Effectiveness of task-oriented circuit training on the motor performance of ischaemic stroke patients: a study protocol for randomised clinical trial by Mohammad Anwar Hossain, Harun Or Rashid, Farzana Sharmin, Abid Hasan Khan, Farjana Sharmin, Md Forhad Hossain, Mahdi Ul Bari, Md Ershad Ali, Arnob Datta, Saiba Muhammad Sabrin, Md Rezaul Karim

“…The investigators have planned an 8-week parallel, two-arm, prospective, randomised clinical study. …”
Get full text

Impact of early haemodynamic assessment by echocardiography on organ dysfunction and outcome of patients admitted to the emergency department with sepsis or septic shock: protocol... by Bruno Giraudeau, Amélie Le Gouge, Philippe Vignon, Thomas Lafon, Samia Brit

“…The dissemination plan includes presentations at scientific conferences and publication of results in a peer-reviewed journal.Trial registration number NCT04580888.…”
Get full text

Longitudinal association between sleep quality and fatigue during pregnancy: an observational cohort study by Zhanhong Fan, Shuhan Yan, Li Sun, Zhiqiu Cao, Huahua Liu, Akinyemi Lydia Idowu, Bin Zhu, Feng Zhang

“…Conclusion There was a two-way connection between sleep quality and fatigue in pregnant women, underscoring the importance of comprehensive management and intervention for poor sleep quality or excessive fatigue during pregnancy. Trial registration number ChiCTR2100053966, 04/12/2021.…”
Get full text

A pilot multicenter randomized controlled trial on individualized blood pressure targets versus standard care among critically ill patients with shock by Rakshit Panwar, Bairbre McNicholas, Ciprian Nita, Alison Gibberd, Amber-Louise Poulter, Marcia Tauares, Lauren Ferguson

“…We conducted a prospective, open label, parallel-group, pilot RCT to assess feasibility and safety of this intervention compared to standard care. …”
Get full text

Effects of couple-based violence prevention education on male partners' knowledge, attitudes and controlling behavior related to intimate partner violence in rural Ethiopia: a clus... by Zeleke Dutamo Agde, Zeleke Dutamo Agde, Jeanette H. Magnus, Nega Assefa, Muluemebet Abera Wordofa

“…This approach holds promise for scaling up and adapting to similar contexts in Ethiopia.Trial registrationThe trial was registered on ClinicalTrials.gov with the identifier NCT05856214 on May 4, 2023.…”
Get full text

Stress management training program to address caregiver burden and perceived stress among family caregivers of patients undergoing hemodialysis: a randomized controlled trial study by Ramisa Khouban-Shargh, Seyedmohammad Mirhosseini, Saeed Ghasempour, Mohammad Hasan Basirinezhad, Ali Abbasi

“…Methods This two-group clinical trial study was conducted in parallel design among 60 family caregivers of patients on hemodialysis in 2023. …”
Get full text

Effect of high-dose N-acetyl cysteine on the clinical outcome of patients with diabetic peripheral neuropathy: a randomized controlled study by Sherien Mohamed Emara, Sarah Farid Fahmy, Mona Mohamed AbdelSalam, Lamia Mohamed El Wakeel

“…Methods A prospective, randomized, parallel, open label, controlled clinical trial. Ninety eligible DPN patients were randomly assigned to either control group receiving standard of care or NAC group receiving standard of care treatment and NAC at a dose of 2400 mg/day for 12 weeks. …”
Get full text

Effect of 4 weeks vs 8 weeks of acupuncture for knee osteoarthritis in China: protocol for a randomised controlled trial by Cun-Zhi Liu, Jian-Feng Tu, Ying Yu, Bao-Hong Mi, Xue-Zhou Wang, Ya-Wei Xi, Yi-Ming Fu

“…Additionally, we plan to present them at selected conferences and scientific meetings.Trial registration number Chinese Clinical Trials Registry (ChiCTR2300073383; https://www.chictr.org.cn/showproj.html?…”
Get full text

Study protocol for the POPART study—Prophylactic Oropharyngeal surfactant for Preterm infants: A Randomised Trial by Peter Doran, Marie Galligan, Madeleine Claire Murphy, Brenda Molloy, Rabia Hussain, Colm O'Donnell

“…The study results will be submitted for publication in a peer-reviewed journal.Trial registration number 2016-004198-41; Pre-results.…”
Get full text

Four-week Nordic hamstring exercise intervention for individuals with ACL reconstruction via hamstrings tendon autograft: feasibility of a pilot randomized controlled trial by Grant E. Norte, Neal R. Glaviano, David A. Sherman, Justin L. Rush, Amanda M. Murray

“…Methods We used a single-blind randomized controlled trial with parallel arms to investigate individuals 18–35 years with primary, unilateral ACLR-HT. …”
Get full text

Efficacy and safety of native type II collagen in modulating knee osteoarthritis symptoms: a randomised, double‐blind, placebo‐controlled trial by Cheng Luo, Weike Su, Ying Song, Shalini Srivastava

“…Methods We conducted a 12‐week randomised, double‐blind, placebo‐controlled, parallel‐group study on 101 participants aged 40–65 years with knee OA. …”
Get full text

In vivo and in situ evaluation of innovative approaches in dentin hypersensitivity treatment by Heba Abd El-Fattah Mohamed, Dina Ezzeldin Mohamed, Elhassan Hassanein, Heba El-din Salah El-din Hamza

“…Methods This randomized, triple-blind, three-parallel-arm clinical and in situ study included a total of 63 participants (age range: 26–46 years), each randomly assigned to one of three treatment groups: PRG Barrier Coat, Embrace varnish, or Duraphat varnish. …”
Get full text

Time to return of bowel function following perioperative probiotics in colorectal cancer surgery (PICCS-1): study protocol for a randomized controlled trial by Dedrick Kok Hong Chan, Bei En Siew, Jerrald Lau, Jasmin Koh, Megan Xin-Hui Lee, Chermaine Ang, Ning Qi Pang, Ker-Kan Tan

“…Methods We propose a parallel three-arm randomized controlled trial. In Arm 1, no nutritional supplementation is provided to the patient. …”
Get full text

The Safety of Non‐immunogenic Recombinant Staphylokinase in Elderly Patients With Massive Pulmonary Embolism: A Randomized Clinical Trial FORPE by Stanislav G. Leontyev, Elena B. Yarovaya, Vladimir A. Kutsenko, Oleg E. Ivlev, Anna G. Soplenkova, Andrey M. Semenov, Mikhail P. Semenov, Sergey V. Ivanov, Yulia A. Romashova, Sergey S. Markin

“…Methods A randomized, open‐label, multicenter, parallel‐group, noninferiority FORPE trial was conducted at 23 clinical sites in Russia. …”
Get full text

The effectiveness of functional inspiratory muscle training on exercise capacity and peripheral muscle strength in patients with essential hypertension: a three-arm randomized cont... by İrem Hüzmeli, Nihan Katayıfçı, Büşra Abay, Oğuz Akkuş, Aysel Yıldız Özer

“…Mobility, HRQoL, and physical activity levels are increased with F-IMT, IMT, and breathing exercises. Trial registration ClinicalTrials.gov Identifier: NCT06343246 (03/29/2024).…”
Get full text

PRevention Intervention and Support in Mental health for people with aphasia (Aphasia PRISM): protocol and mixed methods analysis plan for two feasibility studies by C. Baker, M. L. Rose, D. Wong, B. Ryan, S. Thomas, D. Cadilhac, I. Kneebone

“…Studies A and B were registered with the Australian New Zealand Clinical Trials registry under one registration (ACTRN12620000209998) 20th February 2020.…”
Get full text

Could a feedback device help manage work-related shoulder disorders?: protocol of a mixed methods pilot study by Philippe Meidinger, Quan Nha Hong, Jean Tittley, Alexandre Campeau-Lecours, Jean-Sébastien Roy

“…The quantitative component will consist of a two-arm parallel group external pilot RCT involving 42 participants with WRSDs who will be randomized into one of the two study groups. …”
Get full text

Does proprioceptive training improve joint function and psychological readiness in patients after anterior cruciate ligament reconstruction? A randomized controlled trial by Qun-ya Zheng, Jian-ning Sun, Rui-song Wang, Yun-ru Ma, Peng Chen

“…Methods This was a randomized, parallel-group, controlled trial in which 48 patients were enrolled in either proprioceptive group (n = 24) or control group (n = 24) from the first week up to 12 th weeks of the operation. …”
Get full text

Efficacy and safety of inhaled ambroxol solution in improving sputum of lower respiratory tract infection in children: a multicenter, randomized, double-blind, placebo-controlled t... by Baoping Xu, Peng Han, Yunxiao Shang, Huanji Cheng, Zhiying Han, Lin Zhao, Shaoru He, Min Lu, Enmei Liu, Kunling Shen

“…Study Design This study was a randomized, double-blind, parallel-group, placebo-controlled, multicenter trial. …”
Get full text

The effect of ginseng (the genus panax) on glycemic control: a systematic review and meta-analysis of randomized controlled clinical trials. by Esra' Shishtar, John L Sievenpiper, Vladimir Djedovic, Adrian I Cozma, Vanessa Ha, Viranda H Jayalath, David J A Jenkins, Sonia Blanco Meija, Russell J de Souza, Elena Jovanovski, Vladimir Vuksan

“…Although there was no significant effect on fasting plasma insulin, glycated hemoglobin, or homeostasis model assessment of insulin resistance, a priori subgroup analyses did show significant reductions in glycated hemoglobin in parallel compared to crossover trials (MD = 0.22% [95%CI: 0.06 to 0.37], P = 0.01).…”
Get full text