Transcriptomic analysis reveals the function of m6A regulators in aged cochlea by Yanbing Lai, Bo Su, Xiaodi Wang, Chenghui Zeng, Hanqi Chu, Liangqiang Zhou, Dan Bing

“…Level of evidence: Acknowledging methodological similarities with Level 3 (non-randomized controlled cohort or case-control studies) in clinical research, we reference Level 3 as a comparative framework, while recognizing the distinct differences between clinical and animal research settings.…”
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Effects of separate and combined estradiol and progesterone administration on fear extinction in healthy pre-menopausal women by Michael Kaczmarczyk, Christian Eric Deuter, Hanna Deus, Anna Kallidou, Christian J. Merz, Julian Hellmann-Regen, Christian Otte, Katja Wingenfeld

“…We conducted a placebo-controlled, randomized study in healthy women, who completed a fear conditioning paradigm on three consecutive days: fear acquisition training on day 1, fear extinction training on day 2, and return of fear test on day 3. …”
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Humane stunning or stun/killing in the slaughter of wild-caught finfish: The scientific evidence base by Katy L James, Salvador Prats Aparicio, Nilantha S Jayasuriya, Tharangani K Herath, Jeff Lines, Lynne U Sneddon, Upali S Amarasinghe, Nicola P Randall

“…More scientific testing of stunning methods in commercial wild-capture settings is needed to validate findings of controlled laboratory studies and ensure the methods are practical in fisheries. …”
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Pharmacokinetics of oral moxidectin in individuals with Onchocerca volvulus infection. by Beesan Tan, Nicholas Opoku, Simon K Attah, Kwablah Awadzi, Annette C Kuesel, Janis Lazdins-Helds, Craig Rayner, Victoria Ryg-Cornejo, Mark Sullivan, Lawrence Fleckenstein

“…The pharmacokinetics of orally administered moxidectin in 18- to 60-year-old men and women infected with Onchocerca volvulus were investigated in a single-center, ivermectin-controlled, double-blind, randomized, single-ascending-dose, ascending severity of infection study in Ghana.…”
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Expanding two-way texting for post-operative follow-up: A cost analysis of the implementation and scale-up in routine voluntary medical male circumcision settings in South Africa. by Molly Unsworth, Isabella Fabens, Geoffrey Setswe, Khumbulani Moyo, Jacqueline Pienaar, Calsile Makhele, Motshana Phohole, Nelson Igaba, Sizwe Hlongwane, Maria Sardini, Tracy Dong, Monisha Sharma, Hannock Tweya, Felex Ndebele, Marrianne Holec, Caryl Feldacker

“…The objectives of this study were:1) assess the additive cost of 2wT vs. standard of care (SoC) during a stepped wedge design (SWD) expansion trial; 2) determine the cost of augmenting 2wT implementation with dedicated personnel during peak VMMC periods; and 3) estimate the cost savings of 2wT from the payer perspective if scaled in routine settings. …”
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Client experiences of a task-shifting supported self-management intervention for depression in Vietnam by Leena W. Chau, Hayami Lou, Jill K. Murphy, Vu Cong Nguyen, Will Small, Hasina Samji, John O’Neil

“…Methods This paper is situated within a randomized controlled trial that demonstrated the effectiveness of the SSM intervention in adult populations across eight provinces in Vietnam. …”
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Protocol for the economic evaluation of individualised (early) patient-directed rehabilitation versus standard rehabilitation after surgical repair of the rotator cuff of the shoul... by Chris Littlewood, Marcus Bateman, Vijay S Gc, Andrea Manca, T Chen, Bruno Mazuquin, Apostolos Fakis, Maria Moffatt, Shainur Premji

“…Findings will be disseminated in peer-reviewed journals, at scientific conferences, and via the study website.Trial registration number ISRCTN11499185…”
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Multivalent Co-assembly of LL37-CpG nanoparticles: Enhanced immune response through activating multiple cell internalization pathways by Yushuang Wei, Wenwen Li, Rong Xu, Cheng Xu, Xiangyang Li, Ning Li, Fengdan Xu, Kai Yang, Bing Yuan

“…A deeper understanding of its mechanism is essential for elucidating associated physiological and pathological processes, as well as for designing effective immune adjuvants and clinical therapeutics. In this study, we report that LL37 facilitates the assembly of unmethylated CpG dinucleotides (CpG ODNs), a clinically relevant immune adjuvant, into non-crystalline nanoparticles (NPs) with controlled size and zeta potential in a charge ratio-dependent manner. …”
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Economic evaluation of integrated services for non-communicable diseases and HIV: costs and client outcomes in rural Malawi by Luckson Dullie, Emily B Wroe, Elizabeth L Dunbar, Noel Kalanga, Lawrence Nazimera, Adarsh Shah, Bright Mailosi, Chiyembekezo Kachimanga, Ryan K McBain, Natalie Price, Mahlet Gizaw, Chantelle Boudreaux, Liberty Neba

“…Objective To evaluate the costs and client outcomes associated with integrating screening and treatment for non-communicable diseases (NCDs) into HIV services in a rural and remote part in southeastern Africa.Design Prospective cohort study.Setting Primary and secondary level health facilities in Neno District, Malawi.Participants New adult enrollees in Integrated Chronic Care Clinics (IC3) between July 2016 and June 2017.Main outcome measures We quantified the annualised total and per capita economic cost (US$2017) of integrated chronic care, using activity-based costing from a health system perspective. …”
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OPEN DUCTUS ARTERIOSUS IN PREMATURE INFANTS WITH EXTREMELY LOW AND VERY LOW BODY WEIGHT by Людмила Николаевна Игишева, Жанна Анатольевна Звягина, Елена Глебовна Цой, Андрей Владимирович Шабалдин, Тамара Михайловна Вакулова

“…The aim of the research – to identify significant factors affecting the postnatal functioning of PDA in premature infants with extremely low and very low body weight and to evaluate them from a manageability perspective. Materials and methods. In a continuous prospective study, 98 premature infants in the first 72 hours of life were divided into 2 groups according to the results of an echocardiological examination (67 children with PDA, 31 children without DA At the age of 1 month of life, 90 newborns were monitored, 48 children had open AP, and 42 children had no AP. …”
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Mitigating gas migration with eutectic bismuth alloy plugs by Lewaa Hmadeh, Andriani Manataki, Marcelo Anunciação Jaculli, Behzad Elahifar, Sigbjørn Sangesland

“…Furthermore, we also observed that a slow and controlled cooling approach reduces the volume of inner voids, thus mitigating the plug degradation caused by the migrating gas. …”
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Adipocyte-derived factors induce adherent to suspension transition in breast and pancreatic cancer cells through lipid metabolic alteration by Doru Kwon, Hyun Woo Park, Byung Soh Min, Junjeong Choi

“…The generation of AST cells through AST reprogramming is controlled by fatty acid oxidation (FAO), and pharmacological blockade of CD36 and FAO significantly reduced AST cell generation. …”
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Sleep Quality and Immune Mediators in Asthmatic Children by Ming-Fuu Wang

“…Results: Subjects with an ACT score ≥ 20 were assigned to the well-controlled group and those with a score of ≤ 19 were assigned to the inadequately controlled group. …”
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Early detection to improve outcome in people with undiagnosed psoriatic arthritis: the PROMPT research programme including RCT by Neil McHugh, Laura Bojke, Mel Brooke Turfrey, Rachel Charlton, Myka Ransom, Laura C Coates, Howard Collier, Claire Davies, Emma Dures, Philip Helliwell, Jana James, Anya Lissina, Vishnu B Madhok, Alison L Nightingale, Jonathan Packham, Catherine Smith, Eldon Spackman, Cerys Tassinari, William Tillett, Sarah T Brown

“…(Experiences of screening and diaGnosis from the perspective of pAtients with PSoriasis and psoriatic arthritis study). …”
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Talking about Hot Flashes (潮热) by Anna Bogachko Holmblad

“…This perspective was the foundation for the acupuncture study of our traditional Chinese medicine conducted in 2018–2019 in Shanghai. …”
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Cost-effectiveness of decentralising acute malnutrition treatment with a standard or simplified treatment protocol: an economic evaluation in the region of Gao, Mali by Bernardette Cichon, Noemí López-Ejeda, Salimata Samake, Cornelia Aton, Abdias Ogobara Dougnon, Mahamadou N’tji Samake, Aliou Bagayoko, Magloire Bunkembo, Alexandra Rutishauser-Perera, Pilar Charle-Cuellar

“…The objective of this study was to determine cost per child treated as well as the cost-effectiveness of the hybrid model of treatment delivery (where treatment is provided at both health facilities and CHW sites) using either a standard protocol (Intervention 1) or simplified protocol (Intervention 2) compared to standard treatment at health facilities only (Control) in the conflict affected region of Gao in Northern Mali. …”
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IN VITRO RESPONSE OF COTINUS COGGYGRIA SCOP. TO THE SPETRAL RADIATION AND LEDS INTENSITY by Olga O. Zholobova, Irina V. Mogilevskaya

“…The effect of 15 lighting options, namely 6 ratios of red (R), blue (B), and green (G) spectra, on the composition of LEDs on C. coggygria explants in vitro by methods used in microclonal propagation was studied. The biochemical parameters’ content in the samples of the studied leaves was determined using the optical method. …”
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Cultural Work as a Site of Struggle: Freelancers and Exploitation by Nicole S. Cohen

“…Drawing on Karl Marx’s foundational concepts, labour process theory, and a case study of freelance writers, I argue that the debate over autonomy and control in cultural work ignores exploitation in labour-capital relationships, which is a crucial process shaping cultural work. …”
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Language Development as a Change of the Parameter Pattern of the Language System by Tetiana Dombrovan, Kateryna Oleksandrenko

“…From the perspective of the synergetic approach, a human language is considered an open, dynamic, non-linear, self-organizing system with all its hierarchical subsystems and elements coherently interconnected and controlled by governing parameters. …”
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La Cassette de Louis XVI by Benoît Carré

“…Focusing on the end of the Ancien Régime, this article offers a unique perspective on the relationship of members of the royal family to money and, first of all, to their personal funds. …”
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