RESTORE—Cognitive functional therapy with or without movement sensor biofeedback versus usual care for chronic, disabling low back pain: study protocol for a randomised controlled... by Alison H McGregor, Mark Hancock, Peter Kent, P O'Sullivan, Anne Smith, Terry Haines, Amity Campbell, Jan Hartvigsen, Kieran O'Sullivan, Alistair Vickery, JP Caneiro, Robert Schütze, Robert A Laird, Stephanie Attwell

“…Study findings will be disseminated through publication in peer-reviewed journals and conference presentations.Trial registration number Australian New Zealand Clinical Trials Registry (ACTRN12618001396213).…”
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A Novel Supraglottic Suction Device in Mechanically Ventilated Patients: A Randomized Controlled Trial by Orozco-Levi M, Tiga-Loza DC, Aya O, Reyes CF, Cáceres-Rivera D, Espitia A, Rey D, Pedrozo Arias KP, Pizarro C, Sanabria-Barrera SM, Serrano-Díaz N, Castillo VR, Ramírez-Sarmiento A

“…The relevant clinical benefit in terms of preventing and improving tracheobronchitis earlier on was demonstrated by sequential fiberoptic bronchoscopy.Registration in Clinical Trials: The present study is registered at clinicaltrials.gov NCT03573609.Keywords: critical care, pneumonia, suction, salivation, intratracheal intubation, mechanical ventilation…”
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PRESOLRE: study protocol for a primary school-based, cluster randomised controlled trial of three sun exposure risk prevention strategies on Reunion Island by Cyril Ferdynus, Léa Bruneau, Antoine Bertolotti, Charline Dugast, Adrian Fianu, Karim Boussaid, Juliette Vuichard, Floreana Duloutre, Jessica Dumez, Nathalie Sultan-Bichat

“…Results will be published in peer-reviewed journals.Trial registration number NCT05367180.…”
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Supporting self-management of low back pain with an internet intervention in primary care: a protocol for a randomised controlled trial of clinical and cost-effectiveness (SupportB... by Beth Stuart, Paul Little, Lucy Yardley, Stephanie Hughes, Adam W A Geraghty, Elaine Hay, Gemma Mansell, Nadine E Foster, Jonathan Hill, Gareth Griffiths, Frances Webley, Lorraine Durcan, Alannah Morgan, Sarah Bathers, Stephanie Butler-Walley, Simon Wathall, Linda Leigh

“…Patient representatives will support the implementation of our full dissemination strategy.Trial registration number ISRCTN14736486.…”
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Videoconference-Delivered Acceptance and Commitment Therapy for Family Caregivers of People With Dementia: Pilot Randomized Controlled Trial by Areum Han, Robert Oster, Hon Yuen, Jeremy Jenkins, Jessica Hawkins, Lauren Edwards

“…Future studies should aim to replicate these findings with larger, more diverse caregiver populations and explore the long-term efficacy of videoconference-delivered ACT programs. Trial RegistrationClinicalTrials.gov NCT05043441; https://clinicaltrials.gov/study/NCT05043441…”
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Weight loss for overweight and obese patients with prostate cancer: a study protocol of a randomised trial comparing clinic-based versus Telehealth delivered EXercise and nutrition... by Robert U Newton, Daniel A Galvão, Dennis R Taaffe, Suzanne K Chambers, David Joseph, Amanda Devine, Colin I Tang, Nigel Spry, Emily Jeffery, Dickon Hayne, Pedro Lopez, P Lyons-Wall, Christine Kudiarasu

“…Outcomes from the study will be published in academic journals and presented in scientific and consumer meetings.Trial registration number ACTRN12621001312831.…”
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Exercise interventions of ≥8 weeks improve body composition, physical function, metabolism, and inflammation in older adults with stage I sarcopenic obesity: a systematic review an... by Huiting Wei, Huiting Wei, Jiabao Zhang, Jiabao Zhang, Kaiyin Cui, Kaiyin Cui, Hao Su, Hao Su

“…Heterogeneity (I2 > 50%) was managed using random-effects models.ResultsFifteen parallel-group RCTs involving 623 elderly adults (aged ≥60 years) were included. …”
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'Which treatment do you believe you received?' A randomised blinding feasibility trial of spinal manual therapy by Javier Muñoz Laguna, Astrid Kurmann, Léonie Hofstetter, Emanuela Nyantakyi, Julia Braun, Lauren Clack, Heejung Bang, Mazda Farshad, Nadine E. Foster, Milo A. Puhan, Cesar A. Hincapié, the SALuBRITY Blinding Clinician Group

“…Further methodological work on blinding of SMT is needed. Trial registration number NCT05778396.…”
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A practice and exploration of blended learning in medical morphology during the post-COVID-19 pandemic era by Qinlai Liu, Na Yuan, Yongan Wang, Beibei Sun, Leiying Yang, Zhaopeng Wang, Chen Fang, Wenping Sun, Baihua Luo, Yaling Liu, Xin Liu, Li Ge

“…It also has substantial promotional instructive modeling value. Clinical trial registration Not applicable.…”
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Rehabilitation using virtual gaming for Hospital and hOMe-Based training for the Upper limb in acute and subacute Stroke (RHOMBUS II): results of a feasibility randomised controlle... by Cherry Kilbride, Tom Butcher, Meriel Norris, Nana Anokye, Alyson Warland, Karen Baker, Dimitrios A Athanasiou, Guillem Singla-Buxarrais, Jennifer Ryan, Francesca Gowing, Elmar Kal, Carole Pound, Victoria Stewart, Basaam Aweid, Arul Samiyappan

“…Recruitment, training and support were manageable and completion of data was good, indicating that a future randomised controlled trial would be feasible.Trial registration number ISRCTN11440079.…”
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Effectiveness of an oral health curriculum in reducing dental caries increment and improving oral hygiene behaviour among schoolchildren of Ernakulam district in Kerala, India: stu... by Vijay Kumar, Denny John, Hindol Das, Chandrashekar Janakiram, Venkitachalam Ramanarayanan, Vineetha Karuveettil, Parvathy Balachandran, Balagopal Varma

“…Classroom interventions can serve as a cost-effective tool to increase children’s oral health awareness.Methods and analysis This protocol presents a cluster randomised trial design. It is a parallel-group comparative trial with two arms having a 1:1 distribution—groups A and B with oral health curriculum intervention from a dental professional and a schoolteacher, respectively. …”
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Glucose variability and mode of anaesthesia in major noncardiac surgery (GlucoVITAL): study protocol for a randomised controlled trial by Henrike Janssen, Priyanthi Dias, Louise Hiller, Russell Hewson, Rupert M. Pearse, Nick S. Oliver, Shaman Jhanji, Gareth L. Ackland, Ashok Sundar, Islam Abousharkh, Priyanthi Dias, Jai Varale, Joyce Yeung, Rupert Pearse, Benjamin Shelley, Louise Hiller, Kamran Khan, Peter Jacob, James Noblet, Monica Jefford, Toby Reynolds, Ana Gutierrez del Arroyo, Abeer Samman, Saja Alharbi, Sanjali Ahuja, Helen T. Neo Phatsimo, Keagan Lewis Witts, Muhammad Abdullah Pirwani, Su Yen Lee, Madhura Sivakumar, Divyani Priyavadan Bhudia, Marina Lily Chan, Emmanuella Anobah Adu, Marta Korbonits, Sian Henson, Onika Ottley, Mareena Joseph, Augustine Miguel Saavedra, Ana Santos, Eleanor Reeves, Joanne Gresty, Celinamma Maliaykal, Karthik Iyer, Lesley Horton, Helen Taylor, Ashok Nair, Catriona Frankling, Chloe Uffendell, Caroline Thomas, Catherine Moriarty, Beverley Jackson, Daniel Ruane, Reyhaneh Sadegh Zadeh, Ethel Black, Karmina Claros, Nick Perry, Vasiliki Manou-Stathopoulou, Ravishankar Rao Baikady, Holly Townsend-Thorn, Nicole Whitehead, Kate Tatham, Sophie Uren, Richard Gordon-Williams, Don Milliken, Jaishel Patel, Maxime Cordon-Goudreau, Edward Watson, Tom Craig, Francesca Mazzola, Richard Snooks, Sameer Ganatra

“…Methods: This multicentre, randomised controlled parallel group trial will recruit 450 participants ≥50 yr undergoing elective noncardiac surgery. …”
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Oxygenation targets for endovascular therapy in acute ischemic stroke patients (Oxy-TARGET): protocol for a single-centre, open-label randomised controlled trial by Anxin Wang, Zhengfang Hu, Ruquan Han, Fa Liang, Youxuan Wu, Minyu Jian, Xinyan Wang, Yunzhen Wang, Haiyang Liu, Xuan Hou, Kangda Zhang, Zihui Zhang

“…Therefore, we are conducting a randomised controlled trial (RCT) to evaluate the impact of high-concentration oxygen vs low-concentration normobaric oxygen on early neurological function after EVT.Methods and analysis The Oxy-TARGET trial is an ongoing prospective, open-label, parallel-design RCT being conducted at Beijing Tiantan Hospital, Capital Medical University. …”
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Parameterized Hardware Design on Reconfigurable Computers: An Image Processing Case Study by Miaoqing Huang, Olivier Serres, Tarek El-Ghazawi, Gregory Newby

“…The potential amount of speedup depends on the intrinsic parallelism of the target application as well as the characteristics of the target platform. …”
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Brachial plexus nerve block versus haematoma block for closed reduction of distal radius fracture in adults: The BLOCK Trial – a protocol for a multicentre randomised controlled tr... by Janus Christian Jakobsen, Anders Kehlet Nørskov, Mikkel Brabrand, Ole Mathiesen, Bjarke Viberg, Christian Rothe, Lars Hyldborg Lundstrøm, Kai Henrik Wiborg Lange, Stig Brorson, Christoffer Calov Jørgensen, Jonas Askø Andersen, Cecilie Dupont Harwood, Anne-Sofie Linde Jellestad, Aurelien-Xuan Rosendal Bahuet, Rasmus Linnebjerg Knudsen, Lana Chafranska Andersen, Per Hviid Gundtoft, Mads Terndrup

“…Results from outcomes on the 12-month follow-up will be presented separately.Trial registration number NCT06678438.…”
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CANBERRA: A Phase II Randomized Clinical Trial to Test the Therapeutic Potential of Oral Vicasinabin in Diabetic Retinopathy by Beatriz G. Armendariz, PhD, Ulrich F.O. Luhman, PhD, Brian Berger, MD, Jules Hernandez-Sanchez, PhD, Katrijn Bogman, PhD, Nikolaos Mitrousis, PhD, Martina Wollenhaupt, MD, David Kent, MD, Andreas Wenzel, PhD, Sascha Fauser, MD, PhD

“…Design: CANBERRA was a global, multicentric randomized, double-masked, parallel-group, placebo-controlled, phase II study. …”
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Artificial intelligence–enhanced mapping of the international classification of functioning, disability and health via a mobile app: a randomized controlled trial by Zhandos Kurban, Didar Khassenov, Didar Khassenov, Zhandos Burkitbaev, Sholpan Bulekbayeva, Azat Chinaliyev, Serik Bakhtiyar, Samat Saparbayev, Tokan Sultanaliyev, Ulzhalgas Zhunissova, Natalia Slivkina, Elena Titskaya, Luis Arias, Dana Aldakuatova, Gulfairus Yessenbayeva, Zhanerke Ermakhan

“…A hybrid model, combining AI automation with clinician oversight, may enhance accuracy and reduce documentation burden in time-constrained healthcare environments.Trial registrationClinicalTrials.gov, identifier NCT07021781.…”
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Effectiveness of a brief behavioural intervention on psychological distress among women with a history of gender-based violence in urban Kenya: A randomised clinical trial. by Richard A Bryant, Alison Schafer, Katie S Dawson, Dorothy Anjuri, Caroline Mulili, Lincoln Ndogoni, Phiona Koyiet, Marit Sijbrandij, Jeannette Ulate, Melissa Harper Shehadeh, Dusan Hadzi-Pavlovic, Mark van Ommeren

“…<h4>Methods and findings</h4>In this single-blind, parallel, randomised controlled trial, adult women who had experienced GBV were identified through community screening for psychological distress and impaired functioning in Nairobi, Kenya. …”
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Pragmatic clustered randomised control trial to evaluate a self-regulated learning intervention to be implemented in South Australian primary schools—study protocol by S.A Brinkman, B. Lam, S. Dawson, R. Marrone, D. Schunk, K. Winkel, H. Hermes, F. Gabriel, S. Fowler, D. Engelhardt

“…Methods We will use a standard pragmatic clustered (by school) randomised controlled superiority trial with an additional population-wide matched parallel control arm. Effectively, we will conduct three trials—one for each age/grade level. …”
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Strategic multimodal intervention in at-risk elderly Indians for prevention of dementia (SMRUTHI INDIA): a cohort multiple randomised controlled trial (cmRCT) protocol by Pooja Sharma, Divyani Garg, Maroof Ahmad Khan, Ayush Agarwal, Manish Barvaliya, Shubham Gupta, Alex Rebello, Ashima Nehra, Anu Gupta, Padma Srivastava, Kritika Sharma, Subrata Baidya, Abhik Sinha, Shampa Das, Sunil Kumar Raina, Sakshi Sharma, Venugopalan Y Vishnu, Varuna Sharma, Subarna Roy, P K Anand, Nilima Nilima, Vaibhav Patil, Rajeev Aggarwal, Aditi Dubey, Hina Narzari, Sneha Sneha, Kamini Kashyap, Krishan Kaushal, Kajal Fulara, Shikha Chaudhary, Divya M R, Vasundhara Misra, Phaniraj Vastrad, Priyadarshanraj N, Sandesh J R, Harshath Ajay V, Aishwarya Bhovi, Mailrappa Padiyappa Hooli, Sagar P M, Ambika Y V, Ripanjit Singh, Naveen M R, Shilpa K, Sharanabasavaraj Devaramani, Sandip Bhattacharjee, Bishakha Sen, Shalina Jamatia, Manish Acharjee, Dipankar Deb, Pameli Jamatia, Munmun Debbarma, Shaily Bhushan, Rishabh Gautam, Rishav Bhatia, Arnav Verma, Kalpna Sharma, Gajraj Singh, Priyanka Kumari Meena, Akhilesh Nagar, Hitesh Tiwari, Tinku Yogi, Vikram Raigar, Vinny Wilson, Shradha Singh, Zubia Nasir, Daksha Kumari, Mallamma Duddagi, Basamma R Alur, Sreetama Bahaduri, Aditya Choudhary, Suhas Murali, Jyoti Kattna, Amita Sengupta, Dolan Roy, Tithi Patra, Bandana Kayestha, Yachana Sharma, Nandini Rawat, Kavita Bairwa, Muskan Sharma, Divyani Rathore

“…This intervention will undergo testing for feasibility in the hospital setting at the central coordinating site through a pilot randomised controlled trial (6 months, 30 participants). In parallel, the care bundle will be culturally and linguistically adapted and pilot-tested in 20 participants in each zone. …”
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