North of England Women’s Diet and ActivitY - After Breast Cancer (NEWDAY-ABC) intervention in women diagnosed with early oestrogen-positive, HER2-negative breast cancer: a randomis... by C. Wilson, K. Pickering, S. Wane, J. Cohen, C. Huang, M. Northgraves, H. Crank, A. Anderson, H. Cain, R. Copeland, J. Gray, J. Hargreaves, R. J. Q. McNally, J. M. Saxton

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Human versus Analogue Insulin for Youth with Type 1 Diabetes in Low-Resource Settings (HumAn-1): protocol for a randomised controlled trial by Éimhín Ansbro, Jing Luo, Chung-Chou H Chang, Kaushik Ramaiya, Bruce L Rollman, Sylvia Kehlenbrink, Sae-Rom Chae, Abigail Foulds, Claire Josey, Christina Lalama, Margaret L Prust, Bedowra Zabeen, Graham Ogle

“…To determine whether insulin glargine, a long-acting insulin analogue, reduces the risk of serious hypoglycaemia and/or improves glycaemic time-in-range (TIR) versus human insulin regimens in this population, we are conducting the Human vs Analogue Insulin for Youth with Type 1 Diabetes in Low-Resource Settings randomised controlled trial.Methods and analysis This is a 1:1 randomised, parallel-group clinical trial comparing biosimilar insulin glargine with human insulin (Neutral Protamine Hagedorn (NPH) or premixed 70/30 insulin) in 400 youth with type 1 diabetes (T1D) recruiting in Dhaka, Bangladesh (n=250) and Mwanza, Tanzania (n=150). …”
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A patient self-report disability identifier within health service electronic medical records: evaluation of patient, carer and clinician acceptability by Joanne Rowe, Alexandra Devine, Nicole Merrick, Marie Huska, Kristen Morris, Kath Feely, Ahuva Segal, Louise Mogg, Jenni Medland, Rebecca Jamwal, Alison Smith, Maricar Gleich, Jeremiah Munakabayo, Christine Imms

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Supporting self-management of low back pain with an internet intervention in primary care: a protocol for a randomised controlled trial of clinical and cost-effectiveness (SupportB... by Beth Stuart, Paul Little, Lucy Yardley, Stephanie Hughes, Adam W A Geraghty, Elaine Hay, Gemma Mansell, Nadine E Foster, Jonathan Hill, Gareth Griffiths, Frances Webley, Lorraine Durcan, Alannah Morgan, Sarah Bathers, Stephanie Butler-Walley, Simon Wathall, Linda Leigh

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Flash glucose monitoring with the FreeStyle Libre 2 compared with self-monitoring of blood glucose in suboptimally controlled type 1 diabetes: the FLASH-UK randomised controlled tr... by Gerry Rayman, Christopher Sutton, M Burns, Rachel Ann Elliott, Sankalpa Neupane, Mark Evans, S Lumley, A Krishan, Emma G Wilmot, P Narendran, Katharine Barnard-Kelly, Iain Cranston, G Gkountouras, N Kanumilli, C Kotonya, V P Taxiarchi, H Thabit, L Leelarathna

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Deciphering community-level knowledge of obstetric fistula and determinants: perspectives elucidated by ordinal logistic regression by Miteku Andualem Limenih, Alemakef Wagnew Melesse, Chernet Baye, Beletew Shewabere, Eskedar Getie Mekonnen, Hamid Yimam Hassen, Hamid Yimam Hassen, Aster Berhe, Destaye Shiferaw Alemu, Wagaye Fentahun Chanie

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Protocol for an outcome assessor-blinded pilot randomised controlled trial of an ion-exchange water softener for the prevention of atopic eczema in neonates, with an embedded mecha... by Joanne R Chalmers, Sanja Kezic, Zarif K Jabbar-Lopez, Nikeeta Gurung, Danielle Greenblatt, Annette Briley, Kim Suzanne Thomas, Tony Frost, John E A Common, Heidi H Kong, Julie A Segre, Simon Danby, Michael J Cork, Janet L Peacock, Carsten Flohr

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Impact of a multi-component implementation strategy to increase outdoor free play opportunities in early childhood education and care (ECEC) services: the get outside get active (G... by Sze Lin Yoong, Nicole Pearson, Luke Giles, Hannah Lamont, Luke Wolfenden, Jannah Jones, Christophe Lecathelinais, Patti-Jean Naylor, Anthony Okely, Nicole Nathan, Kathryn Reilly, Rebecca Lorch, John Wiggers, Jacklyn Jackson, Melanie Lum, Karen Gillham, Alice Grady

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First measurements of velocity-space resolved intra-ELM fast-ion losses on the TCV tokamak by J. Poley-Sanjuán, A. Jansen Van Vuuren, J. Galdón-Quiroga, S. Mazzi, M. Podestà, M.B. Dreval, B.P. Duval, A. Fasoli, A.N. Karpushov, B. Labit, U. Kumar, the EUROfusion Tokamak Exploitation Team, the TCV Team

“…Edge Localised Modes (ELMs) induced fast-ion losses have been characterised in the energy, E , and pitch, $\lambda = v_\parallel/v$ , space using a unique Fast Ion Loss Detector (FILD) on the tokamak à configuration variable. …”
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The human gut microbiota is associated with host lifestyle: a comprehensive narrative review by Qin Zeng, Qin Zeng, Xianqiong Feng, Xianqiong Feng, Yanling Hu, Yanling Hu, Shaoyu Su, Shaoyu Su

“…Circadian rhythm disruption was associated with reduced microbial diversity and expansion of pro-inflammatory bacterial taxa, paralleling increases in systemic inflammation markers. …”
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Salivary lactoferrin levels in Down Syndrome: a case-control study by Desireé Antequera, Lucía Sande, Eliane García Mato, Deborah Romualdi, Laura Carrero, Cristina Municio, Pedro Diz, Eva Carro

“…Median of salivary lactoferrin were higher among DS individual, in parallel to salivary total protein, but there were no differences in the ratio of lactoferrin to total protein in saliva between groups. …”
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Effectiveness of case-area targeted interventions including vaccination on the control of epidemic cholera: protocol for a prospective observational study by Lauren D'Mello-Guyett, Ruwan Ratnayake, Andrew S Azman, Yap Boum, Francesco Checchi, W John Edmunds, Placide Okitayemba Welo, Nicolas Peyraud, Iza Ciglenecki, Etienne Gignoux, Maria Lightowler, Primitive Gakima, Jean Patrick Ouamba, Joseph Amadomon Sagara, Rollin Ndombe, Nana Mimbu, Alexandra Ascorra, Elisabeth Mukamba Musenga, Berthe Miwanda, Francisco Luquero, Klaudia Porten, Flavio Finger, Miriam Alia, Bachir Assao, Catherine Bachy, Rob D'hondt, Karl Njuwa Fai, Caroline Henry-Ostian, Abdoul-Moumouni Issa-Soumana, Danish Malik, Herbert Mutubuki, Rodrigue Ntone, Isabella Panunzi, Issaka Soumana, Oumar Touré, Mamady Traore

“…This study will run in parallel to each implementation. The primary outcome is the cumulative incidence of cholera in each CATI ring. …”
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SOFIA/HAWC+ Far-infrared Polarimetric Large-area CMZ Exploration Survey. IV. Relative Magnetic Field Orientation throughout the CMZ by Dylan M. Paré, David T. Chuss, Kaitlyn Karpovich, Natalie O. Butterfield, Jeffrey Inara Iuliano, Xing Pan, Edward J. Wollack, Qizhou Zhang, Mark R. Morris, Mathilda Nilsson, Roy J. Zhao

“…We use the statistical techniques of the Histogram of Relative Orientation and the Projected Rayleigh Statistic to assess whether the CMZ magnetic field preferentially aligns with the structure of the CMZ molecular clouds or the morphology of the nonthermal emission of the GC nonthermal filament (NTF) population. We find that there is a range of magnetic field orientations throughout the population of CMZ molecular clouds, ranging from parallel to perpendicular orientation. …”
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Navigator programme for hospitalised adults experiencing homelessness: protocol for a pragmatic randomised controlled trial by Lucie Richard, Rosane Nisenbaum, Vicky Stergiopoulos, Kerry McBrien, Michael Liu, Rebecca Brown, Anita Palepu, Jesse Jenkinson, Gabriel Fabreau, Cheryl Pedersen, Katherine Francombe Pridham, Sareeha Virani, Fred Ellerington, Alyssa Ranieri, Oluwagbenga Dada, Matthew To, Stephen Hwang

“…Quantitative outcomes are being collected over a 180-day period through linked patient-reported and administrative health data. A parallel mixed-methods process evaluation will be conducted to explore intervention context, implementation and mechanisms of impact.Ethics and dissemination Ethics approval was obtained from the Unity Health Toronto Research Ethics Board. …”
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PRESOLRE: study protocol for a primary school-based, cluster randomised controlled trial of three sun exposure risk prevention strategies on Reunion Island by Cyril Ferdynus, Léa Bruneau, Antoine Bertolotti, Charline Dugast, Adrian Fianu, Karim Boussaid, Juliette Vuichard, Floreana Duloutre, Jessica Dumez, Nathalie Sultan-Bichat

“…This island has a multicultural and multiethnic population of 860 000 inhabitants, a quarter of whom are at high risk of developing skin cancer due to intense ultraviolet radiation. …”
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Accounting for stillbirths in maternal health metrics: a cross-country analysisResearch in context by Ursula Gazeley, Hallie Eilerts-Spinelli, Joshua Wilde, Hannah Blencowe, Li Liu, Wendy Graham, Veronique Filippi

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Randomised placebo-controlled trial of combination ACE inhibitor and beta-blocker therapy to prevent cardiomyopathy in children with Duchenne muscular dystrophy? (DMD Heart Protect... by John P Bourke, Gillian Watson, Francesco Muntoni, Stefan Spinty, Helen Roper, Michela Guglieri, Chris Speed, Elaine McColl, Ashish Chikermane, Sandeep Jayawant, Satish Adwani, Tracey Willis, Jennifer Wilkinson, Andrew Bryant, Thomas Chadwick, Ruth Wood, Kate Bushby

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Effects of Different Interventions Using Taekwondo, Boxing, and Elastic Band Training on Body Composition and Physical Function in Chilean Older Women: A Randomized Controlled Tria... by Edgar Vásquez-Carrasco, Jordan Hernandez-Martinez, Izham Cid-Calfucura, Eduardo Guzmán-Muñoz, Camila Ruiz, Camila Baeza, María José Márquez, Tomás Herrera-Valenzuela, Braulio Henrique Magnani Branco, Eduardo Carmine-Peña, Paulina Sepúlveda, Cristian Sandoval, Pablo Valdés-Badilla

“…<b>Methods</b>: This randomized controlled trial comprised three parallel groups: TKD (<i>n</i> = 10), BOX (<i>n</i> = 10), and EBT (<i>n</i> = 10). …”
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New Report of Cyanobacteria and Cyanotoxins in El Pañe Reservoir: A Threat for Water Quality in High-Andean Sources from PERU by Victor Hugo Rodriguez Uro, Joana Azevedo, Mário Jorge Araújo, Raquel Silva, Jürgen Bedoya, Betty Paredes, Cesar Ranilla, Vitor Vasconcelos, Alexandre Campos

“…This work points out the need to implement continuous monitoring of cyanobacteria and cyanotoxins in the reservoir and effective water management measures to protect the human population from exposure to these contaminants.…”
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Potential effects of Asian-adapted Mediterranean diet in depression and anxiety among women with metabolic dysfunction-associated steatotic liver disease: a secondary analysis by Alicia Salamanca-Sanabria, Yu Chung Chooi, Evelyn Xiu Ling Loo, Evelyn Xiu Ling Loo, Xianning Lai, Vera Sergeyevna Brok Volchanskaya, Yap Seng Chong, Yap Seng Chong, Johan Gunnar Eriksson, Johan Gunnar Eriksson, Johan Gunnar Eriksson, Johan Gunnar Eriksson, Johan Gunnar Eriksson

“…We previously reported that a calorie-restricted MD adapted to the Asian food culture has beneficial effects on body composition, liver fat, and cardiometabolic markers in Chinese Singaporean women with MASLD.ObjectiveThis secondary analysis examines the effects of an Asian-adapted MD on the symptoms of anxiety and depression in the same population.MethodsIn a double-blind, parallel-design, randomized controlled trial, 84 Chinese- Singaporean females with MASLD were randomly assigned to 1 of the 3 groups for 12 weeks: adapted Asian MD with C15:0 supplementation (n = 29), diet without C15:0 supplementation (n = 26), or control (habitual diet and no C15:0 supplementation, n = 29). …”
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