del Nido versus St. Thomas’ blood cardioplegia in the young (DESTINY) trial: protocol for a multicentre randomised controlled trial in children undergoing cardiac surgery by Massimo Caputo, Serban Stoica, Kelly Handley, Timothy J Jones, Nigel E Drury, Barnaby R Scholefield, Martin Kostolny, Alex Robertson, Yongzhong Sun, Carin Van Doorn, Warwick B Dunn, John V Pappachan, Hugh Jarrett, Carly Tooke, Tina Griffin, Indie Bilkhoo

“…Parents will be informed of the results through a newsletter in conjunction with a national charity.Trial registration number ISRCTN13638147; Pre-results.…”
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Improving sleep and learning in rehabilitation after stroke, part 2 (INSPIRES2): study protocol for a home-based randomised control trial of digital cognitive behavioural therapy (... by Nele Demeyere, Simon D Kyle, Colin A Espie, Sara Ajina, Heidi Johansen-Berg, Anton Pick, Ben Seymour, BARBARA ROBINSON, Matthew Weightman, Ricky Fallows, Alasdair L Henry, Emma Garratt, Rachel Teal, Melanie K Fleming

“…Therefore, the aim of this trial is to evaluate the potential for sleep improvement using a dCBT programme, to improve rehabilitation outcomes after stroke.Methods and analysis We will conduct a parallel-arm randomised controlled trial of dCBT (Sleepio) versus treatment as usual among individuals following stroke affecting the upper limb. …”
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Effect of a Primary Care Walking Intervention with and without Nurse Support on Physical Activity Levels in 45- to 75-Year-Olds: The Pedometer And Consultation Evaluation (PACE-UP)... by Tess Harris, Sally M Kerry, Elizabeth S Limb, Christina R Victor, Steve Iliffe, Michael Ussher, Peter H Whincup, Ulf Ekelund, Julia Fox-Rushby, Cheryl Furness, Nana Anokye, Judith Ibison, Steve DeWilde, Lee David, Emma Howard, Rebecca Dale, Jaime Smith, Derek G Cook

“…<h4>Clinical trial registration</h4>isrctn.com ISRCTN98538934.…”
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Cognitive Training for Emotion-Related Impulsivity and Rumination: Protocol for a Pilot Randomized Waitlist-Controlled Trial by K J D Allen, Matthew V Elliott, Eivind Haga Ronold, Liam Mason, Nandini Rajgopal, Åsa Hammar, Sheri L Johnson

“…Individuals assigned to the control group will undergo an identical assessment before joining the waitlist, followed by parallel assessments before and after N-ACT. …”
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Effect of adjunctive intraoral balance appliance in the usual care of patients with chronic temporomandibular joint disorders using Korean medicine in South Korea: study protocol f... by Jae-Heung Cho, Hyungsuk Kim, Woo-Chul Shin, Se yun Kim, Whisung Cho, Jaehyun Park, Won-Seok Chung, Mi-yeon Song

“…The result from this study will be actively disseminated through manuscript publications and conference presentations.Trial registration number The protocol was registered with the Clinical Research Information Service (CRiS), Republic of Korea, on 30 October 2023, CRiS number KCT0008906 prior to the initiation of the study, and was revised on 7 July 2025 (https://cris.nih.go.kr/cris/search/detailSearch.do?…”
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Investigating the impact of couple counseling based on the CHARMS model on sexual quality of life and marital satisfaction of wives of men suffering from myocardial infarction: a r... by Delniya Ghafuri, Soheila Rabeipoor, Kamal Khademvatani, Samira Barjasteh, Atefeh Yas

“…Method This two-group randomized clinical trial study with a parallel design was conducted in 2024 in Urmia, Iran. …”
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Cuff leak test and airway obstruction in mechanically ventilated ICU patients (COSMIC): a pilot feasibility randomized controlled trial protocol by Sangeeta Mehta, Deborah J Cook, Kimberley Lewis, Roman Jaeschke, Dan Perri, Corry Marchildon, Kelly Hassall, Thomas Piraino, Waleed Alhazzani, Erick Huaileigh Duan, Karen Bosma, Jose Estrada, Irene Armanious, Kallirroi Laiya Carayannopoulos

“…Trial results will be disseminated via publication in peer-reviewed journals.Trial registration number NCT05456542.…”
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Evaluation of a personalised adherence intervention to improve photoprotection in adults with Xeroderma Pigmentosum (XP): protocol for the trial of XPAND by John Weinman, Sam Norton, Jessica Walburn, Robert Sarkany, Vera Araujo-Soares, Paul McCrone, Kirby Sainsbury, Martha Canfield, Lesley Foster, Jakob Heydenreich, Adrian Mander, Falko F Sniehotta, Hans Christian Wulf

“…This study tests a novel intervention, which, if successful, will be integrated into routine care.Trial registration number NCT03445052; Pre-results.…”
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Effect of pilates on the physical and mental health of drug-dependent individuals — a randomized controlled trial by Feng Ji, Ensong Zhou, Peng Zhao, Xinliang Chen, Hui Wang, Jiabin Zhong, Yi Zhang, Yunhang Lu, Qing Zhang

“…Methods This study was conducted as a double-blind, parallel-group, randomized controlled trial. A total of 43 substance-dependent individuals were recruited from the Judong Drug Rehabilitation Center and randomly assigned to either the Pilates intervention group (n = 22) or the control group (n = 21). …”
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Optimising AVATAR therapy for people who hear distressing voices: study protocol for the AVATAR2 multi-centre randomised controlled trial by Philippa Garety, Clementine J. Edwards, Thomas Ward, Richard Emsley, Mark Huckvale, Paul McCrone, Mar Rus-Calafell, Miriam Fornells-Ambrojo, Andrew Gumley, Gillian Haddock, Sandra Bucci, Hamish McLeod, Amy Hardy, Emmanuelle Peters, Inez Myin-Germeys, Thomas Craig

“…Methods This multi-site parallel group randomised controlled trial will independently randomise 345 individuals to receive AVATAR-brief (6 sessions) plus TAU or AVATAR-extended (12 sessions) plus TAU or TAU alone (1:1:1 allocation). …”
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Efficacy and Tolerability of a New Facial 2-Mercaptonicotinoyl Glycine-Containing Depigmenting Serum Versus Hydroquinone 4% over 3-Month Treatment of Facial Melasma by Thierry Passeron, Delphine Kerob, Guénaëlle Le Dantec, Anne-Laure Demessant-Flavigny, Alessandro R. do Nascimento, Renato Moura, Samir Salah, Mariana Feiges, Erika Fernandez, Andrew Alexis

“…Methods This comparative, non-inferiority, randomized, investigator-blind, parallel-group investigation included adult women with mild-to-severe epidermal or mixed facial melasma. …”
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Finnish Trial on Practices of Anterior Cervical Decompression and Fusion (FACADE): a protocol for a prospective randomised non-inferiority trial comparing outpatient versus inpatie... by Ville Leinonen, Simo Taimela, Kimmo Lönnrot, Pirjo Toivonen, Pasi Aronen, Anniina Koski-Palken, Janek Frantzen, Marja Silvasti-Lundell, Johannes Förster, Teppo Jarvinen, Jarno Satopää, Behnam Rezai-Jahromi, Marketta Rautanen, Maarit Tuomisto

“…We will disseminate the findings of this study through peer-reviewed publications and conference presentations.Trial registration number NCT03979443.…”
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Efficacy of a Mobile App–Based Behavioral Intervention (DRIVEN) to Help Individuals With Unemployment-Related Emotional Distress Return to Work: Protocol for a Randomized Controlle... by Elizabeth C Danielson, Mystie Saturday, Sarah Leonard, Alexandra Levit, Andrea K Graham, Melissa Marquez, Keith Alperin, Stewart A Shankman, James W Griffith

“…ObjectiveThis study aims to test the efficacy of the 6-week intervention for job seekers in a randomized controlled trial. MethodsThis is a parallel-assignment randomized control trial comparing a 6-week return-to-work intervention versus job seeking as usual for a stratified sample of job seekers (n=150). …”
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Intervention With WhatsApp Messaging to Compare the Effect of Self-Designed Messages and Standardized Messages in Adherence to Antiretroviral Treatment in Young People Living With... by Jeffrey Freidenson-Bejar, Dianne Espinoza, Rodrigo Calderon-Flores, Fernando Mejia, Elsa González-Lagos

“…MethodsA 2-arm randomized controlled trial with a parallel assignment of 1:1, with no blinding of study intervention, was performed. …”
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Effect of Gamification on Improved Adherence to Inhaled Medications in Chronic Obstructive Pulmonary Disease: Randomized Controlled Trial by Xiting Huang, Zhili Jiang, Yifan Dai, Yang Liu, Ziying Dai, Jing Wang, Liping Chen, Zhiqian Wang, Wenxiao Wu, Lihua Huang

“…MethodsIn a randomized, 2-arm, concurrent parallel design, we enrolled 102 patients with COPD from respiratory medicine clinics at 2 hospitals in Zhejiang Province, China, between April and May 2023. …”
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Efficacy of a Web-Based Stress Management Intervention for Beginning Teachers on Reducing Stress and Mechanisms of Change: Randomized Controlled Trial by Hanna Heckendorf, Dirk Lehr

“…Finally, these findings encourage further research on iSMIs for other groups of career starters to support their transition into the workforce. Trial RegistrationGerman Clinical Trials Register (DRKS) DRKS00013880; https://tinyurl.com/3mpsyvw5…”
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Administration of dehydroepiandrosterone improves endometrial thickness in women undergoing IVF/ICSI: a systematic review and meta-analysis by Ling Huang, Ying Gao, Shuo Liang, Mei Jiang

“…The effectiveness of DHEA requires more research before it can be considered for clinical practice. PROSPERO registration CRD42023428885.…”
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Extended Reality Gaming for Exercise and Mindfulness Throughout Pediatric Cancer Rehabilitation: Protocol for a Randomized Controlled Trial by Byron Lai, Kelli Chaviano, Joshua S Richman, Mahmoud Ahmad, Ashley Wright, Raven Young, Drew Davis, James H Rimmer, Avi Madan-Swain, Joseph H Chewning

“…MethodsThis study includes a 2-arm parallel group design with a 1-group crossover (the control group will start the intervention after a waiting period). …”
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Efficiency and effectiveness of intensive multidisciplinary follow-up of patients with stroke/TIA or myocardial infarction compared to usual monitoring: protocol of a pragmatic ran... by Yannick Béjot, Marc Bardou, Mathieu Boulin, Yves Cottin, Maurice Giroud, Anne-Laure Soilly, Gauthier Duloquin, Thibaut Pommier, Gabriel Laurent, Lucie Vadot, Héloïse Adam

“…Patients will be randomised with an allocation ratio of 1:1 in two parallel groups: one group assigned to a multidisciplinary, nurse-based and pharmacist-based 2-year follow-up in association with general practitioners, neurologists and cardiologists versus one group with usual follow-up. …”
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Australasian Resuscitation In Sepsis Evaluation: FLUid or vasopressors In emergency Department Sepsis (ARISE FLUIDS) trial: study protocol by Peter Jones, Gerben Keijzers, John F Fraser, Rinaldo Bellomo, Paul Young, Glenn Arendts, Diana Egerton-Warburton, Alisa Higgins, Anthony Delaney, Stephen P J Macdonald, Sandra L Peake, Daniel Fatovich, Patricia Williams, Belinda D Howe, Jonathon Burcham, Elissa Milford, Andrew Alexander Udy

“…Results will be disseminated in peer-reviewed journals and presented at academic conferences.Trial registration number NCT04569942…”
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