Feasibility of a Web-Based and Mobile-Supported Follow-Up Treatment Pathway for Adult Patients With Orthopedic Trauma in the Netherlands: Concurrent Mixed Methods Study by Gijs J A Willinge, Jelle F Spierings, Kim A G J Romijnders, Elke G E Mathijssen, Bas A Twigt, J Carel Goslings, Ruben N van Veen

“…In response, digital follow-up treatment pathways were implemented for patients with orthopedic trauma, aiming to optimize health care resource use and enhance patient experiences. …”
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Burden of chronic spontaneous urticaria in Italy through healthcare resource utilization and direct costs: a retrospective analysis of real-world using administrative healthcare da... by Giulia Ronconi, Letizia Dondi, Silvia Calabria, Leonardo Dondi, Irene Dell’Anno, Lucia Casoli, Diletta Valsecchi, Ornella Bonavita, Eustachio Nettis, Nello Martini, Carlo Piccinni

“…Conclusions During the first year following the new CSU diagnosis, a lower than recommended antihistamines dispensation while an elevated use of OCS and a low and delayed omalizumab initiation after CSU exacerbation were observed, suggesting the urgent need to optimize treatment management to limit the burden on patients and healthcare systems.…”
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Pathways of soil organic carbon accrual affected by manure combined with different nitrogen application rates: Highlighting microbial life history strategies and biomarker accumula... by Yapeng Jiao, Xiangtian Meng, Peng Qi, Yunuo Li, Xinyao Zhang, Haodong Lu, Jianglan Shi, Xiaohong Tian

“…These findings indicate that plant- and microbial-derived carbon fluxes can be balanced by optimizing the coapplication of manure and N, effectively increasing SOC accrual and stability in dryland agricultural systems.…”
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Antibacterial and cytotoxicity activity of green synthesized silver nanoparticles using aqueous extract of naartjie (Citrus unshiu) fruit peels by Livhuwani Mafhala, Nomcebo Khumalo, Nkosingiphile Excellent Zikalala, Shohreh Azizi, Karen Jacqueline Cloete, Garland Kgosi More, Ilunga Alain Kamika, Touhami Mokrani, Ali Akbar Zinatizadeh, Malik Maaza

“…The results show that AgNPs synthesized from Citrus unshiu fruit peel could serve as antibacterial agents that may in the future be optimized for us in for example nanofiltration systems.…”
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Students’ motives for enrolling in the master of nursing program in Croatia despite degree recognition uncertainties: a cross-sectional study by Andrea Vuksa, Vesna Mijoc, Ivica Matic, Marta Civljak, Marin Cargo, Snježana Cukljek, Kata Ivanisevic, Mario Marendic, Zrinka Puharic, Natasa Skitarelic, Sanja Zoranic, Marijana Neuberg, Dijana Majstorovic, Alen Brecek, Ivana Barac, Livia Puljak

“…Aligning Croatia’s educational and healthcare systems to recognize and utilize MN graduates effectively could strengthen the nation’s healthcare workforce. …”
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Comparative study of endophytic bacterial strains from non-host crops for enhancing plant growth and managing early blight in tomato by Aditya Kukreti, Aditya Kukreti, Chethana Bangi Siddabasappa, Prasannakumar Muthakapalli Krishnareddy, Pramesh Devanna, Yashavanth Basavapatna Subbanna, Manjunatha Channappa, Namburi Karunakar Reddy, Abeer Hashem, Mashail Fahad Alsayed, Elsayed Fathi Abd_Allah

“…Their success in field trials suggests the potential for commercialization and large-scale use across diverse crops and pave the way for further interdisciplinary research to optimize their application in integrated pest management strategies.…”
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Harmonization trial on ESR1 testing strategies in ER+/HER2- breast cancer patients: an Italian experience by Francesco Pepe, Gianluca Russo, Konstantinos Venetis, Claudia Scimone, Lucia Palumbo, Mariantonia Nacchio, Domenica di Giovanni, Claudia Sarracino, Ilaria Tomaiuolo, Elisabetta Zulato, Matteo Fassan, Daniela Righi, Giuseppe Perrone, Dario de Biase, Gabriele Casati, Fabio Pagni, Lucia Gullotti, Antonio Rizzo, Alessandro Perez, Antonio Russo, Katia Zavaglia, Gianluca Gragnano, Domenico Cozzolino, Sabrina Alfano, Cristian Scatena, Sara D’andrea, Monica Schiappacassi, Giuseppina Roscigno, Alessia Paganotti, Renzo Boldorini, Francesco Esposito, Pierlorenzo Pallante, Daniela Furlan, Marta Sbaraglia, Angelo Paolo Dei Tos, Giancarlo Troncone, Nicola Fusco, Umberto Malapelle

“…Harmonized ring trials are key weapons to standardize analytical and post-analytical procedures optimizing clinical stratification of BC patients…”
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Causal inference study of PRRSV-MLV vaccine dosing effects on wean-to-finish performance during outbreaks by Swaminathan Jayaraman, Tyler Bauman, Amy Maschhoff, Caleb Shull, Peng Li, Edison Magalhaes, Giovani Trevisan, Daniel C. L. Linhares, Chunlin Li, Gustavo S. Silva

“…For swine producers and veterinarians, these results indicate that the economic advantage of half-dose vaccination strategies should be carefully weighed against the increased mortality, particularly in systems with recurring PRRSV challenges. This study demonstrates the value of causal inference methods in analyzing real-world vaccination outcomes and provides evidence-based guidance for optimizing PRRSV vaccination protocols in commercial swine production.…”
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Changes in root growth and water uptake contribute to the yield and water productivity improvement in winter wheat during the past three decades: A case study in the North China Pl... by Haotian Li, Na Liu, Liwei Shao, Xiuwei Liu, Hongyong Sun, Suying Chen, Xiying Zhang

“…The contribution of root systems to these improvements should be understood to develop future strategies for breeding and field management. …”
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“They Know You Better Than the Transplant Team”: An Interpretive Description Study Exploring the Perspectives of Living Kidney Donors About Care Received From Family Physicians by Katya Loban, Charo Rodriguez, Antoine Przybylak-Brouillard, Elie Fadel, Heather Badenoch, Peter Nugus, Ann Bugeja, Justin Gill, Marie-Chantal Fortin, Emilie Trinh, Scott McKay, Shaifali Sandal

“…The LKDs provide a valuable gift to our health systems and to patients with kidney failure. It is our responsibility to optimize their experiences and improve their care.…”
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Serum neuritin as a predictive biomarker of early neurological deterioration and poor prognosis after spontaneous intracerebral hemorrhage: a prospective cohort study by Yanwen Xu, Hanyu Zhu, Yuqi Su, Zhizhi Chen, Chuanliu Wang, Ming Yang, Feifei Jiang, Yunping Li, Yongming Xu

“…Furthermore, two specific weighted scoring systems were developed to optimize clinical prediction of poor prognosis and END after ICH.ConclusionElevated serum neuritin levels are strongly associated with disease severity, END, and 90-day poor neurological outcomes following ICH, establishing serum neuritin as a potential prognostic biomarker for ICH.…”
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Ellagic acid on milk production performance, blood and milk hormones, antioxidant capacity and fecal microbial communities in lactating Yili mares by Xinxin Huang, Xinxin Huang, Linjiao He, Linjiao He, Jun Ma, Yuqi Li, Jiahao Li, Jiahao Li, Changjiang Zang, Changjiang Zang, Min Hou, Xiaobin Li, Xiaobin Li

“…Future research could focus on optimizing dosage regimens and validating its efficacy in larger-scale production systems to facilitate practical application in equine husbandry.…”
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Extended-Spectrum Beta-Lactamase Production and Carbapenem Resistance in Elderly Urinary Tract Infection Patients: A Multicenter Retrospective Study from Turkey by Çiğdem Yıldırım, Sema Sarı, Ayşe Merve Parmaksızoğlu Aydın, Aysin Kilinç Toker, Ayşe Turunç Özdemir, Esra Erdem Kıvrak, Sinan Mermer, Hasip Kahraman, Orçun Soysal, Hasan Çağrı Yıldırım, Meltem Isikgoz Tasbakan

“…Multicenter data contribute to regional understanding of resistance trends, aiding clinicians in optimizing management strategies for elderly patients with UTIs. …”
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The role of gut microbiota in traditional Chinese medicine processing: A general review by Rui-Rui Qiao, Ya-Long Chen, Ya-Ya Bai, An-Dong Dong, Rui Tian, Ya-Jun Shi, Chong-Bo Zhao, Peng Zhao, Jing Sun, Qiao Zhang, Yu-Ping Tang

“…Introduction: Traditional Chinese Medicine Processing (TCMP) is an integral component of Chinese medicine culture, playing a crucial role in altering the pharmacological properties of herbs, increasing their efficacy and mitigating their toxicity and adverse reactions, in order to optimize their therapeutic efficacy. Recent research has established a correlation between the gut microbiota (GM) and various physiological systems, implicating their role in disease pathogenesis. …”
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Synthesis of Mixed Metal Nano-Oxides (MMNOs) for Cu (II) adsorption with remarkable removal efficiency: Isothermal, kinetics, and thermodynamics studies by Asmaa.M. Farid, Ahmed abdelkhalek, Ahmed A. Allam, Haifa E. Alfassam, Rehab Mahmoud, Fatma Mohamed

“…The batch adsorption technique was optimized, resulting in (pH = 5.5, temperature = 30 °C, dose = 0.05 gm, concentration = 10 mg/L, time = 120 min). …”
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A case study of the co-creation of the PrEP-SIC: a roadmap to support introduction of pre-exposure prophylaxis into new settings by Kathrine Meyers, Benjamin Lane, Jason Zucker, Yumeng Wu, Caroline Carnevale, Helen Burnside, Sarah Rowan, Eric Mayes, Gilianne Narcisse-Cempini, Melanie A. Gold, Lisa Saldana, Sarit A. Golub

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CPFD Simulation of Operation Characteristics of a 10t/d Sludge and Biomass Co-incineration Fluidized Bed Reactor by REN Shaohui, YU Qiao, LIN Li, XIANG Jiatao, MA Lun, ZHANG Shihong

“…The CPFD framework demonstrates exceptional utility in predicting scaling effects, with the optimized operational envelope (primary air 700-805 Nm³/h, biomass ≤3 cm, dolomite 150-275μm, opposing inlets) reducing theoretical CNO emissions by 38-72% versus conventional configurations. …”
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Efficacy and safety of traditional Chinese medicine for post-COVID-19 syndrome: a systematic review and meta-analysis by Yiting Wang, Xiao Li, Huaizheng Hui, Dianxing Yang

“…Further large-scale, high-quality trials are needed to validate these outcomes and optimize treatment strategies. Systematic Review Registration: https://www.crd.york.ac.uk/PROSPERO/home , CRD420251016442.…”
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Classifying Dry Eye Disease Patients from Healthy Controls Using Machine Learning and Metabolomics Data by Sajad Amouei Sheshkal, Morten Gundersen, Michael Alexander Riegler, Øygunn Aass Utheim, Kjell Gunnar Gundersen, Helge Rootwelt, Katja Benedikte Prestø Elgstøen, Hugo Lewi Hammer

“…The models were evaluated and optimized using nested k-fold cross-validation. To assess the performance of these models, we selected a set of suitable evaluation metrics tailored to the data set’s challenges. …”
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A comparative performance evaluation of 12 HIV-1 viral load testing asssays: advancing the clinical application of HIV-1 nucleic acid testing in China by Yu Wang, Pinliang Pan, Wenge Xing, Xin Zhang, Boxue Han, Cong Jin

“…These findings provide evidence for optimizing HIV-1 NAT strategies, supporting the adoption of cost-effective domestic kits, and guiding future improvements for low-level viremia monitoring.…”
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