Blinded Validation of Breath Biomarkers of Lung Cancer, a Potential Ancillary to Chest CT Screening. by Michael Phillips, Thomas L Bauer, Renee N Cataneo, Cassie Lebauer, Mayur Mundada, Harvey I Pass, Naren Ramakrishna, William N Rom, Eric Vallières

“…Combining breath biomarkers with chest CT could potentially improve the sensitivity and specificity of lung cancer screening.<h4>Trial registration</h4>ClinicalTrials.gov NCT00639067.…”
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Effect of nutrition behavior change communication on nutrition knowledge and dietary practices of pregnant adolescents in West Arsi, Central Ethiopia: a cluster randomized controll... by Adane Tesfaye, Adane Tesfaye, Kefyalew Taye Belete, Dessalegn Tamiru, Tefera Belachew

“…ObjectiveThis study investigated the effect of communication about nutritional behavior changes on the nutritional knowledge and dietary practices of pregnant adolescents in the West Arsi Zone, Central Ethiopia.MethodsA two-arm parallel cluster randomized controlled trial was conducted in West Arsi, Central Ethiopia, to assess a Nutritional Behavioral Change Communication (NBCC) intervention based on the Health Belief Model (HBM). …”
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Muscle uncoupling protein 3 expression is unchanged by chronic ephedrine/caffeine treatment: results of a double blind, randomised clinical trial in morbidly obese females. by Renata Bracale, Maria Letizia Petroni, Sergio Davinelli, Umberto Bracale, Giovanni Scapagnini, Michele O Carruba, Enzo Nisoli

“…Several mechanisms have been proposed, among which an increased thermogenic capacity of skeletal muscle consequent to the EC-induced up-regulation of uncoupling protein 3 (UCP3) gene expression. We did a parallel group double-blind, placebo-controlled, 4-week trial to investigate this hypothesis. …”
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Effectiveness of theory-based breast self-examination intervention for breast cancer prevention among female college teachers in Pakistan: A cluster randomized controlled trial stu... by Benazir Mahar, Malina Binti Osman, Fatimah Binti Ahmad Fauzi

“…This protocol outlines a single-blind, parallel cluster randomized controlled trial (CRCT) with an intervention period of three months. …”
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Topical olive oil is not inferior to hyperoxygenated fatty aids to prevent pressure ulcers in high-risk immobilised patients in home care. Results of a multicentre randomised tripl... by Inmaculada Lupiañez-Perez, Shakira Kaknani Uttumchandani, Juan Carlos Morilla-Herrera, Francisco Javier Martin-Santos, Magdalena Cuevas Fernandez-Gallego, Francisco Javier Navarro-Moya, Yolanda Lupiañez-Perez, Eugenio Contreras-Fernandez, Jose Miguel Morales-Asencio

“…Design: Non-inferiority, triple-blind, parallel, multicentre, randomised clinical trial. Scope: Population attending Primary Healthcare Centres in Andalusia (Spain). …”
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Affective disorders: eliminate WArning signs and REstore functioning—AWARE—a randomised controlled multimodule intervention study, presentation of design and intervention by Maj Vinberg, Lars Vedel Kessing, Kamilla Woznica Miskowiak, Ida Seeberg, Rasmus Schwarz, Lone Decker

“…This study aims to improve functioning and QoL in patients with affective disorders using a comprehensive 360° intervention.Methods and analysis Affective disorders: eliminate WArning signs And REstore (AWARE) functioning is a randomised, controlled, parallel-group design study. Participants will be 120 outpatients, men or women, aged 18–65 years, with a diagnosis of bipolar disorder or major depressive disorder. …”
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Supporting mothers of discharged premature infants: a clinical trial on tele counseling for self-efficacy and anxiety management by Seyedeh Fatemeh Mousavi, Rafat Bakht, Leili Tapak, Mojde Afkhami Goli, Mansoureh Refaei

“…Methods This three-group parallel clinical trial in 2023 involved 135 mothers of premature infants with a gestational age of 32–36 weeks, discharged from the NICU of Fatemieh hospital in Hamadan, Iran. …”
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Mediating role of gut microbiota on Baduanjin for cognitive function in community-dwelling older adults with mild cognitive impairment: a study protocol for a cluster randomised co... by Guohua Zheng, Liwei Sun, Qian Geng

“…Key findings will also be shared with social media, healthcare providers, participants or community-dwelling older adults to support access for non-research audiences.Trial registration number ChiCTR2300078147.…”
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The effect of patellar taping combined with isometric strength training on pain, muscle strength, and functional performance in patients with patellofemoral pain syndrome: a random... by Shahnaz Hasan

“…Objectives This study investigated the efficacy of patellar taping and quadriceps isometric strength training (quadriceps-IST) at 60° knee flexion on quadriceps strength, pain, and functional performance in female patients with PFPS. Methods A two-arm, parallel-group, randomized comparative design was employed. …”
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Study protocol for a stepped-wedge, randomized controlled trial to evaluate implementation of a suicide risk identification model among behavioral health patients in three large he... by Scott P. Stumbo, Stephanie A. Hooker, Rebecca C. Rossom, Kathleen Miley, Brian K. Ahmedani, Elizabeth Lockhart, Hsueh-Han Yeh, Bobbi Jo H. Yarborough

“…A stepped-wedge design using repeated measures pre/post-implementation maximizes statistical efficiency and power with fewer participants compared to a parallel design while allowing all clinics to participate. …”
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Evaluation of the efficacy of integrating digital therapeutics with home-based cardiac rehabilitation on cardiovascular health in high-risk post-PCI patients (DTx-HBCR): Study prot... by Shuangliang Ma, Zhongxiu Chen, Junyan Zhang, Jiani Liu, Lin Xu, Baotao Huang, Mingang Zhou, Hua Wang, Yong Chen, Mian Wang, Chen Li, Yong He

“…Methods The DTx-HBCR trial is a parallel-arm, randomized controlled trial that will enroll 366 high-risk patients undergoing PCI at West China Hospital of Sichuan University. …”
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Effect of a proficiency-based progression simulation programme on clinical communication for the deteriorating patient: a randomised controlled trial by Dorothy Breen, Sinead O’Brien, Nora McCarthy, Anthony Gallagher, Nuala Walshe

“…Objective This study aimed to determine the effectiveness of a proficiency-based progression (PBP) training approach to clinical communication in the context of a clinically deteriorating patient.Design This is a randomised controlled trial with three parallel arms.Setting This study was conducted in a university in Ireland.Participants This study included 45 third year nursing and 45 final year medical undergraduates scheduled to undertake interdisciplinary National Early Warning Score (NEWS) training over a 3-day period in September 2016.Interventions Participants were prospectively randomised to one of three groups before undertaking a performance assessment of the ISBAR (Identification, Situation, Background, Assessment, Recommendation) communication tool relevant to a deteriorating patient in a high-fidelity simulation facility. …”
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Effects of positive sex education and pelvic floor strengthening program on sexual and pelvic health among youngest old: a randomized controlled trial by Ayse Deliktas Demirci, Alime Buyuk, Kamile Kabukcuoglu

“…This study aimed to examine the effects of a positive sex education and pelvic floor strengthening program on youngest-old women’s sexual function, sexual esteem, and quality of sexual life as primary outcomes and pelvic floor health as a secondary outcome. Methods A parallel two arms randomized controlled trial was conducted, involving 70 youngest-old women (mean age = 65.80 ± 5.20). …”
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Standard patient training versus Vik-Asthme chatbot-guided training: ‘AsthmaTrain’ – a protocol for a randomised controlled trial for patients with asthma by Arnaud Bourdin, Nicolas Molinari, Carey Meredith Suehs, David Galeazzi, Isabelle Vachier, François Vaast, Fanny Cardon

“…Results will be published in international peer-reviewed journals.Trial registration number NCT05248126.…”
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The effects of an unsupervised water exercise program on low back pain and sick leave among healthy pregnant women - A randomised controlled trial. by Mette G Backhausen, Ann Tabor, Hanne Albert, Susanne Rosthøj, Peter Damm, Hanne K Hegaard

“…<h4>Methods</h4>In this randomised, controlled, parallel-group trial, 516 healthy pregnant women were randomly assigned to either unsupervised water exercise twice a week for a period of 12 weeks or standard prenatal care. …”
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Internal brace augmentation reconstruction versus standard anterior cruciate ligament reconstruction: a randomised controlled clinical trial study protocol by Xu Liu, Di Liu, Yusheng Li, Wenhao Lu, Zijun Cai, Linyuan Pan, Wenqing Xie, Hongfu Jin, Wenfeng Xiao

“…Data will be published in peer-reviewed journals and presented at national and international conferences.Trial registration number ChiCTR2200057526.…”
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Efficacy of periodontal soft tissue augmentation prior to orthodontic treatment on preventing gingival recession: study protocol for a randomised controlled trial by Jing Chen, Qiang Li, Wei Zhang, Fan Zhang, Jiashu Lv, Yuhui Wang, Yichen Xu, Yichen Pan

“…The results of this study will be reported in journal publications.Trial registration number ChiCTR2100050892.…”
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Early supplementation for cow’s milk allergy prevention in breastfed infants in Poland (ESCAPE-PL): a protocol for randomised controlled trial by Andrea Horvath, Wojciech Feleszko, Agnieszka Bzikowska-Jura, Aleksandra Wesolowska, Agata Stróżyk, Hanna Szajewska, Dominika Ambrożej, Karolina Dumycz

“…The abstract will be presented at relevant national and international conferences.Trial registration number NCT06652698.…”
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The impact of the Change4Life Food Scanner app on children’s diets and parental psychological outcomes: a randomised pilot and feasibility study by Sundus Mahdi, Jim Chilcott, Nicola J. Buckland

“…Methods Adopting a non-blinded parallel trial design, 126 parents of 4-11 year olds were randomly assigned (1:1) through block randomisation sequences into a 3-month intervention consisting of exposure to the Food Scanner app (version 1.6; [n = 62]) or no intervention (n = 64). …”
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Effect of Everyday Life Rehabilitation on recovering quality of life in individuals with serious mental illness in supported accommodation: a pragmatic cluster randomised controlle... by Per Liv, André Sjöberg, Maria Lindström

“…While multilevel approaches must be tailored to specific contexts, the integration of occupational therapists may provide clinical benefits in supported accommodation.Trial registration number NCT05056415.…”
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