Protocol of randomized-controlled trial to examine the effectiveness of three different interventions to reduce healthcare provider burnout by Catalina Ruple, John Brodhead, Lila Rabinovich, Doerte U. Junghaenel, Tiffany Nakamura, Jonathan Wong, Sophia De-Oliveira, Joan Brown, Phuong Nguyen, Jenny Horn, Renee Middleton, Michelle Brahe, Cheng Wen, Sujeet Rao, Caroline Nguyen, Gil Shlamovitz, Dara Marino, Felipe Osorno, Steven Siegel

“…Another innovation is the inclusion of different types of patient-facing providers in the study population (doctors, nurses, and therapists). Trial registration This study was registered at ClinicalTrials.gov (NCT05780892) on March 10th, 2023.…”
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Immunoregulatory programs in anti‐N‐methyl‐D‐aspartate receptor encephalitis identified by single‐cell multi‐omics analysis by Xinhui Li, Yicong Xu, Weixing Zhang, Zihao Chen, Dongjie Peng, Wenxu Ren, Zhongjie Tang, Huilu Li, Jin Xu, Yaqing Shu

“…Differential gene expression analysis, transcription factor activity profiling, and cell‐cell communication modeling were performed to elucidate the immune mechanisms underlying the disease. In parallel, single‐cell B cell receptor sequencing (scBCR‐seq) and repertoire analysis were conducted to assess antigen‐driven clonal expansion within the B cell population. …”
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Cerebrovascular longitudinal atlas: Changes in cerebral arteries in unruptured intracranial aneurysm patients followed with MRA by Aichi Chien, Fernando Vinuela, Viktor Szeder, Geoffrey Colby, Reza Jahan, Anthony Wang, Satoshi Tateshima, Gary Duckwiler, Noriko Salamon

“…Results: Patient characteristics influenced the speed of CV shape change (e.g. diabetes mellitus, faster, p = 0.016), while other factors mapped to older CV age (e.g. hypertension, p = 0.0004). In parallel, we found that groups including autosomal dominant polycystic kidney disease (p = 0.0004), sex (p = 0.005), smoking (p = 0.046), and IA growth (p = 0.020) shared CV morphology characteristics. …”
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Yoga programme for type-2 diabetes prevention (YOGA-DP) among high risk people in India: a multicentre feasibility randomised controlled trial protocol by Mark Hamer, Dorairaj Prabhakaran, Kavita Singh, Nikhil Tandon, Sanjay Kinra, Kaushik Chattopadhyay, Tess Harris, Pallavi Mishra, Sheila Margaret Greenfield, Sarah Anne Lewis, Nandi Krishnamurthy Manjunath, Rukamani Nair, Somnath Mukherjee, David Ross Harper

“…Introduction A huge population in India is at high risk of type-2 diabetes (T2DM). …”
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Machine learning for diabetic foot care: accuracy trends and emerging directions in healthcare AI by Pei-Chun Lin, Pei-Chun Lin, Tsai-Chung Li, Tsai-Chung Li, Tzu-Hsuan Huang, Ying-Lin Hsu, Wen-Chao Ho, Jia-Lang Xu, Ching-Liang Hsieh, Ching-Liang Hsieh, Ching-Liang Hsieh, Zih-En Jhang

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Multimodality local consolidative treatment versus conventional care of advanced lung cancer after first-line systemic anti-cancer treatment: study protocol for the RAMON multicent... by Matthew Evison, Tim Batchelor, Chris A Rogers, Sarah Baos, Elizabeth A Stokes, Rosie Harris, Eric Lim, Chloe Beard, Janette Rawlinson, Nicola Mills, John Conibear, Paulo De Sousa, Thomas Newsom-Davis, Tara Barwick, Leah Fleming

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“VID-KIDS” Video-Feedback Interaction Guidance for Depressed Mothers and Their Infants: Results of a Randomized Controlled Trial by Panagiota D. Tryphonopoulos, Deborah McNeil, Monica Oxford, Cindy-Lee Dennis, Jason Novick, Andrea J. Deane, Kelly Wu, Stefan Kurbatfinski, Keira Griggs, Nicole Letourneau

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Forensic Genetics: A Machine Learning Algorithm for Mutation Modelling by Sofia Antão Sousa, Leonor Gusmão, Marisa Faustino, António Amorim, Nádia Pinto

“… Microsatellites or short tandem repeats (STRs) are the most used markers in population and forensic genetics due to their high polymorphism that is consequence of high germinal mutation rates. …”
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Autism Transition to Adulthood Groups (ATAG): protocol for a feasibility RCT of a new peer-group intervention to promote successful transition to adulthood for autistic young peopl... by Bryony Beresford, Annabel Burnley, W Mandy, Ailsa Russell, Kate Cooper, Leon Allain, Laura Crane, Maximiliano Vazquez Morales, Lucy Portway, Benjamin Redmayne

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Scientific Research on the Issue of Soft Skills Development (Review of the Data in International Databases of Scopus, Web of Science) by I. K. Tsalikova, S. V. Pakhotina

“…In Western countries, the issues and strategies for soft skills formation in different categories of population have been studied for quite some time. Recently, these problems have become much more common among Russian scientists. …”
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International perspective on research priorities and outcome measures of importance in the care of children with acute exacerbations of asthma: a qualitative interview study by Franz E Babl, Ricardo M Fernandes, Charmaine S Gray, Colin V E Powell, Simon Craig, Javier Benito, Yao Xu, Mark D Lyttle, Damian Roland, Suzanne Schuh, Stuart Dalziel, Jenny Couper, Shu-Ling Chong, Mike Johnson, Indumathy Santhanam, Baljit Cheema, Adriana Yock-Corrales

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What drives the development of digital rural life in China? by Chunlin Xiong, Yaling Wang, Zhenyu Wu, Fen Liu

“…It demonstrates a pattern of diverse combinations and parallel pathways encompassing various variables. Among these configurations, six paths stand out with the highest coverage. …”
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Pragmatic clustered randomised control trial to evaluate a self-regulated learning intervention to be implemented in South Australian primary schools—study protocol by S.A Brinkman, B. Lam, S. Dawson, R. Marrone, D. Schunk, K. Winkel, H. Hermes, F. Gabriel, S. Fowler, D. Engelhardt

“…Methods We will use a standard pragmatic clustered (by school) randomised controlled superiority trial with an additional population-wide matched parallel control arm. Effectively, we will conduct three trials—one for each age/grade level. …”
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Sociodemographic factors associated with health-related quality of life in UK healthcare workers: a cross-sectional study by Christopher A. Martin, Rebecca F. Baggaley, Lucy Teece, Daniel Pan, Joshua Nazareth, Luke Bryant, Carol Rivas, Katherine Woolf, Manish Pareek, The UK-REACH study collaborative group

“…Similar associations were demonstrated in a parallel analysis of VAS scores. Conclusions In the largest study of HRQoL in HCWs to date, EQ-5D-5L VAS scores were lower than those reported elsewhere for the general UK population (for ages up 45 years), with high levels of anxiety/depression and pain/discomfort and substantial heterogeneities across EQ-5D-5L dimensions by sex, occupation and deprivation level. …”
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Spatial pattern of Trees in the Riparian Forests (Case Study: Wildlife Refuge of Karkhe) by Shaieste Gholami

“…These factors together with intrinsic population processes constitute proximate controlling factors of population structure. 4- Conclusion The spatial pattern of total species and Tamarix sp. are similar that was shown in correlation. …”
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The “tyranny of distance”: community-based veteran suicide prevention in Guam by Joanna R. Sells, Joanna R. Sells, Kelly A. Stearns-Yoder, Kelly A. Stearns-Yoder, Molly E. Penzenik, Molly E. Penzenik, Nazanin H. Bahraini, Nazanin H. Bahraini, Nazanin H. Bahraini, Molly J. Sullan, Molly J. Sullan, Molly J. Sullan, Selena Cruz, Selena Cruz, Lindsey L. Monteith, Lindsey L. Monteith, Lisa A. Brenner, Lisa A. Brenner, Lisa A. Brenner, Lisa A. Brenner

“…The population of Guam is comprised of a high proportion of Asian and/or Pacific Islander individuals, many of whom have served in the military. …”
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Gucy1α1 specifically marks kidney, heart, lung and liver fibroblasts by Valeria Rudman-Melnick, Davy Vanhoutte, Kaitlynn Stowers, Michelle Sargent, Mike Adam, Qing Ma, Anne Karina T. Perl, Alexander G. Miethke, Ashley Burg, Tiffany Shi, David A. Hildeman, E. Steve S. Woodle, J. Matthew Kofron, Prasad Devarajan

“…Studies in the murine models of cardiac and liver fibrosis revealed Gucy1α1 elevation in activated Pdgfrβ-, Vim- and alpha smooth muscle actin (αSma)-expressing fibroblasts paralleling injury progression and resolution. Overall, we demonstrate Gucy1α1 as an exclusive fibroblast marker in both sexes. …”
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Effects of oat β-glucan-based prebiotic blended formulas on defecation and gut microbiota in Chinese adults: a randomized clinical trial by Aiqi Li, Lei Jin, Hui Xia, Meiyuan Feng, Xirui Zhou, Yifang Chu, Feng Liu, Lanxing Jia, Ximin Chen, Dengfeng Xu, Shanjie Ma, Xiaofan Xu, Xinyu Wang, Xiaoqing Li, Guiju Sun, Liegang Liu

“…A parallel, randomized, double-blind, controlled trial was conducted in 168 eligible adults randomized to 3 groups for 14 days: Intervention groups A and B received 2 different doses of oat β-glucan-based prebiotic blended formulas and a Control group received oat β-glucan mixed with hydroxypropylmethyl-cellulose and microcrystalline cellulose. …”
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Exercise therapy to improve mobility, active behaviour and quality of life of chronic kidney disease patients with peripheral artery disease: study protocol for the EXACT-CKDPAD mu... by Filippo Aucella, Roberto Manfredini, Fabio Manfredini, Carmine Zoccali, Andrea Baroni, Sofia Straudi, Francesca Mallamaci, Nicola Lamberti, Vincenzo Panuccio, Yuri Battaglia, Alda Storari, Giovanni Piva, Marco Veronesi, Rocco Tripepi, Natascia Rinaldo, Anna Crepaldi, Claudia Momentè, Angela Piccinini, Luca Traina, Aaron Thomas Fargion, Alfredo De Giorgi, Carlotta Martinuzzi, Marcello Monesi, Alessandro Capitanini, Adamasco Cupisti

“…Physical exercise is considered an effective treatment for reducing sedentary behaviour and improving quality of life, but several barriers limit patient participation. In this parallel-design, single-blinded, randomised controlled trial, we will enrol 130 patients with concomitant CKD at stages III and IV and PAD at the claudication stage to be randomised into a 6-month exercise (Ex) or control (Co) intervention. …”
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Children’s Health in London and Luton (CHILL) cohort: a 12-month natural experimental study of the effects of the Ultra Low Emission Zone on children’s travel to school by Christina Xiao, James Scales, Jasmine Chavda, Rosamund E. Dove, Ivelina Tsocheva, Helen E. Wood, Harpal Kalsi, Luke Sartori, Grainne Colligan, Jessica Moon, Esther Lie, Kristian Petrovic, Bill Day, Cheryll Howett, Amanda Keighley, Borislava Mihaylova, Veronica Toffolutti, Jonathan Grigg, Gurch Randhawa, Aziz Sheikh, Monica Fletcher, Ian Mudway, Sean Beevers, W. James Gauderman, Christopher J. Griffiths, Esther van Sluijs, Jenna Panter

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