Cost-effectiveness of edoxaban compared to warfarin for the treatment and secondary prevention of venous thromboembolism in the UK by Emilie Clay, Aurélien Jamotte, Peter Verhamme, Alexander T. Cohen, Ben. A. Van Hout, Pearl. Gumbs

“…Objective: The aim was to estimate the cost-effectiveness of edoxaban, a non-VKA oral anticoagulant vs. warfarin, the currently most prescribed treatment for VTE in the UK. Study design: A Markov model was built using data from the Hokusai-VTE randomised controlled trial to estimate the lifetime costs and quality-adjusted life years (QALYs) in patients with VTE treated with edoxaban or warfarin over a lifetime horizon, from the UK National Health Services perspective. …”
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Multidomain Connectivity as a Marker of HIIT-Induced Adaptation in Elite Youth Soccer Players: A Correlational Mapping Approach by Moses Gnanasigamani, Agnieszka Kaczmarek, Jarosław Nosal, Eugenia Murawska-Ciałowicz, Paweł Chmura

“…This study investigated the effects of high-intensity interval training (HIIT) in elite youth soccer players using a novel multidomain correlational mapping approach. …”
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Economic Evaluation of Boceprevir for the Treatment of Patients with Genotype 1 Chronic Hepatitis C Virus Infection in Hungary by Raymond Odhiambo, Jagpreet Chhatwal, Shannon Allen Ferrante, Antoine El Khoury, Elamin Elbasha

“…Efficacy was estimated from SPRINT-2 and RESPOND-2 studies. Disease progression rates and health state utilities used in the model were obtained from published studies. …”
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Reading Tabriz Municipality Building Based on Foucault’s Theory of Power by Noushin Ghorbani, Sahar Toufan, Habib Shah Hosseini, Nima Vali Zadeh, Hassan Sattari Sarbangholi

“…The question here is how architectural space played a vital role in implementing power in the first Pahlavi era from the Foucauldian perspective of power theory. The extant study aimed at matching the spatial configuration of Tabriz Municipality Building with Foucault's spatial discipline techniques. …”
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Hydrochemical characteristic and karst development in typical karst spring area, Northern China by Qiao Xiaojuan, Qiao Xiaojuan, Li Baoling, Liu Kai, Chai Xinyu, Yu Wenjin

“…This study focuses on the relationship and systematically analyzed structure control on hydrochemical indicators for karst development in Fangshan, Beijing, North China. …”
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The Bro-Xre toxin-antitoxin modules in Weissella cibaria: inducing persister cells to escape tetracycline stress by disrupting metabolism by Wen-Liang Xiang, Wen-Liang Xiang, Jie Xiong, Han-Yang Wang, Ting Cai, Ting Cai, Pei Shi, Qiu-Huan Zhao, Jie Tang, Jie Tang, Yi-Min Cai

“…This study found that the Bro-Xre TA modules of W. cibaria function as typical tetracycline regulators. …”
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Transcatheter aortic valve implantation with SAPIEN 3 versus surgical aortic valve replacement in patients with symptomatic severe aortic stenosis at low risk of surgical mortality... by Christophe Alain Wyss, Roberto Corti, Thomas Nestelberger, Pascal Candolfi, Alexis Delbaere, Barbara Fischer, Matthias Schwenkglenks, Harry Telser

“… AIMS OF THE STUDY: The 2021 European Society of Cardiology Guidelines on valvular heart disease recommend transcatheter aortic valve implantation (TAVI) for patients with symptomatic severe aortic stenosis at low surgical risk and age ≥75 years who are suitable for a transfemoral approach (recommendation class IA) based on two large randomised controlled trials (PARTNER 3 and Evolut Low Risk) comparing transcatheter aortic valve implantation with surgical aortic valve replacement (SAVR). …”
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Infliximab for the Treatment of Crohn'S Disease: Review and Indications for Clinical Use in Canada by Remo Panaccione

“…In randomized, placebo-controlled clinical trials, 33% of patients treated with infliximab 5 mg/kg achieved remission (Crohn's Disease Activity Index score less than 150), compared with only 4% of those receiving placebo (P<0.001). …”
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Psychological inoculation improves resilience to and reduces willingness to share vaccine misinformation by Ruth E. Appel, Jon Roozenbeek, Rebecca Rayburn-Reeves, Melisa Basol, Jonathan Corbin, Josh Compton, Sander van der Linden

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Protocol for the economic evaluation alongside the PARTICIPATE (PArticipatory Research model for medicaTIon adherenCe In People with diAbetes and hyperTEnsion) multicenter cluster... by Vivek Verma, Denny John, Tanu Anand, Dinesh Kumar, K Sunitha, Tanveer Rehman, Pooja Reddy, Anuja Jha, Harshal Gupta, Avi Kumar Bansal, Smita Mahapatra, Sudhira Kumar Parida, Mamata Jena, A Charles Pon Ruban, Shantaraman Kalyanaraman, Jerin Jose Cherian

“…Health economic evaluation methods, including a lifetime horizon, a 3% discount rate for costs and benefits and a societal perspective, will be followed. The effects of sampling uncertainty on estimated incremental costs and effectiveness parameters, as well as the influence of methodological assumptions (such as the discount rate and study perspective), will be examined through both deterministic and probabilistic sensitivity analyses. …”
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Perception of Lemborexant Effectiveness as Assessed by the Patient Global Impression&ndash;Insomnia Questionnaire by Drake CL, Yardley J, Pinner K, Moline M, Malhotra M

“…., 200 Metro Blvd, Nutley, NJ, 07110, USA, Email margaret_moline@eisai.comObjective: Using data from a clinical study of lemborexant, evaluate responses to the Patient Global Impression–Insomnia (PGI-I) questionnaire, a simple 4-item questionnaire that assesses patients’ perceptions of the effects of medication on sleep, which may help evaluate clinically meaningful changes from the patient’s perspective.Methods: Study E2006-G001-303, a 12-month, placebo (PBO)-controlled (first 6 months) Phase 3 study in adults with insomnia disorder, randomized subjects (1:1:1) to lemborexant 5 mg (LEM5; n=316), 10 mg (LEM10; n=315), or PBO (n=318). …”
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A Scoping Review on Sex and Gender Differences in the Adverse Health Outcomes of Individuals with Sickle Cell Trait by Angela K. Phillips, Laura Segovia, Alicia A. Livinski, Candy Wilson, Arun S. Shet, Margaret Bevans

“…One-third reported health outcomes by both SCT status and sex, and one-third controlled for sex; no studies addressed gender. Further research is needed on the role of sex and gender for individuals with SCT.…”
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A first-in-human, prospective pilot trial of umbilical cord-derived mesenchymal stem cell eye drops therapy for patients with refractory non-Sjögren's and Sjögren's syndrome dry ey... by Di Zhang, Taige Chen, Qi Liang, Xuebing Feng, Jiaxuan Jiang, Zeying Chen, Yun Tang, Yiran Chu, Bin Wang, Kai Hu

“…Conclusions In this prospective exploratory clinical study, we have demonstrated that MSC eye drops might offer clinical efficacy and manageable safety in treating refractory DED for the first time, potentially bringing a new perspective on the treatment of such patients. …”
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Trends in long-term hydrological data from European karst areas: insights for groundwater recharge evaluation by M. Giese, M. Giese, Y. Caballero, Y. Caballero, A. Hartmann, J.-B. Charlier, J.-B. Charlier

“…The results show that the sensitivity of karst aquifers to climate change is not controlled by their degree of karstification. Long-term trends in spring discharge observed in this study align with the general patterns of river discharge found in the literature. …”
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Records of Chemical Weathering and Plateau Saline Lake Sediments Linked to Paleoclimate Fluctuations During the Eocene by Peng Pang, Xiucheng Tan, Kunyu Wu, Songtao Wu, Haoting Xing, Menglin Zhang, Na Zhang, Wei Deng

“…During the westerly weakening periods, less rainfall leads to a cold and dry paleoclimate conditions, resulting in lower terrigenous input dominated by coarser clastic sediments and weak weathering intensity. Our study provides new evidence and insights into the westerly shift and paleoclimate evolution in the Eocene from the perspective of high‐resolution chemical weathering records.…”
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Perinatal interventions to prevent Adverse Childhood Experiences (ACEs): A scoping review. by Jane Kinsey, Jaime La Charite, Shirley Russ, Adam Schickedanz

“…<h4>Objectives</h4>To (1) identify perinatal ACE prevention interventions, tested in high quality randomized control trials, with a dyadic perspective examining outcomes for mother and child; (2) describe their (a) place on the public health prevention continuum and (b) incorporation of life course characteristics that aim to optimize life health trajectories; and (3) determine which interventions show evidence of effectiveness.…”
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Tofacitinib for the treatment of moderately to severely active ulcerative colitis: a systematic review, network meta-analysis and economic evaluation by Emily Wright, Christoph Lohan, Alex Diamantopoulos, Corinne LeReun, Natalie Bohm, Laura Marie Sawyer

“…However, there have been few head-to-head studies of these therapies. This study aimed to compare the clinical and cost-effectiveness of tofacitinib with biological therapies.Methods A systematic literature review was conducted to identify all relevant randomised controlled trial (RCT) evidence. …”
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Economic evaluation of Maternal Depression Treatment in HIV (M-DEPTH) for perinatal depression among women living with HIV in Uganda: a cost-effectiveness analysis by Ryan McBain, Adeyemi Okunogbe, Rhoda K Wanyenze, Violet Gwokyalya, Glenn Wagner

“…Objective We conducted a cost-effectiveness analysis of an evidence-based collaborative care model for treatment of perinatal depression among women living with HIV in Uganda.Design Maternal Depression Treatment in HIV (M-DEPTH) is a cluster randomised controlled trial implemented from July 2019 to August 2023, during which 391 pregnant women with mild-to-severe depressive symptoms were randomised to receive stepped care for depression (M-DEPTH: behavioural and pharmacological treatments) or care as usual (CAU: hospital referral for severe cases), at one of eight public health facilities in Uganda.Methods We implemented time-driven, activity-based costing to determine the economic cost of M-DEPTH from a societal perspective, compared with CAU. …”
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Pharmacoeconomic analysis of using biological agents in the treatment of rheumatoid arthritis by I. I. Dyakov, D. V. Goryachev

“…By taking into account the fact that there are a few alternative biological agents for the treatment of rheumatoid arthritis (RA), the cost of an annual therapy cycle using the agents is greater than that of high-technology surgical interventions, and a pharmacoeconomic study substantiating the optimal choice of a specific drug has been conducted. …”
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Efficacy and safety of trimethoprim-sulfamethoxazole for the prevention of pneumocystis pneumonia in human immunodeficiency virus-negative immunodeficient patients: A systematic re... by Rui Li, Zhiyong Tang, Fu Liu, Ming Yang

“…There have been few reports on this topic. The aim of this study was to systematically evaluate the efficacy and safety of the use of TMP-SMZ for the prevention of PCP in this population of patients from the perspective of evidence-based medicine.…”
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