An unsupervised online Tai Chi program for people with knee osteoarthritis (“My Joint Tai Chi”): Study protocol for the RETREAT randomised controlled trial by Shiyi Julia Zhu, Rachel K. Nelligan, Rana S. Hinman, Alexander J. Kimp, Peixuan Li, Anurika De Silva, Jenny Harrison, Kim L. Bennell

“…Methods: A two-arm, superiority parallel-design, pragmatic randomised controlled trial will be conducted involving 178 people with a clinical diagnosis of knee OA. …”
Get full text

Preclinical and first-in-human evaluation of AL002, a novel TREM2 agonistic antibody for Alzheimer’s disease by Hua Long, Adam Simmons, Arthur Mayorga, Brady Burgess, Tuan Nguyen, Balasubrahmanyam Budda, Anna Rychkova, Herve Rhinn, Ilaria Tassi, Michael Ward, Felix Yeh, Tina Schwabe, Robert Paul, Sara Kenkare-Mitra, Arnon Rosenthal

“…In the phase 1 study of 64 healthy volunteers, a single intravenous infusion of AL002 demonstrated brain target engagement based on a dose-dependent reduction of sTREM2 in CSF and parallel increases in biomarkers of TREM2 signaling and microglia recruitment. …”
Get full text

Combined treatment with mesenchymal stem cells and therapeutic hypothermia for neonatal hypoxic ischemic encephalopathy: a phase 1/2 randomized trial by Kazuko Wada, Akihito Takeuchi, Yoshinori Katayama, Natsuki Ohkawa, Masato Kantake, Kazumichi Fujioka, Toshiya Nishikubo, Yutaka Yamamoto, Yasumasa Yamada, Seiji Yoshimoto, Kiyoaki Sumi, Tomoaki Ioroi, Takeo Mure, Norihisa Wada, Yukimichi Nakano, Naoko Takasao, Kenji Tada, Tatsuyoshi Yamamoto, Hideaki Hirai, Yuji Sato, Hideyuki Ide, Satoshi Kusuda

“…Therefore, we performed a randomized, parallel-group study to compare combined treatment with Temcell and hypothermia versus hypothermia therapy-alone to evaluate the safety and efficacy of Temcell in nHIE patients. …”
Get full text

Interventions to improve water supply and quality, sanitation and handwashing facilities in healthcare facilities, and their effect on healthcare-associated infections in low-incom... by Benedetta Allegranzi, Julie Watson, Lauren D'Mello-Guyett, Erin Flynn, Jane Falconer, Joanna Esteves-Mills, Alain Prual, Paul Hunter, Maggie Montgomery, Oliver Cumming

“…Additional and higher quality research is urgently needed to fill this gap to understand how WASH services in HCFs can support broader efforts to reduce HCAIs in LMICs.PROSPERO registration number CRD42017080943.…”
Get full text

A systematic review of robotic colorectal surgery programs worldwide and a comprehensive description of local robotic training programme by Valentin Butnari, Harpreet Kaur Sekhon Inderjit Singh, Eshtar Hamid, Shady Gaafar Hosny, Sandeep Kaul, Joseph Huang, Richard Boulton, Nirooshun Rajendran

“…PROSPERO database registration No.-CRD42024530340.…”
Get full text

A multistage research on factors influencing and active learning intervention on health literacy of community-residing elderly adults in Nanjing by Shengxuan Jin, Ruobing Fa, Jianqian Chao, Na Zhang, Min Bao, Yanqian Wu, Leixia Wang, Gangrui Tan

“…The second phase was a two-arm parallel randomized controlled trial (RCT) in which 120 older adults were randomly assigned to a three-month intervention (n = 60) or control group (n = 60). …”
Get full text

Effects of specific symbiotic supplements on anthropometric measurements, glycaemic control, and lipid profiles among individuals with type 2 diabetes mellitus in two teaching hosp... by Sarah Hayder Ali Zalzala, Ban Abdul-Ridha Salman Al-Hashimi, Zahraa Hayder Ali Zalzala, Khalid Saeed Fahad

“…Methods A double-blind, placebo-controlled, parallel clinical trial was conducted at two diabetes outpatient clinics. …”
Get full text

The effect of mindfulness-based counselling on the anxiety levels and childbirth satisfaction among primiparous pregnant women: a randomized controlled trial by Rozhin Feli, Sousan Heydarpour, Kamran Yazdanbakhsh, Fatemeh Heydarpour

“…Methods This two-group, parallel, randomized controlled trial involved 60 eligible primiparous pregnant women who were referred to health centers in Kermanshah province (western Iran). …”
Get full text

The muscle protein synthetic response following corn protein ingestion does not differ from milk protein in healthy, young adults by Philippe J. M. Pinckaers, Michelle E. G. Weijzen, Lisanne H. P. Houben, Antoine H. Zorenc, Imre W. K. Kouw, Lisette C. P. G. M. de Groot, Lex. B. Verdijk, Tim Snijders, Luc J. C. van Loon

“…Clinical Trial Registry number. NTR6548 (registration date: 27–06-2017) https://www.trialregister.nl/ .…”
Get full text

Feasibility and potential effects of breathing exercise for chronic pain management in breast cancer survivors: study protocol of a phase II randomised controlled trial by Tao Wang, Xian-Liang Liu, Daniel Bressington, Jing-Yu (Benjamin) Tan, Si-Lin Zheng, Hou-Qiang Huang, Haiying Wang

“…This pilot study aims to examine the feasibility and preliminary effect of using an evidence-based BE intervention for chronic pain management in breast cancer survivors.Method and analysis This study will be a two-parallel-arm, open-labelled, phase II randomised controlled trial with 1:1 allocation. …”
Get full text

Enhancing community participation for stroke survivors with cognitive impairment: study protocol for a randomised controlled trial in Taiwan by Tsan-Hon Liou, Lu Lu, Feng-Hang Chang, Valeria Chiu, Pengsheng Ni, Yen-Nung Lin, Jiunn-Horng Kang, Der-Sheng Han, Elizabeth R Skidmore

“…The findings will be disseminated through presentations at scientific conferences and through publication in peer-reviewed journals.Trial registration number NCT03792061; pre-results.…”
Get full text

Effect of a transtheoretical model-based intervention and motivational interviewing on hyperphosphatemia management via telehealth (TMT program) among hemodialysis patients during... by Arrom Thongsunti, Chatchawan Silpakit, Thanapoom Rattananupong, Wonngarm Kittanamongkolchai, Wonngarm Kittanamongkolchai, Wonngarm Kittanamongkolchai, Warangkana Sumethpimolchai, Vitool Lohsoonthorn

“…This study aimed to determine the effect of a transtheoretical model-based intervention and motivational interviewing on hyperphosphatemia management via telehealth (TMT program) among hemodialysis patients during the COVID-19 pandemic.MethodA two-arm parallel randomized controlled trial with assessors blinding involved 80 participants who were stratified block-randomized into either the TMT program group (n = 40) or the control group (Usual care; n = 40). …”
Get full text

Improving and preserving cardiorespiratory fitness, muscle strength and adiposity through a complex lifestyle intervention in community-dwelling older adults with elevated cardiome... by Jonas Johansson, Laila Arnesdatter Hopstock, Sameline Grimsgaard, Trygve Sigvart Deraas, André Henriksen

“…This trial will also inform public health strategies for lifestyle interventions among ageing populations.Trial registration number NCT06122441.…”
Get full text

EMpower Parents: Effectiveness of EMDR treatment for parental PTSD related to a child’s medical condition in a randomized controlled trial by Esmée Maria Vesseur, Carlijn de Roos, Linde Scholten, Lotte Haverman

“…Methods In this three-armed parallel randomized controlled trial, parents start with an eligibility assessment (Tscreen), including meeting at least one of the following criteria: increased score on one symptom in each PTSD cluster, fulfillment of three of the four PTSD criteria, or total score >24 on the PCL-5. …”
Get full text

Exploring exhaled breath biomarkers for lactose intolerance diagnosis: the Lactobreath pilot study protocol by Daniel Pohl, Stamatios Giannoukos, Kathryn Jane Burton-Pimentel, Roxane Guillod, Guy Vergères

“…All results derived from the study will be accessible, in line with the Swiss National Science Foundation open access policy.Trial registration number NCT06177938.…”
Get full text

Multisite Randomized Controlled Trial of CareSTEPS: A Supportive Care Intervention for the Family Caregivers of Patients With Advanced Lung Cancer by Maria L. Rangel, DrPH, Kathrin Milbury, PhD, Karen Kayser, PhD, Robert Taylor Ripley, MD, Elizabeth Kvale, MD, Hoda Badr, PhD

“…Overall, the findings emphasize the importance of incorporating caregiver support into the comprehensive management of advanced LC. Clinical Trial Registration: ClinicalTrials.gov NCT02414672.…”
Get full text

Effect of arm-ergometry versus treadmill supervised exercise on health-related quality of life and mental health in patients with peripheral artery disease: secondary outcomes from... by Sandra Magalhães, Mário Santos, Sofia Viamonte, Fernando Ribeiro, Joana Martins, Cristine Schmidt, Henrique Cyrne-Carvalho

“…Methods This was an ancillary study of the ARMEX trial, a single-center, single-blinded, parallel group, randomized clinical trial, enrolling symptomatic PAD patients referred to a cardiovascular rehabilitation program (CRP). …”
Get full text

Reablement in Residential Aged Care (Re-RAC): study protocol for a multi-center pragmatic randomized controlled open-label trial by Anna Philipson, Mialinn Arvidsson Lindvall, Cecilia Pettersson, Lena Strålman, Kajsa Lidström Holmqvist

“…Methods This is a multi-center prospective pragmatic randomized controlled trial has two parallel groups comparing the Re-RAC intervention with usual care. …”
Get full text

Effects of an e-Learning Program (Physiotherapy Exercise and Physical Activity for Knee Osteoarthritis [PEAK]) on Chinese Physical Therapists’ Confidence and Knowledge: Randomized... by Zi-Ru Wang, Yunqi Wang, Shuning Duan, Xier Chen, Guoxin Ni

“…MethodsThis was a randomized controlled trial with 2 parallel arms involving 81 rehabilitation practitioners from 18 Chinese provinces. …”
Get full text

3D imaging cone beam computed tomography versus orthopantomogram to improve the oral health status of patients hospitalized for infective endocarditis (3D STARS): study protocol of... by Alexandra Cloitre, Xavier Duval, David Boutoille, Morgane Péré, Astrid Garreau, Swanny Fouchard, Alexandra Poinas, Philippe Lesclous

“…Methods This is a prospective, 2-parallel arms, superiority and individual-based RCT. …”
Get full text