Switch to second-line versus continued first-line antiretroviral therapy for patients with low-level HIV-1 viremia: An open-label randomized controlled trial in Lesotho. by Alain Amstutz, Bienvenu Lengo Nsakala, Fiona Vanobberghen, Josephine Muhairwe, Tracy Renée Glass, Tilo Namane, Tlali Mpholo, Manuel Battegay, Thomas Klimkait, Niklaus Daniel Labhardt

“…These results endorse lowering the threshold for virologic failure in future WHO guidelines.<h4>Trial registration</h4>The trial is registered at ClinicalTrials.gov, NCT03088241.…”
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Effects and safety of acupuncture versus non-penetrating sham acupuncture for senile pruritus: Rationale and design for a randomized controlled trial by He Chen, Sixing Liu, Shuai Gao, Jiamin Yi, Hangyu Shi, Jiufei Fang, Weiming Wang, Huan Chen, Zhishun Liu

“…Methods: This single-center, parallel, two-arm, randomized, sham-controlled trial will enroll 200 patients diagnosed with SP in a 1:1 ratio to either the acupuncture or sham acupuncture group, receiving acupuncture or sham acupuncture three sessions weekly for six weeks. …”
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A randomised controlled trial of a probiotic and a prebiotic examining metabolic and mental health outcomes in adults with pre-diabetes by Mark Weatherall, Julian Crane, Jeremy Krebs, Mark Huthwaite, Christine Barthow, Fiona Hood, Amber Parry-Strong

“…Aims To evaluate the effect of the probiotic Lactobacillus rhamnosus HN001 and/or cereal enriched with oat-derived beta-glucan (OBG) on metabolic and mental health outcomes when administered to adults with pre-diabetes.Design 2×2 factorial design randomised, parallel-groups placebo-controlled; double-blinded for probiotic, single-blinded for cereals.Participants Community-dwelling adults aged 18–80 years with pre-diabetes: glycated haemoglobin (HbA1c) 41–49 mmol/mol.Interventions Capsules containing Lactobacillus rhamnosus (HN001) (6×109 colony-forming units/day), or placebo capsules; and cereal containing 4 g/day OBG or calorie-matched control cereal, taken daily, for 6 months. …”
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The effect of the modified basic package of oral care on adolescent dental caries status in Zambia; a cluster randomized trial by Severine N. Anthony, Severine N. Anthony, Severine N. Anthony, Hawa S. Mbawalla, Febronia K. Kahabuka, Seter Siziya, Anne N. Åstrøm

“…This study primarily assessed the outcome of applying modified BPOC on dental caries prevalence and secondarily on knowledge and behaviors related to dental caries among adolescents in Copperbelt Province, Zambia.MethodsA parallel arms cluster randomized field trial including 22 public secondary schools (11-intevention, 11-control) was carried out between January 2021 and March 2023 in Copperbelt Province, Zambia. …”
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Early minimally invasive image-guided endoscopic evacuation of intracerebral hemorrhage (EMINENT-ICH): a randomized controlled trial by Tim Jonas Hallenberger, Urs Fischer, Leo Hermann Bonati, Gilles Dutilh, Rosine Mucklow, Andrea Sarti Vogt, Claudia Boeni-Eckstein, Andrea Cardia, Gerrit A. Schubert, Phillipe Bijlenga, Mahmoud Messerer, Andreas Raabe, Kevin Akeret, Christian Zweifel, Jens Kuhle, Alex Alfieri, Jean-Yves Fournier, Javier Fandino, Isabel Charlotte Hostettler, Ulf Christoph Schneider, Raphael Guzman, Jehuda Soleman

“…Methods This is a prospective, parallel-arm, outcome assessor blinded multicenter trial across Switzerland. …”
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Implementation of the Cognitive Daisy (COG-D) for improving care planning and delivery for residents with dementia in care homes: results of a feasibility randomised controlled tri... by Petra M. J. Pollux, Claire Surr, Judith Cohen, Chao Huang, Emma Wolverson, Pauline Mountain, Rebecca Clarke, Emma Hawkesford-Webb, Bethany Winter, John M. Hudson

“…However, the COG-D requires modification if it is to be feasibly implemented in care home settings. Trial registration This trial was registered on (date) (ISRCTN15208844).…”
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Pain control following impacted mandibular third molar surgery: a comparison of the effectiveness of two different protocols by Kamis Gaballah, Tuleen Eldohaji, Maha El Tannir, Roula Shaban, Ruaa Habib, Kamran Ali

“…A single-center, double-masked, parallel-group, randomized controlled clinical trial involved 56 patients undergoing scheduled surgical extraction of impacted mandibular third molars. …”
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Effect of Adapted Mindfulness Training in Participants With Elevated Office Blood Pressure: The MB‐BP Study: A Randomized Clinical Trial by Eric B. Loucks, Zev Schuman‐Olivier, Frances B. Saadeh, Matthew M. Scarpaci, William R. Nardi, Jeffrey A. Proulx, Roee Gutman, Jean King, Willoughby B. Britton, Ian M. Kronish

“…Methods and Results Methods included a parallel‐group phase 2 randomized clinical trial conducted from June 2017 to November 2020. …”
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Group education for adolescents with type 1 diabetes during transition from paediatric to adult care: study protocol for a multisite, randomised controlled, superiority trial (GET-... by Elham Rahme, Elise Mok, Melanie Henderson, Kaberi Dasgupta, Mohammad Hajizadeh, Lorraine Bell, Melinda Prevost, Jennifer Frei, Meranda Nakhla

“…Study results will be disseminated through peer-reviewed publications.Trial registration number NCT03703440.…”
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Efficacy and safety of once-daily single-inhaler triple therapy for mild-to-moderate chronic obstructive pulmonary disease: a study protocol for a randomised and interventional stu... by Hiromasa Inoue, Ayako Takamori, Atsushi Kawaguchi, Takashi Kinoshita, Kazuhiro Yatera, Koichiro Takahashi, Tomotaka Kawayama, Hiroki Tashiro, Koichi Takagi, Kei Yamasaki, Kentaro Machida

“…The results will be disseminated through scientific peer-reviewed publications and domestic and international medical conferences.Trial registration numbers UMIN000046812 and jRCTs031190008.…”
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The effect of chitosan supplementation on liver function, hepatic steatosis predictors, and metabolic indicators in adults with non-alcoholic fatty liver disease: a randomized, dou... by Mohammad Ali Mohsenpoor, Karim Parastouei, Maryam Taghdir, Marzieh Akbarzadeh, Sepideh Abbaszadeh, Mohammad Ali Abyazi Heris, Mohammad Reza Mansouri Rad, Mohammad Amin Jafari, Ronak Borzooei

“…Further investigations are recommended. Trial registration The trial was registered at IRCT.ir as IRCT20140502017522N4 (March 2023).…”
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Adalimumab vs placebo as add-on to Standard Therapy for autoimmune Uveitis: Tolerability, Effectiveness and cost-effectiveness—a protocol for a randomised controlled trial (ASTUTE... by Chris A Rogers, Andrew Dick, Tunde Peto, Robert Wilson, Pearse A Keane, Alastair K Denniston, Srilakshmi M Sharma, Lucy Culliford, Katie Pike, Sarah Baos, Carlos Pavesio, Sarah Wordsworth, Barnaby Reeves, Annie Folkard, Mae Hazell, Mandy P Y Lui, Nicholas A V Beare

“…The findings will be presented at international meetings, by peer-reviewed publications and through patient organisations and newsletters to patients, where available.Trial registration ISRCTN31474800. Registered 14 April 2020.…”
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Effect of spironolactone on cardiovascular morbidity and mortality in patients with hypertension and glucose metabolism disorders (ESCAM): a study protocol for a pragmatic randomis... by Nanfang Li, Lin Wang, Qin Luo, Jing Hong, Yuanyuan Li, Mengyue Lin, Mulalibieke Heizhati, Jina Yili, Xiaoguang Yao, Qing Zhu

“…The results will be disseminated in peer-reviewed journals and at scientific conferences.Trial registration number ChiCTR2000028909.…”
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Increasing Access to Mental Health Supports for 18- to 25-Year-Old Indigenous Youth With the JoyPop Mobile Mental Health App: Study Protocol for a Randomized Controlled Trial by Angela MacIsaac, Teagan Neufeld, Ishaq Malik, Elaine Toombs, Janine V Olthuis, Fred Schmidt, Crystal Dunning, Kristine Stasiuk, Tina Bobinski, Arto Ohinmaa, Sherry H Stewart, Amanda S Newton, Aislin R Mushquash

“…MethodsThe study is a pragmatic, parallel-arm randomized controlled superiority trial design spanning a 4-week period. …”
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Effects of sexual counseling and education based on self-efficacy theory on the sexual function of women with breast cancer by Azadeh Jamshidi, Farzaneh Noroozi, Razieh Bagherzadeh, Tayebeh Gharibi

“…Method The trial was a randomized controlled trial with a parallel design, including a pre-test, post-test, and one-month follow-up. …”
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Somatic acupressure for the management of the fatigue–sleep disturbance–depression symptom cluster in breast cancer survivors: a study protocol for a phase III randomised controlle... by Tao Wang, Xian-Liang Liu, Mengyuan Li, Li-Qun Yao, Jing-Yu (Benjamin) Tan, Ren-Li Deng, Wai Hang Kwok

“…Findings from this trial will be published in peer-reviewed journals and presented at professional conferences.Trial registration number NCT06412107.…”
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HORMONE IMBALANCE AS A MANIFESTATION OF STRESS IN THE FORMATION OF OLIGOMENORRHEA IN TEENAGE GIRLS by В. Диннік, О. Диннік, С. Новохатська

“…E2 is known to influence reproductive potential and correlate with mood alterations; a parallel trend was observed for C. Conversely, DHEA-S levels rose with prolonged OM duration. …”
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The effect of listening to music and drawing on coping with dysmenorrhea complaints in nursing students: randomized controlled trial by Burcu Küçükkaya, Şükran Başgöl

“…Methods The study was a double-blind, three parallel-group randomized controlled trial conducted between August 2023 and May 2024 at Bartın University, Faculty of Health Sciences, Department of Nursing. …”
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Protocol for an adaptive platform trial of intended service user-derived interventions to equitably reduce non-attendance in eye screening programmes in Botswana, India, Kenya and... by Min Kim, David Macleod, Michael Gichangi, Andrew Bastawrous, Matthew J Burton, Jacqueline Ramke, Oathokwa Nkomazana, James R Carpenter, Sailesh Mishra, Shalinder Sabherwal, Luke Allen, Sarah Karanja, Ari Ho-Foster, Nigel Bolster, Malebogo Tlhajoane, Bakgaki Ratshaa

“…Results will be shared via local workshops, social media and peer-reviewed publications.Trial registration number ISRCTN53970958.…”
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The effect of esketamine combined with sufentanil based patient-controlled intravenous analgesia for postoperative pain in patients undergoing third molar surgery and maxillofacial... by Xue Li, Xin He, Mengya Li, Xiao Gu, Ping Wang, Yong Wu, Ying Chen

“…Methods In this single-center, prospective, double-blinded, randomized, parallel-controlled trial, 91 patients were randomly divided into two groups. …”
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