Probiotic efficacy and mechanism of a pigeon derived Ligilactobacillus salivarius strain in promoting growth and intestinal development of pigeons by Puze Zhao, Yumei Li, Yuwei Yang, Qingxing Xiao, Ziyi Zhang, Xiaoqing Hong, Hongyu Ni, Zhuxuan Xia, Kun Zhan, Sibao Yang, Yonghong Zhang

“…In the development of antibiotic alternatives, probiotics, particularly host-associated probiotics, have been found to play a significant role in enhancing the production performance of livestock and poultry. …”
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Plant Dominant Low-Protein Diet, Nutritional Status (Phase Angle) and Progression of Renal Failure: Case-Report Study by Danijela Ristic-Medic, Snjezana Petrovic, Biljana Pokimica, Marija Paunovic, Vesna Vucic

“…The quality of dietary protein may also play a role in kidney health. Several observational studies have shown that compared with protein from plant sources, animal protein is associated with an increased risk of end-stage chronic kidney disease (CKD). …”
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Assessment of male partner involvement in triple ART drug adherence and associated factors among HIV-positive pregnant women in government hospitals of the North Gojjam Zone, Amhar... by Yitayal Ayalew Goshu, Tegegne Wale Belachew, Assefa Kebie Mitiku, Dagnaw Mersha Tegegne, Begizew Yimenu Mekuriaw, Temesgen Dessie Mengistu, Wassie Yazie Ferede, Fillorenes Ayalew Sisay, Besfat Berihun Erega, Selamawit Girma Tadesse, Yaregal Dessalew Tariku

“…Background The involvement of male partners in the care and treatment of HIV-positive pregnant women is essential for improving health outcomes and ensuring optimal adherence to antiretroviral therapy (ART). …”
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Sex-Related Differences in Glioblastoma: A Single-Center Retrospective Cohort Study by Chiara Prosperetti, Meltem Yenigün, Alberto Pagnamenta, Payam Tabaee Damavandi, Giulio Disanto, Francesco Marchi, Vittoria Espeli, Barbara Muoio, Paolo Spina, Gianfranco Pesce, Pamela Agazzi

“…<b>Background</b>: Sex differences play a significant role in the epidemiology, biology, and outcomes of many cancers, including glioblastoma (GB), the most common and aggressive primary brain tumor. …”
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The Mechanism of Aniline Blue Degradation by Short-Chain Dehydrogenase (<i>SDRz</i>) in <i>Comamonas testosteroni</i> by Chuanzhi Zhang, Yong Huang, Jiaxin He, Lei He, Jinyuan Zhang, Lijing Yu, Elshan Musazade, Edmund Maser, Guangming Xiong, Miao Xu, Liquan Guo

“…Through prokaryotic transcriptome analysis, we identified a significantly upregulated short-chain dehydrogenase (<i>SDRz</i>) gene (log₂FC = 2.11, <i>p</i> < 0.05) that plays a crucial role in the degradation process. The SDRz enzyme possessed highly conserved motifs and a typical short-chain dehydrogenase structure. …”
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First-principles investigation of structural, electronic, optical, and mechanical properties of novel metallic ternary halides K3XBr6 (X = Sc, Y) by Jaffer Saddique, Amir Ullah, Khamael M. Abualnaja, Ahmed Azzouz-Rached, Nasir Rahman, Mudasser Husain, M.D. Alshahrani, Amani H. Alfaifi, Eman Almutib, Vineet Tirth, Ali Algahtani, Abid Ali Khan, Rajwali Khan

“…The valence band structure is predominantly shaped by bromine p-orbital contributions, which play a central role in the electronic behavior. Optical analysis highlights their potential in optoelectronic applications such as lasers, solar cells, and plasmonic devices, with K3ScBr6 optimized for ultraviolet response and K3YBr6 covering both ultraviolet and visible regions. …”
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Enhancing Antimicrobial Peptides from Frog Skin: A Rational Approach by Silvana Aguilar, Daniel Moreira, Ana Laura Pereira Lourenço, Natalia Wilke, Matías A. Crosio, Andreanne Vasconcelos, Eder Alves Barbosa, Elizabete C. I. Bispo, Felipe Saldanha-Araujo, Marcelo H. S. Ramada, Franco M. Escobar, Cristina V. Torres, José R. S. A. Leite, Mariela M. Marani

“…These derivatives exhibited enhanced activity against Gram-negative bacteria, emphasizing the role of cationicity and the strategic arginine incorporation. …”
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Prognostic differences between persistent HFrEF and HFrecEF following acute myocardial infarction by Jeong Yoon Jang, Jae Myoung Lee, Yujin Shin, Yong-Lee Kim, Gain Yu, Jae Seok Bae, Yun-Ho Cho, Choong Hwan Kwak, Min Gyu Kang, Kye-Hwan Kim, Jeong Rang Park, Jin-Yong Hwang, Young-Hoon Jeong, Jong-Hwa Ahn

“…Tailored management approaches, combined with routine echocardiographic monitoring and adherence to optimal medical therapy, are essential for optimizing patient care and long-term prognosis.…”
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Impact of CYP3A4 and ABCB1 genetic variants on tacrolimus dosing in Greek kidney transplant recipients by Anna Tsironi, Konstantinos Lazaros, Effrosyni Mendrinou, Marios Papasotiriou, Stavroula Siamoglou, Kyriaki Kydonopoulou, Anne John, Alexandra Gerou, Spyridon Gerou, Bassam R. Ali, Bassam R. Ali, Aristidis G. Vrahatis, George P. Patrinos, George P. Patrinos, George P. Patrinos, George P. Patrinos, George P. Patrinos

“…As a result, investigating the role of genetic variation in Greek transplant recipients becomes crucial to optimizing therapeutic strategies and enhancing the efficacy of immunosuppressive treatment.HypothesisGenetic variants which are known to influence the activity of enzymes or drug-transporters critical to tacrolimus pharmacokinetics, may significantly affect the required kidney post-transplant tacrolimus daily dose.AimTo assess the correlation of ABCB1 genetic variants (rs1128503, rs2229109) and CYP3A4 (rs2242480, rs4986910) with tacrolimus dose-adjusted trough concentration (C0/D), in Greek kidney transplant recipients.MethodsNinety-four unrelated Greek kidney transplant recipients were included in this study from the Department of Nephrology and Kidney Transplantation of the University General Hospital of Patras. …”
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Specific Requirement of the p84/p110γ Complex of PI3Kγ for Antibody‐Activated, Inducible Cross‐Presentation in Murine Type 2 DCs by Despoina Koumantou, Aimé Cézaire Adiko, Pierre Bourdely, Mathilde Nugue, Erwan Boedec, Jamel El‐Benna, Renato Monteiro, Cosmin Saveanu, Muriel Laffargue, Matthias P. Wymann, Marc Dalod, Pierre Guermonprez, Loredana Saveanu

“…Abstract Cross‐presentation by MHCI is optimally efficient in type 1 dendritic cells (DC) due to their high capacity for antigen processing. …”
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Not stealing from the treasure chest (or just a bit): Analyses on plant derived writing supports and non-invasive DNA sampling. by Anna Schulz, Silke Lautner, Jörg Fromm, Markus Fischer

“…Written communication plays a crucial role in the history of modern civilizations as manuscripts do not only exist contemporarily, but are passed on to subsequent generations. …”
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Engineering fibroblast with reprogramming and spheronization for bone defect repair by Yanjiao Li, Bin Jiang, Zhen Wu, Zhaoxia Ma, Lihua Qiu, Wen Cui, Yunhui Zhao, Jinghe Yan, Daiping Ma, Xingfei Wu, Shu Liang, Sitao Wang, Yanqun Zhao, Mengting Wang, Min Hu

“…Osteoblasts play a crucial role in bone formation and are ideal candidates for treating bone diseases and engineering living materials. …”
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Enhanced identification of Morganella spp. using MALDI-TOF mass spectrometry by Mathilde Duque, Cécile Emeraud, Rémy A. Bonnin, Quentin Giai-Gianetto, Laurent Dortet, Alexandre Godmer

“…Introduction: The genus Morganella, including clinically isolated species M. sibonii and M. morganii, has a still underexplored role in clinical microbiology. Despite the clinical relevance of Morganella spp., current MALDI-TOF commercial systems fail to differentiate these species. …”
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Population-based colorectal cancer risk prediction using a SHAP-enhanced LightGBM model by Guinian Du, Hui Lv, Yishan Liang, Jingyue Zhang, Qiaoling Huang, Guiming Xie, Xian Wu, Hao Zeng, Lijuan Wu, Jianbo Ye, Wentan Xie, Xia Li, Yifan Sun

“…This tool shows significant potential for optimizing early diagnosis and personalized risk assessment in CRC management.…”
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Immunogenicity and Safety Profile of Two Adjuvanted-PD-L1-Based Vaccine Candidates in Mice, Rats, Rabbits, and Cynomolgus Monkeys by Camila Canaán-Haden, Javier Sánchez-Ramírez, Rafael Martínez-Castillo, Mónica Bequet-Romero, Pedro Puente-Pérez, Isabel Gonzalez-Moya, Yunier Rodríguez-Álvarez, Marta Ayala-Ávila, Jorge Castro-Velazco, Olivia Cabanillas-Bernal, Marco A. De-León-Nava, Alexei F. Licea-Navarro, Yanelys Morera-Díaz

“…The investigation of potential toxicities associated with PD-L1 blockade by a new therapy in preclinical studies is critical to optimizing the efficacy and safety of that new therapy. …”
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A decade of progress in type 2 diabetes and cardiovascular disease: advances in SGLT2 inhibitors and GLP-1 receptor agonists – a comprehensive review by David Aristizábal-Colorado, David Aristizábal-Colorado, David Corredor-Rengifo, David Corredor-Rengifo, Santiago Sierra-Castillo, Carolina López-Corredor, David-Alexander Vernaza-Trujillo, David-Alexander Vernaza-Trujillo, David-Alexander Vernaza-Trujillo, Danilo Weir-Restrepo, Juan S. Izquierdo-Condoy, Esteban Ortiz-Prado, Jorge Rico-Fontalvo, Jorge Rico-Fontalvo, Juan-Esteban Gómez-Mesa, Juan-Esteban Gómez-Mesa, Alin Abreu-Lomba, Wilfredo-Antonio Rivera-Martínez, Wilfredo-Antonio Rivera-Martínez

“…It also highlights key evidence supporting their combined use and underscores their critical role in optimizing long-term outcomes in patients with T2DM and cardiovascular disease.…”
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Gut microbiota modulation and health benefits of various fasting regimens by Sumel Ashique, Biplab Debnath, Naheed Mojgani, Mohd. Tariq, Tanweer Haider, Eman Shorog, Sabina Yasmin, Anas Islam, Himanshu Sharma, Md Sadique Hussain, Ayush Madan, Tabarak Malik, Mohammad Yousuf Ansari

“…Developing personalized fasting strategies tailored to an individual’s baseline microbiota and metabolic phenotype may optimize the therapeutic potential of fasting for gut and metabolic health.…”
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TET2 orchestrates YAP signaling to potentiate targetable vulnerability in hepatocellular carcinoma by Jing He, Mingen Lin, Fei Teng, Xue Sun, Ziyin Tian, Jiaxi Li, Yan Ma, Yue Dai, Yi Gao, Hongchen Li, Tongguan Tian, Kai Xu, Xinxing Li, Lei Lv, Yanping Xu

“…Although various therapies have substantially ameliorated clinical outcome, patients invariably suffer from cancer relapse, highlighting the need for more optimized therapeutic strategies. Here, we report that deficiency of DNA methylcytosine dioxygenase TET2 sensitizes HCC cells to sorafenib and verteporfin treatments. …”
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Occurrence of Uncultured <i>Legionella</i> spp. in Treated Wastewater Effluent and Its Impact on Human Health (SCA.Re.S Project) by Osvalda De Giglio, Giusy Diella, Francesco Bagordo, Antonella Francesca Savino, Angelantonio Calabrese, Mariavirginia Campanale, Francesco Triggiano, Francesca Apollonio, Valentina Spagnuolo, Marco Lopuzzo, Tiziana Grassi, Maria Clementina Caputo, Silvia Brigida, Federica Valeriani, Vincenzo Romano Spica, Maria Teresa Montagna

“…Wastewater treatment plants (WWTPs) provide optimal conditions for the environmental spread of <i>Legionella</i>. …”
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Central Nervous System Prophylaxis Approach in High‐Risk Diffuse Large B‐Cell Lymphoma Patients: A Retrospectively Collected, Single‐Center Cohort Analysis by Yanli Wang, Xiaolian Wen, Tao Guan, Hongwei Zhang, Wei'e Han, Min Bai, Xiaolan Liu, Min Zhang, Liping Su, Weihua Zhang

“…Conclusion Owing to the lack of robust evidence, the role of HD‐MTX in preventing CNS recurrence could not be conclusively determined. …”
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