Effectiveness of a Family-Based Self-Management Intervention for Type 2 Diabetes Patients Receiving Family Doctor Contract Services: A Community-Based Randomized Controlled Trial by Lan Zhu, Jing Wang, Zhigang Pan, Wei Zhang, Jing Tang, Hua Yan, Fulai Shen, Yi Shen

“…Research Design and Methods: We conducted a community-based, single-center, parallel randomized controlled trial in the Xietu community of Xuhui District, Shanghai. …”
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Community-based palliative care needs and barriers to access among cancer patients in rural north India: a Participatory action research by Mayank Gupta, Ankita Kankaria, Liya E. Joshy, Sandeep Singh, Bhajan Lal, Subhash Choudhary, Sapna Marcus, Anju Grewal, Lajya Devi Goyal, Rakesh Kakkar

“…Situational assessment, community sensitization workshops (CSWs) and door-to-door surveys were planned, conducted and developed over three PAR cycles. A parallel convergent mixed-methods approach was adopted wherein the quantitative data from door-to-door surveys and qualitative data from CSWs and investigator field notes were collected and analyzed to provide a comprehensive understanding of PC needs and barriers to access. …”
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Microinvasive pars plana vitrectomy versus panretinal photocoagulation in the treatment of severe non-proliferative diabetic retinopathy (the VIP study): study protocol for a rando... by Xiaohu Ding, Tao Li, Lin Lu, Ling Jin, Yuan Ma, Yizhi Liu, Ying Lin, Yuqing Wu, Bingqian Liu, Shida Chen, Wenbin Zheng, Kunbei Lai, Sainan Xiao, Jizhu Li

“…The results will be presented at scientific meetings and submitted for publication to peer-reviewed journals.Trial registration number NCT04103671.…”
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Effect of group-based nutritional education combined with individual standard care for outpatients with type 2 diabetes: study protocol for a randomized clinical trial {1} by Aline Busanello, Vanessa Machado Menezes, Olivia Garbin Koller, Ândria Völz Andreia, Jussara Carnevale de Almeida

“…Methods This study is a 12-month, parallel-group, randomized superiority controlled trial. …”
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Acupuncture for fatigue in breast cancer survivors: a study protocol for a pragmatic, mixed method, randomised controlled trial by Hugh MacPherson, Jun Mao, Myeong Soo Lee, Stephen Birch, Tae-Hun Kim, G Deng, Terje Alræk, Hilde Skjerve, Anette Sørensen, S A Lie, Hilde Presterud Ødegård, Weidong Lu, Admassu Nadew Lamu

“…The outcomes of the trial will be disseminated through peer-reviewed publications.Trial registration number NCT04418115.…”
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Dementia Moves: protocol for a feasibility study testing a physical rehabilitation program for long-term care residents with moderate to severe dementia by Caitlin McArthur, Niousha Alizadehsaravi, Rebecca Affoo, Karen Cooke, Natalie F. Douglas, Marie Earl, Melanie K. Farlie, Trudy Flynn, Parisa Ghanouni, Susan W. Hunter, Shannan M. Grant, Laura E. Middleton, Elaine Moody, Cheryl Smith, Linda Verlinden, Lori E. Weeks

“…We will use the collected information to inform a definitive parallel cluster randomized controlled trial. Trial registration. …”
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A primary care nurse-delivered walking intervention in older adults: PACE (pedometer accelerometer consultation evaluation)-Lift cluster randomised controlled trial. by Tess Harris, Sally M Kerry, Christina R Victor, Ulf Ekelund, Alison Woodcock, Steve Iliffe, Peter H Whincup, Carole Beighton, Michael Ussher, Elizabeth S Limb, Lee David, Debbie Brewin, Fredrika Adams, Annabelle Rogers, Derek G Cook

“…<h4>Methods and findings</h4>A total of 988 60-75 year olds, able to increase walking and randomly selected from three UK family practices, were invited to participate in a parallel two-arm cluster randomised trial; randomisation was by household. …”
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A WeChat-Based Decision Aid Intervention to Promote Informed Decision-Making for Family Members Regarding the Genetic Testing of Patients With Colorectal Cancer: Randomized Control... by Huanhuan Li, Yanjie Zhao, Wei Li, Wenxia Wang, Shengze Zhi, Yifan Wu, Qiqing Zhong, Rui Wang, Jiao Sun

“…MethodsA single-center, parallel-group, randomized controlled trial was conducted. …”
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Randomised controlled trial to compare the efficacy of integrated cognitive-behavioural therapy (COPE-A) for substance use and traumatic stress among adolescents and young adults d... by Maree Teesson, Sarah Bendall, Katherine Mills, Frances Kay-Lambkin, Emma L Barrett, Jackie Curtis, Sudie E Back, Sean Perrin, Natalie Peach, Blake Hamilton, Bronwyn Milne, Virginia Winter, Vanessa Cobham, Shalini Arunogiri, Mary Lou Chatterton, Kathleen Brady, Timothy Slade, Debra Rickwood, Sophie Reid, Steven Leicester, Logan Harvey

“…Research findings will be published in peer-reviewed journals and presented at scientific conferences.Trial registration number ACTRN12624000776505.Protocol version V.2.3, 20 March 2025.…”
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Expanding syphilis test uptake using rapid dual self-testing for syphilis and HIV among men who have sex with men in China: A multiarm randomized controlled trial. by Cheng Wang, Jason J Ong, Peizhen Zhao, Ann Marie Weideman, Weiming Tang, M Kumi Smith, Michael Marks, Hongyun Fu, Weibin Cheng, Fern Terris-Prestholt, Heping Zheng, Joseph D Tucker, Bin Yang

“…<h4>Methods and findings</h4>An open-label, parallel 3-arm randomized controlled trial (RCT) was conducted between January 7, 2020 and July 17, 2020. …”
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Decoding glioblastoma survival: unraveling the prognostic potential of olfactory function in a prospective observational study by Christoph Oster, Aylin Matyar, Teresa Schmidt, Thomas Hummel, Elke Hattingen, Martha Jokisch, Daniel Jokisch, Jana Grieger, Giorgio Cappello, Kathrin Kizina, Lazaros Lazaridis, Yahya Ahmadipour, Laurèl Rauschenbach, Martin Stuschke, Christoph Pöttgen, Nika Guberina, Tobias Tertel, Bernd Giebel, Gian Luca Dreizner, Francesco Barbato, Eva-Maria Skoda, Björn Scheffler, Michael Müther, Ken Herrmann, Christoph Kleinschnitz, Ulrich Sure, Cornelius Deuschl, Martin Glas, Sied Kebir

“…Findings may inform risk stratification, guide neuroprotective strategies, and improve survivorship care. Trial registration ClinicalTrials.gov, NCT06954636, date of registration 04-16-2025 (retrospectively registered); https://clinicaltrials.gov/study/NCT06954636?…”
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Efficacy of a Blended Low-Intensity Internet-Delivered Psychological Program in Patients With Multimorbidity in Primary Care: Randomized Controlled Trial by Alicia Monreal-Bartolomé, Adoración Castro, M Ángeles Pérez-Ara, Margalida Gili, Fermín Mayoral, María Magdalena Hurtado, Esperanza Varela Moreno, Cristina Botella, Azucena García-Palacios, Rosa M Baños, Yolanda López-Del-Hoyo, Javier García-Campayo, Jesus Montero-Marin

“…ObjectiveThis study aimed to assess the effectiveness of improved treatment as usual (iTAU) combined with a blended low-intensity psychological intervention delivered using information and communication technologies for the treatment of multimorbidity (depression and type 2 diabetes or low back pain) in primary care settings. MethodsA 2-armed, parallel-group, superiority randomized controlled trial was designed for this study. …”
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Task-sharing with lay counsellors to deliver a stepped care intervention to improve depression, antiretroviral therapy adherence and viral suppression in people living with HIV: a... by Kimberley Goldsmith, Barbara M Barrett, Dixon Chibanda, Melanie Abas, Conall O’Cleirigh, Walter Mangezi, Primrose Nyamayaro, Rebecca Jopling, Tarisai Bere, Samantha M McKetchnie, Calvin Fitch, Emily Saruchera, Thabani Muronzie, Denford Gudyanga, James Hakim, Steven A Safren

“…Study findings will be shared through the community advisory group, conferences and open access publications.Trial registration number NCT04018391.…”
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Facing depression: evaluating the efficacy of the EmpkinS-EKSpression reappraisal training augmented with facial expressions – protocol of a randomized controlled trial by Marie Keinert, Lena Schindler-Gmelch, Lydia Helene Rupp, Misha Sadeghi, Klara Capito, Malin Hager, Farnaz Rahimi, Robert Richer, Bernhard Egger, Bjoern M. Eskofier, Matthias Berking

“…Methods In a four-arm, parallel, single-blind, randomized controlled trial (RCT), we will randomize 128 individuals with depression and 128 matched controls without depression to one of four study conditions: (1) a cognitive reappraisal training (CR); (2) CR enhanced with instructions to display anti-depressive facial expressions (CR + AFE); (3) facial muscle training focusing on anti-depressive facial expressions (AFE); and (4) a sham control condition. …”
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Evaluation of a very brief pedometer-based physical activity intervention delivered in NHS Health Checks in England: The VBI randomised controlled trial. by Wendy Hardeman, Joanna Mitchell, Sally Pears, Miranda Van Emmenis, Florence Theil, Vijay S Gc, Joana C Vasconcelos, Kate Westgate, Søren Brage, Marc Suhrcke, Simon J Griffin, Ann Louise Kinmonth, Edward C F Wilson, A Toby Prevost, Stephen Sutton, VBI Research Team

“…<h4>Methods and findings</h4>The Very Brief Intervention (VBI) Trial was a two parallel-group, randomised controlled trial (RCT) with 3-month follow-up, conducted in 23 primary care practices in the East of England. …”
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Effectiveness of a Mobile Health Intervention (DOT Selfie) in Increasing Treatment Adherence Monitoring and Support for Patients With Tuberculosis in Uganda: Randomized Controlled... by Juliet Nabbuye Sekandi, Esther Buregyeya, Sarah Zalwango, Damalie Nakkonde, Patrick Kaggwa, Trang Ho Thu Quach, David Asiimwe, Lynn Atuyambe, Kevin Dobbin

“…MethodsBetween July 2020 and October 2021, we conducted a 2-arm, parallel-group, open-label randomized trial with a 1:1 assignment to receive either the VDOT intervention (n=72) or UCDOT (n=72) for treatment adherence monitoring at public health clinics in Kampala, Uganda. …”
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Protocol of randomized-controlled trial to examine the effectiveness of three different interventions to reduce healthcare provider burnout by Catalina Ruple, John Brodhead, Lila Rabinovich, Doerte U. Junghaenel, Tiffany Nakamura, Jonathan Wong, Sophia De-Oliveira, Joan Brown, Phuong Nguyen, Jenny Horn, Renee Middleton, Michelle Brahe, Cheng Wen, Sujeet Rao, Caroline Nguyen, Gil Shlamovitz, Dara Marino, Felipe Osorno, Steven Siegel

“…Another innovation is the inclusion of different types of patient-facing providers in the study population (doctors, nurses, and therapists). Trial registration This study was registered at ClinicalTrials.gov (NCT05780892) on March 10th, 2023.…”
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Efficacy of synovectomy in the treatment of femoral head osteonecrosis with vascularised fibular grafting in Shanghai: a protocol for SYNERGY-VGF trial by Changqing Zhang, Wei Zheng, Hao Peng, Kai Fu, Peng Ding, Qianying Cai, Haiyan He, Daoyu Zhu, Chenyi Jiang, Zehao Wang, Jimin Yin, Dongxu Jin, Youshui Gao

“…Results will also be presented at international conferences.Trial registration number Chinese Clinical Trial Registry (ChiCTR) Identifier: ChiCTR2300073385. …”
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Yoga programme for type-2 diabetes prevention (YOGA-DP) among high risk people in India: a multicentre feasibility randomised controlled trial protocol by Mark Hamer, Dorairaj Prabhakaran, Kavita Singh, Nikhil Tandon, Sanjay Kinra, Kaushik Chattopadhyay, Tess Harris, Pallavi Mishra, Sheila Margaret Greenfield, Sarah Anne Lewis, Nandi Krishnamurthy Manjunath, Rukamani Nair, Somnath Mukherjee, David Ross Harper

“…The results will be widely disseminated among key stakeholders through various avenues.Trial registration number CTRI/2019/05/018893.…”
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Adaptive Just-in-Time Intervention to Reduce Everyday Stress Responses: Protocol for a Randomized Controlled Trial by Jillian A Johnson, Matthew J Zawadzki, Martin J Sliwinski, David M Almeida, Orfeu M Buxton, David E Conroy, David Marcusson-Clavertz, Jinhyuk Kim, Robert S Stawski, Stacey B Scott, Christopher N Sciamanna, Paige A Green, Emily M Repka, Meynard John L Toledo, Nicole L Sturges, Joshua M Smyth

“…We will use mixed-effects models to evaluate differences in person-specific stress responses between the intervention and control groups. We will conduct parallel analyses to evaluate whether the intervention is associated with improvement in health behavior enactment (ie, sleep and physical activity). …”
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