Computational Analysis of S1PR1 SNPs Reveals Drug Binding Modes Relevant to Multiple Sclerosis Treatment by Katarina Kores, Samo Lešnik, Urban Bren

“…While there is no known cure for MS, various disease-modifying treatments (DMTs) exist, including those targeting Sphingosine-1-Phosphate Receptors (S1PRs), which play important roles in immune response, CNS function, and cardiovascular regulation. …”
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Scale effects and threshold management in the influence of landscape patterns on non-point source pollution by Jianhong Wu, Ziqing Yang, Hengqin Wang, Jiani Xu

“…Understanding the relationship between landscape proximity and riverine pollutants is crucial for optimizing landscape patterns to mitigate NPS pollution. …”
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VCAM-1 predicts poor prognosis and modulates immune infiltration in gastric cancer: a TCGA-based bioinformatics study by Cheng Wu, Cheng Wu, Yungeng Liu, Yungeng Liu, Chuanyuan Liu, Chuanyuan Liu, Chuanfa Fang, Chuanfa Fang

“…Furthermore, its dual roles in immune regulation highlight its potential to optimize GC immunotherapy.…”
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REM sleep quality is associated with balanced tonic activity of the locus coeruleus during wakefulness by Nasrin Mortazavi, Puneet Talwar, Ekaterina Koshmanova, Roya Sharifpour, Elise Beckers, Alexandre Berger, Islay Campbell, Ilenia Paparella, Fermin Balda, Ismael Dardour Hamzaoui, Christian Berthomier, Christine Bastin, Christophe Phillips, Pierre Maquet, Fabienne Collette, Mikhail Zubkov, Laurent Lamalle, Gilles Vandewalle

“…The associations depend on the cognitive task, suggesting that a balanced level of LC tonic activity during wakefulness is required for optimal expression of REM sleep. The findings may have implications for the high prevalence of sleep complaints reported in aging and for disorders such as insomnia, Alzheimer’s, and Parkinson’s disease, for which the LC may play pivotal roles through sleep.…”
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Urban surface water bodies mapping using the automatic k-means based approach and sentinel-2 imagery by Mateo Gašparović, Sudhir Kumar Singh

“…Rivers, lakes, and open water bodies play crucial roles in environmental development, especially in urban ecosystems. …”
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An Improved m6A-ELISA for Quantifying N6-methyladenosine in Poly(A)-purified mRNAs by Wei Chan, Waleed Albihlal, Folkert Van Werven

“…N6-methyladenosine (m6A) is an abundant internal mRNA modification with roles in regulating cellular and organismal physiology, including development, differentiation, and disease. …”
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5-n-Alk(en)ylresorcinol accumulation across developmental stages of triticale through comparative metabolite profiling: implications of fresh and dry basis by Ronald Marentes-Culma, Ericsson Coy-Barrera

“…Semi-quantitative AR levels varied based on plant parts and ontogeny, suggesting constitutive roles during growth. These insights into temporal and spatial distribution offer valuable information for determining optimal harvesting times, quality, and material condition for future breeding studies in triticale.…”
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Masa depan civil society di Indonesia: prospek dan tantangan by Halili Halili

“…Prospect of ciuil society deuelopmentis influenced by optimalization ofsome factors: 1) establishment of, demo­cratic families, 2) growth of roles of non government organization toward both state and citizen, 3) increase of intellectual middle class, especially students, and 4) implementation of political education formally (e.g. civic or citizenship education) and informally. …”
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Iterative Algorithm for Solving a Class of Quaternion Matrix Equation over the Generalized (P,Q)-Reflexive Matrices by Ning Li, Qing-Wen Wang

“…The matrix equation ∑l=1uAlXBl+∑s=1vCsXTDs=F, which includes some frequently investigated matrix equations as its special cases, plays important roles in the system theory. In this paper, we propose an iterative algorithm for solving the quaternion matrix equation ∑l=1uAlXBl+∑s=1vCsXTDs=F over generalized (P,Q)-reflexive matrices. …”
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Subjective well being children with ADHD by Iriani Indri Hapsari, Aulia Iskandarsyah, Poeti Joefiani, Juke R Siregar

“…It is important to pay attention to the subjective well-being children with ADHD, it is hoped that teachers, parents, and government can further optimize their respective roles and collaborate with each other to jointly pay attention to children's well-being with various strategies and policies.…”
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Methylmap: visualization of modified nucleotides for large cohort sizes by Elise Coopman, Svenn D’Hert, Rosa Rademakers, Wouter De Coster

“…Abstract Background Over the years, there has been growing interest in epigenetics, where nucleotide modifications are increasingly recognized for their roles in health and disease. Understanding methylation patterns at the nucleotide level has become pivotal for advancing this field. …”
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Guideline for antibacterial therapy of adult community-acquired pneumonia in the emergency department under the physicianpharmacist collaborative management model by Wei Gu, Shuo Wang, Ling Wang, Yang Liu, Chuanzhu Lv, Guoqiang Zhang, Yuefeng Ma, Wei Guo, Society of Emergency Medicine of Chinese Medical Association, Emergency Medicine Branch of Chinese Geriatrics Society

“…It outlines the significance of the PPCM model, its applicable scenarios, the respective roles of emergency physicians and clinical pharmacists, and its practical implementation in the antimicrobial treatment of CAP patients. …”
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Production, Transport, Fate and Effects of Lipids in the Marine Environment by Christopher C. Parrish

“…They are generated and metabolized by enzymes under the influence of biotic and abiotic factors, and some—the long-chain polyunsaturated ω3 and ω6 fatty acids and cholesterol—are essential for optimal health in marine organisms. In addition, lipids have direct and indirect roles in the control of buoyancy in marine fauna ranging from copepods to whales. …”
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The efficacy of novel biomarkers for the early detection and management of acute kidney injury: A systematic review. by Mohammed Yousef Almulhim

“…However, factors influencing biomarker performance, optimal cutoffs, cost-effectiveness, and impact on patient outcomes require robust validation across diverse settings before widespread implementation. …”
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A review on anti-cancer properties of quercetin in gastric cancer by Xiaoxia Xie, Yan Wei

“…This review paper focuses on the multifaceted roles and therapeutic potential of quercetin in gastric cancer (GC). …”
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Poly(lactic acid) and its composites as functional materials for 3-D scaffolds in biomedical applications: A mini review of recent trends by S. T. Sikhosana, T. P. Gumede, N. J. Malebo, A. O. Ogundeji

“…In this review, potential roles, general properties, advantages, and disadvantages of poly (lactic acid) and its composites as functional materials for scaffolding will be outlined. …”
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3D printing of bimetallic materials: characteristics and performance by A. El aoudi, A. Ouballouch, M. Nassraoui

“… Bimetals 3D printing is a state-of-the-art technology, in which process parameters and heat treatments play key roles on the mechanical, thermal and structural properties of components. …”
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Method on Efficient Operation of Multiple Models for Vision-Based In-Flight Risky Behavior Recognition in UAM Safety and Security by Byeonghun Kim, Byeongjoon Noh, Kyowon Song

“…It can effectively perform roles such as detecting prohibited items and recognition of dangerous/abnormal behavior. …”
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Challenge of Saudi Vision 2030: Foreign Policy Dilemma of Saudi Arabia by Moh Talabul Amal, Dini Septyana Rahayu

“…This approach should aim to optimize the benefits obtained from partnerships while also limiting the possible risks associated with them.…”
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Current treatment of hereditary nephrogenic diabetes insipidus in children by Jin-Soon Suh

“…Medications, such as thiazide diuretics, potassium-sparing diuretics, and nonsteroidal anti-inflammatory drugs, play pivotal roles in reducing urine output and improving fluid balance. …”
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