CTO inhibits the in situ growth of glioblastoma in mice and regulates the metabolism and inflammatory phenotype of glioma-associated microglia by LI Yunfan, ZOU Jiaming, WANG Yucheng, JU Rui, GUO Lei

“…Methods Tumor volume was regularly monitored by in vivo imaging, and histological examination was performed to detect the extent of tumor infiltration; non-targeted metabolomics analysis was used to detect the level of tricarboxylic acid cycle metabolites in cells; seahorse cell energy measurement method was used to detect the oxygen consumption rate (OCR) and extracellular acidification rate (ECAR) of cells; immunofluorescence was used to detect the degree of hypoxia in cells; quantitative PCR was used to detect the mRNA level of pro-cancer mediators M1/M2 in cells; Western blot was used to detect the protein level of hypoxia-inducible factor-1α (HIF-1α) and programmed death receptor-ligand 1 (PD-L1). Results CTO inhibited the tumor progression in mice, and down-regulated the oxidative phosphorylation level and improved cell hypoxia in vitro(P＜0.01). …”
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Efficacy of reciprocating and rotary retreatment nickel-titanium file systems for removing filling materials with a complementary cleaning method in oval canals by Said Dhaimy, Hyeon-Cheol Kim, Lamyae Bedida, Imane Benkiran

“…The images were imported into a software program to measure the remaining filling material, the apical extrusion, and the root canal space. …”
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Exploring the Cardiorenal Benefits of SGLT2i: A Comprehensive Review by Angelica Cersosimo, Andrea Drera, Marianna Adamo, Marco Metra, Enrico Vizzardi

“…Indeed, several clinical trials, including landmark studies such as EMPA-REG OUTCOME, CANVAS Program, and DECLARE-TIMI 58, have demonstrated robust reductions in cardiovascular events, particularly heart failure hospitalizations and cardiovascular mortality, among patients treated with SGLT2i. …”
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Jasmine Flower Color Degradation User-Coded Computer Vision Image Analysis Tool and Kinetics Modeling by Humeera Tazeen, Astina Joice, Talha Tufaique, C. Igathinathane, Ademola Ajayi-Banji, Zhao Zhang, Craig W. Whippo, Drew A. Scott, John R. Hendrickson, David W. Archer, Lestero O. Pordesimo, Shahab Sokhansanj

“…A developed open-source ImageJ plugin program quantified the color degradation of jasmine petals and pedicles over 25 h. …”
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Zinc-copper bimetallic nanoplatforms trigger photothermal-amplified cuproptosis and cGAS-STING activation for enhancing triple-negative breast cancer immunotherapy by Bangyi Zhou, Mengyao Chen, Zhixing Hao, Lili Li, Yixin Zhang, Baoru Fang, Miner Shao, Guohong Ren, Ke Wang, Huiying Liu, Jingxuan Zhu, Xinyi Zhang, Shuyan Yuan, I Sitou, Jing Zhao, Jian Huang, Zhangsen Yu, Fuming Qiu

“…Within the acidic tumor microenvironment (TME), CZP NPs spontaneously release copper and zinc ions and hydrogen peroxide, generating highly oxidative hydroxyl radicals and downregulating iron-sulfur cluster proteins. …”
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Gel–sol synthesis of hierarchical CaO using pollen as biotemplate for biodiesel production by Zheng, Jingdi, Tao, Shuang, Yang, Ying, Tang, Ying

“…The results indicate that pollen as a biotemplate could be used to improve the basicity and textural parameters of calcium oxide particles, especially for 1/1-CaO(S)-700, presented by its total basicity of 5.90 mmol/g, the specific surface area of 16.47 m2/g, the pore volume of 0.04 cm3/g, the average pore size of 10.28 nm, and the widespread distribution of pore size (2–12.5 nm). …”
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ROS-balancing-engineered bio-heterojunction hydrogel accelerated the infected bone regeneration based on Sono-chemo dynamic therapy by Jiani Xu, Fanshangming Zhou, Lingyan Cao, Huilin Wang, Jiani Hu, Shuo Qiu, Yulan Liu, Yan Zhang, Jie Wang, Xinquan Jiang

“…Therefore, this work introduces a novel strategy for equipping hydrogels with programmed antibacterial and anti-inflammatory functionalities, providing an innovative solution for treating deep-seated infections, particularly in periodontitis therapy.…”
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Stellar Models Also Limit Exoplanet Atmosphere Studies in Emission by Thomas J. Fauchez, Elsa Ducrot, Benjamin V. Rackham, Kevin B. Stevenson, L. C. Mayorga, Julien de Wit

“…At 12.8 μ m, none of the considered bare surface types—basalt, ultramafic, Fe oxidized, and granitoid—can be reliably distinguished when accounting for the 3 σ model precision between SPHINX and PHOENIX. …”
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Neuroinflammation and hypoxia promote astrocyte phenotypic transformation and propel neurovascular dysfunction in brain arteriovenous malformation by Tianqi Tu, Zhenghong Peng, Lihan Zhang, Jieru Yang, Kecheng Guo, Xiaogang Tang, Jiasen Ye, Fan Zhang, An Huang, Jiaxing Yu, Changren Huang, Hongqi Zhang, Donghai Wang, Jianhua Peng, Yong Jiang

“…Specifically, reactive astrocytes undergo phenotypic changes under these pathological conditions, significantly promoting vascular instability. Moreover, nitric oxide (NO) produced by BAVM endothelial cells activates signaling pathways that stabilize HIF-1α in astrocytes, initiating a “hypoxic” gene program under normoxic conditions. …”
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Genetic drivers of tumor microenvironment and immunotherapy resistance in non-small cell lung cancer: the role of KEAP1, SMARCA4, and PTEN mutations by Alessandro Russo, Christian Rolfo, Francesco Drago, Giovanni Nigita, Roberto Borea, Rodrigo Paredes

“…KEAP1 mutations, through constitutive nuclear factor erythroid 2-related factor 2 activation, promote oxidative stress adaptation and metabolic reprogramming, creating an immune-excluded TME that reduces T-cell infiltration. …”
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The Association Between Recombinant Tissue Plasminogen Activator and Post-ischemic Stroke Seizure: A Retrospective Cohort Study by Hanie Khoshtarash, Alia Saberi, Hamidreza Hatamian, Ali Ashraf, Somayeh Ahmadi, Mohammad Ali Yazdanipour

“…Despite its well-established benefits, potential side effects—glutamate release, increased leukocyte activity, and oxidative stress—should also be considered. Among these concerns, the development of post-stroke seizures (PSS) has gained attention as a possible complication. …”
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Regulation of SLC7A11 as an unconventional checkpoint in tumorigenesis through ferroptosis by Zhenyi Su, Yanqing Liu, Lin Wang, Wei Gu

“…It is well accepted that ferroptosis, an iron-dependent programmed cell death, acts as a new type of tumor suppression mechanism tightly linked with numerous metabolic pathways. …”
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Podocyte senescence: from molecular mechanisms to therapeutics by Qian Zhao, Yongzhang Huang, Ningying Fu, Caixia Cui, Xuan Peng, Haiyan Kang, Jie Xiao, Guibao Ke

“…In addition, CCAAT/enhancer-binding protein-α, transforming growth factor-β signaling, glycogen synthase kinase-3β, cycle-dependent kinase, programmed cell death protein 1, and plasminogen activator inhibitor-1 are closely related to aging. …”
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Melting heat transport reliability on dynamics of tri-hybrid nanofluid due to inclined shrinking surface by Muhammad Yasir, Roobaea Alroobaea, N. Ameer Ahammad, Ibrahim E. Elseesy

“…The resulting equations are programmed in MATLAB and processed using the bvp4c function to attain the results graphically. …”
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Alveolar epithelial cells in bacterial sepsis-associated acute lung injury: mechanisms and therapeutic strategies by Guiyang Jia, Guiyang Jia, Erqin Song, Zhiyou Zheng, Mingjiang Qian, Guoyue Liu

“…This review systematically summarizes the pathophysiological changes in AECs during bacterial sepsis, focusing on oxidative stress, programmed cell death, and disruption of the epithelial barrier. …”
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Neovascular pruning by IDO1 inhibitors can potentiate immunogenic cytotoxicity of ischemia-targeted agents to synergistically enhance anti-PD-1 responsiveness by Souvik Dey, Erika Sutanto-Ward, Alexander J Muller, Shih-Chun Shen, James B DuHadaway, Maurice T Hampton, Serguei V Kozlov, George C Prendergast

“…Tumor immunogenicity and programmed death-ligand 1 (PD-L1) elevation were also evaluated. …”
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Differential genetic interactions of yeast stress response MAPK pathways by Humberto Martin, Michael Shales, Pablo Fernandez‐Piñar, Ping Wei, Maria Molina, Dorothea Fiedler, Kevan M Shokat, Pedro Beltrao, Wendell Lim, Nevan J Krogan

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Gold-coated ZnO nanostructures on no-core optical fiber for ammonia detection in food spoilage applications by Suphavit Thaneerat, Karnpote Roekwibunsi, Gaurika Vasan, Kankan Swargiary, Ratchawi Jammee, Dalawan Limthin, Pannathorn Jitpratak, Charusluk Viphavakit

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Single cell autofluorescence imaging reveals immediate metabolic shifts of neutrophils with activation across biological systems by Rupsa Datta, Veronika Miskolci, Gina M. Gallego-López, Emily Britt, Amani Gillette, Aleksandr Kralovec, Morgan A. Giese, Morgan A. Giese, Tongcheng Qian, James Votava, Wenxuan Zhao, Jing Fan, Jing Fan, Anna Huttenlocher, Anna Huttenlocher, Melissa C. Skala, Melissa C. Skala

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Route-Based Emissions Inventory and Energy Consumption of Passenger Vehicles: Case of Addis Ababa, Ethiopia by Amanuel Gebisa Aga, Girma Gebresenbet, Rajendiran Gopal, Ramesh Babu Nallamothu

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