Hierarchical contrastive learning for multi-label text classification by Wei Zhang, Yun Jiang, Yun Fang, Shuai Pan

“…Specifically, we recast multi-label text classification as a multi-task learning problem, incorporating a hierarchical contrastive loss that is computed through a carefully designed sampling process. This unique loss function enables our model to effectively capture both the correlations and distinctions among labels, thereby enhancing the model’s ability to learn the intricacies of the label hierarchy. …”
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Establishment Methods and Application Evaluation of Animal Models in Reproductive Toxicology Research by HUANG Dongyan, WU Jianhui

“…Reproductive toxicology is a discipline that uses toxicological methods to study the mechanisms by which foreign substances interfere with the generation of eggs or sperm and their detrimental effects on offspring. Research includes evaluating the damaging effects of test substances on reproductive function of parents and the toxicity evaluation of offspring embryos. …”
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POSITIVE INTERACTION IN AN INCLUSIVE EDUCATION: MANIFESTATION OF THE INTERNATIONAL CHILD DEVELOPMENT PROGRAMME (ICDP) by Farid Alamdar oglu Suleymanov

“…Fundamental caregiving skills function as particularly important contribution to the quality and effectiveness all caregiving. …”
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GPR56 homozygous nonsense mutation p.R271* associated with phenotypic variability in bilateral frontoparietal polymicrogyria by Tülay Öncü-Öner, Semra Hız-Kurul, Bayram Yüksel, Bekir Ergüner, Aydan Saraç, Handan Güleryüz, Sinem Ağılkaya, İlknur Porsuk-Doru, Aycan Ünalp, Sultan Cingöz

“…Consequently, the present findings show that the same mutation in GPR56 gene can have different phenotypic effects. Therefore, additional functional studies are needed to detect the phenotypic spectrum of the p.R271* mutation in GPR56, and provide insight into the mechanism of normal cortical development and regional patterning of the cerebral cortex. …”
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Identification of the Cold-Related Genes COLD11 and OsCTS11 via BSA-seq and Fine Mapping at the Rice Seedling Stage by Bian Wu, Minghui Fu, Jinghua Du, Mengjing Wang, Siyue Zhang, Sanhe Li, Junxiao Chen, Wenjun Zha, Changyan Li, Kai Liu, Huashan Xu, Huiying Wang, Shaojie Shi, Yan Wu, Peide Li, Aiqing You, Lei Zhou

“…According to the reported functional variation of COLD11, Nipponbare (TCG + 3GCG)×2 presented more GCG repeats in the 1st exon than WD16343 (TCG + 3GCG), partially explaining the difference in cold tolerance between the parents. …”
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PEPITEM, its tripeptide pharmacophores and their peptidomimetic analogues regulate the inflammatory response through parenteral and topical dosing in models of peritonitis and psor... by Anella Saviano, Bonita Apta, Samantha Tull, Laleh Pezhman, Areeba Fatima, Mustafa Sevim, Antonio Mete, Myriam Chimen, Anna Schettino, Noemi Marigliano, Helen M. McGettrick, Asif J. Iqbal, Francesco Maione, G. Ed Rainger

“…PEPITEM is an immune-modulatory peptide that effectively regulates inflammation and mitigates immune-mediated inflammatory diseases (IMIDs). …”
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Magnitude and determinants of stunting among children under five years of age in Ethiopia: a systematic review and meta-analysis by Teshome Bekele Elema, Teshome Bekele Elema, Fetene Nega, Jemal Mohammed Ali, Gemechu Edae, Dube Jara Boneya

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Factors influencing survival outcomes in patients with stroke at three tertiary hospitals in Zimbabwe: A 12-month longitudinal study. by Farayi Kaseke, Lovemore Gwanzura, Cuthbert Musarurwa, Elizabeth Gori, Tawanda Nyengerai, Timothy Kaseke, Aimee Stewart

“…Housing status revealed a protective effect for those residing with parents/relatives (aHR: 0.4, 95% CI: 0.20, 0.64). …”
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Mutant glycyl-tRNA synthetase (Gars) ameliorates SOD1(G93A) motor neuron degeneration phenotype but has little affect on Loa dynein heavy chain mutant mice. by Gareth T Banks, Virginie Bros-Facer, Hazel P Williams, Ruth Chia, Francesca Achilli, J Barney Bryson, Linda Greensmith, Elizabeth M C Fisher

“…We found the Dync1h1(Loa/+);Gars(C201R/+) double heterozygous mice are more impaired than either parent, and this is may be an additive effect of both mutations. …”
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Unique Dermatological and Systemic Manifestations in a Classic Pediatric Case of Kindler Syndrome: A Case Report and Literature Review by Muhammad Aamir, Fahad Faizullah, Malik W. Z. Khan, Touba Azeem, Muhammad Awais Khan

“…However, laboratory findings, including normal liver function and the absence of specific PCT markers, effectively excluded PCT. …”
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The impact of asthma education grounded in virtual reality technology upon the quality of life of pediatric patients with bronchial asthma by Huijuan Wang, Qing Dong, Xiaowei Wang

“…The VR group also had higher PAQLQ scores in symptoms, activity limitation, emotional function, and overall score. They accessed educational materials more often. 92.5% of parents/guardians were satisfied with VR devices and the program.ConclusionImplementing VR technology - based asthma education for children with bronchial asthma can enhance the asthma control status, effectively mitigate the children's negative emotions, augment medication adherence, and ultimately elevate their quality of life.…”
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Associations of prenatal nicotine exposure and the dopamine related genes ANKK1 and DRD2 to verbal language. by John D Eicher, Natalie R Powers, Kelly Cho, Laura L Miller, Kathryn L Mueller, Susan M Ring, J Bruce Tomblin, Jeffrey R Gruen

“…Next, hypothesizing that the effects of prenatal nicotine may also implicate genes that function in nicotine related pathways, we determined whether known nicotine dependence (ND) genes associate with performance on language tasks. …”
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De novo transcriptome assembly and discovery of drought-responsive genes in white spruce (Picea glauca). by Zoé Ribeyre, Claire Depardieu, Julien Prunier, Gervais Pelletier, Geneviève J Parent, John Mackay, Arnaud Droit, Jean Bousquet, Philippe Nolet, Christian Messier

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Mesenchymal stem cell- derived exosomes as cell-free therapeutics for sensorineural hearing loss by Maria Perde-Schrepler, Ioana Brie, Alma Maniu

“…Exosomes derived from MSCs exhibit similar biological functions to their parent cells but with significantly lower risks, as they do not trigger immune responses or pose oncological concerns. …”
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KiKli Fit: Investigating the Implementation of a Physical Activity Program in Pediatric Cancer by Lars Rehbein, Ann Christin Schneider, Christina Hillebrech, Christina Schindera, Amika Singh, Katharina Eva, Valentin Benzing

“…Preliminary findings indicate strong acceptance of the PA program among stakeholders, including patients, parents, and healthcare professionals. Children and their families expressed enthusiasm for engaging in structured PA, reporting perceived benefits such as reduced treatment-related side effects, increased PA levels, and improved self-esteem. …”
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Genome-wide association studies of Alzheimer’s disease and related disorders stratified by sex, onset age, and Apolipoprotein E genotype reveal novel risk loci in African Americans... by Richard Sherva, Congcong Zhu, Rui Zhang, Jesse Mez, Richard Hauger, Victoria C. Merritt, Matthew Panizzon, J. Michael Gaziano, Vidriana Catanzaro, Gerard D. Schellenberg, Margaret Pericak-Vance, Jonathan L. Haines, Li-San Wang, Richard Mayeux, VA Million Veteran Program, Lindsay A. Farrer, Mark W. Logue

“…Abstract Background Alzheimer’s disease (AD) risk variants have been identified in European ancestry cohorts that have stronger effects at certain ages, in individuals with a specific sex, or in those with specific isoforms of APOE, the strongest AD risk locus. …”
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Communication Skills in Toddlers Exposed to Maternal SARS-CoV-2 during Pregnancy by Enrico Apa, Nicole Carrie Tegmeyer, Concetta D’Adamo, Eleonora Lovati, Chiara Cocchi, Paola Allegra, Francesco Ostello, Daniele Monzani, Elisabetta Genovese, Silvia Palma

“…Studies about the effects of SARS-CoV-2 on pregnant women and children born to positive women are controversial with regard to possible inner ear-related damage but most of them do not detect the involvement of this virus in auditory function. …”
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Novel TBC1D8B variant causes neonatal nephrotic syndrome combined with acute kidney injury by Yuanyuan Xu, Chao Dai, Jing He, Yaping Liang, Ying Zhu, Fang Deng, Chang Wang, Danqun Jin

“…Since the TBC1D8B protein interacts with RAB proteins to catalyze the GTPase hydrolysis process, immunofluorescence (IF) can be used to verify the interaction between the TBC1D8B mutant protein and RAB11A/RAB11B, and thus to confirm its effect on the endocytosis and vesicle recycling functions of RAB proteins within the cell. …”
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Mindfulness-based cognitive program as a potential intervention for managing smartphone addiction and resilience in adolescents: a pilot evaluation by Anson Chui Yan Tang, Regina Lai-Tong Lee, Alex Chi-Keung Chan, Rick Yiu Cho Kwan, Paul Hong Lee

“…Further refinement of intervention protocol to boost parents' participation and compliance with daily practice is needed to ensure practice adherence.…”
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The Yin and Yang of Microglia-Derived Extracellular Vesicles in CNS Injury and Diseases by Mousumi Ghosh, Damien D. Pearse

“…In contrast, MGEVs may also offer therapeutic potential by reversing inflammation or being amenable to engineering for the delivery of beneficial biologics or drugs. The effects of MGEVs are determined by the phenotypic state of the parent microglia. …”
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