Linguistic accuracy and authenticity of the content of the Russian version of the module of gastrointestinal symptoms of the PedsQL^™ questionnaire for pediatric patient... by Anna L. Arakelyan, Andrey N. Surkov, Aleksander A. Baranov, Leyla S. Namazova-Baranova, Valeri V. Gorev, Elena B. Moskvina, Tamara A. Skvorcova, Artem V. Nikitin, Vladislav V. Chernikov

“…Health Related Quality of Life (HRQL) is a person’s perception of the effect of a disease on physical, social and psychological functioning and wealth. …”
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Enhanced expression of ten‐eleven translocation 1 reverses gemcitabine resistance in cholangiocarcinoma accompanied by a reduction in P‐glycoprotein expression by Chuanxu Wang, Hua Ye, Lei Zhang, Yayu Cheng, Shifeng Xu, Ping Zhang, Zijie Zhang, Jimin Bai, Fangkang Meng, Lin Zhong, Guangjun Shi, Hao Li

“…This study aims to investigate the effect of TET1 on gemcitabine resistance in CCA and the possible effect on P‐glycoprotein (P‐gp) expression encoded by multidrug resistance (MDR) genes. …”
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Assessment of infiltration and erosion rates in Mediterranean reservoirs’ catchments through rainfall simulation by Jorge Mongil-Manso, Carmen Patino-Alonso, José Nespereira-Jato, José-Luis Molina, Fernando Espejo, Teresa Diez-Castro, Santiago Zazo, Fernando Silla

“…Likewise, the sediment concentration in the runs is 5.48 times higher in olive groves (518.43 g/L) than in forests (94.61 g/L) and 2.94 times higher than in shrublands (176.48 g/L). Soil properties and parent material might have a more important effect on the studied variables than the different vegetation types. …”
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AP1-mediated reprogramming of EGFR expression triggers resistance to BLU-667 and LOXO-292 in RET-rearranged tumors by Daniela Esposito, Claudia Maria Ascione, Stefania Belli, Fabiana Napolitano, Alberto Servetto, Felice Pepe, Umberto Malapelle, Antonino Iaccarino, Giancarlo Troncone, Diletta Barone, Emilio Bria, Roberto Ferrara, Daniele Lorenzini, Giuseppe Lo Russo, Maria Rosa Ghigna, Arianna Marinello, Mihaela Aldea, Benjamin Besse, Luigi Formisano, Roberto Bianco

“…RET inhibitors (RETi) have revolutionized treatment for these patients, but resistance remains an important clinical challenge limiting therapy effectiveness. This study investigated the mechanisms underlying resistance to RETi. …”
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THE BASIC CRITERIA FOR SATISFACTION WITH THE QUALITY OF MEDICAL SERVICES PROVIDED TO CHILDREN IN YAKUTSK by I. P. Lutskan, E. A. Borisova, N. V. Savvina, A. D. Bravin, L. F. Timofeev, O. E. Konovalov

“…Population assessment of the quality and effectiveness of medical services, as well as the activities of medical organizations working with the child population in comparison with 2016–2017.Materials and methods. …”
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SMYD2 epigenetically activates BMP4/SMAD1/5/8/ID3 axis to enhance cancer stem cell properties and drive sorafenib resistance in hepatocellular carcinoma by Shanshan Wang, Weicheng Wu, Zhen Shi, Mei Bin, Fengwei Zhang, Long Cai, Kaiqing Lin, Zhihui Li

“…Background: Drug resistance prominently hampers the effects of sorafenib in hepatocellular carcinoma (HCC). …”
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CONTENT AND STRUCTURE OF THE AUTHOR’S DISCIPLINE “TECHNIQUES OF PEDAGOGICAL MANAGEMENT” by Marianna V. Shvardak

“…It determines the search for those management tools that can be used effectively in the pedagogical process. The technicalization of pedagogical management contributes to its rationalization, eliminates those actions of the superior and specialists that are not necessary to achieve the expected result of management, formalizes the implementation of management functions. …”
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Efficient Marker-Assisted Pyramiding of <i>Xa21</i> and <i>Xa23</i> Genes into Elite Rice Restorer Lines Confers Broad-Spectrum Resistance to Bacterial Blight by Yao Li, Yulong Fan, Yihang You, Ping Wang, Yuxuan Ling, Han Yin, Yinhua Chen, Hua Zhou, Mingrui Luo, Bing Cao, Zhihui Xia

“…The pyramided lines exhibited enhanced resistance against six virulent <i>Xoo</i> pathogenic races while retaining parental yield performance across key agronomic traits. …”
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Reproductive and developmental implications of micro- and nanoplastic internalization: Recent advances and perspectives by Zitong Zhang, Jiahua Meng, Jiaqi Tian, Ning Li, Zhen Chen, Xiang Yun, Dandan Song, Fei Li, Shuyin Duan, Lin Zhang

“…We show a potential relationship between MNP exposure and increased prevalence of infertility and adverse pregnancy outcomes based on the fact that MNPs exert detrimental effects on reproductive parameters, including sperm quality, ovarian function, and steroidogenesis. …”
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Peptide‐Drug Conjugate for Therapeutic Reprogramming of Tumor‐Associated Macrophages in Breast Cancer by Anni Lepland, Elisa Peranzoni, Uku Haljasorg, Eliana K. Asciutto, Maria Crespí‐Amer, Lorenzo Modesti, Kalle Kilk, Manuel Lombardia, Gerardo Acosta, Miriam Royo, Pärt Peterson, Ilaria Marigo, Tambet Teesalu, Pablo Scodeller

“…MACTIDE‐V is proposed as a promising peptide‐drug conjugate for modulating macrophage function in breast cancer immunotherapy.…”
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The transfusion of prematures early school age follow-up (TOP 5): protocol for a longitudinal cohort study by Amy L. Conrad, Sara B. DeMauro, Haresh Kirpalani, Kristina Ziolkowski, Susan R. Hintz, Betty R. Vohr, Victoria Watson, Tarah T. Colaizy, Edward F. Bell, Jane E. Brumbaugh, Carla M. Bann, Sylvia M. Tan, Jamie E. Newman, Abhik Das

“…Children undergo a multidimensional assessment of functional outcomes, and parents complete a battery of questionnaires. …”
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Small extracellular vesicles secreted from TGF-β1-licensed mesenchymal stromal cells reduce inflammation-associated injury following corneal alkali burn by Ellen Donohoe, Aoife Canning, Eanna Johnston, Seyedmohammad Moosavizadeh, Jiemin Wang, Martin Leahy, Oliver Treacy, Aideen E. Ryan, Thomas Ritter

“…Abstract Background It is well established that the mesenchymal stromal cell (MSC) therapeutic potency can be enhanced by cytokine pre-activation or licensing. However, its effects on therapeutic efficacy of small extracellular vesicles (MSC-sEV) have not yet been well established. …”
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Reversal of ABCG2-mediated drug resistance by tinodasertib (ETC-206) by Haigan Yang, Haigan Yang, Zheshen Li, Zhuoxun Wu, Xiang Chen, Letao Bo, Harsh Patel, Bohan Zhang, Wenjun Xiong, Wei Wang, Zhe-Sheng Chen

“…Docking studies predicted high-affinity binding of tinodasertib within the substrate-binding cavity of ABCG2, consistent with competitive inhibition of ATPase function.DiscussionThese data indicate that tinodasertib effectively reverses ABCG2-mediated MDR by blocking the transporter’s ATPase-dependent efflux mechanism without altering ABCG2 expression or trafficking. …”
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20(S)-Ginsenoside Rh2 overcomes gemcitabine resistance in pancreatic cancer by inhibiting LAMC2-Modulated ABC transporters by Yulin Wu, Juan Zhang, Yuanyang Tian, William Chi Shing Cho, Hong-Xi Xu, Zhi-Xiu Lin, Yan-Fang Xian

“…However, the biological function of LAMC2 in GEM resistance and its molecular mechanisms are still unclear. 20(S)-Ginsenoside Rh2 (Rh2), one of the principal active components isolated from Ginseng Radix et Rhizoma, possesses strong anti-tumor effects. …”
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Child and adolescent sleep disturbances and psychopathology in a mental health clinic sample by Aviva Blacher, Katarina N. A. McKenzie, Shannon L. Stewart, Shannon L. Stewart, Shannon L. Stewart, Graham J. Reid, Graham J. Reid, Graham J. Reid, Graham J. Reid

“…Hierarchical regressions examined the effects of sleep disturbances (i.e., difficulty falling asleep, staying asleep, night waking, bedtime resistance, falling asleep during the day) on internalizing and externalizing symptoms, above and beyond established child- (i.e., age, sex, sensory sensitivity, pain) and family-level variables (family functioning, caregiver distress, parenting strengths). …”
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Genome-wide profiling of micro-RNA expression in gefitinib-resistant human lung adenocarcinoma using microarray for the identification of miR-149-5p modulation by Yong Hu, Xiaobing Qin, Dali Yan, Haixia Cao, Leilei Zhou, Fan Fan, Jialan Zang, Jie Ni, Xiaoyue Xu, Huanhuan Sha, Siwen Liu, Shaorong Yu, Jianzhong Wu, Rong Ma, Jifeng Feng

“…To understand the mechanism involved in gefitinib resistance, we established gefitinib-resistant human HCC827/GR-8-1 cell line from the parental HCC827 cell line. We compared the micro-RNA expression profiles of the HCC827 cells HCC827/GR-8-1 using Agilent micro-RNA microarrays. …”
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A Study of Deep Learning Models for Audio Classification of Infant Crying in a Baby Monitoring System by Denisa Maria Herlea, Bogdan Iancu, Eugen-Richard Ardelean

“…By comparing the performance of different machine learning algorithms, this study seeks to determine the most effective approach for the detection of infant crying, enhancing the functionality of baby monitoring systems and contributing to a more advanced understanding of audio-based deep learning applications. …”
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Bullying and depression among adolescents in East Asia: a scoping review on prevalence rates, risk and protective factors by Jennifer Sie Hee Kiing, Jennifer Sie Hee Kiing, Elizabeth Sarah Ragen, Mohamed Sufyan Bin Mohmed Sulaiman, Wei Sheng Goh, Norman Jun Hao Tan, Sok Hui Ng, Yang Luo, Miny Samuel, Doris Young, Doris Young, Victor Weng Keong Loh, Victor Weng Keong Loh

“…In contrast, unique East Asian risk factors included being different (i.e., sexual minority status) and teachers as bullies.ConclusionFindings of this scoping review suggest that strong relationships within families, peers and the school community coupled with adolescents’ positive coping style are protective against the negative effects of bullying. Conversely, poor parent-child attachment in the midst of family dysfunction, poor engagement with peers and the school community together with low self-esteem predispose East Asian adolescents to depressive symptoms as a result of victimization. …”
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Early Childhood Nutrition and Development in Atopic Families from Northeastern Bulgaria by Albena Toneva, Antoniya Hachmeriyan, Rouzha Pancheva, Miglena Marinova-Achkar

“…However, limitations such as the relatively small sample size and reliance on parental reporting may affect the generalizability of the findings. …”
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Evaluation of Relationship between Schemas and Panic Disorder through a Case Treated with Schema Therapy by Esra Yancar Demir, Gonca Soyg&uuml;t

“…She was introduced to the clinic with severe panic attack symptoms which had been effecting her functionality. We started schematherapy for the patient as she had no improvement on her panic disorder symptoms with medical treatment due to her maladaptive schemas and schema modes thet she had used frequently. …”
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