A Multicenter Randomized Double-Blind Vehicle-Controlled Parallel Group Phase 2 Study Evaluating the Efficacy and Safety of GN-037 Cream in Patients with Mild-to-Moderate Plaque Ps... by Burhan Engin, Müge Güler Özden, Özge Sevil Karstarlı Bakay, Selda Pelin Kartal, İlkin Zindancı, Salih Levent Çınar, Recep Dursun, Gizem Pehlivan Ulutaş, Tuğba Özkök Özkök Akbulut, Fatma Aslı Hapa, Emel Bülbül Başkan, Mehmet Melikoğlu, Algün Polat Ekinci, Neslihan Demirel Öğüt, Pelin Hızlı, Zafer Türkoğlu, Özlem Su Küçük, Zeynep Topkarcı, Ümit Türsen, Filiz Canpolat, Hanife Uçgun, Şirin Yaşar, Selami Aykut Temiz, Asena Çiğdem Doğramacı, Sedat Altuğ, Serhat Kozlu, Nadir Ulu, Server Serdaroğlu

“…The present multicenter randomized double-blind vehicle-controlled parallel group phase 2 study aimed to investigate the efficacy and safety of GN-037 in patients with mild-to-moderate plaque psoriasis (MMPP). …”
Get full text

NATIONAL JURISDICTION WITH RESPECT TO OFFENCES COMMITTED ON BOARDS OF AIRCRAFTS VS PRIVATIZATION PROCESSESIN THE CIVIL AVIATION SECTOR - SELECTED ISSUES by Małgorzata Szwejkowska, Kacper Milkowski

“…But are the states of registration of an aircraft really interested in exercising their jurisdiction on offences committed on board of an aircraft, if this aircraft is used by a foreign entrepreneur? …”
Get full text

Increase in colonic propionate as a method of preventing weight gain in adults aged 20–40 years: iPREVENT, a multicentre, double-blind, randomised, parallel-group trial by Gary Frost, Joana C Vasconcelos, Jennifer E Pugh, Aisha Anjum, Katerina Petropoulou, George Thom, Louise McCombie, Martina Tashkova, Sumayya Alshehhi, Daphne Babalis, Leah Holroyd, Christina Prechtl, Tom Preston, Mike J Lean, Waljit Dhillo, A Toby Prevost, and Douglas Morrison

“…Design iPREVENT was a randomised, parallel-group, placebo-controlled, double-blind trial, designed with 90% power to detect a 2 kg between-arm difference in weight gain at 12 months. …”
Get full text

Rationale for a 4-month, parallel-group, randomized controlled trial to assess the Feasibility and Efficacy of a Remotely delivered exercise training intervention for Hispanics/Lat... by Victoria A. Flores, Stephanie L. Silveira, David X. Marquez, Dominique Kinnett-Hopkins, Augusto Miravalle, Fabian Sierra-Morales, Zulma Hernández-Peraza, Robert W. Motl

Get full text

Effects of postoperative antifungal therapy on the recurrence of Aspergillus infection after pulmonary aspergilloma resection: a prospective, randomized, controlled, single-center,... by Jian Yang, Chan Liu, Jianxiong Li, Xianqiu Chen, Beibei Wang, Jing Zhang, Haifeng Wang, Deping Zhao, Yiming Zhou, Haomin Cai, Jin-fu Xu, Shuo Liang

Get full text

Quzhuo tongbi formula for reducing gout flare related to uric acid lowering treatment: Study protocol for a multiple-center, randomized, double-blind, placebo, parallel-controlled... by Hejing Pan, Xuanlin Li, Shan Wu, Donghai Zhou, Haojie Guan, Haoyu Wu, Qiao Wang, Yujun Tang, Xuanming Hu, Meijiao Wang, Mingqian Zhou, Runyue Huang, Lei Liu, Yaolong Chen, Chengping Wen, Lin Huang

“…<h4>Method</h4>This is a multi-center, randomized, double-blind, placebo, parallel-controlled clinical trial conducted in four hospitals in Zhejiang Province, China. …”
Get full text

Comparison of remimazolam-based and propofol-based general anaesthesia on postoperative quality of recovery in patients undergoing laparoscopic sleeve gastrectomy: protocol for a p... by Jing Wang, Anshi Wu, Dong-jiao An, Chuning Ren, Yanjun Zhao, Changwei Wei

“…The findings will be disseminated in peer-reviewed publications.Trial registration number ChiCTR2400083700.…”
Get full text

Protocol for a parallel assignment prospective, randomised, double-blinded, placebo-controlled trial to evaluate the efficacy of 0.01% atropine for near work-induced transient myop... by Sile Yu, Wei He, Lan Hu, Ling Xu, Jiayan Chen, Guanghao Qin, Yifan Qi, Emmanuel Eric Pazo, Xingru He

“…The study’s findings will be shared regardless of the effect’s direction.Trial registration number NCT06034366.…”
Get full text

A systems analysis and improvement approach to optimizing syringe services programs' delivery of HIV testing and referrals: Study protocol for a parallel-group randomized controlle... by Angela R Bazzi, Alexis M Roth, Christopher F Akiba, Shelby L Huffaker, Sheila V Patel, Jessica Smith, Rose Laurano, Stephen Orme, Gary A Zarkin, Antonio Morgan-Lopez, Barrot H Lambdin

Get full text

A phase I, randomized, double-blind, parallel, single-dose pharmacokinetic study to evaluate the biosimilarity of KM118 (proposed pertuzumab biosimilar) with reference pertuzumab (... by Yan Li, Yu Wang, Caixia Yang, Na Zhao, Xinghe Wang

“…This study aimed to prove the pharmacokinetics (PK) biosimilarity and evaluate the safety, tolerability, and immunogenicity of KM118 and the original drug Perjeta® so that it can be approved for the marketing of biosimilar drugs in China.Methods This was a single-center, randomized, double-blind, two-arm, parallel-group, phase 1 study in healthy male subjects. …”
Get full text

Study protocol for a single-blind, parallel-group, randomised, controlled non-inferiority trial of 4-day intensive versus standard cognitive behavioural therapy for adults with obs... by David Mataix-Cols, Oskar Flygare, Erik Andersson, Sofia Dahlén, Volen Z Ivanov, Christian Rück, Filipa Sampaio, Ekaterina Ivanova, Robin Fondberg, Max Sannemalm, Sofia Asplund

Get full text

Rationale and design of the THIRST Alert feasibility study: a pragmatic, single-centre, parallel-group randomised controlled trial of an interruptive alert for oral fluid restricti... by Yang Chen, Anoop Shah, Folkert W Asselbergs, R Thomas Lumbers, Daniel Higgins, Yogini Jani, Nausheen Saleem, Kris Chafer, Matthew Robert Sydes

“…A series of secondary outcomes are specified to evaluate the effectiveness of the alert, adherence to the randomised treatment allocation and the quality of data generated from routine care, relevant to the outcomes of interest.Ethics and dissemination This study was approved by Riverside Research Ethics Committee (Ref: 22/LO/0889) and will be published on completion.Trial registration number NCT05869656.…”
Get full text

Self-administered dual-task training reduces balance deficits and falls among community-dwelling older adults: a multicentre parallel-group randomised controlled trial with economi... by Wai-Chi Chan, Cynthia Huijun Chen, Mohammad Jobair Khan, Kenneth N. K Fong, Thomson Wai-Lung Wong, William Wai-nam Tsang, Stanley Winser

Get full text

Protocol for the RETHINK study: a randomised, double-blind, parallel-group, non-inferiority clinical trial comparing acetaminophen and NSAIDs for treatment of chronic pain in elder... by Tempei Miyaji, Mototsugu Shimokawa, Hiroyuki Aono, Sadamoto Zenda, Makoto Endo, Yasuharu Nakashima, TOSHIHIKO HARA, Shinya Kawahara, Taishi Sato, Masami Tokunaga, Taro Mawatari, Tsutomu Kawano, Sanae Sakamoto, Toshio Takano, Masumi Miyake

“…The results of the study will be submitted to international peer-reviewed journals, and the main findings will be presented at international scientific conferences.Trial registration number jRCTs071200112.…”
Get full text

Use of an electronic medication management application to support Pharmacists Review to Optimise Medicines in Residential Aged Care (PROMPT-RC): a study protocol for a parallel clu... by Kenneth Lee, Dennis Petrie, Dee Mangin, Christopher Etherton-Beer, Amy Theresa Page, Esa Y H Chen, Nagham Ailabouni, Liza Seubert, Rhonda Marise Clifford, Kathleen Potter, Nahal Mavaddat, Sarah Hosking, Jacinta Johnson, Elton Lobo, Kate Wang, Hend Almutairi, Loretta Baldassar, Jenny Tasker

“…Trial findings will be disseminated through national and international peer-reviewed publications and conferences.Trial registration number ACTRN12624001409561.…”
Get full text

Thymosin alpha 1 in the prevention of infected pancreatic necrosis following acute necrotising pancreatitis (TRACE trial): protocol of a multicentre, randomised, double-blind, plac... by Tao Chen, Jing Zhou, Jianfeng Tu, Weiqin Li, XinTing Pan, Wenjian Mao, Lu Ke, Wenhua He, Miao Chen, Chengjian He, Weili Gu, Jingyi Wu, Jingchun Song, Haibin Ni, Junli Sun, Guoxiu Zhang, Weiwei Chen, Bing Xue, Xiangyang Zhao, Min Shao, Yuxiu Liu, Zhihui Tong

Get full text

Comparison of glucose fluctuation between metformin combined with acarbose or sitagliptin in Chinese patients with type 2 diabetes: A multicenter, randomized, active-controlled, op... by Xiaoling Cai, Suiyuan Hu, Chu Lin, Jing Wu, Junfen Wang, Zhufeng Wang, Xiaomei Zhang, Xirui Wang, Fengmei Xu, Ling Chen, Wenjia Yang, Lin Nie, Linong Ji, Jinjiao Li

“…This study was a randomized, open-label, active-con­trolled, parallel-group trial conducted at 15 centers in China from January 2020 to August 2022. …”
Get full text

Timely post-discharge medication reviews to Improve Continuity—the Transitions Of Care stewardship (TIC TOC) study in rural and regional Australia: a parallel-group randomised cont... by Sepehr Shakib, Manya Angley, Jonathan Penm, Charley Budgeon, Kim Nguyen, Rebekah Jane Moles, Faye McMillan, Rohan A Elliott, Paul Yates, Katie Phillips, Jenny Chen, Stephen Ross Carter, Kingston Yeung, Deirdre Criddle, Deborah Rigby, Frank Mario Sanfilippo, Jerry Yik, Deborah Hawthorne, Cristen Fleming, Anna Packer, Linda Krogh, Simon K Poon, Brett Chambers, Shania Liu, Fatemeh Emadi, Klaudia Englezos, Ganga Ratnanayagam, Michelle Penm, Andrew Hawthorne, Alexander Khlentzos, Jilian Khlentzos

Get full text

Combination of a monofocal and one type of extended depth-of-focus (zonal refractive) intraocular lens (COMEDI) in bilateral cataract surgery protocol: a monocentric, randomised, p... by Sorcha Ní Dhubhghaill, Silke Oellerich, Wilfried Cools, Heleen Delbeke, Iva Krolo, Karolien Termote, Roger Van Schoor

“…The purpose of this study is to assess whether implanting an EDOF IOL in the second eye of a patient who received a monofocal IOL in the first eye can improve spectacle independence while maintaining the same optical quality as bilateral monofocal IOL implantation.Methods and analysis This study compares combined monofocal and EDOF IOL implantation versus bilateral monofocal IOL implantation in terms of clinical and patient-reported outcomes in a monocentric, randomised, patient-masked and assessor-masked, parallel group trial in 88 bilateral cataract patients. …”
Get full text

The CHILL BONES (combining high-intensity impact loading and lifting with mind-body exercise for optimisation of nervous system and skeletal health) trial: protocol for a parallel-... by Surendran Sabapathy, Benjamin K Weeks, Belinda R Beck, Jayde Collier

Get full text