Microbiota-derived indole acetic acid extends lifespan through the AhR-Sirt2 pathway in Drosophila by Zheng Cao, Cui Zhang, Lijun Liu, Hehua Lei, Huabao Zhang, Yanmeng He, Xinzhi Li, Qingwei Xiang, Yu-Feng Wang, Limin Zhang, Gang Chen

“…However, the underlying molecular mechanisms by which the AhR-mediated signaling pathway contributes to the aging process remain largely unknown. In this study, we find that aged Drosophila exhibits markedly reduced tryptophan metabolism leading to impaired AhR ligands, especially indole acetic acid (IAA), compared with their young controls. …”
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Home Occupant Archetypes by Marco Antonio ORTIZ SANCHEZ

“…Building upon the aim of this thesis, the following main research question was proposed: How can energy behaviours be studied from a comfort-driven perspective in order to facilitate the development of environmental features that support more efficient occupant behaviours and that provide the comfort needs of the person? …”
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Beyond language: empathy and emotion recognition deficits in primary progressive aphasias by Giulia Giacomucci, Alice Pieri, Valentina Moschini, Chiara Crucitti, Sonia Padiglioni, Carmen Morinelli, Giulia Galdo, Filippo Emiliani, Matilde Nerattini, Silvia Bagnoli, Assunta Ingannato, Sandro Sorbi, Benedetta Nacmias, Valentina Berti, Valentina Bessi

“…Although primary progressive aphasia (PPA) is considered a language disorder, increasing evidence points to the presence of social cognition impairments in PPA variants. The aims of this study were to explore empathy and emotion recognition deficits in the three PPA variants (sv-PPA, lv-PPA, nfv-PPA) and to identify their neural correlates.Eleven sv-PPA, 34 lv-PPA,11 nfv-PPA patients and 34 healthy controls (HC) were included in this study. …”
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Research progress on the conditions and mechanisms of typical dynamic disasters formation in deep coal mining by Ke YANG, Penghui GUO, Liang YUAN, Anye CAO, Yongjiang ZHANG, Yankun MA, Jiazhuo LI

“…The premise and foundation for preventing and controlling these typical dynamic disasters in coal mines is an in-depth study of their occurrence mechanisms. …”
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Mesenchymal stem cell application in pulmonary disease treatment with emphasis on their interaction with lung-resident immune cells by Ali Hazrati, Seyed Mohamad Javad Mirarefin, Kosar Malekpour, Arezou Rahimi, Arezou Khosrojerdi, Ashkan Rasouli, Susan Akrami, Sara Soudi

“…However, the communication between MSCs and immune cells after treatment of pulmonary diseases is essential, and investigating this can help develop a clinical perspective. Different studies in the clinical phase showed that MSCs can reverse fibrosis, increase regeneration, promote airway remodeling, and reduce damage to lung tissue. …”
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Current status and prospects of research on the pollution and treatment technologies of per- and polyfluoroalkyl substances by Xuejiao Tang, He Yang, Xinya Li, Cuiping Wang

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Cost-effectiveness of culturally-adapted counselling mental distress in low-income ethnic minorities in Hong Kong: results based on a randomized clinical trial by Yi Nam Suen, Yik Chun Wong, Winnie Ng, Shilpa Patwardhan, Charlton Cheung, Stephanie Ming Yin Wong, Christy Lai Ming Hui, Michael Tak Hing Wong, Shalini Mahtani, Eric Yu Hai Chen

“…However, its cost-effectiveness for reducing mental distress among EMs remains understudied, particularly in Asian settings. This study evaluated the cost-effectiveness of CAC compared to waitlist controls for low-income South Asian EMs experiencing mental distress in Hong Kong, using a healthcare perspective. …”
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Maximal and sub-maximal exercise tests alter PBMC microRNA expression: insights into sport- and sex-specific variations by Guy Shalmon, Guy Shalmon, Guy Shapira, Guy Shapira, Rawan Ibrahim, Ifat Israel-Elgali, Meitar Grad, Rani Shlayem, Ilan Youngster, Ilan Youngster, Mickey Scheinowitz, Mickey Scheinowitz, Noam Shomron, Noam Shomron

“…IntroductionStudying microRNAs in the immune cells of athletes offers a novel perspective on the molecular regulation of immune function and recovery, potentially uncovering strategies to enhance performance and resilience to physical stress. …”
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The impact of early detection and intervention on congenital heart defects in infants and children: a systematic review by R. T. Akah, J. E. Enoh, B. Nkeh-Chungag

“…These studies, comprising case-control studies from Mount Sinai Medical Center, cohort studies from regions such as Denmark, Paris, Saudi Arabia, and Australia, and cross-sectional studies from China and France/Belgium, highlight the clinical challenges associated with CHD and the long-term developmental and psycho-social implications for affected children. …”
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Robot-assisted activities of daily living (ADL) rehabilitation training with a sense of presence based on virtual reality by L. Li, L. Li, T. Lei, T. Lei, J. Li, J. Li, X. Li

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Exposure to Pollutants and Vaccines’ Effectiveness: A Systematic Review by Carmela Protano, Federica Valeriani, Katia Vitale, Jole Del Prete, Fabrizio Liguori, Giorgio Liguori, Francesca Gallè

“…Perfluorinated compounds were the most studied pollutants. <b>Conclusions:</b> Correlations between exposure to pollutants and reductions in antibody production were found in quite all the selected studies, suggesting that pollution control policies could contribute to increase the efficacy of vaccination campaigns. …”
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Cost-effectiveness analysis of two integrated early childhood development programs into Bangladeshi primary health-care servicesResearch in context by Sheikh Jamal Hossain, Tom Palmer, S.M. Mulk Uddin Tipu, Syeda Fardina Mehrin, Shamima Shiraji, Mohammed Imrul Hasan, Mohammad Saiful Alam Bhuiyan, Nur-E Salveen, Fahmida Tofail, Helen Baker-Henningham, Hassan Haghparast-Bidgoli, Jena D. Hamadani

“…Intervention costs were estimated rom the provider perspective over the time horizon of each study (21 months for the group-based intervention; 24 months for the pair-based intervention). …”
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Construction and validation of a prognostic model of angiogenesis-related genes in multiple myeloma by Rui Hu, Fengyu Chen, Xueting Yu, Zengzheng Li, Yujin Li, Shuai Feng, Jianqiong Liu, Huiyuan Li, Chengmin Shen, Xuezhong Gu, Zhixiang Lu

“…Abstract Background Angiogenesis is associated with tumour growth, infiltration, and metastasis. This study aimed to detect the mechanisms of angiogenesis-related genes (ARGs) in multiple myeloma (MM) and to construct a new prognostic model. …”
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The regulatory variant rs1950834 confers the risk of depressive disorder by reducing LRFN5 expression by Di Luan, Yifan Li, Aini Zhang, Qingqing Bai, Te Zhao, Xi Chen, Xinglun Dang, Junyang Wang, Shaolei Jiang, Yun Sun, Yingjie Zhu, Yan Kong, Xiong-Jian Luo, Zhijun Zhang

“…Abstract Background Genome-wide association studies have identified 14q21.1 as a robust risk locus for major depressive disorder (MDD). …”
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A Novel Research Paradigm for Sarcopenia of Limb Muscles: Lessons From the Perpetually Working Diaphragm's Anti‐Aging Mechanisms by Enhui Li, Rui Wang, Yanli Li, Xiang Zan, Shufen Wu, Yiru Yin, Xiaorong Yang, Litian Yin, Yu Zhang, Jianguo Li, Xin Zhao, Ce Zhang

“…Conclusions In conclusion, this study reveals aging diversities of TA and DIA, explores the sarcopenia of limb muscles based on the anti‐aging properties of DIA, which offers a novel perspective on limb sarcopenia. …”
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Gender Differences for the Associations among Housework, Self-Stigma, and Psychiatric Symptoms among Community Severe Mental Disorder Patients by Li Q, Xu M, Chen Y, Su X, Zhong Y, Wang M, Sun L

“…Linear regression explicit the relationship between the study variables, based on which a mediation analysis is established to verify the internal mechanism which controls confounding variables (age, religion, marriage, education, occupation, labor capacity, living alone, liability, chronic disease, disease status).Results: Most participants did housework for less than 1 hour, with men more likely than women (76.2% vs 56.2%). …”
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Dynamic monitoring and warning system for unstable rock collapse and its engineering application by Chen CHEN, Mowen XIE, Yan DU, Shuangquan LI, Zhengjun HUANG

“…To address the limitations of current macroscopic displacement-based monitoring methods in meeting early warning requirements for rock collapse, we propose a novel slope dynamics theory based on Newton’s second law and develop micro-core intelligent monitoring and early warning technology, thereby establishing an innovative “technology-management integration” framework for situational awareness and disaster prevention/mitigation of sudden geotechnical hazards. This study systematically analyzes and discusses theories of rock mass instability dynamics, monitoring and early warning technologies, critical issues, and application prospects using case studies from four key perspectives: theoretical framework, technological innovation, methodological challenges, and practical implementation. …”
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Ideology and ethics of transitional entrepreneurs: legitimacy, soft law, and overcoming a distressed economy by Maryam Khosravi, Mojtaba Amiri, Nezameddin Faghih

“…Indeed, in transition economies, formal institutions need to be enhanced by informal institutions to control corruption and other misbehavior by authorities. …”
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A benzimidazole derivative as an effective antitumor agent in terms of syngeneic lung tumors and melanoma treatment by E. F. Komarova, A. S. Morkovnik, O. N. Zhukovskaya, E. V. Verenikina, N. A. Shevchenko, D. V. Khodakova, L. Z. Kurbanova, M. V. Mindar, E. V. Zaikina, A. V. Galina

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Unveiling the Impact of Short‐Range Order of Si─Si Dimer in 2D Si2Te3 from First‐Principles Calculations by June Ho Lee, Jaeseon Kim, Youngjun Park, Yonghun Shin, Eun Ho Kim, Donghwa Lee

“…Furthermore, it is demonstrated that strain can control dimer orientation, tuning the bandgap by lowering the energy level of the Si(s)─Te(p) antibonding orbitals. …”
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