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  1. 701
  2. 702

    Organelle stresses and energetic metabolisms promote endothelial–to–mesenchymal transition and fibrosis via upregulating FOSB and MEOX1 in Alzheimer’s disease by Fatma Saaoud, Mohammed Ben Issa, Lu Liu, Keman Xu, Yifan Lu, Ying Shao, Baosheng Han, Xiaohua Jiang, Xiaohua Jiang, Xiaolei Liu, Avrum Gillespie, Jin Jun Luo, Laisel Martinez, Roberto Vazquez-Padron, Sadia Mohsin, Beata Kosmider, Hong Wang, Silvia Fossati, Xiaofeng Yang, Xiaofeng Yang

    Published 2025-08-01
    “…Further mechanistic analysis revealed: (1) mitochondrial stress through upregulation of mitochondrial genes in the brain cells; (2) upregulation of cellular, oxidative, and endoplasmic reticulum (ER) stress genes; (3) nuclear stress via upregulation of nuclear genes, transcription factors (TFs), and differentiation TFs FOSB and MEOX1; (4) metabolic reprogramming/stress through the upregulation of genes related to lipid and lipoprotein metabolism, fatty acid oxidation (FAO), glucose metabolism, and oxidative phosphorylation (OXPHOS); (5) catabolic stress via upregulation of catabolic genes. …”
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  3. 703

    Yield Stability Evaluation of Antioxidant-Enriched Rice (Oryza sativa L.) Genotypes at Multi-Environments Using AMMI and GGE Biplot Model by Muhammad Habibur Rahman Mukul, Mir Mehedi Hasan, Shamsunnaher, Afruz Zahan, Md. Niaz Morshed, Khandoker Khalid Ahmed, Md. Romel Biswash, Sheikh Maniruzzaman, Md Humayun Kabir, Biswajit Karmakar

    Published 2025-05-01
    “…Bangladesh Rice Research Institute (BRRI) have developed many high valued rice varieties and advanced rice genotypes including anti-oxidant properties Cyanidin-3-O-glucoside (C3G), phenolic compounds. …”
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  4. 704

    Senescent cell depletion alleviates obesity-related metabolic and cardiac disorders by Tábatha de Oliveira Silva, Guilherme Lunardon, Caroline A. Lino, Amanda de Almeida Silva, Shiju Zhang, Maria Cláudia Costa Irigoyen, Yao Wei Lu, John D. Mably, Maria Luiza M. Barreto-Chaves, Da-Zhi Wang, Gabriela P. Diniz

    Published 2025-01-01
    “…Additionally, we showed that treatment with the senolytic cocktail corrected gene expression programs associated with fatty acid metabolism, oxidative phosphorylation, the P53 pathway, and DNA repair, which were all downregulated in obese mice. …”
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  5. 705

    RNA-Seq-based analysis of transcriptomic signatures elicited by mutations conferring salt tolerance in Cucurbita pepo by Keshav Gautam, Sonsoles Alonso, Alicia García, María Segura, Álvaro Benítez, Cecilia Martínez, Manuel Jamilena

    Published 2025-03-01
    “…Improving salinity tolerance in plant breeding programs requires not only donor tolerant genotypes but also a thorough knowledge of the genes controlling the trait. …”
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  6. 706

    Transcriptomic analysis elucidates the enhanced skeletal muscle mass, reduced fat accumulation, and metabolically benign liver in human follistatin-344 transgenic pigs by Ke-ren LONG, Xiao-kai LI, Ruo-wei ZHANG, Yi-ren GU, Min-jie DU, Xiang-yang XING, Jia-xiang DU, Miao-miao MAI, Jing WANG, Long JIN, Qian-zi TANG, Si-lu HU, Ji-deng MA, Xun WANG, Deng-ke PAN, Ming-zhou LI

    Published 2022-01-01
    “…Follistatin (FST) is an important regulator of skeletal muscle growth and adipose deposition through its ability to bind to several members of the transforming growth factor-β (TGF-β) superfamily, and thus may be a good candidate for future animal breeding programs. However, the molecular mechanisms underlying the phenotypic changes have yet to be clarified in pig. …”
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  7. 707

    Comparative assessment of on-farm greenhouse gases emission from male-headed and female-headed rice farms in Babol county (Mazandaran province, Iran) by Hadi Veisi, Anahita Valiollahi, Abdol Majid Mahdavi Damghani, Surror Khoramdel

    Published 2019-03-01
    “…Each GHG such as carbon dioxide (CO2), methane (CH4), and nitrous oxide (N2O) has GWP, which is the warming influence relative to that of carbon dioxide. …”
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  8. 708

    Correction possibilities of drug-induced liver toxicity in the treatment of patients with blood system tumors by V. B. Larionova, A. V. Snegovoy

    Published 2020-12-01
    “…The results obtained were the basis for the development of supportive therapy programs to prevent and reduce liver toxicity during chemotherapy. …”
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  9. 709

    EBV CHRONIC INFECTIONS by Eligio Pizzigallo, Delia Racciatti, Valeria Gorgoretti

    Published 2010-08-01
    “…In the pathogenesis, near to the programs of latency of the virus, the genetic and environmental factors, independent from the real natural history of EBV infection, play a crucial role. …”
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  10. 710

    Transcriptome analysis of historic olives reveals stress-specific biomarkers by Hamad A. Alkhatatbeh, Monther T. Sadder, Nizar Haddad, Nizar Haddad, Ibrahim Al-Amad, Mohammad Brake, Nawal A. Alsakarneh, Abdulsalam M. Alnajjar

    Published 2025-06-01
    “…The novel drought genes detected in ‘Frantoio’ included Phytosulfokines 3 (4.9 fold), while Allene oxide synthase (6.5 fold) and U-box domain-containing (6.4 fold) were detected in ‘Manzanillo’.DiscussionThe data revealed both novel and common stress-specific biomarkers under both salinity and drought stress, which can potentially be utilized in olive breeding and genetic improvement programs to mitigate stress.…”
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  11. 711
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  13. 713

    Intermittent hypoxia-hyperoxia therapy in medical rehabilitation: Effects on body composition in patients with metabolic syndrome by Andreea-Bianca Uzun, Andreea-Dalila Nedelcu, Mădălina-Gabriela Iliescu, Liliana-Elena Stanciu, Adina Petcu, Lucian Cristian Petcu, Bogdan Obada, Doina-Ecaterina Tofolean

    Published 2025-03-01
    “…This technique mimics the effects of altitude training and stimulates the body's adaptive mechanisms, contributing to improved mitochondrial function, increased oxidative capacity and the regulation of metabolic processes. …”
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  14. 714

    Antioxidant Effects of Curcumin on the Motility and Structural and Biochemical Parameters of Epididymal Sperm in Shal Rams after the Freezing-Thawing Process by Ramin Farhadi, Abbas Farshad, Jalal Rostamzadeh, Abouzar Najafi

    Published 2024-12-01
    “…Extended Abstract Background: Artificial insemination is widely used as a basic technique in livestock and poultry breeding programs. The use of this technique requires sperm freezing, a process during which superior genes are widely expanded and more progeny can be obtained from a male animal with high genetic characteristics. …”
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  15. 715

    Cold hardiness evaluation and physiological mechanism elucidation in apricot-plum hybrid (Prunus salicina × P. armeniaca) germplasm by WANG Aning, QI Anguo, WANG Mengyao, ZHU Gaopu, LI Taishan, LI Fangdong, YANG Shaobin, HU Haifang, BAI Danfeng

    Published 2025-07-01
    “…Conversely, sensitive genotypes exhibited progressive oxidative damage, evidenced by linearly increasing O2-·, H2O2, and MDA levels (up to 195.4% increase in H2O2 at -30 ℃), coupled with declining SS (44.2% reduction) and Pro contents, which indicated the oxidative damage they suffered increased gradually and the cell osmotic balance was disrupted. …”
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  16. 716

    Whole-rock geochemistry and crystal chemistry of apatite at intrusive suites of the Qeynarjeh-Angouran district (west of Zanjan): an approach to the identification of skarn-causati... by Afsoon Dastour, Ebrahim Tale Fazel, Ashraf Torkian

    Published 2024-10-01
    “…This evidence could be helpful in advancing exploration programs and identifying encouraging mineral areas in the Qeynarjeh-Angouran area. …”
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    Article
  17. 717

    EBV CHRONIC INFECTIONS by Delia Racciatti, Eligio Pizzigallo, Valeria Gorgoretti

    Published 2010-02-01
    “…In the pathogenesis, near to the programs of latency of the virus, the genetic and environmental factors, independent from the real natural history of EBV infection, play a crucial role. …”
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    Article
  18. 718
  19. 719

    Compact Modeling of 3D NAND Flash Memory With Ferroelectric Characteristics: A Comparative Analysis of O/N/O and O/N/F Structures by Sunghyun Woo, Jihwan Lee, Gyunseok Ryu, Myounggon Kang

    Published 2025-01-01
    “…To validate the model, simulation results are compared between TCAD and SPICE. Under identical programming conditions, the proposed oxide/nitride/ferroelectric (O/N/F) structure demonstrates approximately 3 V higher channel potential than the conventional oxide/nitride/oxide (O/N/O) structure, resulting in improved programming accuracy and cell stability. …”
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  20. 720