MHCI trafficking signal‐based mRNA vaccines strengthening immune protection against RNA viruses by Yupei Zhang, Songhui Zhai, Shugang Qin, Yuting Chen, Kepan Chen, Zhiying Huang, Xing Lan, Yaoyao Luo, Guohong Li, Hao Li, Xi He, Meiwan Chen, Zhongwei Zhang, Xingchen Peng, Xin Jiang, Hai Huang, Xiangrong Song

“…Abstract The major histocompatibility complex class I (MHCI) trafficking signal (MITD) plays a pivotal role in enhancing the efficacy of mRNA vaccines. …”
Get full text

A novel stemness-related lncRNA signature predicts prognosis, immune infiltration and drug sensitivity of clear cell renal cell carcinoma by Jia Liu, Lin Yao, Yong Yang, Jinchao Ma, Ruijian You, Ziyi Yu, Peng Du

“…Both in vitro and in vivo experiments confirmed the role of SRlncRNAs in the progression of ccRCC.…”
Get full text

The triptan formulations: a critical evaluation Formulações dos triptanos: avaliacão crítica by Marcelo E. Bigal, Carlos A. Bordini, Ana L. Antoniazzi, José G. Speciali

“…Delivery systems may play an important role in the onset of action of triptans. The selection of an acute antimigraine drug for a patient depends upon the stratification of the patient's migraine attack by peak intensity, time to peak intensity, level of associated symptoms such as nausea and vomiting, time to associated symptoms, comorbid diseases, and concomitant treatments that might cause drug-drug interactions. …”
Get full text

Agro-Ecological Assessment of Lands in Behshahr County for Lentil (Lens culinaris Medik.) Cultivation by Karim Reyahi, Hossein Kazemi, Afshin Soltani, Fardin Sadeghzadeh

“…Introduction Agriculture is one of the most important economic sectors of the country, and it plays a vital role in achieving sustainable development, which requires the use of scientific principles and methods and the recognition of environmental capabilities. …”
Get full text

SSL5-AnxA5 Fusion Protein Constructed Based on Human Atherosclerotic Plaque scRNA-Seq Data Preventing the Binding of Apoptotic Endothelial Cells, Platelets, and Inflammatory Cells by Yifei Zhao, Xingyu He, Teng Hu, Tianli Xia, Fangyang Huang, Changming Li, Yiming Li, Fei Chen, Mao Chen, Jun Ma, Yong Peng

“…We constructed the SSL5-AnxA5 fusion protein and observed its role in preventing the interaction between apoptotic endothelial cells, platelets, and inflammatory cells. …”
Get full text

High-LET Proton Irradiation Significantly Alters the Clonogenic and Tumorigenic Potential of Human Breast Cancer Cell Lines In Vitro and In Vivo by Margarita Pustovalova, Rita Mohammad, Yuzhe Wang, Wenyu Xue, Philipp Malakhov, Viktor Nekrasov, Elizaveta Kontareva, Zain Nofal, Vyacheslav Saburov, Dmitry Kolesov, Andreyan Osipov, Sergey Leonov

“…Our insights into entosis and the effect of extracellular matrix stiffness on metastatic propensity (nanoparticle uptake) enhance the understanding of the role of PBI in BC cells, emphasizing the need for more research to optimize its therapeutic application.…”
Get full text

Research progress of fuel ethanol refining and life cycle carbon footprint by Pan LI, Lulu ZHANG, Hai CHEN, Xingguo WU, Wei CHEN, Jing BAI, Chun CHANG, Junhao HU

“…Life cycle evaluation studies of fuel ethanol production technologies have shown that fuel ethanol plays an important role in mitigating climate change and achieving net zero emission targets by sequestering carbon fixed during biomass growth compared to fossil fuels. …”
Get full text

CURRENT TRENDS IN BONE AUGMENTATION DURING DENTAL IMPLANTATION IN PATIENTS WITH PARODONTAL PATHOLOGY AND JAW BONE ATROPHY (LITERATURE REVIEW) by Yu.O. Kinash, L.V. Kinash

“…Systemic factors and comorbidities in patients also play a significant role in reducing the bone volume of the jaws. …”
Get full text

ORAL MANIFESTATIONS OF VIRAL INFECTIONS IN CHILDREN by N.V. Yanko, L.F. Kaskova, I.Yu. Vashchenko, S.Ch. Novikova, O.S. Pavlenkova

“…Therefore, histological examination plays important role in diagnostics of HPV. Oral manifestations such as candidiasis, herpes labialis, and aphthous stomatitis represent some of the first signs of HIV immunodeficiency. …”
Get full text

Higher baseline platelet and preoperative platelets to lymphocytes ratio was associated with a higher incidence of axillary node pathologic complete response after neoadjuvant chem... by Shuai Yang, Guanying Liang, Junyi Sun, Lingbing Yang, Zitong Fu, Wantong Sun, Bo Wei, Abiyasi Nanding, Qin Wang, Shouping Xu

“…BackgroundHER2 expression has a central role in breast cancer carcinogenesis and is associated with poor prognosis. …”
Get full text

Cervical cerclage for prevention of preterm birth and adverse perinatal outcome in twin pregnancies with short cervical length or cervical dilatation: A systematic review and meta-... by Francesco D'Antonio, Nashwa Eltaweel, Smriti Prasad, Maria Elena Flacco, Lamberto Manzoli, Asma Khalil

“…<h4>Background</h4>The optimal approach to prevent preterm birth (PTB) in twins has not been fully established yet. …”
Get full text

Construction of Carbon Functional Zone in the Demonstration Zone of Green and Integrated Ecological Development of the Yangtze River Delta Based on Carbon Density Correction by Tian ZHANG, Zhen SHEN, Tingting SU, Daixin DAI

“…The growth of carbon sink enhancement zones is largely attributed to ecological restoration policies, such as the conversion of farmland to lakes and forests, underscoring the critical role of policy interventions in enhancing carbon sequestration capacity.ConclusionBased on these findings, the research proposes a spatially differentiated low-carbon governance framework for the Demonstration Zone, and emphasize three pillars. 1) Zonal Regulation: Implement strict protection measures in carbon sink enhancement zones, optimize land use efficiency in balance zones, and enforce emission reduction targets in control zones. 2) Ecological restoration priorities: Scale up reforestation, wetland conservation, and “sponge city” initiatives to amplify carbon sequestration. 3) Cross-regional collaboration: Establish a unified governance platform to harmonize policies, data sharing, and carbon trading mechanisms across administrative boundaries. …”
Get full text

Skimming and storage factors affect the detection of heat shock protein 70 in raw bovine milk by M.R.H. Rakib, V. Messina, J.I. Gargiulo, N.A. Lyons, I.N. Pathirana, P.C. Thomson, S.C. Garcia

“…Heat shock proteins (HSP) play a vital role in maintaining cellular function under elevated temperatures. …”
Get full text

Early hemodynamic impact of SGLT2 inhibitors in overweight cardiometabolic heart failure: beyond fluid offloading to vascular adaptation– a preliminary report by Nadia Salerno, Jessica Ielapi, Angelica Cersosimo, Isabella Leo, Assunta Di Costanzo, Giuseppe Armentaro, Salvatore De Rosa, Angela Sciacqua, Sabato Sorrentino, Daniele Torella

“…Our findings also highlight the potential role of non-invasive hemodynamic monitoring in guiding therapy in HF.…”
Get full text

Use of Large Language Models to Classify Epidemiological Characteristics in Synthetic and Real-World Social Media Posts About Conjunctivitis Outbreaks: Infodemiology Study by Michael S Deiner, Russell Y Deiner, Cherie Fathy, Natalie A Deiner, Vagelis Hristidis, Stephen D McLeod, Thomas J Bukowski, Thuy Doan, Gerami D Seitzman, Thomas M Lietman, Travis C Porco

“…Future studies should further explore LLMs’ potential to support public health monitoring through the automated assessment and classification of potential infectious eye disease or other outbreaks. Their optimal role may be to act as a first line of documentation, alerting public health organizations for the follow-up of LLM-detected and -classified small, early outbreaks, with a focus on the most severe ones.…”
Get full text

Diagnosis of Sarcopenia Using Convolutional Neural Network Models Based on Muscle Ultrasound Images: Prospective Multicenter Study by Zi-Tong Chen, Xiao-Long Li, Feng-Shan Jin, Yi-Lei Shi, Lei Zhang, Hao-Hao Yin, Yu-Li Zhu, Xin-Yi Tang, Xi-Yuan Lin, Bei-Lei Lu, Qun Wang, Li-Ping Sun, Xiao-Xiang Zhu, Li Qiu, Hui-Xiong Xu, Le-Hang Guo

“…By comprehensive comparison, we finally identified the optimal model (SARCO model) as the convenient solution. …”
Get full text

The Effect of Sowing Date on Yield and Quality Characteristics of Autumn Sugar Beet (Beta vulgaris L.) Cultivars in Gonbad Kavous by E Paserakloo, A Biabani, S Yarahamdi, A Saberi, M Naeemi, F Taliei

“…IntroductionIn many countries of the world, sugar production is one of the essential aspects of their agricultural economy, and in the meantime, the sugar beet plant, which is cultivated exclusively as a source of sucrose, plays an important role. In recent years, many studies have been conducted in Iran on various aspects of crop, breed, quality and other agricultural characteristics of autumn sugar beet. …”
Get full text

Evaluation of MODIS and VIIRS BRDF Parameter Differences and Their Impacts on the Derived Indices by Chenxia Wang, Ziti Jiao, Yaowei Feng, Jing Guo, Zhilong Li, Ge Gao, Zheyou Tan, Fangwen Yang, Sizhe Chen, Xin Dong

“…Multi-angle remote sensing observations play an important role in the remote sensing of solar radiation absorbed by land surfaces. …”
Get full text

Diseño, validación y fiabilidad de un instrumento de observación para evaluar la toma de decisión motriz en porteros de fútbol (SEDPO) (Design, validation and reliability of an obs... by Pedro Puigserver, Pere Lavega Burgués, Jorge Serna, Miguel Pic

“…Abstract. The goalkeeper role demarcation presents distinctive characteristics compared to other positions in soccer. …”
Get full text

Extraction and Coordination Chemistry of Mo(Ⅵ)/U(Ⅵ) With Unilateral Derivatized Phenanthroline Amide Ligands by Tao-yuan XIU, Yue-kun LIU, Meng ZHANG, Yi HONG, Guo-an YE, Cai-shan JIAO, Li-yong YUAN, Wei-qun SHI

“…Medical radioactive isotopes play a very important role in disease diagnosis and treatment, with 99Tcm drugs being widely used in disease diagnosis. 99Tcm is primarily obtained from its parent nuclide, 99Mo, through a 99Mo/99Tcm generator. …”
Get full text