Characterization of ion track-etched conical nanopores in thermal and PECVD SiO2 using small angle X-ray scattering by Shankar Dutt, Rudradeep Chakraborty, Christian Notthoff, Pablo Mota-Santiago, Christina Trautmann, Patrick Kluth

“…These findings provide crucial insights for the controlled fabrication of conical nanopores in different materials, which is essential for optimizing membrane performance in applications that require precise pore geometry.…”
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Safety and immunogenicity of freeze-dried human rabies vaccines: A phase 3 clinical trial of Zagreb and Essen regimes by Jia Li, Zhiang Wu, Xiaohong Wu, Yunpeng Wang, Leitai Shi, Danhua Zhao, Haiyan Liang, Zhaojun Mo, Shouchun Cao

“…Recently optimized freeze-dried rabies vaccines (Vero cell) are promising for rabies prevention; however, comparisons of Essen 5-dose and Zagreb 4-dose regimens are needed for clinical applications. …”
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A Near-Infrared Fluorescent Probe for Specific Imaging of Lymph Node Metastases in Ovarian Cancer via Active Targeting of the Gonadotropin-Releasing Hormone Receptor by Qiyu Liu, Jiaan Sun, Xiaobo Zhou, Mingxing Zhang, Tao Pu, Xiaolan Gao, Meng Zhang, Congjian Xu, Xiaoyan Zhang

“…Notably, GnRHa-PEG-Rh760 exhibited excellent biocompatibility with no observed systemic toxicity as evidenced by hematologic and histopathologic analyses. …”
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Dynamic Characterization of Microscopic Pore Structure in Medium–High Permeability Sandstones During Waterflooding by Jiayi Wu, Wenbo Gong, Qingyu Wang, Yuhang He, Junhui Guo, Yi Bao, Shuai Shao, Rubin Li

“…Moreover, the proposed classification framework offers valuable guidance for optimizing enhanced oil recovery strategies in the late stages of ultra-high water cut development.…”
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Deep Brain Stimulation and Brain–Spine Interface for Functional Restoration in Spinal Cord Injury by Barnabas T. Shiferaw, Max Y. Jin, Milan Patel, Lukas J. Henjum, Alaa Abd-Elsayed

“…While further research is needed to optimize these strategies, these advancements hold immense potential for improving the quality of life in SCI patients and advancing the field of neuromodulation.…”
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Blood product administration in the prehospital setting: a multisociety consensus statement by Luca Carenzo, Etrusca Brogi, Vanessa Agostini, Stefania Armani, Roberto Balagna, Maria Grazia Bocci, Antonio Cascio, Michela Ciminello, Andrea Cortegiani, Massimiliano Di Biagio, Patrizia Di Gregorio, Andrea Fabbri, Lara Gianesello, Guglielmo Imbriaco, Cristian Lupi, Lucia Mirabella, Stefano Paglia, Andrea Paoli, Silvia Pini, Silvano Rossini, Giovanni Sbrana

“…Furthermore, close collaboration between emergency medical services and blood banks is essential to ensure compliance with national guidelines and to optimize patient outcomes. This consensus document was developed through a systematic literature review and a modified Delphi method, involving blind voting and consensus evaluation using a Likert scale. …”
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In silico profiling of neem limonoids and gut microbiome metabolites for Alzheimer’s therapeutics: targeted inhibition of BACE1 and elucidation of intricate molecular crosstalk wit... by Oluwaseun E. Agboola, Zainab A. Ayinla, Samuel S. Agboola, Esther Y. Omolayo, Abimbola E. Fadugba, Othuke B. Odeghe, Oluranti E. Olaiya, Babatunji E. Oyinloye

“…These findings establish limonoids’ superiority over gut microbiome metabolites and highlight their therapeutic potential as multi-target inhibitors in AD pathology, warranting investment in nanocarrier systems for optimizing BBB penetration.…”
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Miniaturizable Phase-Sensitive Amplifier Based on Vector Dual-Pump Structure for Phase Regeneration of PDM Signal by Shuaiwei Jia, Zhuang Xie, Wen Shao, Xiaotian Han, Yulong Su, Jiacheng Meng, Duorui Gao, Wei Wang, Xiaoping Xie

“…Similarly, the EVMs of the two polarization states of the deteriorated QPSK signals are optimized from 28.9% and 29.3% to 13.7% and 13.9%, respectively. …”
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Izokibep: Preclinical development and first-in-human study of a novel IL-17A neutralizing Affibody molecule in patients with plaque psoriasis by Susanne Klint, Joachim Feldwisch, Lindvi Gudmundsdotter, Karin Dillner Bergstedt, Elin Gunneriusson, Ingmarie Höidén Guthenberg, Anders Wennborg, Andrew C. Nyborg, Amol P. Kamboj, Paul M. Peloso, David Bejker, Fredrik Y. Frejd

“…Treatment with monoclonal antibodies (mAbs) against IL−17A provides an improvement in the Psoriasis Area and Severity Index compared to conventional systemic agents. In this study, the AffibodyⓇ technology was used to identify and optimize a novel, small, biological molecule comprising three triple helical affinity domains, izokibep (previously ABY-035), for the inhibition of IL-17A signaling. …”
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Modeling and Simulation on the Hybrid Solution of Static Var Generator and Synchronous Condenser for Unlocking Power Output Limitation of Wind Farms Integrated into Weak Grid by Haiyang Liang, Yanbin Zhang, Shuran Liu, Jianling Wu, Jifeng Fan, Yi Zhang, Junjie Yu, Tianlong Zhang, Ziyi Zhu

“…The issues of low inertia, overvoltage, and wide-frequency oscillations in high-proportion renewable energy systems have become prominent, posing major challenges to renewable energy integration and threatening grid stability. …”
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Improvement of Esterifying Power of Isolated <i>Bacillus velezensis</i> from Daqu by Atmospheric Pressure and Room Temperature Plasma Mutagenesis by Chuan Song, Tongwei Guan, Zhuang Xiong, Xiaodie Chen, Wenying Tu, Yanping Xu, Xiyue Yan, Qiang Li

“…This study highlights the potential of ARTP mutagenesis in optimizing brewing microorganisms and improving the quality and consistency of Strong-flavor Baijiu.…”
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Applicability of Machine Learning and Mathematical Equations to the Prediction of Total Organic Carbon in Cambrian Shale, Sichuan Basin, China by Majia Zheng, Meng Zhao, Ya Wu, Kangjun Chen, Jiwei Zheng, Xianglu Tang, Dadong Liu

“…Future directions emphasize real-time drilling data integration and quantum computing-enhanced modeling for ultra-deep shale systems, advancing predictive capabilities in tectonically complex basins.…”
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Partitioned Recirculating Renovation for Traditional Rice–Fish Farming Induced Substantial Alterations in Bacterial Communities Within Paddy Soil by Yiran Hou, Hongwei Li, Rui Jia, Linjun Zhou, Bing Li, Jian Zhu

“…Overall, these results elucidated the ecological impacts of partitioned recirculating renovation on the paddy soil from a microbiomic perspective, providing a microbial basis for optimizing partitioned rice–fish systems.…”
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Crystal Facet Engineering of 2D SnSe₂ Photocatalysts for Efficient Degradation of Malachite Green Organic Dyes by Liying Wen, Fangfang Cheng, Xinyu Zhao, Lin Han, Dongye Zhao, Shifeng Wang

“…By regulating the exposure ratio of the active (001)/(011) facets, we demonstrate that crystal facet engineering directly optimizes carrier separation efficiency, thereby substantially enhancing the catalytic performance of standalone SnSe₂. …”
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Multidrug-Resistant Infections and Metabolic Syndrome: An Overlooked Bidirectional Relationship by Carlo Acierno, Riccardo Nevola, Fannia Barletta, Luca Rinaldi, Ferdinando Carlo Sasso, Luigi Elio Adinolfi, Alfredo Caturano

“…Recognizing this reciprocal relationship is pivotal for refining infection risk stratification, optimizing treatment, and informing public health policies. …”
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Rainfall and High Humidity Influence the Seasonal Dynamics of Spores of <i>Glomerellaceae</i> and <i>Botryosphaeriaceae</i> Genera in Avocado Orchards and Their Fruit Rot Associati... by Lorena Tapia, Diyanira Castillo-Novales, Natalia Riquelme, Ana Luisa Valencia, Alejandra Larach, Ricardo Cautín, Ximena Besoain

“…These findings highlight the potential of incorporating climatic indicators—such as rainfall thresholds and humidity levels—into monitoring and early-warning systems to optimize fungicide application timing, reduce unnecessary chemical use, and improve postharvest disease management in avocado production.…”
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Impact of RAS, BRAF mutations and microsatellite status in peritoneal metastases from colorectal cancer treated with cytoreduction + HIPEC: scoping review by Valentina Zucchini, Fabrizio D’Acapito, Ilario Giovanni Rapposelli, Massimo Framarini, Daniela Di Pietrantonio, Riccardo Turrini, Eleonora Pozzi, Giorgio Ercolani

“…MSI status appears to attenuate the adverse effects of RAS/BRAF mutations on survival, although conflicting data persist.Conclusion RAS and BRAF mutations correlate with poorer outcomes in PM-CRC, underscoring the need for mutation-informed strategies to refine HIPEC and systemic therapies. Recognizing subtypes may improve patient selection for CRS-HIPEC, optimizing both local disease control and long-term survival. …”
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Therapeutic Potential of Rho Kinase Inhibitors in Corneal Disease: A Systematic Review of Preclinical and Clinical Studies by Laura Andreea Ghenciu, Diana Andrei, Claudia Borza, Roxana Iacob, Emil Robert Stoicescu, Sorin Lucian Bolintineanu, Daniela Iacob, Ovidiu Alin Haţegan

“…Future work should explore novel delivery systems and larger controlled trials to optimize dosing, safety, and long-term outcomes.…”
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Tumor-infiltrating lymphocytes in cancer immunotherapy: from chemotactic recruitment to translational modeling by Fatjona Pupuleku Kraja, Vladimir B. Jurisic, Altijana Hromić-Jahjefendić, Nafsika Rossopoulou, Theodora Katsila, Katarina Mirjacic Martinovic, Javier De Las Rivas, Carmen Cristina Diaconu, Árpád Szöőr

“…Special emphasis is placed on preclinical models that evaluate TIL function, including 3D tumor spheroids, organoid co-cultures, syngeneic mouse models, and humanized systems. These provide valuable platforms for optimizing TIL-based therapies. …”
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Investigating the Response of Rainfed Chickpea (Cicer arietinum L.) to Different Nitrogen Fertilizer Levels in Cold Regions by Yaser Azimzadeh, Arash Mohammadzadeh, Hamid Hasanian Khoshroo, Gholamreza Ghahramanian

“…Starter N bolstered early growth and photosynthetic capacity, enhancing yields. Moderate N optimized harvest index by favoring grain over biomass allocation. …”
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