Efficacy and safety of oxaliplatin-based chemotherapy as first-line treatment in elderly patients with metastatic colorectal cancer: a meta-analysis by Shaoqing Fan, Zeming Zhao, Haiqian Wang, Handong Wang, Wenbo Niu

“…Despite oxaliplatin’s established role in first-line metastatic CRC (mCRC) therapy, its clinical utility in older adults remains debated due to concerns over efficacy, toxicity, and survival outcomes. …”
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Grass hay mixed-in creep feed or separately-fed differentially affects digestive development in pre- and post-weaning piglets by Renjie Yao, Tetske G. Hulshof, Hubèrt M. J. van Hees, An Cools, Mattijs Merckx, Dominiek Maes, Geert P. J. Janssens

“…Abstract Background Based on observations in feral pigs, the role of dietary fibre and structure may be underestimated in suckling piglet nutrition. …”
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Development of Machine Learning Prediction Models to Predict ICU Admission and the Length of Stay in ICU for COVID‑19 Patients Using a Clinical Dataset Including Chest Computed Tom... by Seyed Salman Zakariaee, Negar Naderi, Hadi Kazemi-Arpanahi

“…However, there was a lack of information about the prognostic role of radiological manifestations in combination with demographics, clinical manifestations, and laboratory predictors to predict ICU admission and the length of stay (LOS) in the ICU (ICU LOS) of COVID-19 patients. …”
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Potential induction of the relative mRNA expression levels of CYP450 by Zhicaowu-Hezi (Aconiti kusnezoffii radix preparata and Terminalia chebula Retz.) by Junxuan Zhu, Ming An, Weiting Wang, Jingjing Guo, Mengting Chen, Longlong Fang, Cen Wang, Dong Zhang, Guodong Wu

“…Despite extensive studies on their detoxification effects, the role of cytochrome P450 (CYP450) modulation remains unclear.AimThis study aimed to systematically evaluate the regulatory effects of Zhicaowu and Hezi combination on both enzymatic activity and mRNA expression of CYP450 isoforms (CYP1a2, CYP2b1, CYP2c11, CYP2c13, CYP2d2, CYP2e1, and CYP3a1), and to explore their correlation with hepatoprotective effect.MethodsThe effects of Zhicaowu-Hezi formulation on CYP450 enzymes were systematically evaluated through integrated in vivo and in vitro approaches. …”
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Optimasi Algoritma Naive Bayes dengan Diskritisasi K-Means pada Diagnosis Penyakit Jantung by Nafa Fajriati, Budi Prasetiyo

“…This shows that K-means discretization plays a role in optimizing the performance of the Naïve Bayes algorithm to produce better accuracy. …”
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Celastrol attenuates sodium oxalate-induced acute kidney injury and crystal deposition by inhibiting NF-κB by LIU Yiheng, LIU Yiheng, ZHENG Quanyou, ZHANG Wanyuan

“…Objective‍　‍To investigate the role and possible mechanism of celastrol (Cel) in sodium oxalate (NaOx)-induced acute kidney injury (AKI) and crystal deposition in the kidney tissues in mice. …”
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CD56bright cytokine-induced memory-like NK cells and NK-cell engagers synergize against non-small cell lung cancer cancer-stem cells by Paola Orecchia, Maria Cristina Mingari, Martin Felices, Monica Parodi, Luca Roz, Massimo Vitale, Giulia Bertolini, Claudia Cantoni, Maria L Guevara Lopez, Ann Gebo, Stefano Persano, Josephine Maus-Conn, Fabrizio Loiacono, Simona Sivori, Marco Gentili, Federica Facchinetti, Riccardo Ferracini, Daniel A Vallera, Marco Pravetoni

“…Finally, we demonstrate that CIML-NK cells, capable of killing autologous tumor cells and responding to the 1615133 TriKE, could be induced from patients with NSCLC.Conclusions Our study discloses for the first time the therapeutic potential of CIML-NK cells in controlling CSCs and metastatic spread, highlighting the role of the CD56bright subset expansion and 1615133 TriKE for optimizing CIML-NK-based therapies against metastatic tumors.…”
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Developing a Machine Learning Model for Predicting 30-Day Major Adverse Cardiac and Cerebrovascular Events in Patients Undergoing Noncardiac Surgery: Retrospective Study by Ju-Seung Kwun, Houng-Beom Ahn, Si-Hyuck Kang, Sooyoung Yoo, Seok Kim, Wongeun Song, Junho Hyun, Ji Seon Oh, Gakyoung Baek, Jung-Won Suh

“…Furthermore, the significance of predictors linked to previous diagnoses and laboratory measurements underscored their critical role in effectively predicting perioperative risk. …”
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Comparison of Automated Point-of-Care Gram Stainer (PoCGS^®) and Manual Staining by Goh Ohji, Kenichiro Ohnuma, Kei Furui Ebisawa, Mari Kusuki, Shunkichi Ikegaki, Hiroaki Ozaki, Reiichi Ariizumi, Masakazu Nakajima, Makoto Taketani

“…<b>Background/Objectives:</b> Gram staining is an essential diagnostic technique used for the rapid identification of bacterial and fungal infections, playing a pivotal role in clinical decision-making, especially in point-of-care (POC) settings. …”
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“Agent – Environment” Evolution Mechanism of Greenbelt from the Perspective of Complex Adaptive System: A Case Study of Beijing’s Greenbelts by Song LIU, Peiyu SHEN, Dizi LIU, Zhaocheng BAI

“…In the orderly implementation stage, both external environmental forces and self-organizing forces play a strong role in the evolution of greenbelt. Major social and cultural events, “urban and rural integration”, “quantity reduction and quality and greening improvement” policies, and diversified citizen participation have all promoted the improvement of the self-organizing capability of greenbelt. …”
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Dynamic Migration Pattern of Groundwater and Deformation Mechanism in Cataclastic Bedding Rock Landslides: A Case Study of Muyubao Landslide in Three Gorges Reservoir Area by DENG Mao-lin, LIANG Zhi-kang, WANG Guo-fa, WANG Biao, ZHOU Lu-lu, WAN Hang, PENG Xu, SU Peng-min, ZHU Xiao-han

“…Therefore, in landslide disaster prevention, the role of rainfall and groundwater should be carefully considered. …”
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CEREBRAL VENOUS THROMBOSIS IN THE PEDIATRIC AGE GROUP: TWENTY-YEAR EXPERIENCE by JL Sion, DM Celeste, MP Garanito, JDA Carneiro

“…Although treatment issues are not well defined, there is evidence that anticoagulation has an important role in all age groups. Clinical trials are essential to address the optimal therapeutics, efficacy, morbidity and mortality in this disease.…”
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Identification and Ranking of Ethical Human Resources Management Components in Payam Noor University by Saeid Besharati Kivi, Hamid Taboli, Zahra Forotani, Naser Barkhrordar

“…Based on the findings, these components include: equality and development, self-efficacy and self-control, technical-expert factors, professional perfection, interests of stakeholders and competitive content production.ConclusionAccepting any role entails responsibilities, and fulfilling these responsibilities requires observing ethical aspects. …”
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Las aulas fuera del colegio. Aprendizajes docentes de tres experiencias educativas en un período singular (Classrooms outside the school. Lessons for teachers from three education... by Dario Pérez Brunicardi, María Teresa Archilla-Prat, Lucía Benito-Hernando, Marta Martín-del Barrio, Víctor Velasco-González

“…It ends with a message of optimism and realism on the part of educators, who now have the certainty that this pandemic has shown us the great value of outdoor learning. …”
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Investigation of Configurations of \begin{document}${ \left[{\bf{UO}}_{\bf{2}}({\bf{OH}})_{\boldsymbol{m}}({\bf{H}}_{\bf{2}}{\bf{O}})_{\boldsymbol{n}}\right]^{{\bf{2}}-{\boldsymbol... by Xiu-lin ZENG, Meng-ke TIAN, Shuang-ling TANG, Xue-hai JU

“…The above characteristics of [UO2(OH)m(H2O)n]2‒m play an important role on the ion activity, solubility and ion exchange of uranyl in alkaline solutions. …”
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Evaluation of ctDNA-guided adjuvant therapy de-escalation in head and neck squamous cell carcinoma: a comparative cohort study by Xu Zhang, Qigen Fang, Junhui Yuan, Liyuan Dai, Ruihua Luo, Tao Huang, Tao Huang, Yinfei Wu

“…The enhanced therapeutic effect observed in ctDNA-guided patients supports ctDNA’s role as a decision-modifying biomarker for personalization management following neoadjuvant chemoimmunotherapy.…”
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Impact of Pre-Interventional Observational Management Duration on Outcomes of Embolization for Splenic Injuries: Experience from Two Centers by Nguyen VT, Le TD, Pham HD, Tran QL

“…Notably, the timing of the embolization plays a critical role in treatment outcomes; earlier intervention from hospital admission to embolization significantly correlates with improved success rates. …”
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Efek Komposisi Bioadsorben α-Keratin/Alginat Terhadap Kapasitas Adsorpsi Logam Berat Besi (Fe) by Elsa Ninda Karlinda Putri, Syahna Febrianastuti, Easy Vicky Maylinda, Ganjar Fadillah, Candra Purnawan

“…The research aims to determinate the character and adsorption optimation of α-keratin/alginate composite for Fe adsorption in aqueous solution. …”
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Feasibility of automating the determination of changes in forest areas using satellite images (Case Study: Central Alborz protected area) by Amir Satari Rad, Behzad Rayegani, Ali Jahani, Hamid Goshtasb Meigooni

“…Objective and BackgroundDeforestation is one of the biggest global environmental challenges because forests are one of the most important components of the world's ecosystem and play a key role in adjusting the climate and regulating various biochemical cycles. …”
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Tensile force impairs lip muscle regeneration under the regulation of interleukin‐10 by Xu Cheng, Jinfeng Dou, Jinggui Li, Yixuan Huang, Bing Shi, Jingtao Li

“…Abstract Background Orbicularis oris muscle, the crucial muscle in speaking, facial expression and aesthetics, is considered the driving force for optimal lip repair. Impaired muscle regeneration remains the main culprit for unsatisfactory surgical outcomes. …”
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