Predictive Factors for Super Responder Status and Long-Term Effectiveness of Guselkumab in Psoriasis: A Multicenter Retrospective Study by Edoardo Mortato, Marina Talamonti, Lorenzo Marcelli, Matteo Megna, Annunziata Raimondo, Giacomo Caldarola, Nicoletta Bernardini, Anna Balato, Anna Campanati, Maria Esposito, Claudio Bonifati, Viviana Lora, Luca Potestio, Serena Lembo, Francesco Loconsole, Eleonora De Luca, Nevena Skroza, Dario Buononato, Tommaso Bianchelli, Maria Concetta Fargnoli, Nello Tommasino, Felice Primavera, Clara De Simone, Luca Bianchi, Marco Galluzzo

“…The IL-23/Th17 signaling pathway plays a critical role in disease progression. Guselkumab, an IL-23p19 monoclonal antibody, has shown substantial efficacy in clinical trials for treating moderate-to-severe plaque psoriasis. …”
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KEAP1 mutations as key crucial prognostic biomarkers for resistance to KRAS-G12C inhibitors by Linyan Tian, Chengming Liu, Sufei Zheng, Huiyang Shi, Fang Wei, Wenxin Jiang, Yucheng Dong, Haiyan Xu, Enzhi Yin, Nan Sun, Jie He, Yan Wang

“…The findings highlight the urgent need for alternative therapeutic approaches in KEAP1-mutant patients and emphasize the role of molecular profiling in tailored treatment strategies.…”
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Development of a Consensus-based Agenda to Identify Priorities for Clinical Research in Pediatric Orthopaedic Surgery by A. Noelle Larson, MD, Ria Paradkar, Matthew Schmitz, MD, Raymond Liu, MD, Neeraj M. Patel, MD, MPH, MBS, Henry Ellis, MD, Todd A. Milbrandt, MD, Dan Sucato, MD, Kevin Shea, MD, Jennifer Laine, MD

“…The top scoring questions were related to the role of orthopaedic surgical treatment in cerebral palsy and surgical indications for residual hip dysplasia. …”
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Data extraction from free-text stroke CT reports using GPT-4o and Llama-3.3-70B: the impact of annotation guidelines by Jonas Wihl, Enrike Rosenkranz, Severin Schramm, Cornelius Berberich, Michael Griessmair, Piotr Woźnicki, Francisco Pinto, Sebastian Ziegelmayer, Lisa C. Adams, Keno K. Bressem, Jan S. Kirschke, Claus Zimmer, Benedikt Wiestler, Dennis Hedderich, Su Hwan Kim

“…Key Points LLMs have utility in data extraction from radiology reports, but the role of annotation guidelines remains underexplored. …”
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The adaptive mechanism of Ctenopharyngodon idellus to dietary lipid levels: Insights from microbiota-mediated bile acid enterohepatic circulation by Jingjing Lu, Jiming Jin, Libin He, Wenshu Liu, Liyun Ding, Mo Peng, Liu Fang, Lingya Li, Yuzhu Wang, Yanqiang Tang, Haihong Xiao, Siming Li, Xiaoze Guo

“…Results showed that a 6 % dietary lipid level was optimal for achieving the maximum growth performance and maintaining the liver health state of grass carp. …”
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Identification of strengths and weaknesses of the healthcare system for persons living with rare diseases in Catalonia (Spain), and recommendations to improve its comprehensive att... by José Hernández-Rodríguez, Fernando Martínez-Valle, Xènia Acebes, Carmen Alerany, Jordi Antón, Gonzalo Calvo, Marian Corral, Jordi Cruz, M. Antònia Mangues-Bafalluy, José Mateo, Josefa Rivera, Albert Salazar, Roser Francisco, Cristina Mallol, Rita Reig-Viader, Ariadna Tigri-Santiña, Assumpta Ricart, Francesc Palau

“…Results The Catalan Government healthcare model of XUECs for the comprehensive care for RDs is currently valid and adapted to the needs of PLWRD and their families since its strategic optimal and operational framework, and it is aligned with the European Reference Networks (ERNs) thematic areas. …”
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Comparative efficacy of rTMS on different targets in Alzheimer’s disease: a systematic review and meta-analysis by Yushu Zhang, Yushu Zhang, Ke Dong, Ke Dong, Jiajia Yang, Jiajia Yang, Qifan Guo, Qifan Guo, Yan Zhao, Yan Zhao, Xiaoxia Zhu, Xiaoxia Zhu, Dongxu Liu, Dongxu Liu, Peng Liu, Peng Liu

“…Notably, the greater cognitive benefits observed in Asian populations suggest a potential role of genetic and demographic factors that warrant further investigation. …”
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Design and evaluation of novel triazole derivatives as potential anti-gout inhibitors: a comprehensive molecular modeling study by Mohammed Er-rajy, Mohammed Er-rajy, Mohamed El fadili, Sara Zarougui, Somdutt Mujwar, Mourad Aloui, Mohammed Zerrouk, Belkheir Hammouti, Larbi Rhazi, Rachid Sabbahi, Mohammed M. Alanazi, Khalil Azzaoui, Khalil Azzaoui, Rachid Salghi, Menana Elhallaoui

“…Visualization of the contour maps of both models showed that modifying the substituents plays a key role in enhancing the biological activity of anti-gout inhibitors. …”
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Dose-dependent serological profiling of AdCLD-CoV19-1 vaccine in adults by Jung Hyuk Lee, Yuna Shin, Kwang-Soo Shin, Ju Yeon Park, Mi Sun Kim, Young-Shin Park, Wuhyun Kim, Joon Young Song, Ji Yun Noh, Hee Jin Cheong, Chang-Yuil Kang, Sang Hwan Seo, Jae-Ouk Kim, Deok Ryun Kim, Nathaniel S. Hwang, Jae Seung Yang, Jerome H. Kim, Byoung-Shik Shim, Manki Song

“…In addition to neutralizing antibodies, non-neutralizing antibodies that mediate Fc-dependent effector functions play a key role in protection against various infectious diseases, including coronavirus disease 2019. …”
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Longitudinal Assessment of FT3 to FT4 Conversion Ratio in Predicting the Efficacy of First-Line Pembrolizumab-Based Therapy in Advanced Non-Small Cell Lung Cancer: A Propensity-Sco... by Fabrizio Nelli, Enzo Maria Ruggeri, Marta Schirripa, Antonella Virtuoso, Diana Giannarelli, Armando Raso, Daniele Remotti, Agnese Fabbri

“…The longitudinal assessment of fT3/fT4 ratio may play a predictive role in this specific therapeutic setting.…”
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Impact of vancomycin therapeutic drug monitoring on mortality in sepsis patients across different age groups: a propensity score-matched retrospective cohort study by Huaidong Peng, Ruichang Zhang, Shuangwu Zhou, Tingting Xu, Ruolun Wang, Qilin Yang, Xunlong Zhong, Xiaorui Liu

“…Therapeutic drug monitoring (TDM) can optimize personalized vancomycin dosing regimens, enhancing therapeutic efficacy and minimizing nephrotoxic risk, thereby potentially improving patient outcomes. …”
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La formación en Soporte Vital Básico en la etapa escolar obligatoria. Estudio descriptivo (Training in Basic Life Support in the compulsory school stage. Descriptive study) by Lourdes Luque López, Patricia García Pazo, Jesús Molina-Mula

“…Palabras clave: Soporte vital básico; Reanimación Cardiopulmonar; Desfibrilador Externo Semiautomático; enseñanza; Formación del Profesorado Abstract. School is the optimal place to begin training in Basic Life Support and teachers can play a very relevant role for this purpose. …”
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Efficacy of olokizumab against comorbid depressive disorder in patients with rheumatoid arthritis: Preliminary results of the study by T. A. Lisitsyna, A. A. Abramkin, D. Yu. Veltishchev, O. F. Seravina, O. B. Kovalevskaya, A. B. Borisova, V. G. Ignatiev, E. L. Nasonov

“…Interleukin (IL) 6 plays an important role in the pathogenesis of comorbid rheumatoid arthritis (RA) depression, and IL-6 inhibitors (i) used to treat RA patients may have an antidepressant effect.Objective – to evaluate the effectiveness of Russian iIL-6 olokizumab (OKZ) in reducing symptoms of depression in patients with moderate/high RA activity.Material and methods. …”
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Late-gestation heat stress alters placental structure and function in multiparous dairy cows by L.T. Casarotto, H.N. Jones, P. Chavatte-Palmer, J. Laporta, F. Peñagaricano, V. Ouellet, J. Bromfield, G.E. Dahl

“…ABSTRACT: The placenta plays a pivotal role in fetal development and the dam's subsequent lactation performance, because it facilitates nutrient transfer, heat dissipation, and gas exchange with the growing fetus, and regulates key hormones essential for mammary gland development. …”
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Abstract 015: Pioneering NaF‐PET/CT Imaging for Early Detection of Atherosclerosis: Potential Implications for Neurointerventional Surgery by Eric M Teichner, Robert C Subtirelu, Arjun B Ashok, Yvonne Su, Victoria A Anderson, Milo Writer, Omar Al‐Daoud, Miraziz Ismoilov, Chitra Parikh, William Y Raynor, Sahithi Talasila, Poul F Høilund‐Carlsen, Abass Alavi, Mona‐Elisabeth Revheim

“…The findings suggest that NaF‐PET could play a pivotal role in diagnosing and managing CVD where traditional tracers encounter limitations. …”
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Jiangu Granules Regulates Endoplasmic Reticulum Stress-Induced Apoptosis in UMR-106 Cells by Modulating the PERK/eIF2α/ATF4/CHOP Pathway by CHEN Sainan, ZHOU Fen, HUANG Yunmei, LIN Yanping

“…ObjectiveTo observe and analyze the mechanism by which Jiangu Granules containing serum alleviate endoplasmic reticulum stress (ERS)-induced apoptosis in UMR-106 osteoblast-like cells.MethodsUMR-106 osteoblast-like cells were selected for the study, and various concentrations (0, 0.01, 0.02, 0.03, 0.04, 0.05 μmol/L) of GSK2606414 (PERK inhibitor) were employed to intervene in the cells. The optimal intervention concentration of GSK2606414 was determined using the CCK8 method. …”
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Synthesis and antitumoral activity of novel biaryl hydroxy-triazole and fluorene-triazole hybrids by David Chafi Zeitune, Marcelo Folhadella Martins Faria Azevedo, Mariane Senna Rangel, Robert de Sousa Bastos, José de Brito Vieira Neto, Claudia do Ó Pessoa, Camilla Djenne Buarque

“…Conclusions: The results highlight the critical role of bromine substitution on the aryl azide-derived ring in modulating cytotoxic activity. …”
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Effect of mycorrhizal symbiosis and supplemental irrigation on yield, grain nutrients and plant residues of chickpea (Cicer arietinum L.) by Mahmoud Mazlomi Mamyandi, Alireza Pirzad, Jalal Jalilian

“…Supplemental irrigation has a key role to reduce tensions in the critical stages of plant growth, and also compensate the serious yield lost. …”
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Purification technology design, biochemical and immunological characteristics of the recombinant chimeric antigen for evaluation of T cell immunity against coronavirus infection by V. V. Kopat, A. A. Riabchenkova, E. L. Chirak, E. R. Chirak, A. I. Saenko, I. V. Kudryavtsev, A. S. Trulioff, T. V. Savin, E. V. Zueva, A. S. Simbirtsev, A. A. Totolyan, I. V. Dukhovlinov

“…Diagnosis of specific T cell immunity to the antigenic determinants of SARS-CoV-2 in patients seems to be an increasingly important task due to accumulation of data about the role of T cell immune response in course of coronavirus infection and clearance of SARS-CoV-2 in case of secondary infection. …”
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The Impacts of Vapor Transport on Land-atmospheric Water & Heat Exchanges over the Yarlung Zangbo Grand Canyon Area by Qiang ZHANG, jun WEN, yiting YANG, dongyu JIA, wenhui LIU, yaling CHEN, xuancheng LU

“…The Yarlung Zangbo Grand Canyon region （referred to as the YGC）， located in the southeast Qinghai-Xizang Plateau， is the main channel of the warm and humid air transported from the India Ocean to the Qinghai-Xizang Plateau （referred to as the QXP）， and it plays an important role in the water and energy cycle of the QXP.In order to explore the influences of the different horizontal water vapor transport on the water & heat exchanges flux， the water vapor intensity over the YGC from May 20， to July 9， 2013， was divided into three levels： strong， weak， and very weak based on the ECMWF Re-Analyses version5 data.And the fifth-generation public land model （Community Land Model version 5.0， CLM5.0） was deployed to simulate the impact of the horizontal water vapor transport on the YGC-atmospheric water and heat exchanges.The results show that the south （east） boundary of the YGC is the main input （output） boundary of water vapor， and the YGC valley over the south of the YGC is a strong water vapor transport belt.The YGC-atmospheric water & heat exchanges fluxes simulated by CLM5.0 has large errors compared to the actual measurements， the CLM5.0 simulated near-surface water & heat exchanges fluxes over the YGC have a high accuracy by optimizing the thermal roughness length （Z0h） parameterization schemes replacing the default soil attribute data-set.Compared with the simulations by using the CLM5.0 default parameterization scheme， the one developed by Zeng and Dickinson （1998）.…”
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