Association of triglyceride-glucose index and estimated glucose disposal rate with outcomes in patients with acute myocardial infarction: Cumulative effect and mediation analysis. by Yazhao Sun, Pei Sun, Dongsheng Liu

“…Subgroup analyses were conducted, and mediation analysis was performed to explore the potential mediating role of METS-IR in the relationship between TyG index and MACCEs.…”
Get full text

Synthesis and properties of some 3-(5-(4-methoxyphenyl)pyrazol-3-yl)-6-R-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles by S. O. Fedotov, A. S. Hotsulia, O. I. Panasenko

“… Pyrazole and 1,2,4-triazole derivatives play an important strategic role in modern medicine and pharmacy. This fact is due to the significant possibilities of chemical modification and significant pharmacological potential among the derivatives of these heterocycles. …”
Get full text

<italic>WiLongH</italic>: A Custom Hand-Held Platform for Long-Range HaLow Mesh Networks in Human-to-Human Communication by Kavin Kumar Thangadorai, Krishna M. Sivalingam, Anshul Pandey, Kumar Murugesan, Madhan Raj Kanagarathinam

“…Over the past 25 years, IEEE 802.11 (Wi-Fi) has played a vital role in last-mile Internet connectivity. The Wi-Fi HaLow (802.11ah) standard marks a significant leap, offering long-range, low-power connectivity, particularly suited for Internet of Things (IoT) applications. …”
Get full text

Explainable machine learning reveals ribosome biogenesis biomarkers in preeclampsia risk prediction by Jingjing Chen, Dan Zhang, Chengxiu Zhu, Lin Lin, Kejun Ye, Ying Hua, Mengjia Peng

“…Ribosome biogenesis, critical for cellular homeostasis, is hypothesized to drive placental dysfunction in PE, though its role remains underexplored.MethodsWe integrated placental transcriptomic data from two datasets (GSE75010, GSE10588) to systematically investigate ribosome biogenesis dysregulation in preeclampsia. …”
Get full text

Integrative single-cell and exosomal multi-omics uncovers SCNN1A and EFNA1 as non-invasive biomarkers and drivers of ovarian cancer metastasis by Liping Tang, Dong Pang, Chengbang Wang, Jiali Lin, Shaohua Chen, Jiangchun Wu, Junqi Cui

“…CellChat analysis demonstrated that highly differentiated tumor cells extensively engaged with fibroblasts and endothelial cells, implying their role in niche formation.ConclusionsBy coupling single-cell, bulk tissue, and exosomal transcriptomics, we elucidated the key molecular drivers of OV metastasis and established SCNN1A and EFNA1 as promising non-invasive biomarkers. …”
Get full text

Application of a One Health approach to translate policies to action to address priority chemical pollutants: TCDD as an example by Catherine Machalaba, Lauren Cybulska, Fiona Fogarty, Dao Nguyen, Jean Grassman

“…Abstract Pollution is a leading cause of disease burden and deaths globally, with toxic chemicals playing an increasing role. To date, there has been limited focus on a One Health approach for the effective prevention and management of chemical pollution, despite myriad toxicological connections between humans, animals, and the environment. …”
Get full text

Early Identification of Cognitive Impairment in Community Environments Through Modeling Subtle Inconsistencies in Questionnaire Responses: Machine Learning Model Development and Va... by Hongxin Gao, Stefan Schneider, Raymond Hernandez, Jenny Harris, Danny Maupin, Doerte U Junghaenel, Arie Kapteyn, Arthur Stone, Elizabeth Zelinski, Erik Meijer, Pey-Jiuan Lee, Bart Orriens, Haomiao Jin

“…Health professionals working in the community play a critical role in the early detection of cognitive impairment, yet still face several challenges such as a lack of suitable tools, necessary training, and potential stigmatization. …”
Get full text

DFT analysis of the [3 + 2] heterocyclization reaction of ((1,2,4-triazole(1,3,4-oxadiazole)-3(2)-yl)methyl)thiopyrimidines by Yu. V. Karpenko

“…Special attention is given to the role of the solvent and other factors influencing process efficiency. …”
Get full text

Six-month intervention effect of a digital movement behavior intervention on parent- and child intermediary outcomes—results from the Let’s Grow randomized controlled trial by Johanna Sandborg, Katherine L. Downing, Liliana Orellana, Rachael W. Taylor, Lisa M. Barnett, Valerie Carson, Kylie D. Hesketh

“…These included parental cognitions (knowledge, self-efficacy, confidence) and behaviors (co-participation, role modelling, family rules and routines, screens in child’s bedroom), and child developmental skills (motor skills, emotional regulation). …”
Get full text

Exploring METRNL as a novel biomarker in sepsis: diagnostic potential and secretion mechanism by Tian-Ying Xu, Jing-Xin Zhao, Ming-Yao Chen, Zhu-Wei Miao, Zhi-Yong Li, Yong-Qing Chang, Yu-Sheng Wang, Chao-Yu Miao

“…This pilot study explored the role of METRNL as a novel biomarker for sepsis by focusing on its diagnostic potential and rapid secretion mechanism. …”
Get full text

Malassezia responds to environmental pH signals through the conserved Rim/Pal pathway by Kaila M. Pianalto, Calla L. Telzrow, Hannah Brown Harding, Jacob T. Brooks, Joshua A. Granek, Eduardo Gushiken-Ibañez, Salomé LeibundGut-Landmann, Joseph Heitman, Giuseppe Ianiri, J. Andrew Alspaugh

“…These pH-sensing signaling proteins are required for optimal growth in a murine model of atopic dermatitis, a pathological condition associated with increased skin pH. …”
Get full text

Advances in B Cell Targeting for Treating Muscle-Specific Tyrosine Kinase-Associated Myasthenia Gravis by Hu G, Zhao X, Wang Y, Zhu X, Sun Z, Yu X, Wang J, Liu Q, Zhang J, Zhang Y, Yang J, Chang T, Ruan Z, Lv J, Gao F

“…Since B cells play a critical pathogenic role in producing autoantibodies and inflammatory mediators, they are often considered the preferred target for treating MuSK-MG. …”
Get full text

Determining Ligand Binding and Specificity Within the β₂-Integrin Family with a Novel Assay Platform by Carla Johanna Sommer-Plüss, Céline Leiggener, Elira Nikci, Riccardo Vincenzo Mancuso, Said Rabbani, Christina Lamers, Daniel Ricklin

“…The delineation of the molecular role of β₂ integrins and their ligands has been hampered by a shortage of validated assay systems. …”
Get full text

A study on the effect of platelet-rich plasma (PRP) to promote bone fusion in lateral interbody fusion of the lumbar spine using artificial bone by Hiroshi Noguchi, Toru Funayama, Kosuke Sato, Masao Koda, Hiroshi Takahashi, Kousei Miura, Hiroshi Kumagai, Masashi Yamazaki

“…Further research is needed to explore optimal uses of PRP in spinal fusion surgeries.…”
Get full text

Influence of climate factors on the formation of radial increment of walnut wood by Leonid Osadсhuk, Volodymyr Mahuran, Liubov Kondratiuk

“…This factor plays an essential role in ensuring a favorable soil moisture regime. …”
Get full text

Glomerular filtration rate dynamics in patients with diffuse large B-cell lymphoma during induction immunopolychemotherapy by A. S. Nozdricheva, I. B. Lysenko, N. K. Guskova, M. A. Konovalchik, A. A. Maslov, E. V. Shalashnaya

“…The study found that in patients with initially low GFR level, a further, even more pronounced decrease in GFR during pct is observed. at the same time, the absence of significant differences in GFR level depending on disease stage allows us to conclude that the leading role is not so much the stage of the disease and tumor volume, but rather the initial functional status of the kidneys in the development of renal dysfunction in patients with diffuse large B-cell lymphoma during R-CHOP therapy.…”
Get full text

Efficacy Assessment and Prognostic Value of Inflammatory Markers in Patients with Stage IV Acral and Cutaneous Melanoma Receiving PD-1 Inhibitors by Zhang Y, Qu Z, Xuan H, Lu L, Ding C, He Z, Gu K, Zhang Y

“…Pearson’s chi-squared test or Fisher’s exact test was used to compare baseline characteristics. The optimal cut-off values for these markers were stratified using time-dependent receiver operating characteristic curves (t-ROC). …”
Get full text

Design of a Micro-Plant Factory Using a Validated CFD Model by Xinxin Chen, Tengyuan Hou, Shulin Liu, Yongxiu Guo, Jianping Hu, Gaoming Xu, Guoxin Ma, Wei Liu

“…The uniformity of the cultivation environment in a micro-plant factory plays a critical role in ensuring the consistent growth of seedlings, and an optimal airflow pattern is the key to maintaining environmental uniformity. …”
Get full text

Impact of a pharmacist driven antimicrobial stewardship program on inpatient antibiotic consumption in a Chinese Tertiary Hospital: a 5-year retrospective study by Can Qian, Ting Yuan, Fuyong Zhang, Shiyuan Gou, Chunmei Jiang, Xuebing Chen, Ya Huang, Xiaolin Zhao, You Du, Chenglong Li, Yangyun Han, Huaiyu Su

“…The program focused on revising the antibiotic formulary and optimizing key points of antibiotic management, using the inpatient Antibiotic Use Density as the core control indicator. …”
Get full text

Development of a questionnaire to evaluate the management of gestational diabetes mellitus patients among obstetric nurses by Yongyan Zhu, Yongyan Zhu, Yumin Ren, Jing Ma, Feifei Wan, Feifan Liu, Fangfang Du, Weili Li, Tian Tian, Xiaoqian Liu, Lili Li, Zhumin Jia

“…BackgroundThe role of obstetric nurses in the management of gestational diabetes mellitus (GDM) is becoming increasingly important, and their management level will directly affect the patient’s health education and even the pregnancy outcome. …”
Get full text