Chatbot-delivered structured psychological intervention (SPI-Bot) for teenagers with adolescent idiopathic scoliosis in Hong Kong: protocol for a pilot randomised controlled trial by Yan Li, Jiaying Li, Engle Angela Chan, Teng Zhang, Yuan Cao, Nan Meng, Lu Yu, Jason Pui Yin Cheung, Zhaolong Wu, Dennis Chak Fai Ma

“…Conducted as a single-centre, parallel-group randomised controlled trial, the study aims to assess the feasibility, acceptability and preliminary effectiveness of SPI-Bot. …”
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Protein-enriched intermittent meal replacement combined with moderate-intensity training for weight loss and body composition in overweight women by Qisijing Liu, Yi Guo, Bo Peng, Dancai Fan, Jing Wu, Jin Wang, Ruican Wang, Jing-Min Liu, Jian Wu, Shuo Wang, Yanrong Zhao

“…This study aimed to evaluate the impact of a weight loss method incorporating formulated protein-enriched nutritional shake IMR in conjunction with MICT workout for overweight female adults. This 8-week parallel randomized controlled trial investigated the impact of protein-enriched IMR combined with MICT on weight loss and body composition in overweight female adults. …”
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Study protocol for a randomized controlled trial evaluating the effectiveness of a mother-child intervention model of neurogenic tremor as an add-on to treatment for emotional diso... by Yanli Zhao, Jiahua Xu, Jie Zhang, Jiaqi Song, Ning Yang, Hongzhen Fan, Zhe Dong, Shuping Tan

“…Initially, controls receive eight weeks of standard medication with parallel assessments, later transitioning to the same TRE intervention while maintaining continuous evaluation. …”
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Efficacy of cashew nut protein immunotherapy: protocol for a single-centre randomised controlled trial in a Polish paediatric population by Katarzyna Grzela, Marek Kulus, Joanna Zielinska, Anna Krupa-Łaska, Agnieszka Szczukocka, Małgorzata Pietrzyk-Kozińska, Alicja Krejner-Bienias

“…Study findings will be published in peer-reviewed journals and presented at international conferences.Trial registration number NCT06328504.…”
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Comparison of SEEKflex/videolaryngoscopy and fibreoptic bronchoscope for awake tracheal intubation: a randomized clinical trial by Wenyun Xu, Chenglong Zhu, Qinghua Wu, Bin Zhao, Miao Zhou, Yang Liu, Yongchu Hu, Jianhua Xia, Hongbin Yuan, Yaohua Yu, Zui Zou

“…Methods We conducted a pragmatic, multicentre, non-blinded, randomized, parallel-group clinical trial in Shanghai and Putian, China. …”
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Anorexia-cachexia syndrome in cancer patients: pathogenetic aspects and treatment options by A. V. Snegovoy, V. B. Larionova, I. V. Kononenko

“…Patient information was collected using an individual registration card. The patients were randomized according to nutritional support tactics (1:1). …”
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Neuroprotective Activity of Rasayana Formulation and Effect of Shigru Pallava Eye Drops on Intraocular Pressure as an Add-on Therapy Compared to the Standard of Care in Primary Ope... by Manjusha Rajagopala, Deenadayal Devarajan

“…Methods This is an open-label, two-arm, parallel-group randomized controlled trial with a 2:3 (control: intervention) allocation ratio. …”
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Efficacy and safety of two-step acupuncture therapy for symptom relief in adults with mild to moderate ulcerative colitis: rationale and design of the TSA-UC randomised controlled... by Weiming Wang, Zhishun Liu, He Chen, Shuai Gao, Sixing Liu, Hangyu Shi, Jiufei Fang, Ji-Zheng Ma, Xinyu Shen

“…The results will be published in a peer-reviewed medical journal.Trial registration number NCT06615765.…”
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Impact of short-term proton pump inhibitors vs. histamine-2 receptor antagonists on gut microbiota in patients with acute coronary syndrome: A multicenter randomized trial by Chen Chen, Huizhu Liang, Meibo He, Ruqiao Duan, Yu Guan, Fangfang Wang, Liping Duan, Sihan Zhou, Xiuyuan Hao

“…The study was designed as a single-blind, multicenter, three-parallel-arm, randomized controlled trial conducted at three centers in Beijing, China. …”
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Feasibility of a pregnancy intervention mimicking viral transmission mitigation measures on the incidence of preterm birth in high-risk pregnant women enrolled in antenatal clinics... by Renato T Souza, Ben W Mol, Atul Malhotra, Kirsten R Palmer, Daniel L Rolnik, Shivadharshini Sridhar, Ryan Hodges, Suresh Sundram, Rodolfo de Carvalho Pacagnella, Francisco Barbosa-Junior, David Mackin, Joanne Said

“…Study findings will be reported and submitted to peer-reviewed journals for publication, and presentation at conferences.Trial registration number ACTRN12622000753752; Pre-results.…”
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Hybrid cardiac rehabilitation trial (HYCARET): protocol of a randomised, multicentre, non-inferiority trial in South America by Sherry L Grace, Fernando Lanas, Pamela Serón, Maria J Oliveros, Gabriel N Marzuca-Nassr, Gladys Morales, Claudia Román, Sergio R Muñoz, Nicolás Saavedra

“…Research findings will be published in peer-reviewed journals; additionally, results will be disseminated among region stakeholders.Trial registration number NCT03881150; Pre-results.Date and version 01 October 2019.…”
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A feasibility randomised trial evaluating the levitation tri-compartment offloader knee brace for multicompartment knee osteoarthritis by Emily L. Bishop, Justin Bonhomme, Molly Joffe, Chris Cowper-Smith, Janet L. Ronsky, Marcia L. Clark

“…Methods A prospective, 3-group, parallel, single-centre feasibility RCT of individuals with moderate to severe patellofemoral or multicompartment knee OA was undertaken at the University of Calgary (Alberta, Canada). …”
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Protocol for a pilot randomised controlled trial evaluating feasibility and acceptability of cognitive remediation group therapy compared with mutual aid group therapy for people a... by Andrew David Eaton, Shelley L Craig, John W McCullagh, Sharon L Walmsley, Sean B Rourke, Teresa Sota, Barbara A Fallon

“…This protocol outlines a pilot randomised controlled trial (RCT)—designed using community-based participatory research—to pilot cognitive remediation group therapy (CRGT) against an active comparator.Methods and analysis This is a pilot, parallel design, two-arm RCT that will recruit participants diagnosed with the mild neurocognitive disorder form of HAND from a neurobehavioural research unit at a tertiary care hospital in Toronto, Canada. …”
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Assessing the effectiveness of perioperative s-ketamine on new-onset headache after resective epilepsy surgery (ESPAIN-trial): protocol for a randomised, double-blind, placebo-cont... by Sander van Kuijk, Rob P W Rouhl, Jiske Cornelia Theresa Sloekers, Michael Bos, Govert Hoogland, Caroline Bastiaenen, Maurice Theunissen, Kim Rijkers, Jim Dings, Albert Colon, Olaf Elisabeth Maria Ghislaine Schijns

“…The results of this trial will be publicly disclosed and submitted for publication in an international peer-reviewed scientific journal.Trial registration number NTR6480.…”
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ASSERT (Acute Sacral inSufficiEncy fractuRe augmenTation): randomised controlled, feasibility trial in older people by Cassandra Brookes, Matthew Jones, Avril Drummond, Paul Leighton, Paul Hendrick, Terence Ong, Khalid Salem, Nasir Quraishi, Ana Suazo Di Paola, Opinder Sahota

“…No adverse events were directly related to the trial.Conclusions There were significant challenges in recruiting sufficient participants which will need to be addressed prior to a definitive trial.Trial registration number ISRCTN16719542.…”
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Clinical Surveillance vs. Anticoagulation For low-risk patiEnts with isolated SubSegmental Pulmonary Embolism: protocol for a multicentre randomised placebo-controlled non-inferior... by Marc Carrier, Christine Baumgartner, Drahomir Aujesky, Menno V Huisman, Frederikus A Klok, Jeanne Moor, Marc Righini, Jürg-Hans Beer, Martina Peluso, Damiana Rakovic

“…The results of this trial will be published in a peer-reviewed journal.Trial registration number NCT04263038.…”
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Supramaximal high-intensity interval training for older adults in a community setting: a pragmatic feasibility study by Erik Frykholm, Beatrice Pettersson, Mattias Hedlund, Maria Wiklund, Bengt Johansson, Carl-Johan Boraxbekk, Erik Rosendahl, Nina Lindelöf

“…These insights help refine and optimize supramaximal HIT implementation for older adults in community settings. Trial registration Open Science Framework 31 January 2023 ( https://doi.org/10.17605/OSF.IO/B7T2G ).…”
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Tenecteplase Versus Alteplase in Acute Ischemic Stroke in Chinese Patients: Protocol for the ORIGINAL Study by Xia Meng, Shuya Li, Hongguo Dai, Guozhi Lu, Weiwei Wang, Fengyuan Che, Yu Geng, Minghui Sun, Xiyan Li, Yongjun Wang

“…Methods This is a multicenter phase III study that employs a randomized (1:1), active‐controlled, parallel‐group, prospective, open‐label, blinded–end point design. …”
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Pragmatic non-inferiority Randomised trial Investigating Needle aspiration versus ChEst drain for Secondary Spontaneous Pneumothorax (the PRINCE-SSP study): study protocol for a ra... by Nick A Maskell, Edward Carlton, Siobhan Creanor, Ramon Luengo-Fernandez, Heather Cook, Steven Walker, James Connors, Ellie Taylor, Amy McAndrew, Ella Chaudhuri, Pooja Ghorpade, Charlotte Goodwin

“…A plain English summary of the trial results will be prepared and disseminated with the help of our patient advisory group, including via social media, and provided to trial participants via post or email according to their preference.Trial registration number ISRCTN12644940.…”
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Comparative evaluation of BRIX3000 and Carisolv in chemomechanical caries removal in immature permanent first molars: a randomized controlled trial by Mohammad Malek Rajab, Mawia Karkoutly, Samar Alsalameh, Shadi Azzawi

“…Materials and methods It was a single-blinded, randomized, parallel-group, active-controlled trial with three arms. …”
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