A review of the statistical analysis of randomised controlled trials conducted within OCTRU by Alexander Ooms, Caitlin Waldron, Daphne Kounali, Ioana R. Marian, M. Sofia Massa, Nicholas Peckham, Matthew Parkes, Elizabeth Conroy, Jonathan A. Cook

“…All trials that included at least one analysis (26/27) featured at least one additional analysis on the primary outcome, the most popular additional analyses were on an alternative population (for example a per-protocol population), occurring in 20/27, 74% of all trials, or a subgroup (18/27, 67%)). …”
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Etiological shifts and clinical outcomes of acute pancreatitis between urban and rural areas: evidence from a 20-year retrospective database by Ximei Cao, Ximei Cao, Zide Liu, Jingwen Rao, Jie Wu, Xin Huang, Liang Xia, Lingyu Luo, Xu Shu, Yin Zhu, Nonghua Lu, Wenhua He

“…Temporal trends revealed accelerated HTG-AP growth post-2020 in both groups, paralleling metabolic syndrome escalation.ConclusionThese findings underscore the imperative for dual interventions: urban-focused metabolic risk mitigation and rural-targeted biliary disease management, informed by evolving etiological landscapes.…”
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Prominence of Mycobacterium tuberculosis biomarkers among sputum culture-negative clinic attendees, independent of Ultra status by Yingda L. Xie, Nisha Modi, Kattya Lopez, Robert Reiss, Jorge Robledo, Christie Eichberg, Nchimunya Hapeela, Elizabeth Nakabugo, Irene Anyango, Kiranjot Arora, Ronald Odero, Judi Van Heerden, Widaad Zemanay, Vaishnavi S. Kaipilyawar, Samuel Kennedy, Padmapriya Banada, Lydia Nakiyingi, Moses L. Joloba, Chad Centner, Kimberly McCarthy, Jerrold Ellner, Padmini Salgame, David Alland, Susan E. Dorman

“…Conclusion: TB bacterial and host biomarkers were prevalent and no different between sputum-discordant and sputum-negative participants, raising concern for a considerable population of undiagnosed culture-negative TB. These findings parallel new evidence of Mtb aerosolization from sputum-negative individuals and highlight a need for more comprehensive diagnostics that detect sputum culture-negative TB with respect to infectiousness, pathology, and risk of progression.…”
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Physiological serum uric acid concentrations correlate with arterial stiffness in a sex-dependent manner by Oliver Thews, Thomas Schmid, Alexander Kluttig, Andreas Wienke, Melanie Zinkhan, Wolfgang Ahrens, Till Bärnighausen, Hermann Brenner, Stefanie Castell, Berit Lange, Wolfgang Lieb, Karin Halina Greiser, Marcus Dörr, Lilian Krist, Stefan N. Willich, Volker Harth, Nadia Obi, Michael Leitzmann, Annette Peters, Börge Schmidt, Matthias B. Schulze, Henry Völzke, Matthias Nauck, Stephanie Zylla, Anke Hannemann, Tobias Pischon, Ilais Moreno Velásquez, Matthias Girndt, Claudia Grossmann, Michael Gekle

“…In parallel, we applied a machine learning approach to identify and quantify factors associated with PWV in a hypothesis-free manner. …”
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Carer administration of as-needed subcutaneous medication for breakthrough symptoms in people dying at home: the CARiAD feasibility RCT by Zoë Hoare, Clare Wilkinson, Dyfrig A Hughes, Anthony Byrne, Annmarie Nelson, Julia Hiscock, Bee Wee, Marlise Poolman, Annie Hendry, Stella Wright, Paul Perkins, Anne Parkinson, Emily Holmes, Liz Reymond, Betty Foster, Julie O’Connor, Penney Lewis, Nia Goulden, Rossella Roberts, Sian Roberts

“…The intervention was considered acceptable, feasible and safe in the small study population. The intervention group had a considerably shorter time to medication administration than the usual-care group (median time to administer medication in intervention=5 min, usual-care=105 min). …”
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[Artículo traducido] Análisis Rasch del índice de calidad de vida en dermatología by G. Sanclemente, C. Mora-Gaviria, D.C. Aguirre-Acevedo

“…For ordinal item #7, the McDonald's Omega coefficient was 0.87 (95% IC: 0.85-0.89) and Cronbach's α coefficient, 0.84 (95% CI: 0.82-0.87). Horn's parallel analysis revealed the presence of DLQI unidimensionality with a 1-factor solution. …”
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Safety of a co-designed cognitive behavioural therapy intervention for people with type 1 diabetes and eating disorders (STEADY): a feasibility randomised controlled trialResearch... by Marietta Stadler, Natalie Zaremba, Amy Harrison, Jennie Brown, Divina Pillay, Jacqueline Allan, Rachael Tan, Salma Ayis, Emmanouela Konstantara, Janet Treasure, David Hopkins, Khalida Ismail

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Rasch Analysis of the Dermatology Life Quality Index by G. Sanclemente, C. Mora-Gaviria, D.C. Aguirre-Acevedo

“…For ordinal item #7, the McDonald's Omega coefficient was 0.87 (95%IC: 0.85–0.89) and Cronbach's α coefficient, 0.84 (95%CI, 0.82–0.87). Horn's parallel analysis revealed the presence of DLQI unidimensionality with a 1-factor solution. …”
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Gestion intégrée et territorialisée du risque sanitaire en Côte d’Ivoire : cas de la flambée épizootique d’influenza aviaire hautement pathogène en 2021 by Ibrahima Mamby Keita, Rosalie Martine Ndew Seck, Christophe Yao Kouakou, Douyeri Thierry Ouattara, Catherine Linard, Aminata Diène Niang, Nicolas Antoine-Moussiaux, Bassirou Bonfoh, Isaac Tiembre, Vessaly Kallo

“…Une enquête rétrospective a permis d’identifier les acteurs de la riposte et leurs interactions. En parallèle, une régression logistique sur les données épidémiologiques a identifié les facteurs de risque et cartographié les zones sensibles. …”
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Supporting self-management with an internet intervention for low back pain in primary care: a RCT (SupportBack 2) by Adam W A Geraghty, Taeko Becque, Lisa C Roberts, Jonathan Hill, Nadine E Foster, Lucy Yardley, Beth Stuart, David A Turner, Gareth Griffiths, Frances Webley, Lorraine Durcan, Alannah Morgan, Stephanie Hughes, Sarah Bathers, Stephanie Butler-Walley, Simon Wathall, Gemma Mansell, Malcolm White, Firoza Davies, Paul Little

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CD22-targeted chimeric antigen receptor-modified T cells for children and adults with relapse of B-cell acute lymphoblastic leukemia after CD19-directed immunotherapy by Clare Taylor, Carl H June, Joseph A Fraietta, Boris Engels, Gabriela Plesa, Marco Ruella, Stephan A Grupp, Hongyan Liu, Colleen Callahan, Shannon L Maude, Regina M Myers, Caroline Diorio, Yimei Li, Vanessa Gonzalez, Julie K Jadlowsky, Amanda M DiNofia, Gerald Wertheim, Donald L Siegel, Emma Iannone, Laura Shinehouse, Jennifer L Brogdon, Elizabeth O Hexner, Diane Baniewicz, Richard Aplenc, Allison Barz Leahy, Susan E McClory, Susan R Rheingold, Lisa Wray, Noelle V Frey

“…Novel immunotherapeutic strategies for this patient population are urgently needed.Methods We tested a novel, fully human anti-CD22/4-1BB CAR T-cell construct, CART22-65s, in parallel phase I studies for pediatric and adult B-ALL. …”
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Aquatic Environment and Nitrogen and Phosphorus Balance in Micropterus salmoides Culture Under Biofloc Model by Yuqin JIN, Shunlong MENG, Huimin XU, Chao SONG, Limin FAN, Liping QIU, Dandan LI

“…According to the United Nations, the global population is expected to grow by another 2 billion to reach 9.7 billion by 2050. …”
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Phase IV adaptive randomised clinical trials evaluating efficacy and cost-efficacy of pre-emptive pharmacogenetic genotyping strategies in the Spanish National Health System: iPHAR... by Xandra García-González, Alberto M Borobia, Antonio J Carcas, Miriam Estébanez, Montserrat Carmona, Irene García García, Francisco Abad-Santos, Luis A López-Fernández, Esther Cubo, Iñaki Imaz-Iglesia, Alicia Marín-Candón, Miriam Saiz-Rodríguez, Irene Taladriz-Sender, Pedro Arias, Rocío Rosas-Alonso, Enrique Seco-Meseguer, Stefan Stewart, Elena Diago-Sempere, María del Mar García Saiz, Emilio J Laserna-Mendieta, Ana M Peiró, Magí Farré, Consuelo Rodriguez-Jimenez, Judith Sanabria-Cabrera, Lucia Pedrosa, Ignacio Bernardino, Javier Guiijarro-Eguinoa, Arturo Gómez López De Las Huertas, Susana Martín-López, Olga Hladun Alvaro, Vicente Arrate, Ana Fries, Daniel Rodriguez Díaz, Fernando Marqués García, Núria Alonso Pedrol, Modesto M Maestre Muñiz, Leticia Rodríguez Alcolado, Carlos Ortiz-Bautista, Angela Remesal-Doblado, María Isabel Lucena, Zaida Salmón González, Inmaculada Coca-Prieto

“…The first of these studies aims to assess whether a pre-emptive statin therapy genotyping scheme reduces the incidence of statin-associated muscle symptoms (SAMS) in a population at risk of cardiovascular disease susceptible of receiving high-intensity or moderate-intensity doses of statins: The PREVESTATGx trial.Methods and analysis the PREVESTATGX trial is a multicentre, adaptive randomised controlled pragmatic phase IV clinical trial nested to the iPHARMGx master protocol with two parallel arms, aiming for superiority. …”
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Mixed-methods, descriptive and observational cohort study examining feeding and growth patterns among low birthweight infants in India, Malawi and Tanzania: the LIFE study protocol by Christopher R Sudfeld, Karim Manji, Rodrick Kisenge, Tisungane Mvalo, Melda Phiri, Christopher Duggan, Lauren Spigel, Anne CC Lee, Bethany A Caruso, Laura Subramanian, Megan Marx Delaney, Shivaprasad S Goudar, Linda Vesel, Katherine EA Semrau, Irving F Hoffman, Melissa Young, Friday Saidi, Jnanindra Nath Behera, Roopa M Bellad, Leena Das, Sangappa Dhaded, Gowdar Guruprasad, Sujata Misra, Sanghamitra Panda, Latha G Shamanur, Sunil S Vernekar, Sarah Somji, Linda Adair, Kiersten Israel-Ballard, Stephanie L Martin, Kimberly L Mansen, Krysten North, Emily Benotti, Eliza Fishman, Katelyn Fleming, Natalie Henrich, Kate Miller, Danielle E Tuller

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De l’agglomération antique de Cassinomagus au village de Chassenon (Charente) : un bilan des connaissances by Lucie Carpentier, Sandra Sicard

“…This habitat development occurred in parallel with that of monumental ornamentation. The natural topography of the land was, in fact, widely exploited by the builders in order to install a monumental complex. …”
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Evolution of the activities of states as reflected in legal and political Teachings by A. A. Klishin

“…The dilution of legal norms, standards and rules that are customary for the population of the developed countries makes a notable impact on the public con-science, creating the objective preconditions for a boom in “legal nihilism” and the public negation of the necessity to abide with the rules of law, all this going in parallel with such inadequately working principles as the “supremacy of law”, “observance of civil rights”, “democratic basis of social structure” etc. …”
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Comparative analysis of physicochemical properties, bioequivalence, safety and tolerability of the first domestic semaglutide by A. S. Ametov, I. E. Shokhin, E. A. Rogozhina, T. G. Bodrova, M. E. Nevretdinova, P. A. Bely, K. Ya. Zaslavskaya, V. S. Scherbakova, D. V. Kurkin, K. N. Koryanova, E. S. Mishchenko, E. Yu. Kesova, E. D. Kozlov, E. S. Samoshkina, D. N. Andreev, Yu. G. Kazaishvili, S. M. Noskov, L. A. Balykova

“…To assess the bioequivalence of the study drug and the reference drug, an open randomized parallel comparative study with the participation of healthy volunteers (n=54), 54 participants of which had been included in the population, was conducted. …”
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Co-designing and testing the learn together guidance to support patient and family involvement in patient safety investigations: a mixed-methods study by Jane O’Hara, Lauren Ramsey, Siobhan McHugh, Joseph Langley, Justin Waring, Ruth Simms-Ellis, Gemma Louch, Jenni Murray, Carl Macrae, John Baker, Rebecca Lawton, Daisy Halligan, Olivia Rogerson, Penny Phillips, Debra Hazeldine, Sarah Seddon, Joanne Hughes, Rebecca Partridge, Katherine Ludwin, Laura Sheard

“…A synthesis phase ran parallel with the first two, bringing them together through a series of analytical workshops. …”
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Challenges to overcome in a randomised trial for Proper Understanding of Recurrent Stress Urinary Incontinence Treatment in women: the PURSUIT RCT by Caroline Pope, Madeleine Cochrane, Clare Clement, Yumeng Liu, Sangeetha Paramasivan, Sian Noble, Stephanie J MacNeill, Amanda L Lewis, Jodi Taylor, Bethanie Fitzgerald, Nikki Cotterill, Tamsin Greenwell, Hashim Hashim, Swati Jha, Nikesh Thiruchelvam, Philip Toozs-Hobson, Alison White, Wael Agur, J Athene Lane, Marcus Drake

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Multiple Symptoms Study 3 – An extended-role general practitioner clinic for patients with persistent physical symptoms: a Randomised Controlled Trial by Christopher Burton, Cara Mooney, Laura Sutton, David White, Jeremy Dawson, Kate Fryer, Monica Greco, Michelle Horspool, Aileen Neilson, Gillian Rowlands, Tom Sanders, Ruth Thomas, Steve Thomas, Cindy Cooper, Jonathan Woodward, Emily Turton, Waquas Waheed, Pavi Kumar, Katie Ridsdale, Ellen Mallender, Vincent Deary

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