From spheroids to organoids: next-generation models for CAR-T cell therapy research in solid tumors by Mégane Jassin, Alix Block, Alix Block, Laury Désiront, Louise Vrancken, Louise Vrancken, Céline Grégoire, Frédéric Baron, Frédéric Baron, Grégory Ehx, Grégory Ehx, Thi Tham Nguyen, Jo Caers, Jo Caers

“…Moreover, we explore the use of murine models in preclinical CAR-T research, highlighting their role in studying the dynamics of CAR-T cell trafficking, efficacy, and off-target effects. …”
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Exploring Treatment Protocol Adherence and Variations in Paroxysmal Supraventricular Tachycardia in the Emergency Department: A Multi-Center Cohort Study by Kevin Ku, Jack Healy, Christian A. Lee, Maha Khan, Kevin D. Chao, Saleh Hassan, Ching-Fang Tiffany Tzeng, Yu-Lin Hsieh, Andrew Shedd, Toral Bhakta, Dahlia Hassani, Eric H. Chou

“…Recognizing and addressing variations in guideline adherence can play a key role in improving patient care. Further prospective research is warranted to optimize dosing strategies and evaluate the impact of standardized protocols on clinical outcomes.…”
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Two zinc ABC transporters contribute to Rhizobium leguminosarum symbiosis with Pisum sativum and Lens culinaris by Joanna N. Soldek, Marta Ballesteros-Gutiérrez, Laura Díaz-Sáez, Ignacio Delgado-Santamaría, José Manuel Palacios, José Manuel Palacios, Marta Albareda, Marta Albareda

“…We demonstrate that at least one of the two systems must be present for Rlv to grow under zinc-limiting conditions and for optimal symbiotic performance with pea and lentil plants. …”
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Influence of calcium sources on the bio-mineralization behavior of Shewanella putrefaciens and induced microbiologically influenced corrosion inhibition by Yuntian Lou, Yuntian Lou, Yuntian Lou, Hao Zhang, Hao Zhang, Weiwei Chang, Weiwei Chang, Jingzhi Yang, Jingzhi Yang, Xudong Chen, Xiangping Hao, Xiangping Hao, Hongchang Qian, Hongchang Qian, Hongchang Qian, Dawei Zhang, Dawei Zhang, Dawei Zhang

“…These findings emphasize the crucial role of calcium source selection in MICI and provide insights for optimizing microbial mineralization strategies for corrosion mitigation.…”
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Microbial biomarker discovery in Parkinson’s disease through a network-based approach by Zhe Zhao, Jing Chen, Danhua Zhao, Baoyu Chen, Qi Wang, Yuan Li, Junyi Chen, Chaobo Bai, Xintong Guo, Nan Hu, Bingwei Zhang, Rongsheng Zhao, Junliang Yuan

“…Herein, we performed a meta-analysis to investigate the pivotal role of the gut microbiome in PD and its potential diagnostic implications. …”
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Identification of neutralizing nanobodies protecting against poxvirus infection by Xuehua Yang, Li Guo, Huarui Duan, Miao Fan, Fengwen Xu, Xiaojing Chi, Shengnan Pan, Xiuying Liu, Xinhui Zhang, Peixiang Gao, Fangyuan Zhang, Xinyi Wang, Fei Guo, Jiwan Ge, Lili Ren, Wei Yang

“…Notably, the M1R-01-based antibody strategy provided optimal protection against a lethal VACV challenge in mice. …”
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ANALYSIS OF THE INFLUENCE OF SOCIAL CAPITAL ON ENTREPRENEURIAL ORIENTATION AND ENTREPRENEURIAL BEHAVIOR: A STUDY ON STARTUPS IN JABODETABEK by Rendy Gunawan, Novita Ikasari

“…Research implications: Social capital, in the form of robust social networks, plays an important role in enhancing entrepreneurial orientation and behavior, including proactiveness, innovation, and risk taking. …”
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Comparative chemical characters of Ziziphi Spinosae Semen from geographical origins of China by Pengwang Wang, Miao Sha, Weimei Zhang, Hongyue Tian, Xu Liang, Wei Tian, Bo Xu, Guanglu Chang, Xia Li, Wenyuan Gao

“…This study confirmed that ZSS played a synergistic role in improving insomnia through multiple components, targets, and pathways. …”
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Tracheostomy Practice in the Italian Intensive Care Units: A Point-Prevalence Survey by Raffaele Merola, Maria Vargas, Filippo Sanfilippo, Marco Vergano, Giovanni Mistraletti, Luigi Vetrugno, Gennaro De Pascale, Elena Giovanna Bignami, Giuseppe Servillo, Denise Battaglini

“…<i>Conclusions</i>: These findings highlight the critical role of tracheostomy in the management of critically ill patients within Italian ICUs. …”
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A study on the function of methionine in growth, immunity, antioxidant, endoplasmic reticulum stress and apoptosis of largemouth bass (Micropterus salmoides) by Hualiang Liang, Dongyu Huang, Mingchun Ren, Lu Zhang, Haifeng Mi, Ahmed Mohamed Aboseif, Chunyu Xue, Jiaze Gu

“…Hence, Met plays a crucial role in regulating growth, immunity, antioxidant, ERS and apoptosis in largemouth bass.…”
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Urgent and emergent radiotherapy for hematologic malignancies of the central nervous system: a review of the literature and practical approach by Kathryn R. Tringale, Brandon S. Imber, Gustav Y. Cederquist, Joachim Yahalom, Zachary R. Moore, Richard T. Hoppe, Michael S. Binkley, Jason B. Ross, N. Ari Wijetunga, Parag Sanghvi, Dana L. Casey, Susan M. Hiniker

“…Often, mid-treatment re-planning can be considered to address swift volume reduction to improve the therapeutic window. RT plays a promising role for bridging symptomatic patients to novel therapeutics (e.g., chimeric antigen receptor T-cell therapy), but optimal dosing and treatment volumes are evolving topics that require further prospective evaluation.ConclusionsRT is a powerful tool for achieving rapid responses in hematologic malignancies and therefore should be considered early in urgent neurologic settings. …”
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Organic-based remediation of heavy metal-contaminated soils in the Taojia river basin affected by long-term non-ferrous mining and logging activities by Yan Zeng, Taimoor Hassan Farooq, Taimoor Hassan Farooq, Chenglin Yuan, Wang Li, Asma Farooq, Guangjun Wang, Yingchun Fang, Jun Wang, Wende Yan

“…These findings demonstrate CM compost’s dual role in improving fertility and mitigating Pb/Cd uptake, though Zn/Cu accumulation risks require careful management.…”
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Current situation of comprehensive utilization of coal gangue and exploration of ways of high-value utilization:A case study of China National Coal Group Corporation by Lei ZHU, Wenzhe GU, Zhiwei HE, Chengyong LIU, Mengye ZHAO, Tianqi SONG, Yun ZHANG, Yuyi WU, Zhicheng LIU, Xinfu ZHANG, Peng ZHANG, Fengtian SHENG

“…Relying on its rich coal resource reserves, China Coal plays an important role in ensuring the country’s energy supply. However, while high-yield and efficient mining of coal resources, a large amount of coal gangue is produced, causing pollution to soil, air, water and other countries. …”
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Reference Interval for Glycated Albumin, 1,5-AG/GA, and GA/HbA1c Ratios and Cut-Off Values for Type 1, Type 2, and Gestational Diabetes: A Cross-Sectional Study by Yusra Al-Lahham, Waldemar Volanski, Liana Signorini, Ademir Luiz do Prado, Glaucio Valdameri, Vivian Rotuno Moure, Marciane Welter, Alexessander C. Alves, Marcel Henrique Marcondes Sari, Fabiane Gomes de Moraes Rego, Geraldo Picheth

“…Clinicians might leverage GA and AGI ratios for more tailored diabetes management, especially when HbA1c results are not optimal.…”
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A Systematic Review on the Use of Big Data in Tourism by Jafar Ahangaran, Abbas Sadeghnia

“…By describing the need for demand forecasting and price optimization in tourism, Jiang et al. believe that accurate demand forecasting helps tourism businesses to optimize pricing and resource allocation. …”
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Irisin attenuates SARS-CoV-2 entry into cells and cell damage in 2D and 3D cultures of human subcutaneous adipocytes by Maria Teresa De Sibio, Ester Mariane Vieira, Paula Barreto Da Rocha, Miriane De Oliveira, Regiane Marques Castro Olímpio, Vinícius Vigliazzi Peghinelli, Lucas Solla Mathias, Helena Paim Tilli, Bianca Mariani Gonçalves, Igor Deprá, Maria Beatriz Bravin, Mariana Menezes Lourenço, Giovanna Bonatto Luca, Matheus de Souza Marino, Pedro Henrique Soares Kossooski, Camila Renata Corrêa, Marna Eliana Sakalem, Cormarie Fernández Pulido, Célia Regina Nogueira

“…Materials and methods: Preadipocytes were cultured to maturity in 2D or 3D conditions and divided into four groups: Group 1: adipocytes with no treatment; Group 2: adipocytes optimized for angiotensin-converting enzyme 2 (ACE2) expression; Group 3: adipocytes optimized for ACE2 expression, and then exposed to SARS-CoV-2 pseudovirus (ACE2+PV); and Group 4: adipocytes treated with irisin 20 nM for 24 h, optimized for ACE2 expression and exposed to PV (ACE2+I+PV). …”
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Artificial intelligence and machine learning in acute respiratory distress syndrome management: recent advances by Songbei Li, Songbei Li, Ruiming Yue, Sen Lu, Jingchao Luo, Xiaoxiao Wu, Zhao Zhang, Mingzong Liu, Yuxin Fan, Yuxin Fan, Yuxuan Zhang, Yuxuan Zhang, Chun Pan, Xiaobo Huang, Hongli He

“…Furthermore, we detail AI's role in optimizing mechanical ventilation (e.g., PEEP settings, patient-ventilator asynchrony detection, mechanical power-guided strategies), facilitating Extracorporeal Membrane Oxygenation (ECMO) support decisions, and advancing drug discovery. …”
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PARP inhibitors in testicular germ cell tumors: what we know and what we are looking for by Sara Parola, Christoph Oing, Pasquale Rescigno, Salvatore Feliciano, Francesca Carlino, Luca Pompella, Antonella Lucia Marretta, Irene De Santo, Martina Viggiani, Margherita Muratore, Bianca Arianna Facchini, Jessica Orefice, Eleonora Cioli, Francesca Sparano, Domenico Mallardo, Ugo De Giorgi, Giovannella Palmieri, Paolo Antonio Ascierto, Margaret Ottaviano

“…This narrative review explores the potential role of PARP inhibitors (PARPis) in overcoming cisplatin resistance in TGCTs, starting from the rationale of their ability to induce DNA damage in cells with homologous recombination repair (HRR). …”
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Neural stem cell-derived small extracellular vesicles: a new therapy approach in neurological diseases by Mengyao Wang, Mengyao Wang, Dongdong Chen, Dongdong Chen, Renjie Pan, Renjie Pan, Yue Sun, Yue Sun, Xinyu He, Xinyu He, Youming Qiu, Youming Qiu, Yuexin Hu, Yuexin Hu, Xiangsheng Wu, Xiangsheng Wu, Xuxiang Xi, Xuxiang Xi, Rong Hu, Rong Hu, Zhigang Jiao, Zhigang Jiao, Zhigang Jiao, Zhigang Jiao, Zhigang Jiao

“…NSC-derived small extracellular vesicles (NSC-sEVs), a prominent component of the NSC secretome, play a crucial role in modulating various physiological and pathological processes, such as regulating the NSC microenvironment, promoting endogenous NSC differentiation, and facilitating the maturation of neurons and glial cells. …”
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ADAR1 as a prognostic marker for patients with colorectal cancer and synchronous liver metastasis and a predictor of chemotherapy efficacy by Kaori Nitta, Kunitoshi Shigeyasu, Yoshitaka Kondo, Hibiki Umeda, Toshiaki Takahashi, Kazuya Moriwake, Kazuhiro Yoshida, Sho Takeda, Yuki Matsumi, Hiroyuki Kishimoto, Tomokazu Fuji, Kazuya Yasui, Kosei Takagi, Masashi Kayano, Shunsuke Nakamura, Hiroyuki Michiue, Hideki Yamamoto, Nobuhiko Kanaya, Yuhei Kondo, Eiki Miyake, Yusuke Yoshida, Ryohei Shoji, Yoshihiko Kakiuchi, Hiroshi Tazawa, Shunsuke Kagawa, Toshiyoshi Fujiwara

“…Abstract RNA editing by adenosine deaminase acting on RNA (ADAR) enzymes plays a role in cancer progression. However, its clinical significance in metastatic colorectal cancer (CRC) remains unclear. …”
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