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Detection of PD-L1 expression levels in malignant pleural mesothelioma with a targeted MRI nanoprobe in vivo
Published 2024-12-01“…ObjectivesImmune checkpoint inhibitors (ICIs) have demonstrated potential in inhibiting the growth of malignant pleural mesothelioma (MPM), and their efficacy is associated with the expression of programmed death-ligand 1(PD-L1). This study evaluated a PD-L1-targeted nanoprobe for detecting PD-L1 expression in a nude mouse model of malignant pleural mesothelioma (MPM).MethodsA PD-L1-binding peptide (WL-12) was conjugated with superparamagnetic iron oxide nanoparticles (SPIONs) to create the nanoprobe WL-12@Fe₃O₄. …”
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Post-disaster emergency dispatching of distribution network for hydrogen energy port considering the risk of frequency overruns
Published 2025-06-01“…An operational model for port hydrogen energy systems is established through quantitative analysis of reversible solid oxide cells and operating characteristics of hydrogen storage stations, along with their interdependencies. …”
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464
Pathogenic role of lipids in non-alcoholic fatty liver disease
Published 2012-02-01“…In NAFLD pathogenesis other damaging factors, e.g. oxidative stress play important role, therefore the theory of «multiple collateral impulses» is justified today. …”
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BECN1 regulates ferroptosis induced by 2,4-dichlorophenoxyacetic acid in SH-SY5Y cells
Published 2025-07-01“…Exposure to 2,4-D induces ferroptosis, a form of programmed cell death driven by oxidative stress. BECN1, a key autophagy protein, is linked to ferroptosis. …”
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Differential expression of nickel nanoparticles of Lactobacillus plantarum on VDR/LncRNA EIF3J-DT in Colorectal cancer
Published 2024-12-01“…Here, we green-synthesized Lactobacillus plantarum loaded nickel oxide nanoparticles (LpNiONPs) to assess their anticancer potential in CRC by targeting long non-coding RNA EIF3J- divergent transcript (lncRNA EIF3J-DT) and VDR. …”
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The Impact of Perfluorooctanoic Acid (PFOA) on the Mussel <i>Mytilus galloprovincialis</i>: A Multi-Biomarker Evaluation
Published 2024-11-01“…It highlights the potential of <i>M. galloprovincialis</i> as a bioindicator in environmental monitoring programs, providing crucial insights for environmental management and policymaking regarding regulating and monitoring PFOA in marine settings. …”
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Emerging Ferroptosis Involvement in Amyotrophic Lateral Sclerosis Pathogenesis: Neuroprotective Activity of Polyphenols
Published 2025-03-01“…Neurodegenerative diseases are a group of diseases that share common features, such as the generation of misfolded protein deposits and increased oxidative stress. Among them, amyotrophic lateral sclerosis (ALS), whose pathogenesis is still not entirely clear, is a complex neurodegenerative disease linked both to gene mutations affecting different proteins, such as superoxide dismutase 1, Tar DNA binding protein 43, Chromosome 9 open frame 72, and Fused in Sarcoma, and to altered iron homeostasis, mitochondrial dysfunction, oxidative stress, and impaired glutamate metabolism. …”
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MITOCHONDRIAL DYSFUNCTION AS POSSIBLE CAUSE OF IMPAIRED FOLLICULAR DEVELOPMENT
Published 2016-06-01“…Mitochondria play leading role in senescence program realization. One of the early manifestations of this process is loss of reproductive function in female (menopause). …”
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8-week Aerobic Exercise and Vitamin D Supplementation: Impact on Hypertension With Vitamin D Deficiency
Published 2023-11-01“…Background: This research aims to investigate the performance of 8 weeks of aerobic exercise and vitamin D supplementation on nitric oxide (NO) and endothelin 1 (ET-1) indicators in patients with high blood pressure and vitamin D deficiency. …”
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