection performance.ResultsExperimental results show that the AHG-YOLO model achieves 93.5% (FCC), 95.3% (NO), and 93.4% (OBL) in AP, with an mAP@0.5 of 94.1% across all categories. …”
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Xuesaitong Protects Podocytes from Apoptosis in Diabetic Rats through Modulating PTEN-PDK1-Akt-mTOR Pathway by Rui Xue, Ruonan Zhai, Ling Xie, Zening Zheng, Guihua Jian, Teng Chen, Jun Su, Chongting Gao, Niansong Wang, Xifei Yang, Youhua Xu, Dingkun Gui

“…Diabetic kidney disease (DKD) is a major cause of end-stage renal disease (ESRD), and therapeutic strategies for delaying its progression are limited. Loss of podocytes by apoptosis characterizes the early stages of DKD. …”
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Effectiveness of Total Hip Arthroplasty Combined With Hip Braces for Hip Charcot Arthropathy by Long‐Teng Chao, Teng‐Feng Zhuang, Song‐Wei Huan, Si‐Min Luo, Chong‐Jie Wu, Wen‐Rui Wu, Zhen‐Gang Zha, Huan‐Tian Zhang, Ning Liu

“…The Kaplan–Meier survivorship with an end point of reoperation for any reason was 81.8%. Conclusions THA is proved to be reasonable in improving hip joint function, which is suitable for patients with Charcot hip joint. …”
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Severe Joubert syndrome in family with homozygous POC1B p.Arg106Pro variant is due to a co-inherited deep-intronic mutation in the neighboring CEP290 gene by Christian Betz, Björn Reusch, Thomas Langmann, Sandra Habbig, Bodo B. Beck, Hanno J. Bolz

“…We identified a homozygous deep-intronic variant, c.2818-657T>G, in CEP290, a JBTS/Meckel syndrome-associated gene on chromosome 12q21, only 1.28 Mb from the N terminus of POC1B. cDNA analysis revealed aberrant splicing with the frame-shifting inclusion of 37 bp from CEP290 intron 25, predicting the loss of CEP290 function. EOSRD and PKD can fully be ascribed to this CEP290 variant, whose effect outshines the “background” non-syndromic POC1B retinopathy and co-segregates with the severe syndromic phenotype. …”
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Medisinsk overaktivitet: Hva er det, hva er de etiske problemene og hva kan vi gjøre med det? by Bjørn Hofmann

“…An overarching approach is to ensure that medical activity can be directly linked to the moral goal of reducing individuals' pain, loss of function and suffering. Reducing overactivity is key to preserving the moral justification of medicine, but also the quality of services, patient safety, trust in medicine and a sustainable health service. …”
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Research on SeaTreasure Target Detection Technology Based on Improved YOLOv7-Tiny by Xiang Shi, Yunli Zhao, Jinrong Guo, Yan Liu, Yongqi Zhang

“…First, based on the YOLOv7-Tiny network, the MAFPN neck structure is used to replace the ELAN structure to achieve the multi-scale capture of semantic information of underwater sea treasures, and to enhance the UPA-YOLO model to accurately locate the targets of underwater sea treasures; second, the P2ELAN module is constructed and added to the backbone network, which makes use of the redundancy information in the feature map and dynamically adjusts the convolution kernel to adapt to data The P2ELAN module is added to the backbone network, using the redundant information in the feature map, dynamically adjusting the convolutional kernel to adapt to the lack of data, reducing the number of parameters in the model, and introducing the MSCA attention mechanism to inhibit the complex and changeable background features underwater, to improve the semantic feature extraction ability of the UPA-YOLO model for underwater targets, adding the MPDiou loss function to the improved algorithm model and completing the data validation of the detection model; finally, based on the TensorRT acceleration framework, the optimisation of the target detection Finally, based on the TensorRT acceleration framework, the target detection model is optimised, and the Jetson Nano edge device is used to complete the localisation deployment and realise the real-time target detection task of underwater sea treasures. …”
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Electrical Impedance Myography Quantifies Holding and Pushing During Isometric Muscle Contractions by Alfred C. Hulkenberg, Niko Strotmann, Amine Mokni, Leon Greulich, Thea Laurentius, L. Cornelius Bollheimer, Seward Rutkove, Todd Freeborn, Steffen Leonhardt

“…Introduction: To address muscle performance, a local Electrical Impedance Myography (EIM) framework is introduced that targets the quadriceps femoris muscle group, which is sensitive to age-related muscle loss. It can be used for force estimation during the seated leg extension exercise under isometric conditions, providing a novel tool for geriatric assessment and therapy tracking. …”
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A ranking hashing algorithm based on listwise supervision by Anbang YANG, Jiangbo QIAN, Yihong DONG, Huahui CHEN

“…Recently,learning to hash technology has been used for the similarity search of large-scale data.It can simultaneous increase the search speed and reduce the storage cost through transforming the data into binary codes.At present,most ranking hashing algorithms compare the consistency of data in the Euclidean space and the Hamming space to construct the loss function.However,because the Hamming distance is a discrete integer value,there may be many data points sharing the same Hamming distance result in the exact ranking cannot be performed.To address this challenging issue,the encoded data was divided into several subspaces with the same length.Each subspace was set with different weights.The Hamming distance was calculated according to different subspace weights.The experimental results show that this algorithm can effectively sort the data in the Hamming space and improve the accuracy of the query compared with other learning to hash algorithms.…”
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Rapid and accurate detection of peanut pod appearance quality based on lightweight and improved YOLOv5_SSE model by Zhixia Liu, Xilin Zhong, Chunyu Wang, Guozhen Wu, Fengyu He, Jing Wang, Dexu Yang

“…Furthermore, the substitution of various loss functions was investigated, with the Focal-EIoU loss function employed as the regression loss term for predicting bounding boxes, thereby improving inference accuracy.ResultsCompared to the YOLOv5s network model, SSE-YOLOv5s boasts a mere 6.7% of the original model’s parameters, 7.8% of the computation, and an FPS rate 115. 1% higher. …”
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Digitising the on-call medical team's patient list system: a QIP by Fahad-Bin Zahid

“…Feedback was collected after each cycle to address challenges and refine functionality, including: • Removal of unnecessary columns • Removal of the ‘low-priority’ category (eg, falls, social issues), because such patients were delayed for extended periods, raising clinical safety concerns; • Improved navigation by fixing headers and introducing alternate row colouring to support dyslexic users1–3; • Enhanced visibility for same-day emergency care department (SDEC) and patients who were post-take; • Created a video guide for staff and clarified the log-in process; • Created a secure folder for archived spreadsheets to improve data storage; • Developed an automatic timestamp for when details were entered.Efficiency gains: • Reduced handover times by 13.5 min (on average) per handover; • 73% of registrars reported improved workflow efficiency; • Features, such as live updates and centralised tracking, minimised information loss and streamlined referral management.Environmental impact: • Eliminated 100% of official paper-based referral list, aligning with NHS sustainability goalsUser satisfaction: • 91% of registrars preferred the electronic system. • 73% rated the system 8–10 for usabilityEquality impact: • The project had no adverse effects on any protected characteristic groups. …”
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Predictive Model of Endodontic Access in Maxillary Central Incisors Using Cone Beam Computed Tomography by Maria Llacer‐Martínez, María T. Sanz, Mar Jovani‐Sancho, Benjamín Martín Biedma, Elisabet Palazón Radford

“…Twenty‐four variables significantly correlated with three key aspects of access design—access starting point, depth to the pulp horn, and access angle (target variables). …”
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Murine modeling of menstruation identifies immune correlates of protection during Chlamydia muridarum challenge. by Laurel A Lawrence, Mark Elliott Williams, Paola Vidal, Richa S Varughese, Zheng-Rong Tiger Li, Thien Duy Chen, Melissa A Roy, Steven C Tuske, Anice C Lowen, Christopher D Scharer, William M Shafer, Alison Swaims-Kohlmeier

“…Notably, these cell populations were transcriptionally distinct and enriched for programs associated with NK cell effector functions. Depletion of FRT NK cells during the late luteal phase time frame resulted in a loss of protection, enabling productive infection following C. muridarum challenge. …”
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A genome-wide RNAi screen reveals MAP kinase phosphatases as key ERK pathway regulators during embryonic stem cell differentiation. by Shen-Hsi Yang, Tuzer Kalkan, Claire Morrisroe, Austin Smith, Andrew D Sharrocks

“…Through a genome-wide siRNA screen we have identified more than 400 genes involved in loss of pluripotency and promoting the onset of differentiation. …”
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