Is mandibular posterior dento-alveolar intrusion essential in treatment of skeletal open bite in adult patients? A single center randomized clinical trial by Heba E. Akl, Amr M. Abouelezz, Fouad A. El Sharaby, Mohamed Abd-El-Ghafour, Amr R. El-Beialy

“…The objective of this two-arm parallel randomized clinical trial was to compare the effects of mini-screw supported maxillary versus bi-maxillary buccal segments’ intrusion on the amount of anterior open bite closure. …”
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The feasibility of conducting a randomized controlled trial that compares immediate versus optional delayed surgical repair for treatment of acute Anterior cruciate ligament injury... by Feryal Ghafelzadeh Ahwaz, Annemie Smeets, Stijn Bogaerts, Pieter Berger, Koen Peers

“…Methods This is a pragmatic, multicenter, randomized, controlled pilot trial with two parallel groups funded by the Belgian Health Care Knowledge Centre (KCE trials). …”
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Clinical effect of ePRO-based symptom monitoring and management on improving survival outcomes in patients with advanced cancer: a single-centre, prospective, randomised controlled... by Yan Wang, Yi He, Zimeng Li, Lili Song, Lili Tang, Ying Pang, Yening Zhang, Zhongge Su

“…The results of this study will be disseminated through academic seminars, peer-reviewed publications and academic conferences.Trial registration number ChiCTR2400081247.…”
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Raltegravir-intensified initial antiretroviral therapy in advanced HIV disease in Africa: A randomised controlled trial. by Cissy Kityo, Alexander J Szubert, Abraham Siika, Robert Heyderman, Mutsa Bwakura-Dangarembizi, Abbas Lugemwa, Shalton Mwaringa, Anna Griffiths, Immaculate Nkanya, Sheila Kabahenda, Simon Wachira, Godfrey Musoro, Chatu Rajapakse, Timothy Etyang, James Abach, Moira J Spyer, Priscilla Wavamunno, Linda Nyondo-Mipando, Ennie Chidziva, Kusum Nathoo, Nigel Klein, James Hakim, Diana M Gibb, A Sarah Walker, Sarah L Pett, REALITY trial team

“…There was no excess of IRIS-compatible events, suggesting that integrase inhibitors can be used safely as part of standard triple-drug first-line therapy in severely immunocompromised individuals.<h4>Trial registration</h4>ClinicalTrials.gov NCT01825031.<h4>Trial registration</h4>International Standard Randomised Controlled Trials Number ISRCTN 43622374.…”
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Clinical and cost-effectiveness of individualised exercises and foot orthoses in the treatment of plantar heel pain: protocol for the TREADON randomised multi-arm multi-stage adapt... by Thomas Jaki, Melaine A Holden, Anne-Maree Keenan, Royes Joseph, Christian D Mallen, Hylton B Menz, Jesse Kigozi, Edward Roddy, Pavel Mozgunov, Martin J Thomas, Kendra Cooke, Jo Smith, Gemma Hughes, Emma Marshall, Martyn Lewis, Stephanie Butler-Walley, Simon Wathall, Laura Bowyer, June Brammar, Sarah A Lawton, Chris Drake, Thomas Burnett, Gordon J Hendry, Nadine E Foster

“…Discussion The TREADON multi-arm multi-stage RCT will provide new evidence on the clinical and cost-effectiveness of individualised exercises and prefabricated foot orthoses for people with PHP. Trial registration ISRCTN 12418153. Registration date 06 December 2022 https://doi.org/10.1186/ISRCTN12418153…”
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Smart Technology Facilitated Patient-Centered Venous Thromboembolism Management (the SmaVTE Study): Protocol for a Randomized Controlled Trial by Zhi-Geng Jin, Zhe-Qi Zhang, Bin-Bin Liu, Hao Wang, Ying Yang, Li-Na Ren, Hui Zhang, Wei Ji, Zhen-Guo Zhai, Yu-Tao Guo

“…MethodsThe SmaVTE (smart technology facilitated patient-centered venous thromboembolism management) study is a 2-armed, single-center, parallel-group, randomized controlled trial. A total of 256 hospitalized patients with or at high risk of VTE will be recruited on the day of their discharge from August 2024 to June 2025. …”
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Vitamin D in the prevention of exacerbations of asthma in preschoolers (DIVA): protocol for a multicentre randomised placebo-controlled triple-blind trial by Mohsen Sadatsafavi, Megan E Jensen, Francine M Ducharme, Nathalie Alos, Geneviève Mailhot, Benoît Mâsse, John H White, Ali Khamessan, Sze Man Tse, Reza Alizadehfar, Dirk E Bock, Patrick Daigneault, Chantal Lemire, Connie Yang, Dhenuka Radhakrishnan

“…If proven effective, findings may markedly influence the management of URTI-induced asthma in high-morbidity preschoolers and could be directly implemented into practice with an update to clinical guidelines.Trial registration number NCT03365687.…”
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Proposal and Strategy for Nursing-Led Research: Protocol for an Unfunded Clinical Trial by Leticia Carmen Simón-López, Ismael Ortuño-Soriano, Raquel Luengo-González, Paloma Posada-Moreno, Ignacio Zaragoza-García, Rubén Sánchez-Gómez

“…Thus, the entire development of our low-interventional clinical trial was conducted without interfering at any point with the parallel commercial clinical trial. ResultsOur management allowed effective conduct of our study, and we met our aims without external funding and without ethical impact during the commercial clinical trial. …”
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Deep brain stimulation versus vagus nerve stimulation for the motor function of poststroke hemiplegia: study protocol for a multicentre randomised controlled trial by Bin Liu, Xinguang Yu, Qing Chang, Di Liu, Yanyang Zhang, Junpeng Xu, Haonan Yang, Zhiqi Mao, Guosong Shang, Shuzhen Liu, Zhebin Feng, Chen Yuhan

“…Patients are excluded if they have implantable devices that are sensitive to electrical currents, severe abnormalities in their lower limbs or are unable to comply with the trial procedures. The study has two parallel, distinct treatment arms: the Stimulation Group and the Sham Group. …”
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Silk garments plus standard care compared with standard care for treating eczema in children: A randomised, controlled, observer-blind, pragmatic trial (CLOTHES Trial). by Kim S Thomas, Lucy E Bradshaw, Tracey H Sach, Jonathan M Batchelor, Sandra Lawton, Eleanor F Harrison, Rachel H Haines, Amina Ahmed, Hywel C Williams, Taraneh Dean, Nigel P Burrows, Ian Pollock, Joanne Llewellyn, Clare Crang, Jane D Grundy, Juliet Guiness, Andrew Gribbin, Eleanor J Mitchell, Fiona Cowdell, Sara J Brown, Alan A Montgomery, UK Dermatology Clinical Trials Network’s CLOTHES Trial Team

“…<h4>Methods and findings</h4>This was a parallel-group, randomised, controlled, observer-blind trial. …”
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Mindfulness-Based Cognitive Therapy for Life (MBCT-L) Versus Stress Reduction Psychoeducation (SRP) for the Improvement of Mental Well-Being in Health Care and Other Public Sector... by Elena Nixon, Shireen Patel, Priya Patel, James Roe, Neil Nixon, Tim Sweeney, Paul Bernard, Clara Strauss, Michael P Craven, Sam Malins, Rob Goodwin, Laurence Astill Wright, Boliang Guo, Richard Morriss

“…MethodsThe trial is a multisite, single-blind, parallel-group, 2-arm superiority randomized controlled trial. …”
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Randomised controlled trial comparing hydroxyapatite coated uncemented hemiarthroplasty with cemented hemiarthroplasty for the treatment of displaced intracapsular hip fractures: a... by Nicholas Parsons, Matthew L Costa, Juul Achten, Melina Dritsaki, Robin Gillmore Lerner, Alwin McGibbon, Miguel Antonio Fernandez, Katy Mironov, May E Png, Jenny Gould, Xavier Griffin

“…A manuscript for a peer-reviewed journal will be prepared and the results shared with patients via local mechanisms at participating centres.Trial registration number ISRCTN18393176…”
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Long-term follow-up of the treatment for severe COVID-19 with qigong exercise and acupressure: A randomized controlled trial by Shuting Liu, Ranran Zhu, Chongjie Yao, Chao Zhan, Jinxiang Wang, Min Fang, Lei Fang

“…The control group received standard therapies.The study was a single-center, parallel, randomized, prospective follow-up study. …”
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The EmpaTeach intervention for reducing physical violence from teachers to students in Nyarugusu Refugee Camp: A cluster-randomised controlled trial. by Camilla Fabbri, Katherine Rodrigues, Baptiste Leurent, Elizabeth Allen, Mary Qiu, Martin Zuakulu, Dennis Nombo, Michael Kaemingk, Alexandra De Filippo, Gerard Torrats-Espinosa, Elizabeth Shayo, Vivien Barongo, Giulia Greco, Wietse Tol, Karen M Devries

“…<h4>Methods and findings</h4>We conducted a 2-arm cluster-randomised controlled trial with parallel assignment. A complete sample of all 27 primary and secondary schools in Nyarugusu Refugee Camp were approached and agreed to participate in the study. …”
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Post hoc analysis of ADAMANT, a phase 2 clinical trial of active tau immunotherapy with AADvac1 in patients with Alzheimer’s disease, positive for plasma p-tau217 by Branislav Kovacech, Nicholas C. Cullen, Petr Novak, Jozef Hanes, Eva Kontsekova, Stanislav Katina, Vojtech Parrak, Michal Fresser, Jeroen Vanbrabant, Howard H. Feldman, Bengt Winblad, Erik Stoops, Eugeen Vanmechelen, Norbert Zilka

“…Methods ADAMANT was a 24-month, randomized, placebo-controlled, parallel-group, double-blinded, multicenter, phase 2 clinical trial in subjects with mild AD. …”
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Effectiveness of Smart Mama application on postpartum depression, anxiety, and maternal-infant bonding among women during the postnatal period: a randomized controlled trial by Yasmine M. Osman, Miyuki Toda, Ayako Ogasawara, Naoki Hirose, Sanmei Chen, Hiromi Kawasaki, Yoko Shimpuku

“…Materials and methods This prospective parallel-group randomized controlled trial included 148 participants from March 1, 2023, to March 31, 2024. …”
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Web-Based Human Papillomavirus Education and Professional Skills Intervention for Health Care Providers: Protocol for a Randomized Controlled Trial by Jacob Martinez, Jacquelin I Cordero, Meagan Whitney, Katie L LaRoche, Gabriel Frietze, Eva M Moya, Kristin Gosselink

“…Methods We will conduct a randomized, blinded, multiple posttest-only controlled behavioral trial using a parallel group design that will examine the effectiveness of a fully automated, web-based, culturally tailored HPV education and professional skills intervention containing unique reading material and video role-play, as compared to a standard Centers for Disease Control and Prevention fact sheet and video about general communication skills. …”
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Multicentre, randomised waitlist control trial investigating a parent-assisted social skills group programme for adolescents with brain injuries: protocol for the friends project by Rose Gilmore, Leanne Sakzewski, Jenny Ziviani, Sarah Mcintyre, Hayley Smithers Sheedy, Nicola Hilton, Tracey Williams, Kirsten Quinn, Anne Marie Sarandrea, Elizabeth Laugeson, Mark Chatfield

“…The findings will be disseminated in peer-reviewed journals, by conference presentation and newsletters to consumers.Trial registration number ACTRN12617000723381.…”
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Randomised controlled trial comparing low doses of aspirin in the prevention of pre-eclampsia (ASAPP): a study protocol by Phyllis August, Paul Christos, Amrin Khander, Kathy Matthews, Charlene Thomas, Tanvir Alam, Claire Alcus, Leah Bush, Emmaneul Edusei, Line Malha

“…Adverse events will be assessed at each study visit.Trial registration number NCT04070573…”
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Efficacy of Tuina Versus the Proprioceptive Neuromuscular Facilitation (PNF) Technique in Patients With Nonspecific Chronic Neck Pain: Protocol for a Randomized Controlled Trial by Kaiqi Fan, Aicheng Wang, Hainan Gao, Ting Yu, Xiangyu Zhu

“…ObjectiveThis study aims to compare the effects of the PNF technique, tuina, and their combination on patients with NCNP and assess whether combined therapy outperforms monotherapies. MethodsThe parallel, double-blind, three-arm clinical randomized controlled trial (RCT) is being conducted at the Beijing University of Chinese Medicine and its affiliated hospitals. …”
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