Quantification of the Dynamics of the Vascular Flows in the Cerebral Arterial and Venous Trees by Heimiri Monnier, Kimi Owashi, Pan Liu, Serge Metanbou, Cyrille Capel, Olivier Balédent

“…Factors like age and posture influence this network, complicating its study. Phase-contrast MRI is the gold standard for quantifying cerebral circulation. …”
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Genetic Mechanisms and Identification of Low-Resistivity Pay Zones: A Case Study of Pengyang Area, Ordos Basin, China by Peiqiang Zhao, Yuting Hou, Fengqing Ma, Jixin Huang, Xiaoyu Wang, Jiarui Xie, Chengxiang Deng, Zhiqiang Mao

“…However, most of the oil pays in the study formations are low-resistivity or low-contrast reservoirs with low permeability, bringing challenges to the reservoir identification and evaluation by well logs. …”
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Breeding for Heat Tolerant Aromatic Rice Varieties and Identification of Novel QTL Regions Associated with Heat Tolerance During Reproductive Phase by QTL-Seq by Surangkana Chimthai, Sulaiman Cheabu, Wanchana Aesomnuk, Siriphat Ruengphayak, Siwaret Arikit, Apichart Vanavichit, Chanate Malumpong

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On quantitativeness of diffraction-limited quantitative phase imaging by Zdeněk Bouchal, Petr Bouchal, Tereza Chmelíková, Jaromír Fiurášek

“…Hence, it remains unclear whether diffraction-affected QPI provides reliable quantification or merely visualizes phase objects, similar to phase contrast methods. …”
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Development of an eco-friendly UPLC method for simultaneous quantification of six selected phosphodiesterase-5 inhibitors and serotonin reuptake inhibitors in pharmaceutical formul... by Heba Abdel-Hafeez Mohamed, Mohamed Badawi NourEldin, Asmaa Ahmed El-Zaher, Sally Tarek Mahmoud

“…This study employs quality by design (QbD) concepts to optimize chromatographic settings, assuring good selectivity, precision, and resilience, while conforming to green analytical chemistry standards, in contrast to previously published approaches. A face-centered composite design was utilized to systematically optimize critical parameters, resulting in effective separation using a reversed-phase C18 column, an acetate buffer (pH 3), and a mobile phase composed of buffer and methanol (72.5:27.5, v/v) at a flow rate of 0.5 mL/min. …”
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Exploratory analysis of critical event phases and the impact of team size and performance levels in 24 hour ultra cycling. by Carlo Dindorf, Jonas Dully, Lukas Maurer, Stephan Becker, Steven Simon, Eva Bartaguiz, Michael Fröhlich

“…This approach enables the identification of critical event phases that significantly influence the final rank. …”
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Identification of the Notch ligand DLK1 as an immunotherapeutic target and regulator of tumor cell plasticity and chemoresistance in adrenocortical carcinoma by Nai-Yun Sun, Suresh Kumar, Yoo Sun Kim, Diana Varghese, Arnulfo Mendoza, Rosa Nguyen, Reona Okada, Karlyne Reilly, Brigitte Widemann, Yves Pommier, Fathi Elloumi, Anjali Dhall, Daiki Taniyama, Mayank Patel, Etan Aber, Cristina F. Contreras, Rosandra N. Kaplan, Katja Kiseljak-Vassiliades, Margaret E. Wierman, Dan Martinez, Jennifer Pogoriler, Amber K. Hamilton, Sharon J. Diskin, John M. Maris, Robert W. Robey, Michael M. Gottesman, Jaydira Del Rivero, Nitin Roper

“…In ACC, ADCT-701, a DLK1 targeting antibody-drug conjugate (ADC), shows in vitro and in vivo activity but is overall limited due to high expression and activity of the drug efflux protein ABCB1 (MDR1, P-glycoprotein). In contrast, ADCT-701 induces complete responses in DLK1+ ACC and SCLC in vivo models with low or no ABCB1 expression. …”
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Application of “high-fidelity and high-resolution” processing technology in thin reservoir identification: A case study of the deep Permian Maokou Formation in Penglai area, centra... by PENG Haotian, HE Qinglin, CHEN Kang, ZENG Ming, HE Zongqiang, TU Zhihui, KONG Lingxia, QU Bozhang

“…The raw data exhibits high noise levels, low dominant frequencies in deep layers, and narrow frequency bandwidths. …”
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Identification and functional characterization of G6PC2 coding variants influencing glycemic traits define an effector transcript at the G6PC2-ABCB11 locus. by Anubha Mahajan, Xueling Sim, Hui Jin Ng, Alisa Manning, Manuel A Rivas, Heather M Highland, Adam E Locke, Niels Grarup, Hae Kyung Im, Pablo Cingolani, Jason Flannick, Pierre Fontanillas, Christian Fuchsberger, Kyle J Gaulton, Tanya M Teslovich, N William Rayner, Neil R Robertson, Nicola L Beer, Jana K Rundle, Jette Bork-Jensen, Claes Ladenvall, Christine Blancher, David Buck, Gemma Buck, Noël P Burtt, Stacey Gabriel, Anette P Gjesing, Christopher J Groves, Mette Hollensted, Jeroen R Huyghe, Anne U Jackson, Goo Jun, Johanne Marie Justesen, Massimo Mangino, Jacquelyn Murphy, Matt Neville, Robert Onofrio, Kerrin S Small, Heather M Stringham, Ann-Christine Syvänen, Joseph Trakalo, Goncalo Abecasis, Graeme I Bell, John Blangero, Nancy J Cox, Ravindranath Duggirala, Craig L Hanis, Mark Seielstad, James G Wilson, Cramer Christensen, Ivan Brandslund, Rainer Rauramaa, Gabriela L Surdulescu, Alex S F Doney, Lars Lannfelt, Allan Linneberg, Bo Isomaa, Tiinamaija Tuomi, Marit E Jørgensen, Torben Jørgensen, Johanna Kuusisto, Matti Uusitupa, Veikko Salomaa, Timothy D Spector, Andrew D Morris, Colin N A Palmer, Francis S Collins, Karen L Mohlke, Richard N Bergman, Erik Ingelsson, Lars Lind, Jaakko Tuomilehto, Torben Hansen, Richard M Watanabe, Inga Prokopenko, Josee Dupuis, Fredrik Karpe, Leif Groop, Markku Laakso, Oluf Pedersen, Jose C Florez, Andrew P Morris, David Altshuler, James B Meigs, Michael Boehnke, Mark I McCarthy, Cecilia M Lindgren, Anna L Gloyn, T2D-GENES consortium and GoT2D consortium

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Early assessment and treatment of ventricular remodeling in vivo via a targeted ultrasonic molecular probe loaded with oxygen and cholecystokinin by Can Wang, Hongfeng Cheng, Xiaoying Dong, Yue Zhan, Ying Liu, Nianhong Wu, Rui Tang, Hongye He, Yuting Cao, Liping Yang, Jianli Ren, Xingsheng Li, Pan Li

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Development and validation of an LC-MS/MS method for the simultaneous estimation of tadalafil and macitentan in rat plasma: Greenness assessment and design of experiment approach by Sravanthi Gandu, Kumaraswamy Gandla, Lalitha Repudi

“…Optimization of critical parameters, including organic phase composition (50% acetonitrile), flow rate (1.0 mL/min), and pH (3.2), was achieved using a Box-Behnken Design, ensuring accurate separation and quantification. …”
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3D printed hardware for automation of proteomics sample preparation at the Meso-Scale by Sadie R. Schultz, Matthew M. Champion

“…Here, we present modular protocols for the major techniques in proteomics preparation: in-solution and S-Trap digestion; Tip and solid-phase extraction (SPE) based desalting. Both approaches yield dense protein identifications from complex proteomes. …”
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Spatial Distribution of Exhalation Droplets in the Bus in Different Seasons by Wenzhu Duan, Dan Mei, Jiaqian Li, Zihan Liu, Mengfan Jia, Shanshan Hou

“…The integral concentration of droplets at different locations can be quantified, which leads to identification of low-risk areas and high-risk areas in the bus. …”
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Application of photon-counting CT in cardiovascular diseases by WANG Mengzhen, BAO Shouyu, LIU Peng, YAN Fuhua, YANG Wenjie

“…PCCT can obtain stable calcium scoring at low radiation doses. The virtual non-contrast （VNC） algorithm supports reliable calcium scoring from contrast-enhanced images, further reducing the radiation dose. …”
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Cryptococcal Meningitis: Challenges Faced in the Management of a Patient with Cryptococcoma by Priyaadarshini Urjan Mohan, Anupma Jyoti Kindo, SMH Waseem

“…The preferred treatment involves a combination of amphotericin B and 5-flucytosine during the induction phase to reduce the fungal load, followed by oral fluconazole in the maintenance phase. …”
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Geodetector-Based Analysis of Spatiotemporal Distribution Characteristics and Influencing Mechanisms for Rural Homestays in Beijing by Yiyuan Hei, Yifei Sui, Wei Gao, Mei Zhao, Min Hu, Mengyuan Gao

“…Geodetector quantification identifies the proximity to transportation nodes and vegetation coverage as primary spatial determinants, while socioeconomic factors demonstrate comparatively limited influence—contrasting sharply with urban contexts. …”
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Hetero-associative Memory Based New Iraqi License Plate Recognition by Rusul Hussein Hasan, Inaam Salman Aboud, Rasha Majid Hassoon, Ali saif aldeen Aubaid Khioon

“…There is a challenge associated with Vehicle License Plate Recognition (VLPR) because of the variation in viewpoints, multiple formats, and non-uniform lighting conditions at the time of acquisition of the image, shape, and color, in addition, the difficulties like poor image resolution, blurry image, poor lighting, and low contrast, these must be overcome. This paper proposed a model by using Modify Bidirectional Associative Memory (MBAM), which is one type of Hetero-associative memory, MBAM works in two phases (learning and convergence phases) to recognize the number plate, and this proposed model can overcome these difficulties because MBAM's associative memory has a high ability to accept noise and distinguish distorted images, as well as the speed of the calculation process due to the small size of the network. …”
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Spatio-Temporal Characteristics and Driving Forces of Landscape Ecological Risks in Highly Urbanized Areas: A Case Study of Suzhou City by Lingyue LU, Dawei SHAO, Dianming WU

“…The proportion of low-risk areas remains consistently high, widely distributed, and stable. …”
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Advance of DAM-like genes in bud dormancy of deciduous fruit trees in Rosaceae family by ZHAO Yalin, WANG Lirong

“…Under controlled environmental conditions, the expressions of PpDAM5/6 were up-regulated in autumn under the influence of environmental low temperature, while they were down-regulated in winter under the influence of long-term low temperature, and their expression levels were negatively correlated with germination rate. …”
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Selection and characterization of a broadly neutralizing class of HCV anti-E2 VH1-69 antibodies. by Andreas Soerensen, Filip Popovic, Christina Holmboe Olesen, Blanca Lopez Mendez, Brian Lohse, Zhaochun Chen, Patrizia Farci, Robert H Purcell, Harvey J Alter, Lea Klingenberg Barfod, Jens Bukh, Jannick Prentoe

“…Identification and characterization of antibody epitope targets on the hepatitis C virus (HCV) envelope proteins remain crucial for developing an effective vaccine. …”
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