Building a potent TREM2 agonistic, biparatopic, common light chain antibody by Ana da Silva Almeida, Melissa L. Geddie, Anil Bhate, Chao Quan, Joseph W. Arndt, Yang Jiao, Joseph C. Santoro, Liron Noiman, Ramya Vijayakumar, Jorge Sanchez-Salazar, Abhishek Datta, Giovanna Antognetti, Ciputra Adijaya Hartana, Xue Fan Wang, Benjamin A. Smith, Dan Bartlett, Danté Duncan, Chia-Chen Liu, Karel Otero Gutierrez, Thomas O. Cameron, Samir Koirala, Heather A. Cooke

“…Triggering Receptor Expressed on Myeloid cells 2 (TREM2) plays an important role in microglial function and has been genetically linked to Alzheimer’s disease. …”
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The Impact of Chitinase Binding Domain Truncation on the Properties of <i>Ca</i>Chi18B from <i>Chitinilyticum aquatile</i> CSC-1 by Chenxi Gu, Jianrong Chen, Xinyue Huang, Yongqiang Jiang, Na Ou, Dengfeng Yang, Mingguo Jiang, Lixia Pan

“…The chitinase binding domain (ChBD) plays a crucial role in the properties of enzymes. To assess its impact, we cloned a truncated mutant of the chitinase gene <i>CaChi18B</i> from the novel chitinase-producing facultative anaerobic bacterium <i>Chitinilyticum aquatile</i> CSC-1, designated as <i>CaChi18B_ΔChBD_s</i>. …”
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3D copper telluride morphological leaf structure based triboelectric nanogenerator for wearable sensing application by Muhammad Umair Khan, Sumayya M. Ansari, Haila M. Aldosari, Baker Mohammad

“…The highly electronegative nature of PVDF plays a crucial role in optimizing the triboelectric charge separation by significantly enhancing the electron affinity at the interface. …”
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CyberKnife in Pediatric Oncology: A Narrative Review of Treatment Approaches and Outcomes by Costanza M. Donati, Federica Medici, Arina A. Zamfir, Erika Galietta, Silvia Cammelli, Milly Buwenge, Riccardo Masetti, Arcangelo Prete, Lidia Strigari, Ludovica Forlani, Elisa D’Angelo, Alessio G. Morganti

“…This review emphasizes the need for balanced evaluations of CK and highlights the importance of planning prospective studies and long-term follow-ups to refine its role in pediatric oncology. A recent German initiative to establish a CK registry for pediatric CNS lesions holds significant promise for advancing evidence-based applications and optimizing treatment strategies in this vulnerable population.…”
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Defining acceptance criteria for silver nanoparticles: correlating synthesis quality with biological outcomes in an In Vitro Lung Cancer Model by Bárbara Gomes, Marjorie Dardis Murucci, Wanderson de Souza, Beatriz Kopke Dal-Cheri, Ana Resende, Natália Yoshihara, Luths Geaquinto, José Mauro Granjeiro, Celso Sant'Anna, Leonardo Boldrini

“…Surface coatings played a pivotal role, with citrate-stabilized AgNPs exhibiting rapid cytotoxicity and PVA-stabilized AgNPs showing sustained effects. …”
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Gibberellin-induced germination enhancement in Chinese sour jujube seeds under cold stress by Qiang Chen, Guolong Li, Jinao Duan, Zhishu Tang, Zhongxing Song, Hongbo Liu, Xinbo Shi

“…Although Gibberellin A3 (GA3) regulates seed germination, its role in alleviating low temperature stress and its potential mechanisms in Chinese sour jujube are still unclear. …”
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Preparation of Nitrogen-Doped Carbon-Supported Co-V Catalyst for Catalystic Depolymerization of Lignin to Produce Monophenolic Compounds by Yuqiao MA, Xingwang LIU, Yong QIAN, Xinping OUYANG

“…Notably, Co1-V3/NC (30) outperformed commercial catalysts (Co1-V3/AC and Co1-V3/ZSM-5), demonstrating the critical role of nitrogen-doped carbon in anchoring and dispersing metal active components. 2D-HSQC NMR analysis confirmed the catalyst′s exceptional activity in cleaving both C—O and C—C bonds between lignin structural units, enabling efficient degradation into monophenolic compounds. …”
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Comparative Analysis of Laboratory Markers, Severity Scores, and Outcomes in 179 Patients with Severe Acute Pancreatitis by Tudorel Mihoc, Catalin Pirvu, Amadeus Dobrescu, Dan Brebu, Anca Monica Oprescu Macovei, Stelian Pantea, Claudia Borza, Patrick Dumitrescu, Monica Laura Cara

“…Further research should explore targeted management strategies for high-risk groups and refine the role of delayed or minimally invasive approaches in severe acute pancreatitis management.…”
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Development and Validation of a Large Language Model–Powered Chatbot for Neurosurgery: Mixed Methods Study on Enhancing Perioperative Patient Education by Chung Man Ho, Shaowei Guan, Prudence Kwan-Lam Mok, Candice HW Lam, Wai Ying Ho, Calvin Hoi-Kwan Mak, Harry Qin, Arkers Kwan Ching Wong, Vivian Hui

“… BackgroundPerioperative education is crucial for optimizing outcomes in neuroendovascular procedures, where inadequate understanding can heighten patient anxiety and hinder care plan adherence. …”
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Surgical timing and clinical factor predicting in-hospital mortality in older adults with hip fractures: a neuronal network analysis by Raffaele Vitiello, Elisa Pesare, Giacomo Capece, Emidio Di Gialleonardo, Andrea De Matthaeis, Francesco Franceschi, Giulio Maccauro, Marcello Covino

“…This study aims to evaluate the relationship between surgical timing and in-hospital mortality, analyzing the role of both acute events and chronic preexisting comorbidities in patient outcomes. …”
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Penguatan Pola Asuh Orang Tua bagi Perkembangan Kognitif Anak di Desa Guci Kecamatan Sirampog by Jamiah Jamiah

“…In the family, parents have a big role in influencing the development of children's cognitive intelligence. …”
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Effect of diabetes mellitus on spinal cord high signal relief after anterior cervical spine surgery in patients with cervical spondylotic myelopathy by Zichuan Wu, Xuhong Zhang, Hanlin Song, Aochen Xu, Baifeng Sun, Chen Xu, Min Qi, Yang Liu

“…By focusing on this intersection, the research intends to provide deeper insights into personalized treatment strategies for optimizing neurological recovery in CSM patients with concomitant diabetes. …”
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Association of SP-A and SP-D Surfactant Proteins with the Severity of CommunityAcquired Pneumonia by O. S. Kharlamova, K. Y. Nikolayev, Y. I. Ragino, M. I. Voyevoda

“…Surfactant proteins SP-A and SP-D play a key role in the pathogenesis of the response to microbial invasion of lung tissue, which participate in a cascade of reactions of both innate and adaptive immunity, and therefore proteins SP-A and SP-D may be considered as markers of the severity of community-acquired pneumonia (CAP).Aim of study. …”
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Engineering FcRn binding kinetics dramatically extends antibody serum half-life and enhances therapeutic potential by Sanghwan Ko, Migyeong Jo, Munsu Kyung, Wonju Lee, Woo Hyung Ko, Jung-Hyun Na, Youn Seo Chun, Byoung Joon Ko, Sang Taek Jung

“…Abstract Background Optimizing the IgG Fc domain for neonatal Fc receptor (FcRn) binding is crucial for enhancing antibody pharmacokinetics. …”
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Staphylococcus biofilm dynamics and antibiotic resistance: insights into biofilm stages, zeta potential dynamics, and antibiotic susceptibility by T. Lavoie, K. E. Daffinee, M. L. Vicent, K. L. LaPlante

“…Furthermore, it highlights the efficacy of daptomycin in eradicating biofilm while identifying possibilities of optimal antibiotic concentration windows, a critical consideration for mitigating resistance and achieving effective infection control. …”
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Assessment of biochar filter application in improving chromium stress tolerance and plant physiology in Chinese cabbage (Brassica rapa) under a flow-through water setup by Shuangqi Yue, Weidong Li, Fengyue Qin, Menglu Dong, Guojie Weng, Hayssam M. Ali, Jiechang Weng, Sajid Mehmood

“…The 2.5 g/L dose was identified as optimal, reducing Cr accumulation in aerial tissues by 62.4% and increasing soluble protein content by 114%. …”
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Riboflavin Status in Pregnancy and Its Relationship with Blood Pressure, Heart Rate and Risk of Hypertension: Findings from the OptiPREG Observational Study by Bethany Duffy, Helene McNulty, Mary Ward, Elina Psara, Emma O’Sullivan, Geraldine Horigan, Kristina Pentieva

“…Clinical riboflavin deficiency is common in low- and middle-income countries, whilst sub-optimal riboflavin status may be much more prevalent globally than generally recognized, including in high-income countries. …”
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Inflammatory Burden Index: A Superior Prognostic Biomarker of Systemic Inflammation in Patients on Peritoneal Dialysis by Chen J, Tang R, Tian N, Deng J, Ao S, Peng F, Zhan X, Wen Y, Wang X, Feng X, Su N, Tang X, Wu X, Zhou Q, Xu Q

“…However, studies focusing on the comparisons of their role on predictive efficacy for prognosis of PD patient are limited and results are inconsistent. …”
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Production performance of eel Anguilla bicolor bicolor with the addition of calsium carbonat by Ardyen Saputra, Tatag Budiardi, Eddy Supriyono

“…The objective of the study was to determining the optimal media levels of calcium and alkalinity that can support the survival and growth of eel Anguilla bicolor bicolor and evaluate the role of calcium and alkalinity. …”
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Diet quality, food security and traditional food intake of pregnant and breastfeeding women, and children 6 months to 5 years, living in eight remote Australian Aboriginal and Torr... by Emma Tonkin, Mark D. Chatfield, Julie Brimblecombe, Sue Kleve, Ellie Chan, Caroline Deen, Clare Brown, Emma Stubbs, Sue Booth, Kani Thompson, Jenna Pauli, Dympna Leonard, Amanda Lee, Bronwyn Fredericks, Megan Ferguson

“…Conclusions Remote community families carry out practices that protect and support the diet quality of children despite conditions that challenge food security and optimal diets. The role of traditional food consumption in reducing the impact of food insecurity on diet quality provides further evidence for Aboriginal and Torres Strait Islander food systems to be at the centre of comprehensive efforts to address food insecurity. …”
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