The Role and Pathogenesis of Tau Protein in Alzheimer’s Disease by Xiaoyue Hong, Linshu Huang, Fang Lei, Tian Li, Yi Luo, Mengliu Zeng, Zhuo Wang

“…Tau, a microtubule-associated protein predominantly localized to neuronal axons, orchestrates microtubule stabilization and axonal transport through dynamic tubulin interactions under physiological conditions. In AD pathogenesis, however, tau undergoes pathogenic post-translational modifications (PTMs), encompassing hyperphosphorylation, lysine acetylation, methylation, ubiquitination, and glycosylation. …”
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