Randomized single-dose crossover comparative bioavailability study of two novel oral cannabidiol (CBD) formulations in healthy volunteers under fed conditions, compared to a standa... by Mehmet Nevzat Pisak, Edibe Bereket, Aydin Erenmemisoglu

“…The 7-hydroxy-CBD metabolite reached much lower plasma levels than parent CBD for all treatments (C_max 0.4–1.8 ng/mL, ~ 5–13% of parent C_max), with a slightly delayed tmax (~ 2–6 h) and similar elimination half-life. …”
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Altered Metabolism of Phospholipases, Diacylglycerols, Endocannabinoids, and N-Acylethanolamines in Patients with Mastocytosis by Anne Lise Ferrara, Fabiana Piscitelli, Angelica Petraroli, Roberta Parente, Maria Rosaria Galdiero, Gilda Varricchi, Giancarlo Marone, Massimo Triggiani, Vincenzo Di Marzo, Stefania Loffredo

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Green solvents assisted de-novo synthesis and defect-engineered UiO-66 for improved CO2 adsorption and kinetics- experimental and DFT approach by Saleem Nawaz Khan, Ming Zhao

“…Furthermore, through periodic Density Functional Theory (DFT) calculations, a variety of linker defects are engineered onto the UiO-66 structure to preserve more open metal sites. …”
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High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. by Lisa F Barcellos, Suzanne L May, Patricia P Ramsay, Hong L Quach, Julie A Lane, Joanne Nititham, Janelle A Noble, Kimberly E Taylor, Diana L Quach, Sharon A Chung, Jennifer A Kelly, Kathy L Moser, Timothy W Behrens, Michael F Seldin, Glenys Thomson, John B Harley, Patrick M Gaffney, Lindsey A Criswell

“…We characterized 1,610 Caucasian SLE cases and 1,470 parents for 1,974 MHC SNPs, the highly polymorphic HLA-DRB1 locus, and a panel of ancestry informative markers. …”
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Integration of nontarget screening and QSAR modeling to identify novel butachlor transformation products of high priority in soil and water environment by Feng Chen, Chi Wu, Lan Zhang, Liangang Mao, Lizhen Zhu, Xingang Liu

“…Butachlor (BTR), a widely used chloroacetanilide herbicide in rice paddies worldwide, has raised concerns due to limited data on its environmental transformation products (TPs) and their ecotoxicological effects. This study systematically investigates BTR’s degradation kinetics, mechanisms, pathways, and ecotoxicity in water and soil through batch tests, integrating Non-Target Screening (NTS) with Quantitative structure–activity relationship (QSAR) modeling. …”
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Clinical Evidence of Mesenchymal Stromal Cells for Cerebral Palsy: Scoping Review with Meta-Analysis of Efficacy in Gross Motor Outcomes by Madison C. B. Paton, Alexandra R. Griffin, Remy Blatch-Williams, Annabel Webb, Frances Verter, Pedro S. Couto, Alexey Bersenev, Russell C. Dale, Himanshu Popat, Iona Novak, Megan Finch-Edmondson

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Digital Transformation in Voluntary Sports Organizations: A Scoping Review on Multi-Level Drivers, Promoting Factors, Forms and Consequences by Pascal Stegmann, Grazia Lang

“…Ibsen, & J. Scheerder (Eds.), Functions of sports clubs in European societies: A cross-national comparative study (pp. 289–313). …”
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Facial Expression Recognition and Digital Images Infosecurity for Prevention Care System Application in Sudden Infant Death Syndrome Monitoring by Chih-Te Tsai, Chia-Hung Lin, Hsiang-Yueh Lai, Yu-En Cheng, Ping-Tzan Huang, Neng-Sheng Pai, Chien-Ming Li

“…Hence, while assisting parents in effectively caring for their infants, it is also expected to contribute to reducing the incidence of SIDS under secure monitoring conditions.…”
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Barriers and facilitators to accessing healthcare services among elderly people living in a rural Amazonian community, Brazil by Gleica Soyan Barbosa Alves, Fernando José Herkrath, Rosana Cristina Pereira Parente, Rita Dariene da Silva Pinheiro, Mario Vianna Vettore

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Translation and Response Validation of Cerebral Palsy Quality of Life Questionnaire for the Child’s Primary Caregiver (Kannada Version): A Cross-sectional Study by KB Komal, Navami Mahaveer, Anvita Shiggavi, Prashanth Mukkannavar, Aditi Prayag

“…Children with CP experience a variety of effects on their Quality of Life (QOL), including social, emotional and physical aspects. …”
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A novel intronic variant in the ASAH1 gene enhances aberrant splicing, causing spinal muscular atrophy with progressive myoclonic epilepsy by Jinli Bai, Ping Li, Hui Jiao, Yuwei Jin, Hong Wang, Qinglin Jiang, Fang Song, Xiaoyin Peng, Yujin Qu

“…However, the c.264 + 11A > G variant in intron 3 was reported for the first time, and its functional impact has not yet been fully elucidated. …”
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Depression and non-suicidal self-injury: the mediating roles of childhood trauma and impulsivity by Wenjing Su, Hao Liu, Xiaoyan Zhou, Xueping Huang

“…All participants completed self- report questionnaires assessing demographic characteristics, NSSI behaviors, depression, anxiety, childhood trauma, impulsivity, family environment, parenting, and experiences in close relationships. …”
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Non-Suicidal Self-Injury in College Students: Differences Between the Subject Group and Comparison Group by Hye-seung Kim, Yong-won Seo, Youngil Lee, Chang Min Lee, Do Hyun Kim, Minsun Kim, Myung Ho Lim

“…The participants consisted of 403 Korean college students aged 18–29 who were divided into a subject group with a history of NSSI (n = 198) and a comparison group (n = 205) with no history of NSSI. The Functional Assessment of Self-Mutilation (FASM), Childhood Trauma Questionnaire (CTQ-SF), Social Experience Questionnaire (SEQ), Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorder 7-item scale (GAD-7), Difficulties in Emotion Regulation Scale—16 item version (DERS-16), Experiences in Close Relationship Questionnaire-Revised (ECR-R), Rosenberg Self-Esteem Scale (RSES), Parents as Social Context Questionnaire-Kids (PSCQ-KA), and Barratt Impulsiveness Scale-11-Revised (BIS-11). …”
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Multi-Objective Optimal Trajectory Planning for Woodworking Manipulator and Worktable Based on the INSGA-II Algorithm by Jiaping Yi, Changqing Zhang, Sihan Chen, Qinglong Dai, Hang Yu, Guang Yang, Leyuan Yu

“…In practical applications, selecting suitable weightings to construct a normalized weight function can identify the optimal solution from the Pareto frontier curve. …”
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Cognitive benefits of folic acid supplementation during pregnancy track with epigenetic changes at an imprint regulator by L. Hilman, M. Ondičová, A. Caffrey, M. Clements, C. Conway, M. Ward, K. Pentieva, R. E. Irwin, H. McNulty, C. P. Walsh

“…Abstract Background The human ZFP57 gene is a major regulator of imprinted genes, maintaining DNA methylation marks that distinguish parent-of-origin-specific alleles. DNA methylation of the gene itself has shown sensitivity to environmental stimuli, particularly folate status. …”
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p27^Kip1 and Tumors: Characterization of <i>CDKN1B</i> Variants Identified in MEN4 and Breast Cancer by Debora Bencivenga, Emanuela Stampone, Jahanzaib Azhar, Daniela Parente, Waqar Ali, Vitale Del Vecchio, Fulvio Della Ragione, Adriana Borriello

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Operational Modes and Technical Points for Empowering Urban Park Green Spaces by Digital Technology by Yang ZHANG, Changlin LI, Ninglu ZHANG, Fei WU

“…Vertically integrate consumption scenarios in depth, connect court services, equipment rental, and healthy catering support with the sports consumption chain, and connect outdoor science education, natural practice classes, and theme derivatives development with the parent – child consumption chain; besides, horizontally expand cross-domain cooperation, jointly build a ticket intercommunication and point conversion system with surrounding scenic spots and commercial entities, and activate the regional consumption synergy effect.…”
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Fc-competent TIGITx4-1BB bispecific antibody exerts potent long-lasting antitumor activity by potentiating CD8+ T cell activity and Fcγ receptor-mediated modulation of the tumor mi... by Sang Hoon Lee, Jonghwa Won, Sora Kim, Wonjun Son, Yangsoon Lee, Yelim Park, Kyeong-Su Park, Hyunseong Youn, Arim Seo, Byungje Sung

“…In H22 tumor models expressing high levels of endogenous CD155, both ABL112 and parent TIGIT single-domain Ab showed potent tumor-suppressive activity; however, only ABL112 exerted long-lasting antitumor activity. …”
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Analysis of genomic ancestry and characterization of a new variant in MPS type VII by Andreza Juliana Moreira da Costa, Isabel Cristina Neves de Souza, Raimunda Helena Feio, Laurent Ketlen Leão Viana, Mislene Cisz, Célio Luiz Rafaelli, Franciele Barbosa Trapp, Maira Graeff Burin, Kristiane Michelin-Tirelli, Ana Carolina Brusius-Facchin, Alice Brinckmann Oliveira Netto, André Salim Khayat, Ney Pereira Carneiro dos Santos, Roberto Giugliani, Luiz Carlos Santana-da-Silva

“…Allelic variations in specific ethnic groups explain the higher incidence in some groups due to founder effects and/or endogamy. In Brazil, the most common variant is p.Leu176Phe. …”
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Assessment of test-retest reproducibility by [18F]Bavarostat for PET imaging of HDAC6 by Mika Naganawa, Ming-Qiang Zheng, Jean-Dominique Gallezot, Robin Bonomi, Jiwei Gu, Hong Gao, Swanee Jacutin-Porte, Nabeel B. Nabulsi, Michel Koole, Koen Van Laere, David Matuskey, Yiyun Huang, Richard E. Carson

“…Arterial blood sampling and metabolite analysis were performed to derive the input function. The two scans were 28 ± 12 days apart (14–43 days, n = 6). …”
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