Multiomics in silico analysis identifies TM4SF4 as a cell surface target in hepatocellular carcinoma. by Kah Keng Wong, Suzina Sheikh Ab Hamid

“…To address this, an in silico multomics analysis was conducted to identify an optimal therapeutic target in HCC. A longlist of genes (n = 12,948) expressed in HCCs according to The Human Protein Atlas database were examined. …”
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Investigating the mediating effects of motivation on academic performance in a synchronous EFL online learning by Pham Minh Ngoc An, Tran Ngoc Phuong Anh, Cao-Tuong Dinh

“…These findings are crucial for educators and policymakers who aim to optimize online educational strategies to enhance students' ... …”
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SGLT2 inhibitors as metabolic modulators: beyond glycemic control in type 2 diabetes by Qian Wu, Jian Zhang, Fuli Zhang, Dongnan Li

“…This review systematically explores the significant roles of SGLT2is in metabolic regulation, cardiovascular protection, and combination therapy, with the aim of providing a comprehensive foundation for optimizing individualized treatment strategies in T2DM management.…”
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Where We Rate: The Impact of Urban Characteristics on Digital Reviews and Ratings by Özge Öztürk Hacar, Müslüm Hacar, Fatih Gülgen, Luca Pappalardo

“…The geometric features of streets play varying roles across different prediction tasks. The model achieved a 65% F1-score for review volume classifications and a 62% for visitor score. …”
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Evaluating the Effects of Circuit Training and Motivation on Gender-Specific Waist Reduction in Overweight Populations by Grace Kharisma Tambunan, Heny Setyawati, Setya Rahayu, Bambang Priyono, Jujur Gunawan Manullang

“…Motivation and exercise type, including circuit training, are believed to play significant roles in the success of weight management programs. …”
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The Use of Tissue Concentrations of Biological and Small-Molecule Therapies in Clinical Studies of Inflammatory Bowel Diseases by Ahmed B. Bayoumy, Luc J. J. Derijks, Bas Oldenburg, Nanne K. H. de Boer

“…While blood-based biomarkers have shown limited utility in optimizing treatment (except for TNF-alpha inhibitors and thiopurines), tissue drug concentrations may offer valuable insights. …”
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Fuel Price Fluctuation and SME Financial Performance: A Case Study of the Agricultural Sector in Kagadi Town Council. by Bitaka, Raymond

“…The analysis of fuel price determinants highlights the roles of global oil prices, geopolitical tensions, exchange rates, government policies, and market demand. …”
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Peptide Profiling in Dairy Cow Dry Secretions: Temporal Changes and Comparative Analysis Between Healthy and Subclinical Mastitis Cows by Barjam Hasanllari, Benjamin P. Willing, Liang Li, Xian Luo, Burim N. Ametaj

“…The dairy industry relies on the health and well-being of dairy cows for the optimal production of milk and dairy products. Mastitis, a prevalent and economically burdensome disease characterized by udder inflammation, poses significant challenges to dairy farmers worldwide. …”
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Identification of the Casparian strip integrity factor (CIF) gene family in Brassica napus and functional prediction of mature CIF small peptides by Miao Cheng, Hanbing Hu, Rui Chen, Ling He, Shanshan Wang, Yuling Zheng, Jiten Yadav, Hosam O. Elansary, Nisha Jaswal, Deepak Bhanot, Changli Zeng, Xiaoyun Liu

“…Abstract Background Small peptides of the CIF family act as signaling molecules and participate in important signaling pathways, playing crucial roles in the processes of plant development and the environmental response. …”
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Serum glial fibrillary acidic protein and protein gene product 9.5 for predicting neurological outcomes in cardiac arrest patients with cortical response to somatosensory evoked po... by Chenchen Hang, Rui Shao, Xingsheng Wang, Luying Zhang, Weijie Cheng, Zihao Jiang, Ziqi Zhong, Le An, Ziren Tang

“…Glial fibrillary acidic protein and protein gene product 9.5 are potential biomarkers for brain injury, yet their roles in cardiac arrest patients with preserved somatosensory evoked potential N20 remain underexplored. …”
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STRATEGI DIGITAL BRANDING MELALUI WEBSITE GUNA MENUMBUHKAN BRAND AWARENESS MUSEUM SONOBUDOYO YOGYAKARTA by Jefri Eko Cahyono, Novianto Yudha Laksana

“…In this study, the data source collection was based on a purposive sampling technique which had determined the criteria for the informants based on their roles. There were nine informants in this study consisting of Structural Officials, Technical Teams and Branding Management Teams at the Sonobudoyo Museum, Yogyakarta. …”
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Early detection to improve outcome in people with undiagnosed psoriatic arthritis: the PROMPT research programme including RCT by Neil McHugh, Laura Bojke, Mel Brooke Turfrey, Rachel Charlton, Myka Ransom, Laura C Coates, Howard Collier, Claire Davies, Emma Dures, Philip Helliwell, Jana James, Anya Lissina, Vishnu B Madhok, Alison L Nightingale, Jonathan Packham, Catherine Smith, Eldon Spackman, Cerys Tassinari, William Tillett, Sarah T Brown

“…EPIdemiology of psoriatiC arthritis study The EPIC study aimed to describe the evolution of musculoskeletal symptoms in people with psoriasis and their comorbidities, and investigate the role of smoking, alcohol and obesity in PsA development. …”
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Genome-resolved metatranscriptomics unveils distinct microbial functionalities across aggregate sizes in aerobic granular sludge by A.Y.A. Mohamed, Laurence Gill, Alejandro Monleon, Mario Pronk, Mark van Loosdrecht, Pascal E. Saikaly, Muhammad Ali

“…This study highlights distinct functional roles and metabolic activities of crucial microbial communities depending on aggregate size within AGS systems, offering new insights into optimizing wastewater treatment processes.…”
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Legislative framework of career guidance and counselling in Serbia by Miljković Jovan, Čairović-Pavlović Neda, Robertson Kristina

“…For career guidance and counselling to be managed adequately and to optimize its expected outcomes, it is necessary to have a consistent, carefully designed legislative framework in place. …”
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Natural small molecules regulating the mitophagy pathway counteract the pathogenesis of diabetes and chronic complications by Du Ye, Junping Zhu, Siya Su, Yunfeng Yu, Jun Zhang, Yuman Yin, Chuanquan Lin, Xuejiao Xie, Qin Xiang, Rong Yu

“…This review systematically evaluates the mechanistic roles of natural small molecules—including ginsenosides, resveratrol, and berberine—in enhancing mitophagy and restoring mitochondrial homeostasis via activation of core signaling pathways (e.g., PINK1/Parkin, BNIP3/NIX, and FUNDC1). …”
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Maize and Pea Root Interactions Promote Symbiotic Nitrogen Fixation, Thereby Accelerating Nitrogen Assimilation and Partitioning in Intercropped Pea by Yali Sun, Zefeng Wu, Falong Hu, Hong Fan, Wei He, Lianhao Zhao, Congcong Guo, Xiaoyuan Bao, Qiang Chai, Cai Zhao

“…This study reveals the positive roles of IRIs to the NUE and yield and provides useful reference material for increasing N contents derived from SNF to maximize NUE and crop yields in intercropped legumes.…”
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Construction of a multimodal esophageal cancer prognostic model with screening of key genes and investigation of their biological functions by Zhengsong Chang, Yiru Li, Mengyao Wang, Xin Zhang, Qiang Bai, Huan Luo, Pengyun Deng, Liping Yang, Xiaomei Li

“…We aimed to develop a multimodal prognostic model to optimize treatment strategies and elucidate biological mechanisms of key regulatory genes. …”
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In Vitro Structure–Activity Relationship Stability Study of Antisense Oligonucleotide Therapeutics Using Biological Matrices and Nucleases by Jelena Lovrić, Jingjing Yan, XueQing Li, Tony Karlsborn, Mattias Bood, Anders Dahlén, Constanze Hilgendorf, Deepak Kumar Bhatt

“…Employing nucleases and comparing stability data with matrices of animal origin holds promise for a future fast‐track assessment of drug stability, enabling the efficient selection of optimal drug candidates for subsequent in vivo studies.…”
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A Framework for Leveraging Digital Technologies in Reverse Logistics Actions: A Systematic Literature Review by Sílvia Patrícia Rodrigues, Leonardo de Carvalho Gomes, Fernanda Araújo Pimentel Peres, Ricardo Gonçalves de Faria Correa, Ismael Cristofer Baierle

“…Simultaneously, Industry 4.0 technologies are transforming RL operations by enhancing their collection, transportation, storage, sorting, remanufacturing, recycling, and disposal processes. Understanding the roles of these technologies is essential for improving efficiency and sustainability. …”
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Systematic analysis of chemotherapy, immunotherapy, and combination therapy in Head and Neck Squamous Cell Carcinoma (HNSCC) clinical trials: Focusing on overall survival and progr... by Priya Ganesan, Saravanan Sekaran, Pasiyappazham Ramasamy, Dhanraj Ganapathy

“…It also underscores the importance of ongoing research to refine therapeutic strategies and optimize patient outcomes.…”
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