Estimating the budget impact of innovative pharmacological treatments for patients with type 2 diabetes mellitus in Italy: the case of liraglutide (GLP-1). by Stefano Capri, Marco Barbieri

“…However, for these additional costs, the Italian NHS would get more patients with glycaemic control.</p><span> </span><p><strong> </strong><strong>Conclusions</strong></p><span> </span>This study has shown that an increase in the use of liraglutide would determine a relatively low extra cost per patient with T2DM in the Italian NHS. …”
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Comprehensive analysis on the regulatory mechanism of active ingredient accumulation during fermentation process of Massa Medicata Fermentata: microbe and metabolic profiles by Yun Li, Yun Li, Ya-Juan Wang, Xiao-Peng Guo, Hong-Yuan Zhao, Hai-Wei Ren, Hong-Yu Li

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Cost-effectiveness of percutaneous mitral repair for patients with severe secondary mitral regurgitation: an updated evaluation using a modelling approach based on COAPT final data... by Xavier Armoiry, Peter Auguste, Martin Connock, Jean-Francois Obadia

“…Sensitivity analyses were undertaken.Setting The French healthcare system perspective assuming a lifetime horizon.Participants Published data at 5 years obtained from patients enrolled in the Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy for Heart Failure Patients with Functional Mitral Regurgitation study.Results In our base case, we chose cubic spline models to extrapolate overall survival, and we used log-logistic models to estimate cumulative HFH. …”
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Clonal relatedness and resistance patterns of Salmonella Corvallis from poultry carcasses in a Brazilian slaughterhouse by Ricardo S. Yamatogi, Heverton C. Oliveira, Carlos H. Camargo, Sueli A. Fernandes, Rodrigo T. Hernandes, José PAN Pinto, Vera LM Rall, João P. Araújo

“…Moreover, from a public health perspective, continuous surveillance on Salmonella is needed to control the dissemination of this important zoonotic pathogen and its resistance determinants. …”
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Application of “Internet +” continuous emotion management training in patients with depression by Yanping Zhang, Jiaxin Wang, Linlin Qiao, Yating Li, Runing Hou, Xiaojing Gu, Jingyuan Zhao, Fang Yan

“…ObjectiveExplore the application effects of “Internet +” continuous emotional management training in depression patients and analyze the feasibility of innovative rehabilitation training methods.MethodsConveniently selected 100 discharged patients meeting the diagnostic criteria for depression from the Second Affiliated Hospital of Xinxiang Medical University between August 2022 and January 2023 as study subjects. They were divided into an intervention group and a control group according to their discharge time, with 50 patients in each group. …”
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Abnormal methylation of Mill1 gene regulates osteogenic differentiation involved in various phenotypes of skeletal fluorosis in rats and methionine intervention by Niannian Chen, Jing Zhang, Congyu Yin, Yudan Liao, Lei Song, Ting Hu, Xueli Pan

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Cognitive mechanisms of mindfulness-based pain management in chronic pain by Emily Mohr, Sophie Matthew, Lipika Narisetti, Colin Duff, Poppy Schoenberg

“…Since aberrations in cognitive executive functioning are apparent in chronic pain and corroborate with higher pain severity and poorer clinical outcomes, we conducted a two-part mechanistic clinical study that aimed to examine; (1) cognitive performance deficits measured during neurophysiology tasks, in chronic pain patients versus healthy controls; and (2) a mechanistic trial into whether Mindfulness-Based Pain Management/MBPM modulates cognitive functioning, and its interplay with clinical symptoms, in chronic pain patients versus a treatment-as-usual/TAU matched patient control. …”
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Investigating overlapping deformation patterns of the Beijing Plain by independent component analysis of InSAR observations by Shangjing Lai, Jinxin Lin, Jie Dong, Jianzhong Wu, Xinlei Huang, Mingsheng Liao

“…The ICA results benefit the estimation of the time lag between groundwater rise and strata rebound in the Beijing Plain, as well as the estimation of the increase in groundwater storage capacity in the Miyun-Huairou-Shunyi region. This study provides a new perspective for extracting deformation information from InSAR observations, gaining a deeper understanding of deformation patterns related to hydrogeological phenomena, and assessing the effectiveness of groundwater management and land subsidence control policies.…”
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Complete mitogenomes reveal high diversity and recent population dynamics in Antarctic krill by Shuai Sun, Shuo Li, Inge Seim, Xiao Du, Xianwei Yang, Kaiqiang Liu, Zhanfei Wei, Changwei Shao, Guangyi Fan, Xin Liu

“…Furthermore, our investigation into selection pressures on mitochondrial genes reveals evidence of purifying selection across all 13 protein-coding genes, underscoring the pivotal role of mtDNA conservation in maintaining mitochondrial function under extreme environments. Conclusions This study provides a repository of Antarctic krill mitogenomes and insights into the population genetics and evolutionary history of this ecologically important species from a mitogenomic perspective, with implications for krill conservation and management in the Southern Ocean.…”
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Alteration mineral identification and metallogenic prediction of porphyry deposits based on geochemical data by Weikang ZHANG, Qing ZHANG, Cheng ZHANG, Zhengxi GAO, Liquan XU, Lei CAO, Aobing LI, Chunwei JIANG

“…Objective Traditional exploration and geochemical studies have primarily focused on the extraction, interpretation and evaluation of metallogenic element anomalies. …”
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Susceptibility assessment of freeze-thaw erosion induced debris flow using random forest, Eastern Tibetan Plateau by Yongjie Yang, Yongjie Yang, Yongjie Yang, Yuqi Zhang, Yuqi Zhang, Yuqi Zhang, Hai Huang, Hai Huang, Jinsong Zhu, Jinsong Zhu, Jinsong Zhu, Qiwei Lv, Qiwei Lv, Qiwei Lv, Jiang Peng, Jiang Peng

“…These results depend on selecting control factors that align with the actual conditions of the study area. …”
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Se-methylselenocysteine inhibits inflammatory response in an LPS-stimulated chicken HD11 macrophage-like cell model through the NFKB2 pathway by Min Yao, Binyu Wang, Zitong Li, Suqing Wu, Bingyu Zhao, Ning Sun, Huiping Xiao, Jianwu Wang, Guoping Liu, Tinghua Huang

“…This study identified key transcription factors and revealed one of the potential mechanisms through which SeMC exerts its anti-inflammatory effects from the perspective of transcriptional regulation.…”
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LINC01271 promotes fracture healing via regulating miR-19a-3p/PIK3CA axis by Qinghua Chen, Lina Huang, Wenjun Ji, Miao Huang, Jincheng Sima, Jin Li, Hao Song, Wei Xiong, Bin Chen

“…Abstract Objective Osteoporosis increases the risk of fragility fractures, impacting patients’ lives. This study aimed to investigate whether LINC01271 was involved in the process of fragility fractures and healing, providing a new perspective for its diagnosis and treatment. …”
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Impact of human activities and building characteristics on indoor air quality in low-income urban settlement by Fathina Izmi Nugrahanti, Mochamad Donny Koerniawan, Dewi Larasti, Agustinus Adib Abadi, Müslüm Arıcı, Surjamanto Wonorahardjo

“…Beside human activity control, this study offers a new IAQ mitigation perspective on the impact of interior characteristics on pollutant accumulation and dilution inside buildings. …”
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Pet Dog Choice in Hong Kong and Mainland China: Exploring Owners’ Motivations, Behaviours, and Perceptions by Hei Tung Yim, Kate Jade Flay, Omid Nekouei, Paulo Vinicius Steagall, Julia A. Beatty

“…Encouragingly from an animal welfare perspective, brachycephalic breeds were the least preferred type. …”
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Enhancing Farmer Resilience Through Agricultural Insurance: Evidence from Jiangsu, China by Xinru Chen, Yuan Jiang, Tianwei Wang, Kexuan Zhou, Jiayi Liu, Huirong Ben, Weidong Wang

“…Using Jiangsu Province—a representative high-risk agricultural region in China—as a case study, we administered 608 structured questionnaires to farmers. …”
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The impact of 12C6 heavy ion irradiation-induced cellular mutations on the replication of the foot-and-mouth disease virus and the role of Cbr3 by Xiangdong Song, Shiyu Tao, Fanglan An, Xiaoming Li, Yanyan Chang, Xuerong Liu, Yan Cui

“…This method can increase the production efficiency of FMDV vaccines while reducing manufacturing costs. This study innovatively employed 12C6 heavy ion irradiation technology to induce cell transformation and explored its impact on FMDV, offering a new perspective for understanding virus replication mechanisms and potentially providing a target and idea for developing novel antiviral strategies.…”
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Altitudinal Differences in Decreasing Heat Deficit at the End of the Growing Season of Alpine Grassland on the Qinghai–Tibetan Plateau from 1982 to 2022 by Yusi Zhang, Gang Bao, Yuhai Bao, Zhihui Yuan, Wendu Rina, Siqin Tong

“…By providing a long-term perspective on CDD variations and their climatic drivers, this study enhances our understanding of vegetation–climate interactions in alpine ecosystems. …”
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A simple pedotransfer function to estimate fine fraction organic carbon contents of surface horizons in French soils by Eva Rabot, Pierre Barré, Claire Chenu, Amicie A. Delahaie, Manuel P. Martin, José-Luis Munera-Echeverri, Nicolas P.A. Saby

“…., fine fraction organic carbon (OCfine) and coarse fraction organic carbon, to improve our ability to understand controlling factors and predict SOC contents and SOC stability. …”
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Out-of-pocket costs, time burden, and caregiver quality of life associated with pediatric medically attended respiratory syncytial virus illnesses by Angela M. Rose, Kerra R. Mercon, Acham Gebremariam, Jamison Pike, Lisa A. Prosser

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