Molecular mechanisms and therapeutic prospects of 4-aminobenzoic acid in neuropsychiatric disorders: a comprehensive review of neurotransmitter modulation, anti-inflammatory pathwa... by Siyu Chen, Yan Su, Weiyan Wu, Yuting Chen, Tiandong Lin, Yangyang Liu

“…4-Aminobenzoic acid (PABA, para-aminobenzoic acid) exhibits multifaceted therapeutic potential in neuropsychiatric disorders through its roles in neurotransmitter modulation, anti-inflammatory action, and antioxidant defense. …”
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Regulation of tiller angle by gravity-sensing genes in rice by Tao Yin, Yao Sun, Yuxin Tai, Zixiang Cheng, Chuanyin Wu, Yi Sui

“…In this study, we investigated the roles of these genes in rice (Oryza sativa), a model monocot, using CRISPR-Cas9 to generate single, double, and higher-order mutants. …”
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Analyzing crop production: Unraveling the impact of pests and pesticides through a fractional model by Navnit Jha, Akash Yadav, Ritesh Pandey, A.K. Misra

“…Furthermore, we have identified the optimal time profile for pesticide spraying rate. …”
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Collaborative modification strategy to improve the formation of biochar-derived persistent free radicals for aniline removal via peroxymonosulfate activation by Zilong Zhao, Shuting Zhu, Shuyu Qi, Ting Zhou, Yang Yang, Feng Wang, Qi Han, Wenyi Dong, Hongjie Wang, Feiyun Sun

“…By adjusting pyrolysis temperatures and doping ratios, optimal conditions were established. Spearman's analysis highlighted the importance of C=C bonds, the ID/IG ratio, and pyridinic N in generating PFRs. …”
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Design and Evaluation of AgileBPM SDLC–An Agile SDLC for Business Process Management Systems by Roberto Davila-Campos, Manuel Mora, Paola Yuritzy Reyes Delgado, Sergio Galvan-Cruz, Gabriela Citlalli Lopez Torres

“…The resulting AgileBPM SDLC includes three agile roles, four phases, fifteen activities, and twelve structured artifacts, all comprehensively documented through an open-access Electronic Process Guide (EPG). …”
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Arginine as host directed therapy in tuberculosis: insights from modulating arginine metabolism by supplementation and arginase inhibition by Qingkui Jiang, Ranjeet Kumar, Yi Zhao, Selvakumar Subbian, Lanbo Shi

“…These findings underscore the complementary roles of Nos2 and arginase-mediated pathways in maintaining immune equilibrium during Mtb infection. …”
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Flavonoids of Mao Jian Green Tea Ameliorate Glycemic Metabolism in Type-2-Diabetic Rats via AMPK Signaling Pathways and Gut Microbiota Regulation by Lei Wu, Yao Niu, Fei Liu, Jiongling Tian, Zhilin Ma, Jiahui Yang, Xiaomeng Guo, Yaogui Sun

“…These findings highlight MJGT_F’s dual regulatory roles in glucose metabolism and microbiota, supporting its potential for diabetes management.…”
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Beyond Barriers: Achieving True Equity in Cancer Care by Zaphrirah S. Chin, Arshia Ghodrati, Milind Foulger, Lusine Demirkhanyan, Christopher S. Gondi

“…This manuscript explores the multifaceted nature of these disparities, examining the roles of socioeconomic status, race, ethnicity, and insurance status in influencing cancer care access and outcomes. …”
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Mapping and tracing Grem1+ stromal cells in an ApcMin/+ mouse utilizing cryopreserved intestinal sections prepared via modified Swiss-roll technique by Youheng Jiang, Zhang Fu, Yanfang Chen, Qunlong Jin, Yanming Yang, Zerong Lin, Changxue Li, Yunfei Gao, Zepeng Dong, Yang He, Xinjun Mao, Yulong He, Qingyuan Zhang, Qi Zhang, Ningning Li

“…Summary: Grem1+ cancer-associated fibroblasts (CAFs) are crucial in colorectal cancer (CRC) development, yet technical challenges have limited understanding of their origins, spatiotemporal distribution, and potential roles. Here, we devised a custom mold, optimizing the gut Swiss-roll technique to create a single cryopreserved slide for comprehensive staining. …”
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A comprehensive review of unlocking the potential of lignin-derived biomaterials: from lignin structure to biomedical application by Jixiang Zhao, Minyu Zhu, Wei Jin, Jinlan Zhang, Guangyu Fan, Yifan Feng, Zhuo Li, Siming Wang, Jung Seung Lee, Guangxiang Luan, Zhengqi Dong, Ying Li

“…Structural modifications through chemical/physical treatments or microbial/enzymatic can optimize lignin’s bioactivity, mechanical strength, and adhesion, enabling applications in drug delivery, Ultraviolet (UV) shielding, sensing, and wound healing. …”
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Synergistic Effects of <i>Paenibacillus polymyxa</i> NBmelon-1 Inoculation and Grafting Restructure of Rhizosphere Microbiome and Enhanced Disease Resistance in Melon Self-Rootstoc... by Wenjie Dong, Quanyu Zang, Yuhong Wang, Erlei Ma, Weihong Ding, Leiyan Yan, Fangmin Hao

“…Rhizosphere microorganisms play pivotal roles in mitigating the challenges associated with continuous cropping in melon cultivation. …”
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Alternative data in finance and business: emerging applications and theory analysis (review) by Yunchuan Sun, Lu Liu, Ying Xu, Xiaoping Zeng, Yufeng Shi, Haifeng Hu, Jie Jiang, Ajith Abraham

“…In recent years, alternative data have been leveraged by businesses and investors to adjust credit scores, mitigate financial fraud, and optimize investment portfolios because they can be used to conduct more in-depth, comprehensive, and timely evaluations of enterprises. …”
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Glycoproteomic profiling of serum-derived small extracellular vesicles enriched via ultracentrifugation and affinity-based techniques by Mojibola Fowowe, Cristian D. Gutierrez Reyes, Judith Nwaiwu, Joy Solomon, Oluwatosin Daramola, Sherifdeen Onigbinde, Joseph Andrew Whitley, Houjian Cai, Yehia Mechref

“…However, the glycosylation of EVs and the specific roles of their glycans remain poorly understood. …”
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Machine learning based predictive model of the risk of Tourette syndrome with SHAP value interpretation: a retrospective observational study by Aimin Li, Yueying Liu, Yufan Luo, Xue Xiao, Wei Xiao, Ruijin Xie, Xianhui Deng, Zhe Chen, Qian Zhou, Yue Gong, Zhen Chen, Hua Xu

“…Feature selection was conducted using Boruta and multivariable logistic regression analyses, and model construction was undertaken employing 9 distinct machine learning algorithms. 10 distinct features were selected for machine learning algorithm development, and our results indicated that the Gradient Boosting Machine algorithm is the optimal model. Our study successfully established a predictive model for the risk of Tourette syndrome using Gradient Boosting Machine, and the SHAP method highlighted the key roles of β2-microglobulin and serum 25-hydroxyvitamin D3 levels in predicting TS risk.…”
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Colour Preference of Post Hatchling Hawksbill (<i>Eretmochelys imbricata</i>) and Green (<i>Chelonia mydas</i>) Sea Turtles in Captivity by Jordan Drake, Mohammed F. Khayat, Rhondda Jones, Ellen Ariel

“…Variations in the ecological roles of sea turtle species may lead to differentiations in ocular design and visual sensitivity to the colour spectrum. …”
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How Insects Balance Reproductive Output and Immune Investment by Jimena Leyria, Leonardo L. Fruttero, Pedro A. Paglione, Lilián E. Canavoso

“…Additionally, macromolecules like vitellogenin and lipophorin, primarily known for their functions as yolk protein precursors and lipid carriers, play crucial roles in pathogen recognition and transgenerational immune priming. …”
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F− surface modified ZnO for enhanced photocatalytic H2O2 production and its fs-TAS investigation by Xin Zhou, Chenbin Ai, Xiaojing Wang, Zhen Wu, Jianjun Zhang

“…This study has revealed the roles of F− surface modification in the photocatalytic H2O2 production by ZnO and provides guidance for ionic modification to improve photocatalytic performance.…”
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The molecular mechanism by which heat stress during the grain filling period inhibits maize grain filling and reduces yield by Xiaohu Li, Shilin Zhuge, Jiyuan Du, Peng Zhang, Xingyu Wang, Tianjian Liu, Donghui Li, Haoran Ma, Xinzheng Li, Yongxin Nie, Changjian Liao, Haiping Ding, Zhiming Zhang

“…The two inbred lines were exposed to controlled conditions of 30°C/20°C (optimal) and 42°C/30°C (heat stress) during the grain filling period. …”
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Shoulder Pain: To Think Beyond the Myo-osseous Elements: A Case Report by MJ Abhinand, B Vijayanand, Karthikeyan

“…Diagnostic tools such as Magnetic Resonance Imaging (MRI), Electromyography (EMG) and Nerve Conduction Studies (NCS) play crucial roles in identifying and evaluating suprascapular nerve dysfunction. …”
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Developing a bespoke capacity-strengthening program for the clinical pharmacy profession in India by Dr Vrinda Nampoothiri, Mr Muhammed Rashid, Dr Dena Van Den Bergh, Dr Esmita Charani, Dr Mohamed Hisham

“…As of March 2024, five participants reported to be on track with their milestones and others have revised their timelines which is being documented in the goal-setting document. Discussion: To optimize clinical opportunities for pharmacists in India, in addition to recognizing their roles, they need structured continuous professional development in different clinical specialties. …”
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