CCR2 Regulates Referred Somatic Hyperalgesia by Mediating T-Type Ca²⁺ Channel Currents of Small-Diameter DRG Neurons in Gastric Ulcer Mice by Ziyan Yuan, Huanhuan Liu, Zhijun Diao, Wei Yuan, Yuwei Wu, Simeng Xue, Xinyan Gao, Haifa Qiao

“…<b>Background</b>: Referred pain frequently co-exists with visceral pain. However, the exact mechanism governing referred somatic hyperalgesia remains elusive. …”
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Geographic Differences in the Quality of Life Associated With Chronic Pancreatitis: An International, Multicenter Study by Misbah Unnisa, Mahya Faghih, Asbjørn Mohr Drewes, Vikesh K. Singh, Dhiraj Yadav, Rupjyoti Talukdar, Søren Schou Olesen, Anna Evans Phillips

“…Compared to the Indian cohort, the Western cohort had higher mean age at enrollment (54.5 ± 13.5 v 35.9 ± 11.8 years), older age distribution, higher rates of current alcohol use (34% v 2%) and alcohol etiology of CP (53% v 17%), more constant pain (50% v 20%), higher prevalence of exocrine pancreatic insufficiency (66% v 44%), and higher rates of endoscopic treatment (61% v 43%) (all P < .001). …”
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The Impact of Cognitive-Behavioral Intervention (CBI) on Enhancing Mental Health and Quality of Life in Lung Cancer Patients Undergoing Chemotherapy Nursing by Fan M, Wei X

“…The Simplified Health Survey Scale (SF-36) was utilized to assess overall quality of life across eight dimensions: physical functioning, role limitations due to physical health, bodily pain, general health, vitality, social functioning, role limitations due to emotional problems, and mental health. …”
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Scaphoid and Lunate Dislocation as a Unit—A Rare Variant of Perilunate Injury: Case Report and Literature Review for Management Recommendations by Ajin Edwin, Vigneswaran Varadharajan, Praveen Bhardwaj, Shanmuganathan Raja Sabapathy

“…Case description: We report a unique case involving a 50-year-old male who experienced a high-energy motorbike accident, leading to acute pain and swelling in his left wrist. His clinical examination was significant for localized swelling and tenderness, wrist deformity, and restricted painful range of motion, but without sensory loss in the median and ulnar nerve distribution areas. …”
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Incidental left paraaortic mass in a patient with gall bladder adenocarcinoma: A diagnostic challenge by Manali Bhatta, Sharma Paudel, Ongden Yonjen Tamang, Prajwal Dahal, Santosh Shrestha, Sabina Parajuli

“…Histopathological analysis, including immunohistochemistry, biochemical testing, and functional imaging, can offer valuable insights to help diagnose and aid in predicting prognosis.…”
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Assessing chikungunya's economic burden and impact on health-related quality of life: Two systematic literature reviews. by Giorgia Tiozzo, Adrianne M de Roo, Gabriel S Gurgel do Amaral, Hinko Hofstra, Gerard T Vondeling, Maarten J Postma

“…HRQoL studies consistently revealed high pain levels and diminished physical functioning among chikungunya patients, particularly in chronic cases, where these impacts persisted for months to years.…”
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Unsupervised machine learning to identify subphenotypes among cardiac intensive care unit patients with heart failure by Jacob C. Jentzer, Yogesh N.V. Reddy, Sabri Soussi, Ruben Crespo‐Diaz, Parag C. Patel, Patrick R. Lawler, Alexandre Mebazaa, Shannon M. Dunlay

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Topologically Optimized Anthropomorphic Prosthetic Limb: Finite Element Analysis and Mechanical Evaluation Using Plantogram-Derived Foot Pressure Data by Ioannis Filippos Kyriakidis, Nikolaos Kladovasilakis, Marios Gavriilopoulos, Dimitrios Tzetzis, Eleftheria Maria Pechlivani, Konstantinos Tsongas

“…These issues could result in mobility impairments due to failed mimicry of the actual stress distribution, causing discomfort, chronic pain, and tissue damage or possible infections. …”
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Clinicopathological analysis of eyelid malignancies - A review of 85 cases by Satish M. Kale, Surendra B. Patil, Nishant Khare, Mahantesh Math, Arvind Jain, Sumeet Jaiswal

“…Background: Resection of eyelid malignancies leads to complex reconstructive problems due to the functional and aesthetic importance of an eyelid. Hence, a large number of such cases are referred to plastic surgery facilities. …”
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Investigating the regulation of the miR-199a-3p/TGF-β/Smad signaling pathway by BSHXF drug-containing serum combined with ADSCs for delaying intervertebral disc degeneration by Enxu Liu, Enxu Liu, Yu Sun, Yu Sun, Lei Yang, Lei Yang, Haobo Jiang, Haobo Jiang, Fei Sun, Long Chen, Jiahao Duan, Jiahao Duan, Shaofeng Yang, Shaofeng Yang

“…BackgroundIntervertebral disc degeneration (IDD) significantly contributes to low back pain (LBP), yet effective treatment options are scarce. …”
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From Bank Preparation to Clinical Use of Homologous Skin Allografts in Wound Healing: A Sustainable Approach by Laura Amoroso, Serena Agueci, Elisa Pianigiani, Francesca Ierardi, Laura Calabrese, Pietro Rubegni, Linda Tognetti

“…Globally, the clinical advantages obtained include: acceleration of healing process, pain sparing, resistance to bacterial contamination, dermal regeneration (instead of scarring), and better aesthetic–functional outcome.…”
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Rehabilitation using virtual gaming for Hospital and hOMe-Based training for the Upper limb post Stroke (RHOMBUS II): protocol of a feasibility randomised controlled trial by Cherry Kilbride, Tom Butcher, Meriel Norris, Nana Anokye, Alyson Warland, Karen Baker, Dimitrios A Athanasiou, Guillem Singla-Buxarrais, Jennifer Ryan, Francesca Gowing, Carole Pound, Victoria Stewart, Basaam Aweid, Arul Samiyappan

“…Outcomes assessed at baseline and 7 weeks include gross level of disability, arm function, spasticity, pain, fatigue and quality of life (QoL). …”
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THE PSYCHOMETRIC PROPERTIES OF A RUSSIAN VERSION OF THE DISEASE-SPECIFIC LUPUSQOL QUESTIONNAIRE ASSESSING THE HEALTH-RELATED QUALITY OF LIFE IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEM... by E. A. Aseeva, L. D. Vorobyeva, S. K. Solovyev, V. N. Amirdzhanova, S. I. Glukhova, G. M. Koilubaeva, M. V. Letunovich

“…A correlation (r &gt; 0.4) was found on all the 8 LupusQol domains: physical functioning (PF), role-physical functioning (RPF), general health (GH), viability (V), social functioning (SF), and role-emotional functioning (REF) of the SF-36 questionnaire. …”
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What Matters in Psoriatic Arthritis: A Comparison of Patient and Clinician Perspectives by Philip J. Mease, M. Elaine Husni, Evan Siegel, Daniel E. Furst, Melissa Mcilraith, Vibeke Strand, M. Cameron Hay

“…Items with the top 10 mean scores for both groups included arthritis, disease activity, pain, fatigue, physical function, and spine symptoms. …”
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The fibrin-derived peptide FX06 protects human pulmonary endothelial cells against the COVID-19-triggered cytokine storm by Zhiran Wang, Dmitrii Lebedev, Simeng Li, Sudharshan Rao, Kevin Wu, Lorcan Doyle, Kieran Wynne, Alfonso Blanco, Margaritha M. Mysior, Jeremy C. Simpson, Dimitri Scholz, Petra Wülfroth, Kai Zacharowski, Walter Kolch, Vadim Zhernovkov, Günther Eissner

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Talus Avascular Necrosis: Demographics, Epidemiology, and Activity Level by Akhil Sharma, Urvi J Patel, Rishin J Kadakia, Aman Chopra, Selene Parekh

“…A 36-question survey was distributed to determine baseline demographics, epidemiology of talar AVN, and functional status. …”
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Clinical manifestations, histopathological changes and quality of life in patients with advanced knee osteoarthritis caused by age, trauma, obesity and their combination by Kristina V. Korochina, Tatyana V. Chernysheva, Irina E. Korochina

“…Clinical examination of patients with pain and their functional status evaluation (via Visual Analogue Scale, WOMAC, Lequesne index), quality of life assessment (MOS SF-36 questionnaire), along with histopathological study of medial tibial plateau cartilage and synovial membrane, were caried out, followed by statistical data processing. …”
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Atypical presentation of forearm compartment syndrome in a child by P.A. Saxena, M. Veylamuthen, L. Kitsi, A. Crawford, A.P. Dekker, N. Ashwood

“…She presented 2 weeks post injury with significant pain, flexed fingers and agitated. Following an urgent forearm fasciotomy and carpal tunnel decompression, her symptoms improved. 72 hours later, her fasciotomy wounds were closed and her symptoms continued to improve. 9 weeks post injury her forearm fracture had radiological union. 6 months post injury her TENS nails were removed.8 months post injury, she had no functional motor deficit but residual sensory deficit in median nerve distribution. …”
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In Vivo and In Vitro Evaluation of the Feasibility and Safety Profiles of Intraarticular Transplantation of Mitochondria for Future Use as a Therapy for Osteoarthritis by Carlos Vaamonde-Garcia, Tamara Hermida-Gómez, Sara Paniagua-Barro, Elena F. Burguera, Francisco J. Blanco, Mercedes Fernández-Moreno

“…Osteoarthritis (OA) is the most common rheumatologic disease and a major cause of pain and disability in older adults. No efficient treatment is currently available. …”
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Total Arthroscopic Resection of the Talocalcaneal Coalition in Adults: Key Points of Surgical Technique by Yiyuan Sun, Wufeng Cai, Xihao Huang, Jian Li, Qi Li

“…Radiographics showed that the coalition disappeared and pain was relieved postoperatively. The mean VAS score decreased from 4.31 ± 1.54 to 1.81 ± 0.98 points (p < 0.001). …”
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