A CRISPR‐nonhomologous end‐joining‐based strategy for rapid and efficient gene disruption in Mycobacterium abscessus by Sanshan Zeng, Yanan Ju, Md Shah Alam, Ziwen Lu, H. M. Adnan Hameed, Lijie Li, Xirong Tian, Cuiting Fang, Xiange Fang, Jie Ding, Xinyue Wang, Jinxing Hu, Shuai Wang, Tianyu Zhang

“…This discovery challenges current perspectives and suggests that NHEJ repair in M. abscessus may involve components from both homologous recombination and single‐strand annealing pathways, highlighting the complex interactions among the three DSB repair mechanisms in M. abscessus.…”
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The diagnostic potential of extracellular vesicles in virus-related diseases by Qing Gao, Qing Gao, Yuqing Zhan, Yuqing Zhan, Jianhao Zhang, Jianhao Zhang, Dongyu Sun, Dongyu Sun, Huayuan Xiang, Huayuan Xiang, Chenxuan Bao, Chenxuan Bao, Qianqian Gao, Mengyu Zhang, Jianjun Wang, Lingxiang Mao, Lingxiang Mao

“…Recent advances reveal their dual functionality in viral pathogenesis: while facilitating viral dissemination through transport of pathogenic components, they simultaneously orchestrate host antiviral defense mechanisms. …”
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Research participants' perception of ethical issues in stroke genomics and neurobiobanking research in Africa. by Ayodele Jegede, Olubukola Balogun, Olorunyomi Felix Olorunsogbon, Michelle Nichols, Joshua Akinyemi, Carolyn Jenkins, Mayowa Ogunronbi, Arti Singh, Reginald Obiako, Kolawole Wahab, Abiodun Bello, Albert Akpalu, Fred S Sarfo, Lukman F Owolabi, Babatunde Ojebuyi, Muyiwa Adigun, Dorcas Olujobi, Rabiu Musbahu, Musibau Titiloye, Ibukun Afolami, Benedict Calys-Tagoe, Ezinne Uvere, Ruth Laryea, Adekunle Fakunle, Osi Adeleye, Deborah Adesina, Nathaniel Mensah, Wisdom Oguike, Nathaniel Coleman, Sunday Adeniyi, Lanre Omotoso, Shadrack Asibey, Lois Melikam, Jibril Yusuf, Abdullateef Gbenga, Aliyu Mande, Muhammed Uthman, Rajesh N Kalaria, Mayowa Owolabi, Bruce Ovbiagele, Oyedunni Arulogun, Rufus O Akinyemi

“…Concerns were raised about understanding, disclosure and absence of coercion as components of true autonomous decision making in research participation. …”
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Barriers and facilitators for social inclusion among people with concurrent mental health and substance use problems. A qualitative scoping review. by Silje Nord-Baade, Ottar Ness, Camilla Bergsve Jensen, Michael Rowe, Elin Opheim, Anne Landheim

“…<h4>Methods</h4>We explored first-person perspectives on social inclusion among people with concurrent mental health and substance use problems, employing Arksey and O'Malleys framework. …”
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FACTORS ENDANGERING THE PROFESSIONAL ACTIVITY OF THE EMERGENCY MEDICAL PROFESSIONALS by D. Todorova, A. Andonova

“…The implemented structural and organizational changes still do not outline fully clear perspectives ahead of the work of the emergency rooms. …”
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L’idéo-scénarisation sonore du paysage comme support métaphorique de sa médiation by Philippe Woloszyn

“…The resulting ideoscenes describe the representations of the sonic environment of the neighbourhood by defining the function of the mediating transfer between the real and imaginary components of the soundscape. This mediation method thus makes it possible to share the sensory dimensions of the landscape via a participative approach to combine transversal and interdisciplinary perspectives of the landscape and its design.…”
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A Review of the Health Implications of Heavy Metals in Food Chain in Nigeria by Ugonna C. Nkwunonwo, Precious O. Odika, Nneka I. Onyia

“…Aquatic foods, fruits, vegetables, and major staple food such as tubers are the major host of carcinogenic and mutagenic components of heavy metals in Nigeria. This study motivates the Standard Organisation of Nigeria (SON), along with other food and agricultural agencies, to intensify their efforts in monitoring and analysing food components, and we advise consumers to eat with certain degrees of caveat.…”
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A modern view on potential biomarkers of Parkinson’s disease (review) by A. V. Demchenko, V. V. Biriuk

“…The negative impact of oxidative stress in PD is a significant trigger for irreversible pathogenetic processes that affect the development of neurodegenerative changes. Perspectives of further researches may lay not only in identifying the concentrations of nitrotyrosine and oxidative stress components and antioxidants in the blood of PD patients, but also in determining of the effect of antiparkinsonian and neuroprotective drugs on the antioxidant system in order to pathogenetically justify their use for reducing of oxidative stress. …”
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Colour guided ground-to-UAV fire segmentation by Rui Zhou, Tardi Tjahjadi

“…First, we identify domain-invariant fire features by deriving fire-discriminating components (u*VS) defined in colour spaces Lu*v*, YUV, and HSV. …”
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COVID-19 governance and decision-making at provincial level in South Africa by Godwell Nhamo, Gideon W. Mutanda

“…This paper mainly investigates the perspectives of government officials on the effectiveness of COVID-19 governance in Limpopo Province. …”
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Graduate teachers’ sense of belonging anchored in experiences of preservice internships and employability by Sandi Fielder, Chad Morrison, Susan Ledger

“…Through surveys and interviews, graduates shared their experiences and perspectives of what they gained from their involvement. …”
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Assessing the influence of metabolic syndrome on thyroid cancer: insights from a Mendelian randomization approach by Xiaosong Ru, Ziying Su, Yong Guo

“…These findings offer fresh perspectives on the potential causal link between MetS and TC.…”
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BLENDED LEARNING IN THE SYSTEM OF PROFESSIONAL TRAINING OF STUDENTS AT HIGHER MEDICAL EDUCATIONAL INSTITUTIONS by V.O. Ruzhanska, Y.P. Pashkova, G.O. Palahniuk, L.M. Sursaieva, M.O. Matohniuk

“…Discussions primarily focus on achieving a balanced integration of face-to-face and online education rather than a comprehensive understanding of blended learning itself. Clarifying the components of blended learning enhances comprehension of its underlying principles, including student autonomy in determining when, where, and how they learn, the use of technology to enhance personalization, and the creation of an integrated learning experience where face-to-face and online components are synergistically aligned. …”
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An optimization-based analytics model for sustainable and blockchain-enabled supply chains in uncertain environments by S. Priyan

“…The carbon footprint is highly uncertain and directly impacts demand forecasting, with uncertainty arising from both positive and negative perspectives. This duality highlights the contrasting viewpoints of decision-makers during the decision-making process. …”
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Carbon dots-based drug delivery for bone regeneration by Christy Liu, Yingzi Li, Xiaohua Liu, Xiaohua Liu

“…Finally, the review highlights the challenges and future perspectives in optimizing CDs for enhanced therapeutic outcomes.…”
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Phase Space Formulation of Light Propagation on Tilted Planes by Patrick Gioia, Antonin Gilles, Anas El Rhammad, San Vũ Ngọc

“…These derivations lead to new algorithms that open unprecedented perspectives in various domains involving the propagation of coherent light.…”
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Verifying learning success: assessment and certification of student ultrasound education by Ricarda Neubauer, Florian Recker, Johannes Weimer, Christian Jenssen, Dieter Nürnberg, Thomas Karlas, Susan Campbell Westerway, Johannes P. Ruppert, Nils Daum, Anna Gschmack, Yi Dong, Kathleen Möller, Nasenien Nourkami-Tutdibi, Gregor Barth, Roxana Şirli, Claudia Lucius, Michael Prats, Sophie-Luise Sänger, Michael Keil, Constantinos Zervides, Beatrice Hoffmann, Christoph F. Dietrich

“…In addition to cognitive skills, the examination format should cover translational and behavioral components. Self-assessments and evaluations provide additional valuable perspectives. …”
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Experimental and Numerical Study of Wrought Inconel 718 Under Thermal Cycles of Variable Amplitude Coupled with Mechanical Loading by Sining Pan, Shouwen Xu, Gang Yu

“…This paper offers extensive experimental and numerical perspectives on the damage process occurring under thermal cycles of varying amplitudes combined with mechanical loading, highlighting its substantial engineering importance for conducting failure analyses and optimizing the design of hot-end components.…”
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The role of renin-angiotensin system and angiotensin-converting enzyme 2 (ACE2) in the development and course of viral infection COVID-19 in patients with diabetes mellitus by O. K. Vikulova, Zamira Zuraeva, L. V. Nikankina, M. V. Shestakova

“…This&nbsp;review presents the data on the interaction between the virus and the main components of RAS and the factors influencing their expression level, the impact of ACE &shy;inhibitors and ARBs therapy on the disease outcome, and presents the&nbsp;perspectives of the treatment with recombinant ACE 2.…”
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Balancing public interest, fundamental rights, and innovation: The EU’s governance model for non-high-risk AI systems by Michael Gille, Marina Tropmann-Frick, Thorben Schomacker

“…Based on a doctrinal legal reconstruction of the rules for codes of conduct and considering the European Union's stated goal of achieving a market-oriented balance between innovation, fundamental rights, and public interest, we explore our topic from three different perspectives: an analysis of specific regulatory components of the governance mechanism is followed by a reflection on ethics and trustworthiness implications of the EU´s approach and concluded by an analysis of a case study from an NLP-based, language-simplifying artificial intelligence application for assistive purposes.…”
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