Pharmacopuncture therapy for adhesive capsulitis: A pragmatic randomized controlled pilot study by Doori Kim, Kyoung Sun Park, Sun-A Kim, Ji Yeon Seo, Hyun-Woo Cho, Yoon Jae Lee, Changsop Yang, In-Hyuk Ha, Chang-Hyun Han

“…Methods: This pragmatic, randomized, controlled, parallel-group pilot study enrolled patients with limitations of shoulder movement and a numeric rating scale (NRS) score for shoulder pain ≥5 randomized (1:1) to the pharmacopuncture therapy (PPT) and physiotherapy (PT) groups. …”
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Clinical outcomes of nonsurgical root canal treatment using C-root SP combined with different obturation techniques in older patients: a randomized controlled clinical trial by Liping Dong, Jianshe Li, Peng Xue, Suixin Hu, Chen Xu, Lin Wang, Liu Liu, Qiang Luo, Huixia He, Fei Chen

“…Methods This prospective, single-center, single-blind, parallel, randomized clinical trial included 240 patients aged ≥ 60 years. …”
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Patient navigation in German emergency care (NODE). Study protocol of a multi-center mixed-methods trial by Daniela Krüger, Maria Altendorf, Felix Holzinger, Cornelia Wäscher, Hanna Winkler, Martin Möckel, Christoph Heintze, Judith Stumm, Konrad Schmidt, Konrad Schmidt, Anna Slagman

“…The study is expected to contribute to health services and systems research. Trial registrationDRKS00030398.…”
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Benralizumab Depletes IL‐5Rα‐Bearing Cells in Skin Lesions of Patients With Atopic Dermatitis by Christiane E. Whetstone, Ruth P. Cusack, Emma L. Price, Karen J. Howie, Caitlin Stevens, Dhuha Al‐Sajee, Suzanne Beaudin, Jennifer Wattie, Nadia Alsaji, Abbey Schlatman, Vanessa Luk, Paul M. O'Byrne, Mark D. Inman, Roma Sehmi, Hermenio Lima, Gail M. Gauvreau

“…Methods After a 4‐week washout from oral anti‐inflammatory medications 20 patients with moderate to severe AD completed a randomized, double‐blind, placebo‐controlled parallel‐group study comparing 3 doses q4wk 30 mg subcutaneous benralizumab to placebo. …”
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Evaluating Whether Nonimmersion Virtual Reality Simulation Training Improves Nursing Competency in Isolation Wards: Randomized Controlled Trial by Dandan Zhang, MuLi Fu, Jianzhong Zhang, Yuxuan Li, Li Chen, Yong-Jun Chen, Zhefeng Zhong, Yin-Ping Zhang

“…MethodsThis study was a prospective, parallel, open-label, randomized controlled trial. …”
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Phase 2 trial design of BMS-986278, a lysophosphatidic acid receptor 1 (LPA1) antagonist, in patients with idiopathic pulmonary fibrosis (IPF) or progressive fibrotic interstitial... by Jeffrey J Swigris, Toby M Maher, Tamera J Corte, Aryeh Fischer, Hong Xiao, Lisa Lancaster, Takafumi Suda, Xiaojiang Zhan, Jonathan G Goldin, Scott M Palmer, Hideaki Watanabe, Takashi Ogura, Anne Minnich, Giridhar S Tirucherai, Brandon Elpers, R Adam Smith, Edgar D Charles

“…Results will be reported in a peer-reviewed publication.Trial registration number NCT04308681.…”
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Comparison of the prophylactic antithrombotic effect of indobufen and warfarin in patients with nephrotic syndrome: a randomized controlled trial by Xin-Yi Gao, Yue-Ming Liu, Dan-Na Zheng, Yi-Wen Li, Hua Li, Xiao-Ling Xiong, Hong-Yu Chen, Hua Wang, Xiao-Yong Yu, Kai Qu, Juan Jin, Bo Lin, Qiang He

“…This study aimed to compare the efficacy and safety of indobufen with that of warfarin in patients with nephrotic syndrome.Materials and methods This multicenter, randomized, three-arm, open-label, parallel controlled trial involved a total of 180 adult patients with nephrotic syndrome from four centers in China. …”
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DREAM: an adaptive, randomised, placebo-controlled trial of duloxetine for reducing leg pain in people with chronic sciatica—trial protocol by Martin Underwood, Chung-Wei Christine Lin, Bethan Richards, Michael Dinh, Ralph Stanford, Christopher G Maher, Andrew J McLachlan, Thomas Lung, Peter Youssef, Laurent Billot, James McAuley, Giovanni E Ferreira, Richard O Day, Rowena Ivers, Melanie Hamilton, Ralph Audehm, Christopher Needs, Nanna B Finnerup, Monika Boogs, Melissa Webb, Hanan McLachlan, Nanna Finnerup, Ananthila Anandacoomarasamy, Masoud Jamshidi, Kate Tong

“…Trial results will be disseminated by publications, conference presentations and via the media.Trial registration number ACTRN12624000919516.…”
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Effects of tai chi on postural control during dual-task stair negotiation in knee osteoarthritis: a randomised controlled trial protocol by Bo Chen, Feng Xiong, Xiangbin Wang, Meijin Hou, Shaoqing Chen, Jiao Yu, Dalu Qi, Yanxin Zhang, Shengxing Fu, Zhenhui Li, Fengjiao Yang, Alison Chang, Anmin Liu, Xuerong Xie

“…Study findings will be disseminated through presentations at scientific conferences or publications in peer-reviewed journals.Trial registration number ChiCTR1800018028.…”
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Guided self-determination intervention versus attention control for people with type 2 diabetes in outpatient clinics: a protocol for a randomised clinical trial by Christian Gluud, Jane Lindschou, Thordis Thomsen, Janus C Jakobsen, Vibeke Zoffmann, Anne Sophie Mathiesen, Tine Bruhn Skytte, Bodil Rasmussen, Emilie Marqvorsen, Mette Rothmann

“…We describe the protocol for a pragmatic randomised, dual-centre, parallel-group, superiority clinical trial testing a GSD intervention versus an attention control for people with type 2 diabetes in outpatient clinics. …”
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Smartphone-Based Intervention Targeting Norms and Risk Perception Among University Students with Unhealthy Alcohol Use: Secondary Mediation Analysis of a Randomized Controlled Tria... by Joseph Studer, John A Cunningham, Elodie Schmutz, Jacques Gaume, Angéline Adam, Jean-Bernard Daeppen, Nicolas Bertholet

“…These findings lend support to using normative feedback interventions to discourage unhealthy alcohol use. Trial RegistrationISRCTN Registry 10007691; https://doi.org/10.1186/ISRCTN10007691…”
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Rehabilitation using virtual gaming for Hospital and hOMe-Based training for the Upper limb post Stroke (RHOMBUS II): protocol of a feasibility randomised controlled trial by Cherry Kilbride, Tom Butcher, Meriel Norris, Nana Anokye, Alyson Warland, Karen Baker, Dimitrios A Athanasiou, Guillem Singla-Buxarrais, Jennifer Ryan, Francesca Gowing, Carole Pound, Victoria Stewart, Basaam Aweid, Arul Samiyappan

“…Safety will be assessed by recording adverse events and using pain, spasticity and fatigue scores. A parallel process evaluation will assess feasibility and acceptability of the intervention. …”
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Randomised controlled trial of integrated trauma-focused psychotherapy for traumatic stress and substance use among adolescents: trial protocol by Maree Teesson, Sarah Bendall, Joanne Ross, Katherine L Mills, Emma Barrett, Sudie E Back, Vanessa E Cobham, Sean Perrin, Kathleen T Brady, Natalie Peach, Ivana Kihas, Joanne Cassar, Olivia Schollar-Root

“…Findings will be published in peer-reviewed journals and presented at scientific conferences.Trial registration number ACTRN12618000785202; Pre-reults.Protocol version Version 1, 31 July 2017.…”
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Effectiveness and feasibility of a theory-informed intervention to improve Mediterranean diet adherence, physical activity and cognition in older adults at risk of dementia: the Me... by A. Jennings, O. M. Shannon, R. Gillings, V. Lee, R. Elsworthy, R. Bundy, G. Rao, S. Hanson, W. Hardeman, S-M. Paddick, M. Siervo, S. Aldred, J. C. Mathers, M. Hornberger, A. M. Minihane

“…Methods Participants (n = 104, 74% female, 57–76 years) were randomised to three parallel intervention arms: (1) control, (2) MD, or (3) MD + PA for 24 weeks and invited to an optional 24-week follow-up period with no active intervention. …”
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The VIP trial: a randomised controlled trial of the clinical effectiveness of a Victim Improvement Package (VIP) for the reduction of continued symptoms of depression or anxiety in... by Victoria Vickerstaff, Vari M Drennan, Marta Buszewicz, Anthony Kessel, Gerard Leavey, Jonathan Cooke, Chris Brewin, Teresa Lee, Marc Serfaty, Jessica Satchell, Gloria Laycock

“…Further research on victim care and improving the delivery and quality of therapy is required.Trial registration number All procedures were approved by the University College London (UCL) Research Ethics Committee on 17 March 2016 (6960/001). …”
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Rehabilitation after bone marrow transplant compared with usual care to improve patient outcomes (REBOOT): protocol for a randomised controlled trial by Linda Denehy, Shaza Abo, Christopher Swain, Camille E. Short, Nicole Kiss, Amit Khot, Eric Wong, Duncan Purtill, Clare O’Donnell, Marlena Klaic, Catherine L. Granger, Michelle Tew, Tim Spelman, Vinicius Cavalheri, Lara Edbrooke, on behalf on the REBOOT research team

“…Methods This is a multisite, pragmatic two-arm parallel-group, randomised controlled trial (RCT) with stratified randomisation, powered for superiority, recruiting 170 participants at 30 days following either allogeneic or autologous bone marrow transplant (ACTRN12622001071718). …”
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Effects and mechanisms of supramaximal high-intensity interval training on extrapulmonary manifestations in people with and without chronic obstructive pulmonary disease (COPD-HIIT... by Johan Jakobsson, Chris Burtin, Mattias Hedlund, Carl-Johan Boraxbekk, Jonas Westman, Nina Karalija, Per Stål, Thomas Sandström, David Ruttens, Harry R. Gosker, Jana De Brandt, André Nyberg

“…The goal of the COPD-HIIT trial is to improve the treatment of extrapulmonary manifestations of the disease. Trial registration Clinicaltrials.gov: NCT06068322. Prospectively registered on 2023-09-28.…”
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Study protocol for a randomised controlled trial assessing the clinical and cost-effectiveness of the Journeying through Dementia (JtD) intervention compared to usual care by Tom Dening, Jessica Wright, Gail Mountain, Kirsty Sprange, Cindy Cooper, Ellen Lee, Stephen Walters, Alexis Foster, Katherine Berry, Esme Moniz-Cook, Amanda Loban, Tracey Anne Young, Claire Craig, Julie Beresford-Dent, Benjamin John Thompson, Emma Young, Benjamin David Thomas

“…Intervention materials will be made open access.Trial registration number ISRCTN17993825.…”
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Effect of fecal microbiota transplantation on patients with sporadic amyotrophic lateral sclerosis: a randomized, double-blind, placebo-controlled trial by Renyi Feng, Qingyong Zhu, Ao Wang, Hanzhen Wang, Jiuqi Wang, Pei Chen, Rui Zhang, Dongxiao Liang, Junfang Teng, Mingming Ma, Xuebing Ding, Xuejing Wang

“…Methods Conducted as a double-blind, placebo-controlled, parallel-group, randomized clinical trial, the study enrolled 27 participants from October 2022 to April 2023. …”
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Clinical research on the effectiveness and safety of Uchasingihwan for low back pain with radiculopathy caused by herniated intervertebral disc of the lumbar spine: A multicenter,... by Bonhyuk Goo, Jung-Hyun Kim, Eun-Jung Kim, Dongwoo Nam, Hyun-Jong Lee, Jae-Soo Kim, Yeon-Cheol Park, Yong-Hyeon Baek, Sang-Soo Nam, Byung-Kwan Seo

“…Methods: This was a multicenter, randomized, controlled, equivalence trial with two parallel arms. Seventy-four participants with LHIVD were recruited and randomly allocated to the experimental and control groups. …”
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