Enhancing dyadic outcomes of stroke survivors and caregivers: protocol for a randomised controlled trial by Tsan-Hon Liou, Feng-Hang Chang, Valeria Chiu, Pengsheng Ni, Yen-Nung Lin, Jiunn-Horng Kang, Der-Sheng Han, Shih-Pin Hsu, Juleen Rodakowski

“…Findings will be disseminated through presentations at scientific conferences and publications in peer-reviewed journals.Trial registration number NCT05571150; Preresults.…”
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Transcutaneous auricular vagus nerve stimulation prevents postoperative delirium in elderly patients (VNSTAR): protocol for a multicentre, randomised controlled trial by Anxin Wang, Bo Wang, Ruquan Han, Fa Liang, Youxuan Wu, Minyu Jian, Xinyan Wang, Haiyang Liu, Xuan Hou, Kangda Zhang, Tianyuan Wang

“…The results of this study will be published in a peer-reviewed journal and presented at national or international conferences.Trial registration number NCT06421077.…”
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Safety planning and transdiagnostic cognitive behavioral therapy for adolescent suicide prevention in Mozambique: study protocol for the SPI/TCBT-S hybrid effectiveness/implementat... by Bradley H. Wagenaar, Alberto Muanido, Morgan Turner, Kathryn L. Lovero, Doyanne Darnell, Monisha Sharma, Katherine Anne Comtois, Isaías Ramiro, Vasco F. J. Cumbe

“…Methods Using a three-arm, parallel, Hybrid Type-1 cluster randomized trial design, we will randomize 7 secondary schools each to Enhanced Usual Care (EUC), SPI alone, and TBCT-S (21 schools total) to evaluate effects on suicidal behaviors (primary) and suicidal ideation/depressive symptoms (secondary). …”
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Study protocol for a randomised controlled trial evaluating the effect of folic acid supplementation beyond the first trimester on maternal plasma unmetabolised folic acid in late... by Thomas Sullivan, Debbie Palmer, Simon Wood, Tim Green, Maria Makrides, Dian Sulistyoningrum, Monika Skubisz, Karen P Best

“…The results of this trial will be presented at scientific conferences and published in peer-reviewed journals.Trial registration number ACTRN12619001511123.…”
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Effect of acupuncture on patients with mild cognitive impairment assessed using functional near-infrared spectroscopy on week 12 (close-out): a pilot study protocol by Jung Eun-Sun, Lee Jun-Hwan, Kim Hyun-Tae, Park Sang-Soo, Kim Ji-Eun, Cha Ji-Yoon, Seol In-Chan, Choi Young-Eun, Ho-Ryong Yoo

“…Methods: This study is designed to be a prospective, two-arm, parallel clinical trial involving 24 participants. …”
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Circular pOlyethylene drape in preVEntion of suRgical site infection (COVER trial): study protocol for a randomised controlled trial by Ri Na Yoo, Hyung Jin Kim, Jae Im Lee, Won-Kyung Kang, Bong-Hyeon Kye, Chang Woo Kim, Sung Uk Bae, Soomin Nam, Byung Mo Kang

“…The COVER trial is a multicentre, randomised controlled clinical trial with two parallel arms—one using a dual-ring wound protector with circular polyethylene drape and the other using conventional surgical dressing gauze. …”
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Multicenter evaluation of the Quantra with the QStat Cartridge in adult trauma patients by Francesco Viola, Ernest E Moore, Edward A Michelson, Michael W Cripps, Deborah A Winegar, Meghan Brennan, Kofi Vandyck, Katrina Gabriel-Ramos, Antolin Flores, Brian Thurston

“…Citrated blood samples drawn on arrival at the hospital or after blood transfusions were analyzed in parallel on QStat, ROTEM or TEG. Correlation between QStat and equivalent VET measurements was assessed by linear regression. …”
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Impact of functional re-education and environmental adaptation in cancer patients with respiratory pathology: Study protocol. by Eduardo Jose Fernandez-Rodriguez, Maria Isabel Rihuete-Galve, Alberto Garcia-Martin, Celia Sanchez-Gomez, Fausto Jose Barbero-Iglesias, Roberto Mendez-Sanchez, Ana Silvia Puente-Gonzalez, Susana Saez-Gutierrez, Emilio Fonseca-Sanchez, Juan Jesus Cruz-Hernandez

“…<h4>Methods</h4>A two-arm, randomized, parallel, controlled clinical trial will be conducted by the University of Salamanca, Spain, in collaboration with the Medical Oncology Service of the University Health Care Complex of Salamanca. …”
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Effect of clindamycin and a live biotherapeutic on the reproductive outcomes of IVF patients with abnormal vaginal microbiota: protocol for a double-blind, placebo-controlled multi... by Niels Uldbjerg, Nina La Cour Freiesleben, Anja Pinborg, Peter Humaidan, Henriette Svarre Nielsen, Thor Haahr, Vibeke Hartvig, Anne-Lis Mikkelsen, Thomas Parks, Jørgen Skov Jensen

“…Ethics committee, Central Denmark Region approved this protocol.Trial registration number ICH-GCP monitored trial, EudraCT 2016-002385-31; Pre-results.…”
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Intermittent theta burst stimulation applied during early rehabilitation after stroke: study protocol for a randomised controlled trial by Gereon R Fink, Lukas Hensel, Christian Grefkes, Caroline Tscherpel, Corinna Ringmaier, Daria Kraus, Stefanie Hamacher, Lukas J Volz

“…Patients (n=150) with hemiparesis receive either iTBS (600 pulses) applied to the ipsilesional motor cortex (M1) or a control stimulation (ie, coil placement over the parieto-occipital vertex in parallel to the interhemispheric fissure and with a tilt of 45°). …”
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Comparison of complications and recovery after laparoscopic and abdominal hysterectomy for benign disease: the LAparoscopic Versus Abdominal hysterectomy (LAVA) randomised controll... by Laura Jones, Rebecca Woolley, Paul Smith, Lee Middleton, Ertan Saridogan, Lina Antoun, T Justin Clark, William McKinnon, Kevin Cooper, Sheriden Bevan, Jayne Fullard, Monique Morgan, Kamila Ziomek, Zeyah Sairally

“…It is important that larger comparative trials are conducted now that LH, including robotics, is becoming adopted as standard practice.Trial registration number ISRCTN14566195, IRAS ID 287988.…”
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The ARMADILLO text message intervention to improve the sexual and reproductive health knowledge of adolescents in Peru: Results of a randomized controlled trial. by Jose E Perez-Lu, Fiorella Guerrero, César P Cárcamo, Mónica Alburqueque, Marina Chiappe, Michelle J Hindin, Ndema Habib, Lale Say, Lianne Gonsalves, Angela M Bayer

“…<h4>Trial design</h4>This trial was an unblinded, three-arm, parallel-group, individual RCT with a 1:1:1 allocation. …”
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Metabolic adverse events associated with systemic corticosteroid therapy—a systematic review and meta-analysis by Szilard Nemes, Veronica Phillips, Spoorthy Kulkarni, Hannah Durham, Luke Glover, Osaid Ather, Leslie Cousens, Parmis Blomgran, Philip Ambery

“…CST was significantly associated hyperglycaemia, hypertension and weight gain as noted in double-blinded placebo-controlled parallel-arms studies: OR of 2.13 (95% CI 1.66 to 2.72), 1.68 (95% CI 0.96 to 2.95) and 5.20 (95% CI 2.10 to 12.90), respectively. …”
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Inhaled beclomethasone in the treatment of early COVID-19: a double-blind, placebo-controlled, randomised, hospital-based trial in Sri Lanka by Chamila Mettananda, Arunasalam Pathmeswaran, Chathura Peiris, Dharani Abeyrathna, Aloka Gunasekara, Thimira Egodage, Channaka Dantanarayana, Channa Ranasinha

“…There were no adverse events.Conclusions Early initiation of inhaled beclomethasone in patients with asymptomatic, mild or moderate COVID-19 did not reduce disease progression to severe COVID-19.Trial registration number Sri Lanka Clinical Trials Registry; SLCTR/2021/017.…”
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Evaluation of the impact of the GRACE risk score on the management and outcome of patients hospitalised with non-ST elevation acute coronary syndrome in the UK: protocol of the UKG... by Deborah D Stocken, Chris P Gale, David Brieger, Keith AA Fox, Derek P Chew, Andrew T Yan, Harry Hemingway, Shaun G Goodman, Colin C Everett, Catherine Reynolds, Catherine Fernandez, Linda Sharples, Kathryn Carruthers

“…Findings will be announced at relevant conferences and published in peer-reviewed journals in line with the funder’s open access policy.Trial registration number ISRCTN29731761; Pre-results.…”
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Effect of bundling auricular acupressure and fluid restriction program on salivary flow rate and fluid control adherence among children undergoing hemodialysis: a randomized contro... by Zohour Ibrahim Rashwan, Marwa Mohamed Mahmoud Abdellah, Ferial Moursi, Esraa Mohammed Abd El-Samie Ismail

“…A sample of 60 children receiving HD was randomly assigned to two parallel groups. The control group received the fluid restriction program through general small-group discussion sessions, individualized consultations, and follow-up. …”
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Effects of a theory driven and culturally tailored educational program on promoting cervical cancer screening in rural populations by Mengyue Zhang, Janet W. H. Sit, Kai Chow Choi, Ka Ming Chow, Carmen W. H. Chan

“…The study, a two-arm parallel, non-randomized controlled trial, was conducted in 10 villages. …”
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Effects of multisystem exercises on balance, postural stability, mobility, walking speed, and pain in patients with diabetic peripheral neuropathy: a randomized controlled trial by Sidra Khurshid, Aruba Saeed, Muhammad Kashif, Aniqa Nasreen, Huma Riaz

“…Methods This double-blinded, two-arm parallel design randomized controlled trial was conducted at DHQ Hospital, Pakpattan, Pakistan. …”
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Interferon alpha-2b addition to intravitreal bevacizumab for diabetic macular edema: a randomized controlled trial by Saeed Karimi, Mehdi Nouri, Amir Reza Mansouri, Golnar Hassanzadeh, Hosein Nouri, Saber Mohsen Rikani, Seyed-Hossein Abtahi

“…Methods In this double-blind, placebo-controlled, parallel clinical trial, eligible eyes of DME patients were randomized into two treatment arms: (1) three monthly doses of intravitreal bevacizumab (IVB) (2) three monthly doses of IVB plus interferon alpha 2b eye drops (IVB + IFN). …”
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Heart failure with preserved ejection fraction (HFpEF) pathophysiology study (IDENTIFY-HF): does increased arterial stiffness associate with HFpEF, in addition to ageing and vascul... by Prithwish Banerjee, Gordon McGregor, Richard Powell, Francesco P Cappuccio, Danish Ali, Nualla Callan, Stuart Ennis, Scott McGuire, Martin O Weickert, Michelle A Miller

“…Group E; patients with heart failure and reduced ejection fraction (parallel group). Vascular function and arterial compliance will be assessed using pulse wave velocity, as the primary outcome measure. …”
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