Protocol for an adaptive platform trial of intended service user-derived interventions to equitably reduce non-attendance in eye screening programmes in Botswana, India, Kenya and... by Min Kim, David Macleod, Michael Gichangi, Andrew Bastawrous, Matthew J Burton, Jacqueline Ramke, Oathokwa Nkomazana, James R Carpenter, Sailesh Mishra, Shalinder Sabherwal, Luke Allen, Sarah Karanja, Ari Ho-Foster, Nigel Bolster, Malebogo Tlhajoane, Bakgaki Ratshaa

“…The access rate is even lower for certain population groups. This platform trial aims to test multiple, iterative, low-risk public health interventions and simple service modifications with a series of individual randomised controlled trials (RCT) conducted in each country, with the aim of increasing the proportion of people attending.Methods and analysis We will set up a platform trial in each country to govern the running of a series of pragmatic, adaptive, embedded, parallel, multiarm, superiority RCTs to test a series of service modifications suggested by intended service users. …”
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Mitigating Diarrhoea-Related Inflammation in Frail Older Adults with Postbiotic-Enhanced Oral Rehydration Solution: Insights from a Randomised, Double-Blind, Placebo-Controlled Stu... by Julian Andrés Mateus Rodríguez, Patricia Rodríguez Sanz, Edgar Kostandyan, Rubén Palacios Sanchez, María Luz Pino Roque, Patricia Chaves Vasquez, Pedro Roy Millán

“…This randomised study evaluated the effects of a novel oral rehydration solution (ORS) with the postbiotic ABB C22^®, known for its anti-inflammatory properties, on diarrhoea-associated inflammation in an elderly population. <b>Methods</b>: A randomised, double-blind, placebo-controlled, parallel-group trial was conducted at two hospital centres in Barcelona, Spain. …”
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Efficacy and safety of two-step acupuncture therapy for symptom relief in adults with mild to moderate ulcerative colitis: rationale and design of the TSA-UC randomised controlled... by Weiming Wang, Zhishun Liu, He Chen, Shuai Gao, Sixing Liu, Hangyu Shi, Jiufei Fang, Ji-Zheng Ma, Xinyu Shen

“…This study aims to assess the efficacy and safety of acupuncture for symptom relief in mild to moderate UC.Methods and analysis This single-centre, parallel-arm, randomised, sham-controlled, the two-step acupuncture (TSA)-UC trial, will involve 64 adults with mild to moderate UC, randomly assigned in a 1:1 ratio to either the acupuncture or sham acupuncture group. …”
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Prognostic significance of stress hyperglycemia ratio in patients with type 2 diabetes mellitus and acute coronary syndromes by Xiaoteng Ma, Huijun Chu, Yan Sun, Yujing Cheng, Dai Zhang, Lixia Yang, Zhijian Wang, Xiaoli Liu, Yujie Zhou

“…The follow-up incidence of MACCE increased in parallel with SHR tertiles (15.6%, 21.9%, and 36.1%, respectively; P for trend < 0.001). …”
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Effect of arm-ergometry versus treadmill supervised exercise on health-related quality of life and mental health in patients with peripheral artery disease: secondary outcomes from... by Sandra Magalhães, Mário Santos, Sofia Viamonte, Fernando Ribeiro, Joana Martins, Cristine Schmidt, Henrique Cyrne-Carvalho

“…Methods This was an ancillary study of the ARMEX trial, a single-center, single-blinded, parallel group, randomized clinical trial, enrolling symptomatic PAD patients referred to a cardiovascular rehabilitation program (CRP). …”
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Impact of daily fasting duration on body composition and cardiometabolic risk factors during a time-restricted eating protocol: a randomized controlled trial by A. Sampieri, A. Paoli, G. Spinello, E. Santinello, T. Moro

“…Thus, we aimed to compare the effects of 8 weeks of different fasting durations on body composition and biochemical parameters in metabolically healthy, non-trained individuals using a parallel randomized controlled trial. Methods Forty-one volunteers were randomly assigned to one of the four experimental groups: TRE 16:8 (16 h of fasting,8 h of eating), TRE 14:10 (14 h of fasting,10 h of eating), TRE 12:12 (12 h of fasting,12 h of eating) or a normal diet group (ND; no dietary restriction). …”
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An investigation into male infertility caused by hormonal imbalance and hypertension brought on by SARS-CoV-2 by Parameswari R, Kasthuri K, Babujanarthanam R, Ganesamoorthy R, Gomathi R, Yogesh T

“…Abstract Background Recent statistics suggest that birth rates are declining worldwide; in parallel, recent studies have also shown that birth rates have decreased since the emergence of SARS-CoV-2. …”
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Multicentre open label randomised controlled trial of immediate enhanced ambulatory ECG monitoring versus standard monitoring in acute unexplained syncope patients: the ASPIRED stu... by Steve Goodacre, Praveen Thokala, Neil Grubb, Chris Lang, Rachel O’Brien, Christopher J Weir, Trudie Lobban, Matthew J Reed, Nicola Freeman, Julia Boyd, Lynn Dinsmore, Caroline Blackstock, Imad Adamestam, Pam Macrae, Robert Hannigan

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Effectiveness of electroacupuncture for the treatment of refractory overactive bladder disease in women: study protocol for a randomised controlled clinical trial by Shuo Zhang, Yulong Ding, Yuan Ji, Huai-Yu Wang, Hong-Chao Zhao

“…A secondary objective is to assess whether electroacupuncture is more effective than conventional acupuncture for treating patients with refractory OAB.Methods and analysis The study is designed as a two-arm, parallel, participant-blinded randomised controlled trial (RCT). …”
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A graded personalized exercise program’s effect on muscle and body fat: randomized controlled trial by Jung Yeon Son, Jiyun Jung, Jung Eun Son, Sang Gyu Park, Eo Jin Park, Junga Lee, Seung Don Yoo

“…Abstract Objectives With population aging, personalized exercise programs considering clinical and demographic factors like sex, age, and physical activity level are essential; however, research on their effects remains limited. …”
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An observational post-authorization study to assess the effectiveness of a single dose Ad26.COV2.S for the prevention of COVID-19 using real-world data by Amelia Boehme, Raymond A. Harvey, Ann Madsen, Lexie Rubens, Astra Toyip, Michael Batech, Deborah Ricci, Mawuli Nyaku

“…The results of subgroup analyses generally showed a similar pattern as the main analyses with VE increasing in parallel with seriousness of outcomes, albeit with lower VE in groups thought to be at higher risk of COVID-19.DiscussionThis population-representative cohort study in U.S. clinical practice showed that a single dose of Ad26.COV2.S is effective for at least 12 months against several COVID-19 related outcomes. …”
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Effect of a tailored multidimensional intervention on the care burden among family caregivers of stroke survivors: a randomised controlled trial by Michiko Moriyama, Mahmoud Ahmed Elsheikh, Md Moshiur Rahman, Mayumi Kako, Ahmed Hashem El-Monshed, Mohamed Zoromba, Hamada Zehry, Maha Hazem Khalil, Mostafa Amr, Abdel-Hady El-Gilany

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Reinforcement of Peer-Coaching and Clinical Audit to improve Implementation of the Package of Essential Non-Communicable Diseases (PEN) in Nepal: A Pilot Implementation Study Metho... by Dipanker Prajapati, Sujata Sapkota, Punya Shori Suwal, Anu Aryal, Rashmi Maharjan, Sudip Ale Magar, Kamala Rana Magar, Kabita Poudel, Prajjwal Pyakurel, Abhinav Vaidya, Archana Shrestha

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Switching Mediterranean Consumers to Mediterranean Sustainable Healthy Dietary Patterns (SWITCHtoHEALTHY): Study Protocol of a Multicentric and Multi-Cultural Family-Based Nutritio... by Lorena Calderón-Pérez, Djamel Rahmani, Metin Güldaş, Asmaa El Hamdouchi, Simona Mincione, Noemí Boqué

“…The population from Mediterranean countries is abandoning the Mediterranean traditional dietary and lifestyle pattern (MD), moving to unhealthier habits because of profound socio-economic changes. …”
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Impact of functional re-education and environmental adaptation in cancer patients with respiratory pathology: Study protocol. by Eduardo Jose Fernandez-Rodriguez, Maria Isabel Rihuete-Galve, Alberto Garcia-Martin, Celia Sanchez-Gomez, Fausto Jose Barbero-Iglesias, Roberto Mendez-Sanchez, Ana Silvia Puente-Gonzalez, Susana Saez-Gutierrez, Emilio Fonseca-Sanchez, Juan Jesus Cruz-Hernandez

“…<h4>Methods</h4>A two-arm, randomized, parallel, controlled clinical trial will be conducted by the University of Salamanca, Spain, in collaboration with the Medical Oncology Service of the University Health Care Complex of Salamanca. …”
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Comparison of complications and recovery after laparoscopic and abdominal hysterectomy for benign disease: the LAparoscopic Versus Abdominal hysterectomy (LAVA) randomised controll... by Laura Jones, Rebecca Woolley, Paul Smith, Lee Middleton, Ertan Saridogan, Lina Antoun, T Justin Clark, William McKinnon, Kevin Cooper, Sheriden Bevan, Jayne Fullard, Monique Morgan, Kamila Ziomek, Zeyah Sairally

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Performance evaluation of a medium axial field-of-view sparse PET system based on flat panels of monolithic LYSO detectors: a simulation study by Maya Abi-Akl, Jens Maebe, Boris Vervenne, Othmane Bouhali, Christian Vanhove, Stefaan Vandenberghe

“…Both configurations achieved uniform spatial resolution below 2 mm in the two directions parallel to the panels and an average of 3–3.5 mm in the direction towards the panels, with slight degradation observed away from the center of the AFOV. …”
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Patient Reported Outcomes from an Open Label, Multi-Center, Retrospective Study of a Biodegradable Graft for Soft Tissue Reconstruction in Patients Suffering from Chronic Lateral A... by Bryan G. Vopat MD, Ryan Scott DPM

“…Future studies will address Flexband augmentation vs. modified Brostrom in parallel in a randomized, prospective study.…”
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Piloting the Extension for Community Healthcare Outcomes (ECHO) Pediatric Oncology Telehealth Education Program in Western Kenya: Implementation Study by Tyler Severance, Gilbert Olbara, Festus Njuguna, Martha Kipng'etich, Sandra Lang'at, Maureen Kugo, Jesse Lemmen, Marjorie Treff, Patrick Loehrer, Terry Vik

“…The Moi Teaching and Referral Hospital (MTRH) serves a population of 25 million people, including 10 million children. …”
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Oxford Vaccine Hesitancy Scale (OVHS): a UK-based and US-based online mixed-methods psychometric development and validation study of an instrument to assess vaccine hesitancy by Samantha Vanderslott, Andrew J Pollard, Michael Morrison, Jonathan Kantor, Robert C Carlisle

“…A scree plot, minimum average partial correlation analysis and parallel analysis suggested a three-factor 13-item scale with domains of vaccine beliefs (seven items), pain (three items) and personal deliberation (three items). …”
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